| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanne Ng, Serena Barral, Simon N Waddington, Manju A Kuria. Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases. Movement disorders : official journal of the Movement Disorder Society. 2023-05-06. PMID:37147851. |
here, we review recent advances in gene therapy, focused on the targeted delivery of dopaminergic genes for parkinson's disease and the primary neurotransmitter disorders, aadc deficiency and dopamine transporter deficiency syndrome (dtds). |
2023-05-06 |
2023-08-14 |
Not clear |
| P Tall, M A Qamar, L Batzu, V Leta, C Falup-Pecurariu, K Ray Chaudhur. Non-oral continuous drug delivery based therapies and sleep dysfunction in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-05-01. PMID:37126118. |
cdd aims to mimic the physiological tonic dopamine release from striatal dopaminergic neurons and thus reduces the severity and duration of motor and non-motor fluctuations partly related to pulsatile levodopa stimulation. |
2023-05-01 |
2023-08-14 |
Not clear |
| Emily C Mahoney-Rafferty, Heidi R Tucker, Kainat Akhtar, Rachael Herlihy, Aliyah Audil, Dia Shah, Megan Gupta, Eliyahu M Kochman, Paul J Feustel, Eric S Molho, Julie G Pilitsis, Damian S Shi. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats. Neuroscience. 2023-04-28. PMID:37116741. |
limited research suggests that dopaminergic signaling exists in the cerebellum with functional dopamine receptors, tyrosine hydroxylase (th) and dopamine transporters (dats); however, much of this information is largely derived from healthy animals and humans. |
2023-04-28 |
2023-08-14 |
rat |
| Thomas Akam, Mark E Walto. What is dopamine doing in model-based reinforcement learning? Current opinion in behavioral sciences. vol 38. 2023-04-21. PMID:37082448. |
here we examine two possible accounts for dopamine's involvement in model-based rl: the first that dopamine neurons carry a prediction error used to update a type of predictive state representation called a successor representation, the second that two well established aspects of dopaminergic activity, rpes and surprise signals, can together explain dopamine's involvement in model-based rl. |
2023-04-21 |
2023-08-14 |
Not clear |
| Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn D R Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yi. Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement. eLife. vol 12. 2023-04-21. PMID:37083584. |
these neurons are located in the dentate gyrus, receive dopaminergic projections from the locus coeruleus, and express d1 dopamine receptors. |
2023-04-21 |
2023-08-14 |
mouse |
| Renata Aparecida Nedel Pertile, Rachel Brigden, Vanshika Raman, Xiaoying Cui, Zilong Du, Darryl Eyle. Vitamin D: A potent regulator of dopaminergic neuron differentiation and function. Journal of neurochemistry. 2023-04-21. PMID:37084159. |
here we provide further evidence of vitamin d's role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein redistribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including sh-sy5y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures. |
2023-04-21 |
2023-08-14 |
Not clear |
| I N Rozhkova, S V Okotrub, E Yu Brusentsev, K E Uldanova, E А Chuyko, V A Naprimerov, T V Lipina, T G Amstislavskaya, S Ya Amstislavsk. Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 2. 2023-04-17. PMID:37063509. |
thus, a change in social-conditioned place preference in clstn2-ko mice as well as a higher number of neurons expressing type 2 dopamine receptors and tyrosine hydroxylase in the vta, the key structure of the mesolimbic dopaminergic pathway, were observed. |
2023-04-17 |
2023-08-14 |
mouse |
| Julia E R Nickols, Serdar M Dursun, Anna M W Taylo. Preclinical evidence for the use of the atypical antipsychotic, brexpiprazole, for opioid use disorder. Neuropharmacology. 2023-04-17. PMID:37068603. |
recently, the use of dopamine partial agonists has been proposed as a potential strategy to restore dopaminergic signalling during drug withdrawal, while avoiding the adverse side effects associated with stronger modulators of dopaminergic transmission. |
