| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clement C Zai, Sahar Ehtesham, Esther Choi, Behdin Nowrouzi, Vincenzo de Luca, Larisa Stankovich, Kristen Davidge, Natalie Freeman, Nicole King, James L Kennedy, Joseph H Beitchma. Dopaminergic system genes in childhood aggression: possible role for DRD2. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 1. 2012-04-25. PMID:21247255. |
excessive or deficient levels of extracellular dopamine have been hypothesized to contribute to a broad spectrum of mood, motor, and thought abnormalities, and dopaminergic system genes have been implicated in aggressive behaviour from animal and human studies. |
2012-04-25 |
2023-08-12 |
human |
| Russell C Callaghan, James K Cunningham, Jenna Sykes, Stephen J Kis. Increased risk of Parkinson's disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugs. Drug and alcohol dependence. vol 120. issue 1-3. 2012-04-25. PMID:21794992. |
since methamphetamine and other amphetamine-type stimulants (meth/amphetamine) can damage dopaminergic neurons, researchers have long speculated that these drugs may predispose users to develop parkinson's disease (pd), a dopamine deficiency neurological disorder. |
2012-04-25 |
2023-08-12 |
Not clear |
| Min Jeong Kang, Sang Sun Lee, Hyun Chul Ko. Prooxidant properties of ascorbic acid in the nigrostriatal dopaminergic system of C57BL/6 mice. Toxicology. vol 294. issue 1. 2012-04-25. PMID:22285708. |
in this study, we investigated the effect of aa on dopamine (da) and glutathione levels in the nigrostriatal dopaminergic system of male seven-week-old c57bl/6 mice (weight, 23-25 g). |
2012-04-25 |
2023-08-12 |
mouse |
| Flora Klara Szabó, Wei-Wei Le, Natalie S Snyder, Gloria E Hoffma. Comparison of the temporal programs regulating tyrosine hydroxylase and enkephalin expressions in TIDA neurons of lactating rats following pup removal and then pup return. Journal of molecular neuroscience : MN. vol 45. issue 2. 2012-04-24. PMID:21125428. |
dopamine (da) and enkephalin (enk) release from the tuberoinfundibular dopaminergic neurons (tida) into the hypophysial portal circulation is fundamentally different under non-lactating and lactating conditions. |
2012-04-24 |
2023-08-12 |
rat |
| Shuyan Wang, Ping Ren, Xiaobo Li, Yunqian Guan, Yu Alex Zhan. 17β-estradiol protects dopaminergic neurons in organotypic slice of mesencephalon by MAPK-mediated activation of anti-apoptosis gene BCL2. Journal of molecular neuroscience : MN. vol 45. issue 2. 2012-04-24. PMID:21327582. |
it was found that long-term exposure to e2 exerted marked effects on restoring the number of dopaminergic neurons, maintaining normal morphology of dopaminergic neurons, and preserving their ability to release dopamine at the presence of 6-ohda. |
2012-04-24 |
2023-08-12 |
Not clear |
| Hassan Niknejad, Tina Deihim, Abolhassan Ahmadiani, Masoumeh Jorjani, Habibollah Peirov. Permanent expression of midbrain dopaminergic neurons traits in differentiated amniotic epithelial cells. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22037229. |
hplc analysis revealed that dopamine was released into the medium upon depolarization, indicating that functional dopaminergic neurons were present in the culture. |
2012-04-24 |
2023-08-12 |
human |
| Lydia M Mexas, Virginia R Florang, Jonathan A Door. Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Neurotoxicology. vol 32. issue 4. 2012-04-23. PMID:21514317. |
parkinson's disease (pd) is a neurodegenerative disorder marked by the selective loss of dopaminergic neurons, leading to a decrease of the neurotransmitter dopamine (da). |
2012-04-23 |
2023-08-12 |
Not clear |
| Michael A Schwarzschild, Kenneth Marek, Shirley Eberly, David Oakes, Ira Shoulson, Danna Jennings, John Seibyl, Alberto Ascheri. Serum urate and probability of dopaminergic deficit in early "Parkinson's disease". Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 10. 2012-04-23. PMID:21538532. |
the objective of this study was to investigate whether higher levels of urate, an antioxidant linked to a lower likelihood of developing parkinson's disease, is also a predictor of having a dopamine transporter brain scan without evidence of dopaminergic deficit. |
2012-04-23 |
2023-08-12 |
human |
| Michael A Schwarzschild, Kenneth Marek, Shirley Eberly, David Oakes, Ira Shoulson, Danna Jennings, John Seibyl, Alberto Ascheri. Serum urate and probability of dopaminergic deficit in early "Parkinson's disease". Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 10. 2012-04-23. PMID:21538532. |
a scan without evidence of dopaminergic deficit was defined as lowest putamen iodine-123-labeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane > 80% age-expected putamen dopamine transporter density. |
2012-04-23 |
2023-08-12 |
human |
| Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhar. Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174877. |
the neurons exhibit expression profiles and electrophysiological characteristics consistent with midbrain dopaminergic neurons, notably including spontaneous pacemaking activity, stimulated release of dopamine, and calcium oscillations. |
2012-04-23 |
2023-08-12 |
Not clear |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum, and tyrosine hydroxylase (th) immunoreactivity and 4',6-diamidino-2-phenylindole (dapi)/fluoro-jade b staining in the substantia nigra were measured to assess dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
rat |
| Morten Ziebell, Usman Khalid, Anders B Klein, Susana Aznar, Gerda Thomsen, Peter Jensen, Gitte M Knudse. Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:21176997. |
striatal dopamine transporter binding correlates with serum bdnf levels in patients with striatal dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
Not clear |
| G Aleph Prieto, Azucena Perez-Burgos, Marcela Palomero-Rivero, Elvira Galarraga, Rene Drucker-Colin, Jose Barga. Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion. Journal of neurophysiology. vol 105. issue 5. 2012-04-17. PMID:21389298. |
the loss of dopaminergic neurons in the substantia nigra compacta followed by striatal dopamine depletion is a hallmark of parkinson's disease. |
2012-04-17 |
2023-08-12 |
Not clear |
| G Aleph Prieto, Azucena Perez-Burgos, Marcela Palomero-Rivero, Elvira Galarraga, Rene Drucker-Colin, Jose Barga. Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion. Journal of neurophysiology. vol 105. issue 5. 2012-04-17. PMID:21389298. |
after dopamine depletion, dopaminergic d(2) receptor (d(2)r)-class supersensitivity develops in striatal neurons. |
2012-04-17 |
2023-08-12 |
Not clear |
| Salvatora Succu, Fabrizio Sanna, Antonio Argiolas, Maria Rosaria Meli. Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21496460. |
this in turn increases mesolimbic and mesocortical dopaminergic activity, releasing dopamine in the nucleus accumbens and in the prelimbic medial prefrontal cortex. |
2012-04-17 |
2023-08-12 |
rat |
| A M Oster, B S Gutki. A reduced model of DA neuronal dynamics that displays quiescence, tonic firing and bursting. Journal of physiology, Paris. vol 105. issue 1-3. 2012-04-17. PMID:21939761. |
midbrain dopaminergic neurons send numerous projections to cortical and sub-cortical areas, and in a manner dependent upon their activities, diffusely release dopamine (da) to their targets. |
2012-04-17 |
2023-08-12 |
Not clear |
| Sudarat Nimitvilai, Devinder S Arora, Mark S Brodi. Reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21976045. |
reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase c. adaptation of putative dopaminergic (pda) neurons in the ventral tegmental area (vta) to drugs of abuse may alter information processing related to reward and reinforcement and is an important factor in the development of addiction. |
2012-04-17 |
2023-08-12 |
rat |
| Amanda L C Chen, Kenneth Blum, Thomas J H Chen, John Giordano, B William Downs, David Han, Debmalya Barh, Eric R Braverma. Correlation of the Taq1 dopamine D2 receptor gene and percent body fat in obese and screened control subjects: a preliminary report. Food & function. vol 3. issue 1. 2012-04-16. PMID:22051885. |
while there is a considerable body of literature correlating the role of dopaminergic genes and obesity, body mass index, body type, overeating, carbohydrate binging, energy expenditure and low dopamine d2 receptor (d2r) receptor density, there is a paucity of research concerning the dopamine d2 receptor gene (drd2) variants and percent body fat. |
2012-04-16 |
2023-08-12 |
human |
| Patricia Vergara-Aragón, Leonardo Eduardo Domínguez-Marrufo, Patricia Ibarra-Guerrero, Heidi Hernandez-Ramírez, Beatriz Hernández-Téllez, Irma Elena López-Martínez, Ivonne Sánchez-Cervantes, Patricia Santiago-Jacinto, Jorge Alberto García-Macedo, Guadalupe Valverde-Aguilar, Julio Santiag. Tio2-dopamine complex implanted unilaterally in the caudate nucleus improves motor activity and behavior function of rats with induced hemiparkinsonism. Proceedings of the Western Pharmacology Society. vol 54. 2012-04-16. PMID:22423573. |
parkinson's disease (pd) is characterized by malfunction of dopaminergic systems, and the current symptomatic treatment is to replace lost dopamine. |
2012-04-16 |
2023-08-12 |
rat |
| David J Brooks, Nicola Paves. Imaging biomarkers in Parkinson's disease. Progress in neurobiology. vol 95. issue 4. 2012-04-09. PMID:21896306. |
while loss of putamen dopaminergic function leads to motor disability, lewy bodies not only target dopamine neurons but have also been observed in serotoninergic, noradrenergic, and cholinergic neurons. |
2012-04-09 |
2023-08-12 |
Not clear |