| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ricardo J Ramírez-Carreto, Víctor J Zaldívar-Machorro, Dafne J Pérez-Ramírez, Blanca E Rodríguez-López, Claudia Meza, Esperanza García, Abel Santamaría, Anahí Chavarrí. Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice. Molecular neurobiology. 2023-07-22. PMID:37480498. |
both exert neuroprotective effects, preserving dopamine levels and dopaminergic neurons when administered in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse pd model, being probably sb the potential therapeutic molecule behind this effect. |
2023-07-22 |
2023-08-14 |
mouse |
| Robert B Kargb. Microbiome-Gut-Brain Axis Modulation: New Approaches in Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis. ACS medicinal chemistry letters. vol 14. issue 7. 2023-07-19. PMID:37465304. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by symptoms like resting tremor, rigidity, bradykinesia, and postural instability, mainly due to dopamine depletion and degeneration of dopaminergic neurons. |
2023-07-19 |
2023-08-14 |
Not clear |
| Haoran Peng, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue L. Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease. Journal of the neurological sciences. vol 451. 2023-07-16. PMID:37454572. |
parkinson's disease (pd), the most common neurological motor system disorder, which characterised by the irreversible loss of dopaminergic neurones in the substantia nigra pars compacta, and leads to the deficiency of dopamine in the striatum. |
2023-07-16 |
2023-08-14 |
human |
| Yiming Wang, Yun Xia, Liang Kou, Sijia Yin, Xiaosa Chi, Jingwen Li, Yadi Sun, Jiawei Wu, Qiulu Zhou, Wenkai Zou, Zongjie Jin, Jinsha Huang, Nian Xiong, Tao Wan. Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease. Neurobiology of disease. 2023-07-11. PMID:37433411. |
the primary pathological features include a reduction in the number of dopaminergic neurons in the substantia nigra and decrease in dopamine levels in the nigrostriatal pathway. |
2023-07-11 |
2023-08-14 |
human |
| Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, Gary W Mille. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425736. |
synaptic vesicle glycoprotein 2c enhances vesicular storage of dopamine and counters dopaminergic toxicity. |
2023-07-10 |
2023-08-14 |
mouse |
| Harry Costello, Anette-Eleonore Schrag, Robert Howard, Jonathan P Roise. Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson's disease. medRxiv : the preprint server for health sciences. 2023-07-10. PMID:37425947. |
loss of dopaminergic innervation of the striatum is associated with emergence of motivational symptoms in pd, and mood fluctuations correlate with dopamine availability. |
2023-07-10 |
2023-08-14 |
Not clear |
| Harry Costello, Anette-Eleonore Schrag, Robert Howard, Jonathan P Roise. Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson's disease. medRxiv : the preprint server for health sciences. 2023-07-10. PMID:37425947. |
accordingly, optimising dopaminergic treatment for pd can improve depressive symptoms, and dopamine agonists have shown promising effects in improving apathy. |
2023-07-10 |
2023-08-14 |
Not clear |
| Xu Cao, Zhong-Rui Du, Xin Liu, Xiong Wang, Chong Li, Sai-Nan Zhou, Jia-Rui Liu, Ping-Yi Xu, Jun-Li Ye, Qing Zhao, Fang Zhao, Ka-Hing Wong, Xiao-Li Don. Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-07. PMID:37418977. |
the present study found both low and high dose ma treatment significantly prevented dopaminergic neuronal loss in a classical chronic pd mouse model by ameliorating motor functions and improving tyrosine hydroxylase expressions in the substantia nigra pars compacta (snpc) and increasing dopamine and its metabolite homovanillic acid levels in the striatum. |
2023-07-07 |
2023-08-14 |
mouse |
| Pepin Marshal. Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling. Cellular and molecular neurobiology. 2023-07-06. PMID:37410316. |
the basic research literature on dopaminergic effects of gdnf in animal models is reviewed, concluding that a twofold increase in natively expressing cells increases dopamine turnover and maximises neuroprotective and beneficial motor effects whilst minimising hyperdopaminergia and other side-effects. |
2023-07-06 |
2023-08-14 |
human |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 13. 2023-07-03. PMID:37395283. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-07-03 |
2023-08-14 |
Not clear |
| Huanfeng Hao, Li Song, Luoying Zhan. Wolfram syndrome 1 regulates sleep in dopamine receptor neurons by modulating calcium homeostasis. PLoS genetics. vol 19. issue 7. 2023-07-03. PMID:37399203. |
