| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naveen Kumar Singhal, Garima Srivastava, Sonal Agrawal, Swatantra Kumar Jain, Mahendra Pratap Sing. Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation? Molecular neurobiology. vol 45. issue 1. 2012-09-24. PMID:22198804. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by the selective degeneration of the nigrostriatal dopaminergic neurons, continuing or permanent deficiency of dopamine, accretion of an abnormal form of alpha synuclein in the adjacent neurons, and dysregulation of ubiquitin proteasomal system, mitochondrial metabolism, permeability and integrity, and cellular apoptosis resulting in rigidity, bradykinesia, resting tremor, and postural instability. |
2012-09-24 |
2023-08-12 |
Not clear |
| Katsuya Nakamura, Yoshiki Sekijima, Kiyoshiro Nagamatsu, Kunihiro Yoshida, Shu-ichi Iked. A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea. Journal of the neurological sciences. vol 313. issue 1-2. 2012-09-20. PMID:21982616. |
the dopamine agonist, ropinirole hydrochloride, reduced her choreic movements, suggesting that levodopa and/or dopamine agonists may compensate for underdeveloped dopaminergic pathways in this disorder. |
2012-09-20 |
2023-08-12 |
Not clear |
| Pamela Sabioni, Vânia D'Almeida, Monica L Andersen, Roberto Andreatini, José C F Galduró. SKF 38393 reverses cocaine-conditioned place preference in mice. Neuroscience letters. vol 513. issue 2. 2012-09-18. PMID:22387069. |
some studies using animal models have shown positive effects of dopaminergic agents such as partial agonists of the dopamine d1 receptor. |
2012-09-18 |
2023-08-12 |
mouse |
| C Ruiz, M J Casarejos, I Rubio, S Gines, M Puigdellivol, J Alberch, M A Mena, J G de Yebene. The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins. Brain research. vol 1459. 2012-09-18. PMID:22560595. |
pridopidine and (-)-osu6162 are members of a new family of compounds referred to as dopaminergic stabilizers, which normalize abnormal dopamine neurotransmission. |
2012-09-18 |
2023-08-12 |
mouse |
| C Ruiz, M J Casarejos, I Rubio, S Gines, M Puigdellivol, J Alberch, M A Mena, J G de Yebene. The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins. Brain research. vol 1459. 2012-09-18. PMID:22560595. |
as we found prevention of toxicity of some of these neurotoxins, we investigated the putative neuroprotective mechanisms of action of (-)-osu6162 measuring the effects of this dopaminergic stabilizer on expression and release of bdnf, the ratios of bcl2/bax proteins and of p-erk/erk, the levels of chaperones and gsh, and the effects of (-)-osu6162 on dopamine uptake and release. |
2012-09-18 |
2023-08-12 |
mouse |
| Jun Kawamata, Syuuichirou Suzuki, Shun Shimoham. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Current drug targets. vol 13. issue 5. 2012-09-17. PMID:22300030. |
parkinson's disease (pd) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. |
2012-09-17 |
2023-08-12 |
Not clear |
| Richard L Dot. Olfaction in Parkinson's disease and related disorders. Neurobiology of disease. vol 46. issue 3. 2012-09-14. PMID:22192366. |
the role of dopamine in the production of olfactory system pathology is enigmatic, as overexpression of dopaminergic cells within the bulb's glomerular layer is a common feature of pd and most animal models of pd. |
2012-09-14 |
2023-08-12 |
Not clear |
| Lakkakula V K S Bhaskar, Kumarasamy Thangaraj, Samiksha Wasnik, Lalji Singh, Vadlamudi Raghavendra Ra. Dopamine transporter (DAT1) VNTR polymorphism and alcoholism in two culturally different populations of south India. The American journal on addictions. vol 21. issue 4. 2012-09-14. PMID:22691013. |
dopamine transporter (dat1) mediates the active re-uptake of da from the synapse and is a principal regulator of dopaminergic neurotransmission. |
2012-09-14 |
2023-08-12 |
human |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Juan Segura-Aguila. Dopamine oxidation and autophagy. Parkinson's disease. vol 2012. 2012-09-12. PMID:22966478. |
here, we discuss the relationship between the oxidation of dopamine to aminochrome, the precursor of neuromelanin, autophagy dysfunction in dopaminergic neurons containing neuromelanin, and the role of dopamine oxidation to aminochrome in autophagy dysfunction in dopaminergic neurons. |
2012-09-12 |
2023-08-12 |
Not clear |
| M Emdadul Haque, Matthew P Mount, Farzaneh Safarpour, Elizabeth Abdel-Messih, Steve Callaghan, Chantal Mazerolle, Tohru Kitada, Ruth S Slack, Valerie Wallace, Jie Shen, Hymie Anisman, David S Par. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. The Journal of biological chemistry. vol 287. issue 27. 2012-09-11. PMID:22511790. |
