| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia Alejandra Brand-Rubalcava, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Angelica Yanet Nápoles-Medina, Verónica Chaparro-Huerta, Mario Eduardo Flores-Sot. β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome. Parkinsonism & related disorders. vol 117. 2023-11-04. PMID:37924806. |
parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (snpc), resulting in diminished dopamine levels in the striatum (str) and chronic neuroinflammation. |
2023-11-04 |
2023-11-08 |
Not clear |
| Rafael Rivas-Santisteban, Alberto Rico, Ana Muñoz, Ana I Rodriguez, Irene Reyes-Resina, Gemma Navarro, José Luis Labandeira-García, José Luis Lanciego, Rafael Franc. Boolean analysis shows a high proportion of dopamine D Neurobiology of disease. 2023-11-02. PMID:37918757. |
boolean analysis shows a high proportion of dopamine d the antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine d |
2023-11-02 |
2023-11-08 |
Not clear |
| Antonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandor. Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919088. |
dopaminergic neurons are constantly threatened by the thin boundaries between functional α-synuclein (as) structural disorder and pathogenic aggregation, and between dopamine (da) neurotransmitter activity and accumulation of cytotoxic by-products. |
2023-11-02 |
2023-11-08 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plcγ1 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
the enhancement of dopamine release was accompanied by increased colocalization of vesicular monoamine transporter 2 (vmat2) at dopaminergic axon terminals. |
2023-11-01 |
2023-11-08 |
mouse |
| Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| David A Vogelsang, Daniella J Furman, Derek E Nee, Ioannis Pappas, Robert L White, Andrew S Kayser, Mark D'Esposit. Dopamine Modulates Effective Connectivity in Frontal Cortex. Journal of cognitive neuroscience. 2023-10-30. PMID:37902578. |
using a randomized, double-blind, within-subject design, we analyzed resting-state fmri data of 66 healthy young participants who were scanned once each after administration of bromocriptine (a dopamine agonist with preferential affinity for d2 receptor), tolcapone (an inhibitor of catechol-o-methyltransferase), and placebo, to determine whether dopaminergic stimulation modulated effective functional connectivity between hierarchically organized frontal regions in the left hemisphere. |
2023-10-30 |
2023-11-08 |
human |
| Priya Rathor, Ratnasekhar C. Metabolic Basis of Circadian Dysfunction in Parkinson's Disease. Biology. vol 12. issue 10. 2023-10-27. PMID:37887004. |
impaired α-synuclein secretion and dopamine release may cause mitochondrial dysfunction and perturb energy metabolism, subsequently altering the activity and survival of dopaminergic neurons, thus perpetuating the neurodegenerative process in pd. |
2023-10-27 |
2023-11-08 |
human |
| M López-Aguirre, M Matarazzo, J Blesa, M H G Monje, R Rodríguez-Rojas, A Sánchez-Ferro, J A Obeso, J A Pineda-Pard. Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson's disease patients. NPJ Parkinson's disease. vol 9. issue 1. 2023-10-20. PMID:37852988. |
loss of dopaminergic neurons in the substantia nigra pars compacta (snc) and a profound reduction of striatal dopamine are two hallmarks of parkinson's disease (pd). |
2023-10-20 |
2023-11-08 |
human |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Jeonghyun Park, Eunsoo Moon, Hyun Ju Lim, Kyungwon Kim, Yoo Rha Hong, Jung Hyun Le. Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 21. issue 4. 2023-10-20. PMID:37859441. |
: as dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. |
2023-10-20 |
2023-11-08 |
mouse |
| Elena Contaldi, Silvia Gallo, Lucia Corrado, Sandra D'Alfonso, Luca Magistrell. Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation. Cerebellum (London, England). 2023-10-19. PMID:37857779. |
patients underwent dopamine transporter single-photon emission computed tomography to assess dopaminergic degeneration. |
2023-10-19 |
2023-11-08 |
Not clear |
| Merlin Monzel, Jana Karneboge, Martin Reute. The role of dopamine in visual imagery-An experimental pharmacological study. Journal of neuroscience research. 2023-10-18. PMID:37849328. |
additional exploratory analyses will use genetic data to investigate possible effects of variations on dopaminergic gene loci (e.g., dat1) on dopamine levels and strength of mental imagery. |
2023-10-18 |
2023-11-08 |
human |
| Iman Touati, Mohnad Abdalla, Yassir Boulaamane, Nawal Al-Hoshani, Abdulaziz Alouffi, Mohammed Reda Britel, Amal Maurad. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors. Journal of biomolecular structure & dynamics. 2023-10-18. PMID:37850444. |
pd is the second most ubiquitous neurological disorder after alzheimer's disease, characterized by the depletion of dopamine in the central nervous system due to the impairment of dopaminergic neurons, leading to involuntary movements or dyskinesia. |
2023-10-18 |
2023-11-08 |
Not clear |
| Sairam Ramesh, Arosh S Perera Molligoda Arachchig. Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature. AIMS neuroscience. vol 10. issue 3. 2023-10-16. PMID:37841347. |
in individuals with parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. |
2023-10-16 |
2023-11-08 |
Not clear |
| Sheila A Villa-Cedillo, Daniel Matta-Yee-Chig, Adolfo Soto-Domínguez, Humberto Rodríguez-Rocha, Aracely García-García, Carlos R Montes-de-Oca-Saucedo, María de Jesús Loera-Arias, Jesús Valdés, Odila Saucedo-Cárdena. CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model. Neuropeptides. vol 102. 2023-10-14. PMID:37837805. |
neurotrophic factors, such as cerebral dopamine neurotrophic factor (cdnf), have shown a neuroprotective effect on dopaminergic neurons. |
2023-10-14 |
2023-11-08 |
mouse |
| Mohana Devi Subramaniam, P Aishwarya Janaki, B Abishek Kumar, Janani Gopalarethinam, Aswathy P Nair, I Mahalaxmi, Balachandar Vellingir. Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis. Cellular and molecular neurobiology. 2023-10-13. PMID:37831228. |
parkinson's disease (pd) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) which leads to the depletion of dopamine in the body. |
2023-10-13 |
2023-10-15 |
Not clear |
| Hao Liu, Haibin Dong, Chunxiao Wang, Wenjuan Jia, Guangqiang Wang, Hua Wang, Lin Zhong, Lei Gon. Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells. DNA and cell biology. 2023-10-10. PMID:37815547. |
cerebral dopamine neurotrophic factor (cdnf) is a unique neurotrophic factor (ntf) that has shown significant neuroprotective and neurorestorative functions on midbrain dopaminergic neurons. |
2023-10-10 |
2023-10-15 |
human |
| Xuanxiang Jin, Xiaoli Si, Xiaoguang Lei, Huifang Liu, Anwen Shao, Lingfei L. Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson's Disease Pathogenesis. Aging and disease. 2023-10-10. PMID:37815908. |
vestigial dopaminergic cells in pd have selectivity for a sub-class of hypersensitive neurons with the nigrostriatal dopamine (da) tract. |
2023-10-10 |
2023-10-15 |
Not clear |
| Xiu-Ying He, Ru-Rong Wang, Ting-Hua Wan. The role of immune cells in the course of Parkinson's disease. Ibrain. vol 7. issue 2. 2023-10-03. PMID:37786903. |
the pathological manifestations mainly consist of α-synuclein accumulation, degeneration and death of dopaminergic neurons, and insufficient dopamine secretion. |
2023-10-03 |
2023-10-07 |
Not clear |