| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jihong Wang, Zheng Li, Ye Tu, Feng Ga. The Dopaminergic System In The Ventral Tegmental Area Contributes To Morphine Analgesia And Tolerance. Neuroscience. 2023-06-07. PMID:37286162. |
existing studies show that dopamine receptors and μ-opioid receptors participate in morphine tolerance through the altered activities of dopaminergic and/or non-dopaminergic neurons in the vta. |
2023-06-07 |
2023-08-14 |
Not clear |
| Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. |
and strikingly, high serum tmao significantly promoted the metabolism of striatal dopamine (da) of pd model mice, although it had no significant effect on the number of dopaminergic neurons or the content of da. |
2023-06-02 |
2023-08-14 |
mouse |
| Chuanqi Chu, Tiantian Li, Leilei Yu, Yiwen Li, Miaoyu Li, Min Guo, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Che. A Low-Protein, High-Carbohydrate Diet Exerts a Neuroprotective Effect on Mice with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease by Regulating the Microbiota-Metabolite-Brain Axis and Fibroblast Growth Factor 21. Journal of agricultural and food chemistry. 2023-06-02. PMID:37267589. |
here, we found that an lphc diet ameliorated 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (mptp)-induced motor deficits, decreased dopaminergic neuronal death, and increased the levels of striatal dopamine, serotonin, and their metabolites in pd mice. |
2023-06-02 |
2023-08-14 |
mouse |
| Anthony L Gaeta, Karolina Willicott, Corey W Willicott, Luke E McKay, Candice M Keogh, Tyler J Altman, Logan C Kimble, Abigail L Yarbrough, Kim A Caldwell, Guy A Caldwel. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a iScience. vol 26. issue 6. 2023-06-01. PMID:37260751. |
mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a failure of inherently protective cellular processes and misfolded protein-associated stress contribute to the progressive loss of dopamine (da) neurons characteristic of parkinson's disease (pd). |
2023-06-01 |
2023-08-14 |
Not clear |
| Mydirah Littlepage-Saunders, Michael J Hochstein, Doris S Chang, Kari A Johnso. G protein-coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects. British journal of pharmacology. 2023-05-31. PMID:37258878. |
g protein-coupled receptors (gpcrs) that bind a variety of neuromodulators including dopamine, endocannabinoids, acetylcholine, and endogenous opioid peptides regulate dopamine release by acting on several components of dopaminergic circuitry. |
2023-05-31 |
2023-08-14 |
Not clear |
| Carmen Costas-Ferreira, Rafael Durán, Lilian Ferreira Far. Neurotoxic effects of exposure to glyphosate in rat striatum: Effects and mechanisms of action on dopaminergic neurotransmission. Pesticide biochemistry and physiology. vol 193. 2023-05-29. PMID:37248010. |
so, two possible hypotheses could explain this additive effect: both glyphosate and nomifensine act through different mechanisms at the dopaminergic terminals to increase dopamine levels; or both nomifensine and glyphosate act on dat, with glyphosate simultaneously inhibiting reuptake and stimulating dopamine release by reversing the dat function. |
2023-05-29 |
2023-08-14 |
rat |
| Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wan. Spatial Distribution of Neurons Expressing Single, Double, and Triple Molecular Characteristics of Glutamatergic, Dopaminergic, or GABAergic Neurons in the Mouse Ventral Tegmental Area. Journal of molecular neuroscience : MN. 2023-05-27. PMID:37243808. |
the vta contains three main neuronal populations, namely, dopamine (da), γ-aminobutyric acid (gaba), and glutamate neurons, but some neurons exhibit combinatorial molecular characteristics of dopaminergic, gabaergic, or glutamatergic neurons. |
2023-05-27 |
2023-08-14 |
mouse |
| Makito Hirano, Makoto Samukawa, Chiharu Isono, Yoshitaka Naga. The effects of safinamide on dysphagia in Parkinson's disease. PloS one. vol 18. issue 5. 2023-05-25. PMID:37228084. |
the transdermal dopamine agonist rotigotine alleviates dysphagia in patients with pd and is more effective than oral levodopa, suggesting the importance of continuous dopaminergic stimulation (cds) in swallowing. |
2023-05-25 |
2023-08-14 |
Not clear |
| Le-le Liu, Yu Han, Zi-Jia Zhang, Yi-Qi Wang, Yu-Wei Hu, Elena Kaznacheyeva, Jian-Qing Ding, Dong-Kai Guo, Guang-Hui Wang, Bin Li, Hai-Gang Re. Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation. Acta pharmacologica Sinica. 2023-05-24. PMID:37225849. |
parkinson's disease (pd) is a common neurodegenerative motor disorder characterized by a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal dopamine (da) levels. |
2023-05-24 |
2023-08-14 |