consistently, the influence of wfs1 on sleep is blocked or partially rescued by inhibiting or knocking down the rate-limiting enzyme of dopamine synthesis, suggesting that wfs1 modulates sleep via dopaminergic signaling. |
2023-07-03 |
2023-08-14 |
drosophila_melanogaster |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
in the current study, administration of 100 mg/kg lap in rotenone-treated rats for 21 days ameliorates motor impairment, debilitated histopathological alterations, and revived dopaminergic neurons by increasing tyrosine hydroxylase (th) expression in sn, along with increased dopamine level. |
2023-06-29 |
2023-08-14 |
rat |
| Julieta Griselda Mendoza-Torreblanca, Noemi Cárdenas-Rodríguez, Jazmín Carro-Rodríguez, Itzel Jatziri Contreras-García, David Garciadiego-Cázares, Daniel Ortega-Cuellar, Valentín Martínez-López, Alfonso Alfaro-Rodríguez, Alberto Nayib Evia-Ramírez, Iván Ignacio-Mejía, Marco Antonio Vargas-Hernández, Cindy Bandal. Antiangiogenic Effect of Dopamine and Dopaminergic Agonists as an Adjuvant Therapeutic Option in the Treatment of Cancer, Endometriosis, and Osteoarthritis. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373348. |
antiangiogenic effect of dopamine and dopaminergic agonists as an adjuvant therapeutic option in the treatment of cancer, endometriosis, and osteoarthritis. |
2023-06-28 |
2023-08-14 |
Not clear |
| Iveta Vojtechova, Klara Tuckova, Radomir Juza, Ales Stuchlik, Eduard Kelemen, Jan Korabecny, Ondrej Soukup, Tomas Petrase. Dopaminergic and glutamatergic models of psychosis show differential sensitivity to aripiprazole and a novel experimental compound modulating D Progress in neuro-psychopharmacology & biological psychiatry. 2023-06-28. PMID:37379895. |
dopaminergic and glutamatergic models of psychosis show differential sensitivity to aripiprazole and a novel experimental compound modulating d dopamine type 2 receptors (d |
2023-06-28 |
2023-08-14 |
Not clear |
| Raymond Brewer, Kenneth Blum, Abdalla Bowirrat, Edward J Modestino, David Baron, Rajendra D Badgaiyan, Mark Moran, Brent Boyett, Mark S Gol. Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-Induced Hyperalgesia. Current psychopharmacology. vol 9. issue 3. 2023-06-27. PMID:37361136. |
neuroscientists and psychiatrists working in the areas of "pain and addiction" are asked in this perspective article to reconsider the current use of dopaminergic blockade (like chronic opioid agonist therapy), and instead to consider induction of dopamine homeostasis by putative pro-dopamine regulation. |
2023-06-27 |
2023-08-14 |
Not clear |
| Willian Goulart Salgueiro, Marcell Valandro Soares, Cassiano Fiad Martins, Fávero Reisdorfer Paula, Rafaela Maria Rios-Anjos, Thiago Carrazoni, Marcelo A Mori, Roman-Ulrich Müller, Michael Aschner, Cháriston André Dal Belo, Daiana Silva Ávil. Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model. Chemico-biological interactions. 2023-06-22. PMID:37348670. |
this led to suggestive evidence on how quercetin may act as a dopaminergic modulator by interacting with c. elegans' dopamine transporter and alter the nematode's exploratory behavior. |
2023-06-22 |
2023-08-14 |
caenorhabditis_elegans |
| Emile F van Vliet, Maarten J Knol, Raymond M Schiffelers, Massimiliano Caiazzo, Marcel H A M Fen. Levodopa-loaded nanoparticles for the treatment of Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. 2023-06-21. PMID:37343725. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) resulting in dopamine (da) deficiency, which manifests itself in motor symptoms including tremors, rigidity and bradykinesia. |
2023-06-21 |
2023-08-14 |
Not clear |
| Ilene Trinh, Angeni Muralidhar, Justin Yang, Nicolás Phielip. Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 6. 2023-06-19. PMID:37332639. |
dopamine transporter single-photon emission computed tomography (dat-spect) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (dat). |
2023-06-19 |
2023-08-14 |
Not clear |
| Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Li. Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms. Cells. vol 12. issue 11. 2023-06-11. PMID:37296570. |
given that dopaminergic neurotransmission has been found to be disrupted in depression, we investigated the dopamine(da)-dependent mechanism of the antidepressant-like effects of hfs of the prelimbic cortex (hfs prl). |
2023-06-11 |
2023-08-14 |
rat |
| Tarique Bagalkot, Alexander Sorki. Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293021. |
acute amph is proposed to cause transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2023-06-09 |
2023-08-14 |
mouse |