| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. |
here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n = 31, within-subjects; placebo, 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol). |
2023-09-04 |
2023-09-07 |
human |
| Jarkko Johansson, Nina Karalija, Alireza Salam. Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum. Aging brain. vol 4. 2023-08-30. PMID:37645244. |
extant research suggest aging-related losses of different dopaminergic markers, including presynaptic dopamine transporters as well as post-synaptic da receptors. |
2023-08-30 |
2023-09-07 |
human |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Hidekazu Sotoyam. Putative neural mechanisms underlying release-mode-specific abnormalities in dopamine neural activity in a schizophrenia-like model: The distinct roles of glutamate and serotonin in the impaired regulation of dopamine neurons. The European journal of neuroscience. 2023-08-23. PMID:37611917. |
dopaminergic neuronal activity in the resting state related to tonic release was increased by disinhibition of the dopamine neurons due to the impairment of 5ht2 (5ht2a) receptor-regulated gabaergic inputs. |
2023-08-23 |
2023-09-07 |
Not clear |
| Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Hoda Ranjbar, Narges Hosseinmardi, Gila Behzadi, Kristi A Kohlmeier, Mehran Ilaghi, Mohammad Shaban. Preventive putative effect of agmatine on cognitive and molecular outcomes in ventral tegmental area of male offspring following physical and psychological prenatal stress. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607891. |
ps is known to result in heightened dopamine release in the ventral tegmental area (vta), in part through the effects of corticotropin-releasing hormone, which directly excites dopaminergic cells. |
2023-08-22 |
2023-09-07 |
mouse |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
motor deficits observed in parkinson's disease (pd) are caused by the loss of dopaminergic neurons and the subsequent dopamine depletion in different brain areas. |
2023-08-20 |
2023-09-07 |
mouse |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
the most common therapy to treat motor symptoms for patients with this disorder is the systemic intake of l-dopa that increases dopamine levels in all the brain, making it difficult to discern the main locus of dopaminergic action in the alleviation of motor control. |
2023-08-20 |
2023-09-07 |
mouse |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
we conclude that optical delivery of dopamine in the striatum resembles the motor effects induced by systemic injection of dopaminergic agonists in unilateral dopamine-depleted mice. |
2023-08-20 |
2023-09-07 |
mouse |
| Linlin Wang, Qing Dan, Bingxuan Xu, Yun Chen, Tingting Zhen. Research progress on gas signal molecular therapy for Parkinson's disease. Open life sciences. vol 18. issue 1. 2023-08-17. PMID:37588999. |
among the pathological manifestations is the progressive degeneration of the nigrostriatal dopaminergic pathway, leading to massive loss of neurons in the substantia nigra pars compacta and dopamine (da) depletion. |
2023-08-17 |
2023-09-07 |
Not clear |
| Justine H Liang, Viktor Akhanov, Anthony Ho, Mohamed Tawfik, Shane P D'Souza, Morven A Cameron, Richard A Lang, Melanie A Samue. Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina. Current biology : CB. 2023-08-12. PMID:37572663. |
dopamine production by canonical dopaminergic amacrine interneurons is dispensable for these events. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yasemin Baranoglu Kilinc, Ibrahim Ethem Torun, Erkan Kilin. D2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine. The European journal of neuroscience. 2023-08-04. PMID:37539658. |
d2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine. |
2023-08-04 |
2023-08-14 |
rat |
| Rubina Roy, Rajib Paul, Pallab Bhattacharya, Anupom Bora. Combating Dopaminergic Neurodegeneration in Parkinson's Disease through Nanovesicle Technology. ACS chemical neuroscience. 2023-08-03. PMID:37534999. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration, resulting in dopamine depletion and motor behavior deficits. |
2023-08-03 |
2023-08-14 |
Not clear |
| Deepika Suri, Giulia Zanni, Darshini Mahadevia, Nao Chuhma, Rinki Saha, Stephen Spivack, Nicolò Pini, Gregory S Stevens, Annette Ziolkowski-Blake, Eleanor H Simpson, Peter Balsam, Stephen Rayport, Mark S Ansorg. Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression. Molecular psychiatry. 2023-08-02. PMID:37532798. |
lastly, using optogenetics to drive dopamine neurons, we find that increased vta but not snc dopaminergic activity mimics the increase in impulsive behavior in the go/nogo task observed after adolescent dat blockade. |
2023-08-02 |
2023-08-14 |
mouse |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
inspired by the recent observations that besides rpe, the firing rates of midbrain dopaminergic neurons correlate with motor and cognitive variables, we propose a model in which dopamine signal in the striatum carries a vector-valued error feedback signal (a loss gradient) instead of a homogeneous scalar error (a loss). |
2023-08-01 |
2023-08-14 |
Not clear |
| Can Tao, Guang-Wei Zhang, Junxiang J Huang, Zhong Li, Huizhong W Tao, Li I Zhan. The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections. Nature neuroscience. 2023-07-31. PMID:37524978. |
these projections enhance activity of dopaminergic neurons in the vta and serotonergic neurons in the dorsal raphe, respectively, with increased release of dopamine and serotonin, possibly through disinhibition mechanisms. |
2023-07-31 |
2023-08-14 |
mouse |
| Rohit Bhatt, Devendra Vaishnav, Vishal Airao, Tejas Sharma, Mahesh Rachamalla, Shalini Mani, Ashish Kumar Gupta, Vijay Upadhye, Saurabh Kumar Jha, Niraj Kumar Jha, Sachin Parma. Neuroprotective potential of saroglitazar in 6-OHDA induced Parkinson's disease in rats. Chemical biology & drug design. 2023-07-30. PMID:37518817. |
degeneration of dopaminergic neurons resulted in reduced dopamine turnover, consequently induced behavioural abnormalities in rats. |
2023-07-30 |
2023-08-14 |
rat |
| Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhan. Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson's disease patients and healthy controls. BMC medicine. vol 21. issue 1. 2023-07-25. PMID:37491235. |
we therefore aim to investigate the role of coffee consumption in nigrostriatal dopaminergic neurodegeneration using dopamine transporter (dat) imaging in pd and healthy controls (hc). |
2023-07-25 |
2023-08-14 |
Not clear |
| Ricardo J Ramírez-Carreto, Víctor J Zaldívar-Machorro, Dafne J Pérez-Ramírez, Blanca E Rodríguez-López, Claudia Meza, Esperanza García, Abel Santamaría, Anahí Chavarrí. Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice. Molecular neurobiology. 2023-07-22. PMID:37480498. |
both exert neuroprotective effects, preserving dopamine levels and dopaminergic neurons when administered in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse pd model, being probably sb the potential therapeutic molecule behind this effect. |
2023-07-22 |
2023-08-14 |
mouse |
| Robert B Kargb. Microbiome-Gut-Brain Axis Modulation: New Approaches in Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis. ACS medicinal chemistry letters. vol 14. issue 7. 2023-07-19. PMID:37465304. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by symptoms like resting tremor, rigidity, bradykinesia, and postural instability, mainly due to dopamine depletion and degeneration of dopaminergic neurons. |
2023-07-19 |
2023-08-14 |
Not clear |
| Haoran Peng, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue L. Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease. Journal of the neurological sciences. vol 451. 2023-07-16. PMID:37454572. |
parkinson's disease (pd), the most common neurological motor system disorder, which characterised by the irreversible loss of dopaminergic neurones in the substantia nigra pars compacta, and leads to the deficiency of dopamine in the striatum. |
2023-07-16 |
2023-08-14 |
human |