| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Cappelletti, E V Carsana, G Lunghi, S Breviario, C Vanetti, A B Di Fonzo, E Frattini, M Magni, S Zecchini, M Clerici, M Aureli, C Fenizi. SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons. Experimental and molecular pathology. 2023-09-29. PMID:37775022. |
sars-cov-2 hampers dopamine production in ipsc-derived dopaminergic neurons. |
2023-09-29 |
2023-10-07 |
human |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
the increase in presynaptic striatal dopamine is the main dopaminergic abnormality in schizophrenia (scz). |
2023-09-28 |
2023-10-07 |
mouse |
| Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Ana Paula Horn, Mariana Appel Hor. Effects of curcumin to counteract levodopa-induced toxicity in zebrafish. Journal of toxicology and environmental health. Part A. 2023-09-28. PMID:37767720. |
currently, treatment of pd has focused on increasing dopamine levels, using a dopamine precursor, levodopa (l-dopa) or stimulation of dopaminergic receptors. |
2023-09-28 |
2023-10-07 |
zebrafish |
| Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B Schulz, Judith Stegmülle. Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects. Journal of neurochemistry. 2023-09-27. PMID:37753846. |
nex-cre;fbxo7fl/fl mice revealed an increase in striatal dopamine concentrations, changes in the glutamatergic, gabaergic and dopaminergic pathways, astrogliosis and microgliosis and little or no neuronal loss in the striatum. |
2023-09-27 |
2023-10-07 |
mouse |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Jingjing Song, Yang Zhao, Xiaoqian Shan, Yongyin Luo, Nan Hao, Lan Zha. Active ingredients of Chinese medicine with immunomodulatory properties: NF-κB pathway and Parkinson's disease. Brain research. 2023-09-25. PMID:37748570. |
it has been found that an increasing number of active ingredients in chinese medicines, such as flavonoids, alkaloids, saponins, terpenoids, phenols and phenylpropanoids, have anti-inflammatory properties that can regulate neuroglia cell activation and ameliorate neuroinflammation through the nf-κb pathway, and increase dopamine release or protect dopaminergic neurons for neuroprotection to improve behavioural dysfunction in pd. |
2023-09-25 |
2023-10-07 |
Not clear |
| Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Amir Shojaei, Yaghoub Fathollahi, Nahid Roohi, Vicrotia Barkley, Javad Mirnajafi-Zade. Age-dependent effects of dopamine on working memory and synaptic plasticity in hippocampal CA3-CA1 synapses in mice. Neuroscience. 2023-09-23. PMID:37741356. |
regarding the role of the dopaminergic system's changes in old age, we examined the effect of age and applied dopamine on working memory, synaptic transmission, and long-term potentiation (ltp) induction and maintenance in young adult and mature adult mice. |
2023-09-23 |
2023-10-07 |
mouse |
| Xin Gong, Mengyi Huang, Lei Che. NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m CNS neuroscience & therapeutics. 2023-09-22. PMID:37735974. |
nrf1 mitigates motor dysfunction and dopamine neuron degeneration in mice with parkinson's disease by promoting glrx m the feature of parkinson's disease (pd) is the heavy dopaminergic neuron loss of substantia nigra pars compacta (snpc), while glutaredoxin (glrx) has been discovered to modulate the death of dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
mouse |
| Victor Pando-Naude, Tomas Edward Matthews, Andreas Højlund, Sebastian Jakobsen, Karen Østergaard, Erik Johnsen, Eduardo A Garza-Villarreal, Maria A G Witek, Virginia Penhune, Peter Vuus. Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms. The European journal of neuroscience. 2023-09-19. PMID:37724707. |
dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (bg) dopaminergic systems in plumm. |
2023-09-19 |
2023-10-07 |
human |
| Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim, Eng King Ta. Role of dopamine in the pathophysiology of Parkinson's disease. Translational neurodegeneration. vol 12. issue 1. 2023-09-17. PMID:37718439. |
a pathological feature of parkinson's disease (pd) is the progressive loss of dopaminergic neurons and decreased dopamine (da) content in the substantia nigra pars compacta in pd brains. |