2023-04-17 |
2023-08-14 |
mouse |
| Yoon-Sang Oh, Joong-Seok Kim, Chul Hyoung Lyoo, Hosung Ki. Obstructive Sleep Apnea and Striatal Dopamine Availability in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-04-13. PMID:37046390. |
striatal dopamine uptake is a surrogate marker of nigral dopaminergic cell damage. |
2023-04-13 |
2023-08-14 |
Not clear |
| Zevelou Koza, Mohamad Ayajuddin, Abhik Das, Rahul Chaurasia, Limamanen Phom, Sarat Chandra Yenisett. Sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: Insights from Frontiers in neuroscience. vol 17. 2023-04-07. PMID:37025374. |
sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: insights from sexual dysfunction (sd) is one of the most common non-motor symptoms of parkinson's disease (pd) and remains the most neglected, under-reported, and under-recognized aspect of pd. |
2023-04-07 |
2023-08-14 |
Not clear |
| Brianna Cocuzzo, Kristy A Fisher, Clara L Alvarez Villalb. Neuroleptic Malignant Syndrome Status Post Anoxic Brain Injury: A Case Presentation of Heightened Susceptibility in the Brain Injury Population. Cureus. vol 15. issue 3. 2023-04-07. PMID:37025743. |
further investigation is necessary to expand upon the existing literature suggesting the role of alternative agents, including amantadine, due to its impact on dopaminergic transmission, as well as dopamine and glutamine release. |
2023-04-07 |
2023-08-14 |
Not clear |
| Purnima Padmanabhan, Agostina Casamento-Moran, Aram Kim, Anthony J Gonzalez, Alexander Pantelyat, Ryan T Roemmich, Vikram S Chi. Dopamine facilitates the translation of physical exertion into assessments of effort. NPJ Parkinson's disease. vol 9. issue 1. 2023-04-03. PMID:37005418. |
to test dopamine's role in the translation of effortful exertion into assessments of effort, we had participants with parkinson's disease, in dopamine depleted (off dopaminergic medication) and elevated (on dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. |
2023-04-03 |
2023-08-14 |
human |
| Berhanu Geresu Kibret, Ana Canseco-Alba, Emmanuel S Onaivi, Ephrem Engidawor. Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation. Frontiers in behavioral neuroscience. vol 17. 2023-04-03. PMID:37009000. |
crosstalk between the endocannabinoid and mid-brain dopaminergic systems: implication in dopamine dysregulation. |
2023-04-03 |
2023-08-14 |
Not clear |
| Berhanu Geresu Kibret, Ana Canseco-Alba, Emmanuel S Onaivi, Ephrem Engidawor. Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation. Frontiers in behavioral neuroscience. vol 17. 2023-04-03. PMID:37009000. |
the cross-talk between the ecs and the dopaminergic system has important influence in various dopamine-related neurobiological and pathologic conditions and investigating this interaction might help identify therapeutic targets and options in disorders of the cns associated with dopamine dysregulation. |
2023-04-03 |
2023-08-14 |
Not clear |
| Juan Segura-Aguilar, Bengt Mannervi. A Preclinical Model for Parkinson's Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978921. |
the presence of neuromelanin-containing dopaminergic neurons in the postmortem brain of healthy elderly people suggests that neuromelanin synthesis is a normal and harmless process despite the fact that it requires oxidation of dopamine to three ortho-quinones that are potentially toxic, especially aminochrome. |
2023-03-29 |
2023-08-14 |
Not clear |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the main histopathological hallmarks of parkinson's disease (pd) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. |
2023-03-29 |
2023-08-14 |
Not clear |
| Jana Lubec, Ahmed M Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lube. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979402. |
although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (dat) inhibitors are not sufficiently specific as they also target other transporters and receptors, thus showing unwanted side effects. |
2023-03-29 |
2023-08-14 |
rat |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). |
2023-03-29 |
2023-08-14 |
rat |