| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fouad El-Shehabi, Amira Taman, Lorena S Moali, Nelly El-Sakkary, Paula Ribeir. A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system. PLoS neglected tropical diseases. vol 6. issue 2. 2012-06-22. PMID:22389736. |
in addition, we show that dopamine, epinine and other dopaminergic agents have strong effects on the motility of larval schistosomes in culture. |
2012-06-22 |
2023-08-12 |
Not clear |
| Kenneth Blum, Amanda L C Chen, Marlene Oscar-Berman, Thomas J H Chen, Joel Lubar, Nancy White, Judith Lubar, Abdalla Bowirrat, Eric Braverman, John Schoolfield, Roger L Waite, Bernard W Downs, Margaret Madigan, David E Comings, Caroline Davis, Mallory M Kerner, Jennifer Knopf, Tomas Palomo, John J Giordano, Siobhan A Morse, Frank Fornari, Debmalya Barh, John Femino, John A Baile. Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. International journal of environmental research and public health. vol 8. issue 12. 2012-06-19. PMID:22408582. |
we evaluated the potential association of four variants of dopaminergic candidate genes in rds (dopamine d1 receptor gene [drd1]; dopamine d2 receptor gene [drd2]; dopamine transporter gene [dat1]; dopamine beta-hydroxylase gene [dbh]). |
2012-06-19 |
2023-08-12 |
human |
| C Ciron, S Lengacher, J Dusonchet, P Aebischer, B L Schneide. Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function. Human molecular genetics. vol 21. issue 8. 2012-06-18. PMID:22246294. |
in the adult rat nigrostriatal system, adeno-associated virus (aav)-mediated overexpression of pgc-1α induces the selective loss of dopaminergic markers and increases dopamine (da) catabolism, leading to a reduction in striatal da content. |
2012-06-18 |
2023-08-12 |
rat |
| F-M Werner, R Coveña. Classical neurotransmitters and neuropeptides involved in generalized epilepsy: a focus on antiepileptic drugs. Current medicinal chemistry. vol 18. issue 32. 2012-06-13. PMID:22050744. |
gamma aminobutyric acid (gaba) hypoactivity induces dopamine hyperactivity because dopaminergic neurons are affected by the inhibitory influence of the gabaergic system through gaba(a) receptors. |
2012-06-13 |
2023-08-12 |
Not clear |
| Jung Hoon Kan. Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides. BMB reports. vol 45. issue 2. 2012-06-13. PMID:22360890. |
salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegeneration. |
2012-06-13 |
2023-08-12 |
Not clear |
| Xu Yue, Torsten Falk, Leslie A Zuniga, Lajos Szabò, Frank Porreca, Robin Polt, Scott J Sherma. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain research. vol 1413. 2012-06-12. PMID:21840512. |
taken together, the results from these two models are consistent with the glycopeptide opioid agonist mmp-2200 having a potent effect on movements related to dopaminergic hyper-stimulation following striatal dopamine depletion that are best explained by a reduction in the downstream effects of dopamine agonists in these models. |
2012-06-12 |
2023-08-12 |
rat |
| Matthew J Van Hook, Kwoon Y Wong, David M Berso. Dopaminergic modulation of ganglion-cell photoreceptors in rat. The European journal of neuroscience. vol 35. issue 4. 2012-06-12. PMID:22304466. |
because dendrites from one subclass of these cells - the m1-type iprgcs - make presumptive synaptic contacts at sites of dopamine release from dopaminergic amacrine cells, they are prime targets for modulation by dopamine, a neuromodulator implicated in retinal circadian rhythms and light adaptation. |
2012-06-12 |
2023-08-12 |
rat |
| Silke Anders, Benjamin Sack, Anna Pohl, Thomas Münte, Peter Pramstaller, Christine Klein, Ferdinand Binkofsk. Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain : a journal of neurology. vol 135. issue Pt 4. 2012-06-08. PMID:22434215. |
neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant parkin or pink1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. |
2012-06-08 |
2023-08-12 |
human |
| Jarosław Sławe. [Levodopa in the treatment of Parkinson disease -- yesterday and today]. Neurologia i neurochirurgia polska. vol 46. issue 1. 2012-06-07. PMID:22426764. |
at the late stages the levodopa treatment is a challenge due to the changes in reactivity to single doses as a result of changes in its pharmacokinetics, reactivity of dopamine receptors and progressive loss of dopaminergic neurons. |
2012-06-07 |
2023-08-12 |
Not clear |
| Xue-Feng Tan, Guo-Hua Jin, Mei-Ling Tian, Jian-Bing Qin, Lei Zhang, Hui-Xia Zhu, Hao-Ming L. The co-transduction of Nurr1 and Brn4 genes induces the differentiation of neural stem cells into dopaminergic neurons. Cell biology international. vol 35. issue 12. 2012-06-06. PMID:21663595. |