mouse |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
mechanistically, bh4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ros, maintains neuronal excitability and promotes mitochondrial atp production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical pd animal models, human dopaminergic midbrain-like organoids and primary cells from pd-affected individuals. |
2023-05-23 |
2023-08-14 |
mouse |
| Peiyu Xu, Sijie Huang, Brian E Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xinheng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L Roth, H Eric X. Structural genomics of the human dopamine receptor system. Cell research. 2023-05-23. PMID:37221270. |
the dopaminergic system, including five dopamine receptors (d1r to d5r), plays essential roles in the central nervous system (cns); and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders, including parkinson's disease (pd) and schizophrenia. |
2023-05-23 |
2023-08-14 |
human |
| María Elena Quintanilla, Yedy Israe. Role of Metabolism on Alcohol Preference, Addiction, and Treatment. Current topics in behavioral neurosciences. 2023-05-23. PMID:37221350. |
studies presented in this chapter show that: (1) in the brain, ethanol is metabolized by catalase to acetaldehyde, which condenses with dopamine forming salsolinol; (2) acetaldehyde-derived salsolinol increases the release of dopamine mediating, via opioid receptors, the reinforcing effects of ethanol during the acquisition of ethanol consumption, while (3) brain acetaldehyde does not influence the maintenance of chronic ethanol intake, it is suggested that a learned cue-induced hyperglutamatergic system takes precedence over the dopaminergic system. |
2023-05-23 |
2023-08-14 |
Not clear |
| Hannah R Stutt, Matthew A Weber, Rachael C Cole, Alexandra S Bova, Xin Ding, Madison S McMurrin, Nandakumar S Narayana. Sex similarities and dopaminergic differences in interval timing. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205472. |
because dopamine powerfully affects interval timing, we also examined sex differences with drugs targeting dopaminergic receptors. |
2023-05-19 |
2023-08-14 |
human |
| Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
a well-established dopamine replacement therapy for pd is based on dopamine deficiency, primarily due to dopaminergic neuronal loss in the substantia nigra. |
2023-05-17 |
2023-08-14 |
Not clear |
| Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
current dopaminergic pharmacotherapy for pd consists of levodopa and other dopaminergic drugs, such as a dopamine agonist (da) and monoamine oxidase b (maob) inhibitor, and patients with pd are administered these mainly according to age, disability of parkinsonism, and tolerance of the drugs. |
2023-05-17 |
2023-08-14 |
Not clear |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-05-15 |
2023-08-14 |
mouse |
| Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova, Volodymyr V Shvadcha. Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity. ACS chemical neuroscience. 2023-05-10. PMID:37162160. |
current treatment involves approaches that compensate the death of dopaminergic neurons by increasing the dopamine levels in remaining cells. |
2023-05-10 |
2023-08-14 |
rat |
| Mahesh Rachamalla, Arash Salahinejad, Maria Khan, Ashok Kumar Datusalia, Som Niyog. Chronic dietary exposure to arsenic at environmentally relevant concentrations impairs cognitive performance in adult zebrafish (Danio rerio) via oxidative stress and dopaminergic dysfunction. The Science of the total environment. 2023-05-10. PMID:37164085. |
dopaminergic system in the brain is known to play a critical role in regulating cognitive behaviours in fish, and our observations suggested that chronic dietary treatment with medium and high arsenic doses leads to significant alterations in the expression of genes involved in dopamine signalling (dopamine receptors), synthesis (thyroxine hydroxylase) and metabolism (monoamine oxidase) in the zebrafish brain. |
2023-05-10 |
2023-08-14 |
zebrafish |
| D Woitalla, C Buhmann, R Hilker-Roggendorf, G Höglinger, J Koschel, T Müller, D Weis. Role of dopamine agonists in Parkinson's disease therapy. Journal of neural transmission (Vienna, Austria : 1996). 2023-05-10. PMID:37165120. |
the occurrence of side effects can be explained by the different receptor affinity to the individual dopaminergic and non-dopaminergic receptors of the individual dopamine agonists. |
2023-05-10 |
2023-08-14 |
Not clear |
| Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang, Hsiung-Lin T. Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection. ACS sensors. 2023-05-08. PMID:37155824. |
dopamine (da) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |