| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niklas Reich, Michael Mannino, Steven Kotle. Using caffeine as a chemical means to induce flow states. Neuroscience and biobehavioral reviews. 2024-02-08. PMID:38331128. |
caffeine may facilitate flow through various effects, including: i) upregulation of dopamine d1/d2 receptor affinity in reward-associated brain areas, leading to greater energetic arousal and 'wanting'; ii) protection of dopaminergic neurons; iii) increases in norepinephrine release and alertness, which offset sleep-deprivation and hypoarousal; iv) heightening of parasympathetic high frequency heart rate variability, resulting in improved cortical stress appraisal, v) modification of striatal endocannabinoid-cb1 receptor-signalling, leading to enhanced stress tolerance; and vi) changes in brain network activity in favour of executive function and flow. |
2024-02-08 |
2024-02-11 |
Not clear |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
since dopamine transporter (dat) gene is known as a marker for dopaminergic neurons, we inserted chr2-mcherry into the downstream of the dat gene locus of the rat genome by clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (crispr-cas9) genome editing and created dat-chr2-mcherry knock-in rats. |
2024-02-07 |
2024-02-10 |
rat |
| Larissa Pereira Dantas da Silva, Erika da Cruz Guedes, Isabel Cristina Oliveira Fernandes, Lucas Aleixo Leal Pedroza, Gustavo José da Silva Pereira, Priscila Guber. Exploring Caenorhabditis elegans as Parkinson's Disease Model: Neurotoxins and Genetic Implications. Neurotoxicity research. vol 42. issue 1. 2024-02-06. PMID:38319410. |
c. elegans has a conserved neurotransmission system during evolution; it produces dopamine, through the eight dopaminergic neurons; it can be used to study the effect of neurotoxins and also has strains that express human α-synuclein. |
2024-02-06 |
2024-02-09 |
human |
| Larissa Pereira Dantas da Silva, Erika da Cruz Guedes, Isabel Cristina Oliveira Fernandes, Lucas Aleixo Leal Pedroza, Gustavo José da Silva Pereira, Priscila Guber. Exploring Caenorhabditis elegans as Parkinson's Disease Model: Neurotoxins and Genetic Implications. Neurotoxicity research. vol 42. issue 1. 2024-02-06. PMID:38319410. |
here, we identified that nematodes exposed to the neurotoxins, such as 6-ohda, mptp, paraquat, and rotenone, had a progressive loss of dopaminergic neurons, dopamine deficits, and decreased survival rate. |
2024-02-06 |
2024-02-09 |
human |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |
| Anna B Szabo, Farès Sayegh, Sèbastien Gauzin, Camille Lejards, Bruno Guiard, Luc Valton, Laure Verret, Claire Rampon, Lionel Daha. No major effect of dopamine receptor 1/5 antagonist SCH-23390 on epileptic activity in the Tg2576 mouse model of amyloidosis. The European journal of neuroscience. 2024-02-03. PMID:38308520. |
here, we tested the implication of dopaminergic transmission in vivo in the tg2576 mouse model of alzheimer's disease by monitoring epileptic activities via intracranial eeg before and after treatment with dopamine antagonists. |
2024-02-03 |
2024-02-05 |
mouse |
| Suzita Mohd Noor, Chee Ern David Wong, Pooi-Fong Wong, Anwar Norazi. Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. Methods in cell biology. vol 181. 2024-02-01. PMID:38302238. |
dopaminergic neurons in the brain are an important source of dopamine, which is a crucial neurotransmitter for wellbeing, memory, reward, and motor control. |
2024-02-01 |
2024-02-04 |
human |
| Xingyue Zeng, ChengYan Wu, Yongkai Cao, Huijun Li, Xiaohan Zhan. Mdm2-mediated ubiquitination of PKCβII is responsible for insulin-induced heterologous desensitization of dopamine D FEBS letters. 2024-02-01. PMID:38302840. |
mdm2-mediated ubiquitination of pkcβii is responsible for insulin-induced heterologous desensitization of dopamine d the insulin and dopaminergic systems in the brain are associated with schizophrenia and parkinson's disease with respect to etiology and treatment. |
2024-02-01 |
2024-02-04 |
Not clear |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
inactivation of erk1/2 signaling in dopaminergic neurons by map kinase phosphatase mkp3 regulates dopamine signaling and motivation for cocaine. |
2024-01-31 |
2024-02-03 |
rat |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
together, these results indicate that erk1/2 signaling plays a critical role in shaping the dopamine response to cocaine and may provide additional insights into the function of dopaminergic neurons. |
2024-01-31 |
2024-02-03 |
rat |
| Mikkel C Vinding, Allison Eriksson, Igori Comarovschii, Josefine Waldthaler, Cassia Low Manting, Robert Oostenveld, Martin Ingvar, Per Svenningsson, Daniel Lundqvis. The Swedish National Facility for Magnetoencephalography Parkinson's disease dataset. Scientific data. vol 11. issue 1. 2024-01-31. PMID:38296972. |
parkinson's disease (pd) is characterised by a loss of dopamine and dopaminergic cells. |
2024-01-31 |
2024-02-03 |
Not clear |
| Ana Perez-Villalba, María Salomé Sirerol-Piquer, Raúl Soriano-Cantón, Virginia Folgado, Azucena Pérez-Cañamás, Martina Kirstein, Isabel Fariñas, Francisco Pérez-Sánche. Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging. Scientific reports. vol 14. issue 1. 2024-01-30. PMID:38291230. |
these motor disturbances correlate with reduced dopamine (da) levels, increased da turnover, synaptic terminal loss, and notably, the depletion of dopaminergic neurons in the substantia nigra and noradrenergic neurons in the locus coeruleus. |
2024-01-30 |
2024-02-02 |
mouse |
| Bing Chen, Qian Zhang, Xiaoru Zhong, Xinwei Zhang, Xin Liu, Hongyang Wang, Fan Yang, Jingjing Zhang, Jingnan Huang, Yin-Kwan Wong, Piao Luo, Jigang Wang, Jichao Su. Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson's disease. Cell communication and signaling : CCS. vol 22. issue 1. 2024-01-30. PMID:38287374. |
dopamine (da), the neurotransmitter produced by dopaminergic neurons, and its metabolites can covalently modify proteins, and dysregulation of this process has been implicated in neuronal loss in pd. |
2024-01-30 |
2024-02-01 |
Not clear |
| Hayder M Al-Kuraishy, Majid S Jabir, Ali I Al-Gareeb, Ali K Albuhadil. New insight on the possible role of statins in Vascular Parkinsonism: A need for presumptive therapy. Ageing research reviews. 2024-01-29. PMID:38286334. |
dopamine transporters are normal in vp but are highly reduced in pd, and dopaminergic agonists had no effective role on vp. |
2024-01-29 |
2024-02-01 |
Not clear |
| Vasanthi Chinraj, Ramakkamma Aishwarya Reddy, Jubie Selvaraj, Raman Sureshkuma. Design, Synthesis and In Vitro Evaluation of Levodopa Stearic Acid Hydrazide Conjugate for the Management of Parkinson's DiseaseNovel Conjugate for Parkinson's Disease. Drug research. 2024-01-29. PMID:38286420. |
the pathological identification for parkinson's disease is loss of dopaminergic neurons in substantia nigra region of the brain that in turn leads to dopamine deficiency that affects the body's normal physiological and neurological disorder. |
2024-01-29 |
2024-02-01 |
Not clear |
| Yousef Rasmi, Ameneh Shokati, Shima Hatamkhani, Yeganeh Farnamian, Roya Naderi, Ladan Jalal. Assessment of the relationship between the dopaminergic pathway and severe acute respiratory syndrome coronavirus 2 infection, with related neuropathological features, and potential therapeutic approaches in COVID-19 infection. Reviews in medical virology. vol 34. issue 1. 2024-01-29. PMID:38282395. |
most immune cells express dopamine receptors and other dopamine-related proteins, indicating the importance of dopaminergic immune regulation. |
2024-01-29 |
2024-01-31 |
human |
| Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. |
consequently, we continue to study the dopaminergic system with a focus on dopamine levels and dopamine's effect on behaviors in relation to pfoa exposure. |
2024-01-28 |
2024-01-31 |
human |
| Karen Manoutcharian, Goar Gevorkia. Recombinant Antibody Fragments for Immunotherapy of Parkinson's Disease. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2024-01-27. PMID:38280078. |
multiple genetic and environmental factors leading to progressive loss of dopaminergic neurons in the substantia nigra pars compacta (sn) and consequent depletion of dopamine were described. |
2024-01-27 |
2024-01-30 |
Not clear |
| Bruno P Guiard, Guillaume Gott. The High-Precision Liquid Chromatography with Electrochemical Detection (HPLC-ECD) for Monoamines Neurotransmitters and Their Metabolites: A Review. Molecules (Basel, Switzerland). vol 29. issue 2. 2024-01-26. PMID:38276574. |
this review highlights the advantages of high-precision liquid chromatography with an electrochemical detector (hplc-ecd) in detecting and quantifying biological samples obtained through intracerebral microdialysis, specifically the serotonergic and dopaminergic systems: serotonin (5-ht), 5-hydroxyindolacetic acid (5-hiaa), 3,4-dihydroxyphenylacetic acid (dopac), dopamine (da), 3-metoxytryptamin (3-mt) and homovanillic acid (hva). |
2024-01-26 |
2024-01-28 |
Not clear |
| Elena Kotsyuba, Arman Pahlevaniane, Sergei Maslennikov, Vyacheslav Dyachu. Development of Serotonergic and Dopaminergic Neuronal Networks of the Central Nervous System in King Crab, Biology. vol 13. issue 1. 2024-01-22. PMID:38248466. |
development of serotonergic and dopaminergic neuronal networks of the central nervous system in king crab, this article presents recent findings as regards distribution of cells producing serotonin and dopamine in the larval central nervous system at different developmental stages, including four pelagic larval stages (zoea i-iv), a semibenthic postlarval stage glaucothoe (megalopa), benthic juveniles, and adult red king crabs, |
2024-01-22 |
2024-01-24 |
Not clear |