| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meret Nora Gaugler, Ozgur Genc, Wojciech Bobela, Safa Mohanna, Mustafa Taleb Ardah, Omar Mukhtar El-Agnaf, Marco Cantoni, Jean-Charles Bensadoun, Ralf Schneggenburger, Graham W Knott, Patrick Aebischer, Bernard Laurent Schneide. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta neuropathologica. vol 123. issue 5. 2012-08-01. PMID:22361813. |
interestingly, the membrane-binding-deficient a30p mutant does neither notably reduce dopamine release nor it cause ultrastructural changes in dopaminergic axons, showing that α-syn's membrane-binding properties are critically involved in the presynaptic defects. |
2012-08-01 |
2023-08-12 |
human |
| Meret Nora Gaugler, Ozgur Genc, Wojciech Bobela, Safa Mohanna, Mustafa Taleb Ardah, Omar Mukhtar El-Agnaf, Marco Cantoni, Jean-Charles Bensadoun, Ralf Schneggenburger, Graham W Knott, Patrick Aebischer, Bernard Laurent Schneide. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta neuropathologica. vol 123. issue 5. 2012-08-01. PMID:22361813. |
overall, these results demonstrate that α-syn overabundance is detrimental to dopamine neurotransmission at early stages of the degeneration of nigrostriatal dopaminergic axons. |
2012-08-01 |
2023-08-12 |
human |
| Tadashi Saigusa, Yuri Aono, Reiko Sekino, Takuya Uchida, Koji Takada, Yoshiyuki Oi, Noriaki Koshikawa, Alexander R Cool. In vivo neurochemical evidence that newly synthesised GABA activates GABA(B), but not GABA(A), receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21964521. |
gaba released from accumbal gabaergic interneurons plays an inhibitory role in the regulation of dopamine efflux through gaba(b) and gaba(a) receptors located on accumbal dopaminergic nerve endings. |
2012-07-27 |
2023-08-12 |
rat |
| Aldo A Rodriguez-Menchaca, Ernesto Solis, Krasnodara Cameron, Louis J De Felic. S(+)amphetamine induces a persistent leak in the human dopamine transporter: molecular stent hypothesis. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:22014068. |
wherever they are located, dopamine transporters (dats) clear dopamine (da) from the extracellular milieu to help regulate dopaminergic signalling. |
2012-07-27 |
2023-08-12 |
human |
| b' Valentina Di Liberto, Johanna M\\xc3\\xa4kel\\xc3\\xa4, Laura Korhonen, Melania Olivieri, Timofey Tselykh, Annika M\\xc3\\xa4lki\\xc3\\xa4, Hai Do Thi, Natale Belluardo, Dan Lindholm, Giuseppa Mud\\xc3\\xb. Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22041555.' |
involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. |
2012-07-27 |
2023-08-12 |
mouse |
| Uwe Oberländer, Katrien Pletinckx, Anja Döhler, Nora Müller, Manfred B Lutz, Thomas Arzberger, Peter Riederer, Manfred Gerlach, Eleni Koutsilieri, Carsten Schelle. Neuromelanin is an immune stimulator for dendritic cells in vitro. BMC neuroscience. vol 12. 2012-07-26. PMID:22085464. |
parkinson's disease (pd) is characterized at the cellular level by a destruction of neuromelanin (nm)-containing dopaminergic cells and a profound reduction in striatal dopamine. |
2012-07-26 |
2023-08-12 |
Not clear |
| Houbo Jiang, Yong Ren, Eunice Y Yuen, Ping Zhong, Mahboobe Ghaedi, Zhixing Hu, Gissou Azabdaftari, Kazuhiro Nakaso, Zhen Yan, Jian Fen. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature communications. vol 3. 2012-07-26. PMID:22314364. |
parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. |
2012-07-26 |
2023-08-12 |
mouse |
| Mehmet Fatih Ceylan, Sahnur Sener, Aslihan Cavunt Bayraktar, Mustafa Kavutc. Changes in oxidative stress and cellular immunity serum markers in attention-deficit/hyperactivity disorder. Psychiatry and clinical neurosciences. vol 66. issue 3. 2012-07-26. PMID:22443244. |
according to the prevailing view, the main factors contributing to the disorder are prefrontal dopamine deficiency and central dopaminergic dysfunction, but the factors/mechanisms involved in the brain dysfunction and its consequences are not well known. |
2012-07-26 |
2023-08-12 |
Not clear |
| Mercedes Unzeta, Elisenda San. Novel MAO-B inhibitors: potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson's disease. International review of neurobiology. vol 100. 2012-07-24. PMID:21971010. |
parkinson's disease (pd) is a neurodegenerative disease that is characterized by preferential loss of dopaminergic neurons in the substantia nigra pars compacta, leading to declining levels of dopamine in the striatum. |
2012-07-24 |
2023-08-12 |
Not clear |
| Kao Chin Chen, I Hui Lee, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Yen Kuang Yang, Ru-Band Lu, Chwen Cheng Che. Schizotypy trait and striatal dopamine receptors in healthy volunteers. Psychiatry research. vol 201. issue 3. 2012-07-24. PMID:22429746. |
dopaminergic hyperactivity in the striatum has been related to the positive symptoms of schizophrenia, and brain-imaging studies of dopamine uptake in the striatum are thought to be linked to the pathophysiological mechanisms underlying schizophrenia. |
2012-07-24 |
2023-08-12 |
human |
| M Bousquet, I St-Amour, M Vandal, P Julien, F Cicchetti, F Calo. High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21971528. |
as expected, the mptp treatment produced nigral dopaminergic degeneration as evidenced by the loss of striatal dopamine and the decreased number of nigral tyrosine hydroxylase (th)- and dopamine transporter-expressing neurons (23% and 25%, respectively). |
2012-07-23 |
2023-08-12 |
mouse |
| M Bousquet, I St-Amour, M Vandal, P Julien, F Cicchetti, F Calo. High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21971528. |
however, exposure to hfd exacerbated the effects of mptp on striatal th (23%) and dopamine levels (32%), indicating that diet-induced obesity is associated with a reduced capacity of nigral dopaminergic terminals to cope with mptp-induced neurotoxicity. |
2012-07-23 |
2023-08-12 |
mouse |
| Éva M Szego, Ellen Gerhardt, Pawel Kermer, Jörg B Schul. A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:22001606. |
dopamine (da) replacement is the most effective therapy for ameliorating the motor symptoms of pd; however, it remains controversial whether da-replacement boosts regeneration in the dopaminergic system or accelerates disease progression and enhances neuronal loss. |
2012-07-23 |
2023-08-12 |
mouse |
| Xiao Sun, Qiu-Wan Zhang, Ming Xu, Jian-Jun Guo, Shu-Wen Shen, Yong-Quan Wang, Feng-Yan Su. New striatal neurons form projections to substantia nigra in adult rat brain after stroke. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:22005319. |
these new striatal neurons express glutamate nr2 and dopamine d2l receptors, which form the molecular basis for responding to the inputs from cortical glutamatergic and nigral dopaminergic projection neurons. |
2012-07-23 |
2023-08-12 |
rat |
| Philip Gorwood, Yann Le Strat, Nicolas Ramoz, Caroline Dubertret, Jean-Marie Moalic, Michel Simonnea. Genetics of dopamine receptors and drug addiction. Human genetics. vol 131. issue 6. 2012-07-20. PMID:22350797. |
dopamine plays a key role in reward behavior, yet the association of drug dependence as a chronic, relapsing disorder with the genes encoding the various dopaminergic receptor subtypes remains difficult to delineate. |
2012-07-20 |
2023-08-12 |
Not clear |
| Philip Gorwood, Yann Le Strat, Nicolas Ramoz, Caroline Dubertret, Jean-Marie Moalic, Michel Simonnea. Genetics of dopamine receptors and drug addiction. Human genetics. vol 131. issue 6. 2012-07-20. PMID:22350797. |
in the context of subsequent genome-wide association (gwas) research and post-gwas investigations, we summarize the novel data that link genes encoding molecules involved in the dopaminergic system (dopamine receptors, transporter and enzymes in charge of its metabolism) to drug addiction. |
2012-07-20 |
2023-08-12 |
Not clear |
| David J G Watson, Florence Loiseau, Manuela Ingallinesi, Mark J Millan, Charles A Marsden, Kevin C F Fon. Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22030711. |
these data have important implications for exploitation of dopaminergic mechanisms in the treatment of schizophrenia and other cns disorders, and support the potential therapeutic utility of dopamine d(3) receptor antagonism. |
2012-07-19 |
2023-08-12 |
mouse |
| K Misono, A Lessar. Apomorphine-evoked redistribution of neurokinin-3 receptors in dopaminergic dendrites and neuronal nuclei of the rat ventral tegmental area. Neuroscience. vol 203. 2012-07-19. PMID:22200547. |
in the present study, trafficking of the nk(3) receptor in somatodendritic profiles of dopaminergic and non-dopaminergic neurons of the rat vta was investigated following acute systemic administration of the dopamine d(1)/d(2) receptor agonist apomorphine. |
2012-07-19 |
2023-08-12 |
rat |
| Tomohiro Abekawa, Koki Ito, Yasuya Nakato, Tsukasa Koyam. [Innovation of an animal model for the pathophysiology of schizophrenia]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 114. issue 2. 2012-07-19. PMID:22568111. |
the pharmacological treatment of schizophrenia now faces a turning point where we are preparing for the introduction of medications which have the mechanism of modulating glutamatergic neurotransmission, in contrast to antipsychotics which have the main mechanism of blocking and modulating d2-type dopamine receptor-mediated dopaminergic neurotransmission. |
2012-07-19 |
2023-08-12 |
Not clear |
| A M Smith, K A Wellmann, T M Lundblad, M L Carter, S Barron, L P Dwoski. Lobeline attenuates neonatal ethanol-mediated changes in hyperactivity and dopamine transporter function in the prefrontal cortex in rats. Neuroscience. vol 206. 2012-07-18. PMID:22119644. |
in the current study, lobeline, which interacts with proteins in dopaminergic presynaptic terminals, was evaluated for its ability to attenuate neonatal ethanol-induced locomotor hyperactivity and alterations in dopamine transporter (dat) function in striatum and prefrontal cortex (pfc). |
2012-07-18 |
2023-08-12 |
rat |