2023-09-17 |
2023-10-07 |
Not clear |
| Toshiro Niwa, Yuka Yamamot. Stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome P450 2D6. Drug metabolism and bioanalysis letters. 2023-09-15. PMID:37711131. |
stimulatory and inhibitory effect of antipsychotic agents including dopaminergic neuro-depressants on dopamine formation from p-tyramine mediated by cytochrome p450 2d6. |
2023-09-15 |
2023-10-07 |
Not clear |
| Bruno Vincent, Mayuri Shukl. The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse. Current neuropharmacology. 2023-09-11. PMID:37691228. |
methamphetamine-induced neurodegeneration involves altered dopamine homeostasis that promotes the aggregation of α-synuclein protofibrils in the dopaminergic neurons and drives these neurons to make them more vulnerable to degeneration as recognized in parkinson's disease. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
one of the hallmarks of parkinson's disease (pd) is the progressive loss of dopaminergic neurons and associated dopamine depletion. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
several mechanisms, previously considered in isolation, have been proposed to contribute to the pathophysiology of dopaminergic degeneration: dopamine oxidation-mediated neurotoxicity, high dopamine transporter (dat) expression density per neuron, and autophagy-lysosome pathway (alp) dysfunction. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
in pd, alp dysfunction could increase dat density per neuron, and enhance dopamine reuptake, oxidation, and neurotoxicity, potentially contributing to the progressive loss of dopaminergic neurons. |
2023-09-11 |
2023-10-07 |
Not clear |
| Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvell. Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685899. |
the dopamine transporter (dat) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. |
2023-09-09 |
2023-10-07 |
Not clear |
| Liaqat Hussain, Ina Masood, Matloob Ahmad, Muhammad Yasir Ali, Uzma Saleem, Musaddique Hussain, Syed Haroon Khalid, Zunera Chauhdar. Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies. Toxicology and applied pharmacology. 2023-09-08. PMID:37683697. |
in parkinson's disease (pd), degradation of dopaminergic neurons in substantia nigra causes striatal deficiency of dopamine, which results in tremors, bradykinesia with instability in posture, rigidity and shuffled gait. |
2023-09-08 |
2023-10-07 |
mouse |
| Jan Booij, Sem P Tellier, John Seibyl, Chris Vrien. Dopamine Transporter Availability in Early Parkinson's Disease is Dependent on Sunlight Exposure. Movement disorders : official journal of the Movement Disorder Society. 2023-09-06. PMID:37670567. |
preliminary studies suggested seasonality of dopaminergic functioning, but it is unknown whether dopamine transporter (dat) expression in humans is also dependent on the seasons. |
2023-09-06 |
2023-10-07 |
Not clear |
| Natalia F Sardi, Ana C Pescador, Evellyn M Azevedo, José A Pochapski, Caroline Kukolj, Katherinne M Spercoski, Anderson J M Andrade, Claudio da Cunha, Luana Fische. Sleep and pain: a role for the anterior cingulate cortex, nucleus accumbens and dopamine in the increased pain sensitivity following sleep restriction. The journal of pain. 2023-09-06. PMID:37673193. |
data on indirect dopaminergic parameters, dat glycosylation and darpp-32 phosphorylation, as well as dopamine, serotonin and norepinephrine levels, suggest that dopaminergic function decreases in the nucleus accumbens and anterior cingulate cortex after sleep restriction. |
2023-09-06 |
2023-10-07 |
rat |
| Luiz Henrique Dias de Oliveira, Jorddy Neves Cruz, Cleydson Breno Rodrigues Dos Santos, Eduardo Borges de Mel. Multivariate QSAR, similarity search and ADMET studies based in a set of methylamine derivatives described as dopamine transporter inhibitors. Molecular diversity. 2023-09-05. PMID:37670118. |
the dopamine transporter (dat), responsible for the regulation of dopaminergic neurotransmission, is implicated in the etiology of several neuropsychiatric disorders which, in turn, have contributed to high rates of disability and numerous deaths in recent years, significantly impacting the global health system. |
2023-09-05 |
2023-10-07 |
Not clear |