nonetheless, these cells exhibited an immature neuronal morphology with small cell bodies and short neurite processes, and they seldom expressed dat (dopamine transporter), a late marker of mature dopaminergic neurons. |
2012-06-06 |
2023-08-12 |
Not clear |
| Chaquettea M Felton, Casonya M Johnso. Modulation of dopamine-dependent behaviors by the Caenorhabditis elegans Olig homolog HLH-17. Journal of neuroscience research. vol 89. issue 10. 2012-06-04. PMID:21688290. |
the soil nematode caenorhabditis elegans has been used to model dopamine signaling and reacts reproducibly to alterations in dopamine levels through eight well-characterized dopaminergic neurons located in the head. |
2012-06-04 |
2023-08-12 |
caenorhabditis_elegans |
| Vidyulata Kamath, Paul J Moberg, Raquel E Gur, Richard L Doty, Bruce I Turetsk. Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia. Behavioral neuroscience. vol 126. issue 1. 2012-06-04. PMID:22148860. |
given the rich dopaminergic innervations of the olfactory bulb and the influence of dopamine on the transmission of olfactory signals, the authors examined the influence of comt genotype status on the olfactory processing impairment observed in schizophrenia. |
2012-06-04 |
2023-08-12 |
Not clear |
| Eric Michael Hecht, David C Land. Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. Schizophrenia research. vol 134. issue 2-3. 2012-06-04. PMID:22169246. |
animal models have shown that adding an alpha-2 adrenergic receptor antagonist to a d2 antagonist can efflux dopamine into the frontal cortex increasing dopaminergic activity. |
2012-06-04 |
2023-08-12 |
Not clear |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Yu-Hua Tian, Seung Hwan Kim, Seok-Yong Lee, Choon-Gon Jan. Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425352. |
finally, we performed autoradiographic receptor binding assays for dopamine (da) d₁ and d₂ receptors, dopamine transporter (dat), and the n-methyl-d-aspartic acid (nmda) receptor after behavioral tests to examine whether alterations occurred in the dopaminergic and nmdaergic systems of the brain. |
2012-05-30 |
2023-08-12 |
mouse |
| Rui D S Prediger, Argelia E Rojas-Mayorquin, Aderbal S Aguiar, Caroline Chevarin, Raymond Mongeau, Michel Hamon, Laurence Lanfumey, Elaine Del Bel, Hisako Muramatsu, José Courty, Rita Raisman-Vozar. Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 8. 2012-05-29. PMID:21301897. |
these findings indicate that the genetic deletion of midkine causes a partial loss of dopaminergic neurons and depletion of dopamine, resulting in olfactory and memory deficits with no major motor impairments. |
2012-05-29 |
2023-08-12 |
mouse |
| Hironori Ohshiro, Shunichiro Kubota, Takayuki Murakosh. Dopaminergic modulation of oscillatory network inhibition in the rat basolateral amygdala depends on initial activity state. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21683087. |
the amygdala receives dopaminergic innervation, and dopamine (da) enhances various activities in cognitive and emotional behaviors. |
2012-05-25 |
2023-08-12 |
rat |
| Fabrizio Stocchi, Rupam Borgohain, Marco Onofrj, Anthony H V Schapira, Mohit Bhatt, Valentina Lucini, Rodolfo Giuliani, Ravi Anan. A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson's disease patients. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 1. 2012-05-21. PMID:21913224. |
safinamide is an α-aminoamide with both dopaminergic and nondopaminergic mechanisms of action evaluated as an add-on to dopamine agonist (da) therapy in early-stage pd. |
2012-05-21 |
2023-08-12 |
Not clear |
| Laura D Perju-Dumbrava, Gabor G Kovacs, Susanne Pirker, Kurt Jellinger, Martha Hoffmann, Susanne Asenbaum, Walter Pirke. Dopamine transporter imaging in autopsy-confirmed Parkinson's disease and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 1. 2012-05-21. PMID:22102521. |
dopamine transporter single-photon emission computerized tomography can visualize dopaminergic degeneration in parkinson's disease and multiple system atrophy. |
2012-05-21 |
2023-08-12 |
Not clear |
| Y Iris Chen, Jia-Qian Ren, Ted J Kaptchuk, Kenneth K Kwon. Restoring cerebral dopamine homeostasis by electrical forepaw stimulation: an FMRI study. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22170513. |
as dopamine function is tightly regulated within the basal ganglia circuitry, cortical perturbation would lead to modulation of dopaminergic activity in the striatum. |
2012-05-21 |
2023-08-12 |
rat |