this sensitivity was associated with greater loss of dopaminergic neurons in the substantia nigra pars compacta and terminal dopamine fiber density in the striatum region. |
2012-09-11 |
2023-08-12 |
mouse |
| Garrett E Alexande. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues in clinical neuroscience. vol 6. issue 3. 2012-09-10. PMID:22033559. |
the characteristic motor impairments - bradykinesia, rigidity, and resting tremor - result from degenerative loss of midbrain dopamine (da) neurons in the substantia nigra, and are responsive to symptomatic treatment with dopaminergic medications and functional neurosurgery. |
2012-09-10 |
2023-08-12 |
human |
| Mika Takeshima, Maiko Murata, Natsuho Urasoe, Shinki Murakami, Ikuko Miyazaki, Masato Asanuma, Taizo Kit. Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity. Neurological research. vol 33. issue 10. 2012-09-10. PMID:22196758. |
the present study was undertaken to investigate the neuroprotective effect of baicalein against dopamine (da) neurotoxicity induced by exposure to a synthetic da precursor, l-3,4-dihydroxyphenylalanine (l-dopa), in cultured dopaminergic cath.a cells. |
2012-09-10 |
2023-08-12 |
Not clear |
| Andrea Anzalone, José E Lizardi-Ortiz, Maria Ramos, Claudia De Mei, F Woodward Hopf, Ciro Iaccarino, Briac Halbout, Jacob Jacobsen, Chisato Kinoshita, Marc Welter, Marc G Caron, Antonello Bonci, David Sulzer, Emiliana Borrell. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 26. 2012-09-10. PMID:22745501. |
dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (da) levels are causally linked to parkinson's disease, schizophrenia, and addiction. |
2012-09-10 |
2023-08-12 |
mouse |
| Beatriz De la Casa-Fages, Francisco Granda. Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Journal of the neurological sciences. vol 312. issue 1-2. 2012-09-07. PMID:21872889. |
dopamine dysregulation syndrome is a complication of the dopaminergic treatment for parkinson's disease, probably related to sensitization of the mesolimbic dopamine system. |
2012-09-07 |
2023-08-12 |
Not clear |
| Beatriz De la Casa-Fages, Francisco Granda. Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Journal of the neurological sciences. vol 312. issue 1-2. 2012-09-07. PMID:21872889. |
we hypothesized that the combined effect of dopaminergic replacement therapy and deep brain stimulation on the limbic territory of the subthalamic nucleus could have precipitated the dopamine dysregulation syndrome in these patients, by inducing hyperstimulation of the mesolimbic dopamine system. |
2012-09-07 |
2023-08-12 |
Not clear |
| Beatriz De la Casa-Fages, Francisco Granda. Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Journal of the neurological sciences. vol 312. issue 1-2. 2012-09-07. PMID:21872889. |
the outcome of postoperative dopamine dysregulation syndrome is poor despite deep brain stimulation adjustments, attempts to reduce the dose of dopaminergic drugs and the addition of quetiapine or antidepressants. |
2012-09-07 |
2023-08-12 |
Not clear |
| K Kawamoto, K Otsuguro, M Ishizuka, S It. Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats. British journal of pharmacology. vol 166. issue 2. 2012-09-07. PMID:22168428. |
dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. |
2012-09-07 |
2023-08-12 |
rat |
| Wen Jun Li, Chang Gui Kou, Yaqin Yu, Shilong Sun, Xuan Zhang, Thomas R Kosten, Xiang Yang Zhan. Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 4. 2012-09-04. PMID:22354729. |
the gene encoding catechol-o-methyltransferase (comt), a dopamine catabolic enzyme, has been associated inconsistently with schizophrenia in spite of consistent evidence for dopaminergic dysfunction in the prefrontal cortex (pfc) of schizophrenia. |
2012-09-04 |
2023-08-12 |
Not clear |
| Ghiabe-Henri Guibinga, Gorjan Hrustanovic, Kathryn Bouic, Hyder A Jinnah, Theodore Friedman. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Human molecular genetics. vol 21. issue 3. 2012-08-30. PMID:22042773. |
our findings in sh-sy5y cells demonstrate that hprt deficiency is accompanied by dysregulation of some of the important pathways that regulate the development of dopaminergic neurons and dopamine pathways and that this defect is associated with and possibly due at least partly to aberrant expression of mir181a. |
2012-08-30 |
2023-08-12 |
human |
| Jeong Won Jahng, Sang Bae Yoo, Jin Young Kim, Bom-Taeck Kim, Jong-Ho Le. Increased mesohippocampal dopaminergic activity and improved depression-like behaviors in maternally separated rats following repeated fasting/refeeding cycles. Journal of obesity. vol 2012. 2012-08-30. PMID:22934157. |
fasting/refeeding cycles increased dopamine levels not only in the hippocampus but also in the midbrain dopaminergic neurons in ms rats, but not in nh controls. |
2012-08-30 |
2023-08-12 |
rat |