| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Spoleti, Livia La Barbera, Emma Cauzzi, Maria Luisa De Paolis, Luana Saba, Ramona Marino, Giuseppe Sciamanna, Vincenzo Di Lazzaro, Flavio Keller, Annalisa Nobili, Paraskevi Krashia, Marcello D'Ameli. Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease. Molecular psychiatry. 2024-01-16. PMID:38228889. |
here, using the tg2576 mouse model of ad, we prove that reduced hippocampal dopaminergic innervation, due to vta dopamine neuron degeneration, impairs pv-in firing and gamma-waves, weakens the inhibition of pyramidal neurons and induces hippocampal hyperexcitability via lower d2-receptor-mediated activation of the creb-pathway. |
2024-01-16 |
2024-01-19 |
mouse |
| Zhijian Pan, Min Shao, Chen Zhao, Xuanjun Yang, Haitao Li, Guozhen Cui, Xiaonan Liang, Chao-Wu Yu, Qingqing Ye, Cheng Gao, Lijun Di, Ji-Wang Chern, Hefeng Zhou, Simon Ming-Yuen Le. J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024-01-10. PMID:38199443. |
animal behavioral tests demonstrated that j24335 markedly improved motor function and loss of th-positive neurons and dopaminergic nerve fibers, and contributed to an increase in the levels of dopamine and its metabolites in brain tissue. |
2024-01-10 |
2024-01-13 |
mouse |
| Pinar Eser, Ersoy Kocabicak, Ahmet Bekar, Yasin Teme. Insights into neuroinflammatory mechanisms of deep brain stimulation in Parkinson's disease. Experimental neurology. 2024-01-10. PMID:38199508. |
parkinson's disease, a progressive neurodegenerative disorder, involves gradual degeneration of the nigrostriatal dopaminergic pathway, leading to neuronal loss within the substantia nigra pars compacta and dopamine depletion. |
2024-01-10 |
2024-01-13 |
Not clear |
| Milan D Valyear, Alexa Brown, Ghislaine Deyab, Franz R Villaruel, Soraya Lahlou, Nina Caporicci-Dinucci, Nadia Chaudhr. Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context. The European journal of neuroscience. 2024-01-08. PMID:38185906. |
although dopaminergic inputs to the nac shell were previously shown to be necessary for cs responding in an alcohol context, here, chemogenetic excitation of ventral tegmental area (vta) dopamine neurons and their inputs to the nac shell did not affect cs responding. |
2024-01-08 |
2024-01-10 |
rat |
| Makito Hirano, Makoto Samukawa, Chiharu Isono, Susumu Kusunoki, Yoshitaka Naga. The effect of rasagiline on swallowing function in Parkinson's disease. Heliyon. vol 10. issue 1. 2024-01-08. PMID:38187336. |
the transdermal dopamine agonist rotigotine alleviates dysphagia in patients with parkinson's disease and is more effective than oral levodopa, suggesting the importance of continuous dopaminergic stimulation during swallowing. |
2024-01-08 |
2024-01-10 |
Not clear |
| Yunjiang Yu, Shihui Tan, Hongzhi Guo, Xin Hua, Haibo Chen, Yue Yang, Dongli Xie, Chuan Yi, Haibo Ling, Mingdeng Xian. Chronic neurotoxicity of Tetrabromobisphenol A: Induction of oxidative stress and damage to neurons in Caenorhabditis elegans. Chemosphere. 2024-01-07. PMID:38185427. |
furthermore, 100 μg/l tcbpa exposure caused a reduction in dopamine and serotonin levels, and damage in dopaminergic and serotoninergic neurons, which was further confirmed by the downregulated expression of related genes (e.g., dop-1, dop-3, cat-1, and mod-1). |
2024-01-07 |
2024-01-10 |
caenorhabditis_elegans |
| Alessia Cavallo, Wolf-Julian Neuman. Dopaminergic reinforcement in the motor system: Implications for Parkinson's disease and deep brain stimulation. The European journal of neuroscience. 2024-01-05. PMID:38178558. |
dopaminergic neurons innervate large-scale brain networks, and accordingly, many different roles for dopamine signals have been proposed, such as invigoration of movement and tracking of reward contingencies. |
2024-01-05 |
2024-01-07 |
human |
| Marcello Serra, Giulia Costa, Emmanuel Onaivi, Nicola Simol. Divergent acute and enduring changes in 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine and dopaminergic antagonists: new insights on the role of dopamine in calling behavior. The international journal of neuropsychopharmacology. 2024-01-04. PMID:38174899. |
divergent acute and enduring changes in 50-khz ultrasonic vocalizations in rats repeatedly treated with amphetamine and dopaminergic antagonists: new insights on the role of dopamine in calling behavior. |
2024-01-04 |
2024-01-06 |
rat |
| Filip Grill, Marc Guitart-Masip, Jarkko Johansson, Lars Stiernman, Jan Axelsson, Lars Nyberg, Anna Rieckman. Dopamine release in human associative striatum during reversal learning. Nature communications. vol 15. issue 1. 2024-01-03. PMID:38167691. |
the dopaminergic system is firmly implicated in reversal learning but human measurements of dopamine release as a correlate of reversal learning success are lacking. |
2024-01-03 |
2024-01-06 |
human |
| Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. |
acute amph administration leads to transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2024-01-02 |
2024-01-05 |
mouse |
| Giovanni Mirabella, Andrea Pilotto, Andrea Rizzardi, Martina Montalti, Enrica Olivola, Cinzia Zatti, Veronica Di Caprio, Elisabetta Ferrari, Nicola Modugno, Alessandro Padovan. Effects of dopaminergic treatment on inhibitory control differ across Hoehn and Yahr stages of Parkinson's disease. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162902. |
a progressive loss of the midbrain's dopamine neurons characterizes parkinson's disease and causes motor features responsive to dopaminergic treatments. |
2024-01-01 |
2024-01-05 |
Not clear |
| Surabhi Shastry, Junkai Hu, Mingyao Ying, Xiaobo Ma. Cell Therapy for Parkinson's Disease. Pharmaceutics. vol 15. issue 12. 2023-12-23. PMID:38139997. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons of the substantia nigra pars compacta with a reduction in dopamine concentration in the striatum. |
2023-12-23 |
2023-12-25 |
Not clear |
| Ryu Mochizuki, Yasumitsu Ogr. Determination of intracellular dopamine by liquid chromatography-fluorescence detection with post-column derivatization using the König reaction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1232. 2023-12-21. PMID:38128164. |
dopamine is an important neurotransmitter, and the disruption of dopaminergic homeostasis causes various neurological diseases such as parkinson's disease. |
2023-12-21 |
2023-12-24 |
Not clear |
| Narmadhaa Sivagurunathan, Mohamudha Parveen Rahamathulla, Hussein Al-Dossary, Latchoumycandane Calivaratha. Emerging Role of Long Noncoding RNAs in Regulating Inflammasome-Mediated Neurodegeneration in Parkinson's Disease. Molecular neurobiology. 2023-12-17. PMID:38105409. |
the underlying pathophysiology involves the progressive loss of dopaminergic neurons within the substantia nigra pars compacta, leading to dopamine depletion in the basal ganglia circuitry. |
2023-12-17 |
2023-12-21 |
Not clear |
| Moriah E Weese-Myers, Ashley E Ros. Subsecond Codetection of Dopamine and Estradiol at a Modified Sharkfin Waveform. Analytical chemistry. 2023-12-16. PMID:38103188. |
in particular, it is a well-known dopamine (da) regulator and is responsible for modulating the expression of dopaminergic receptors and transporters. |
2023-12-16 |
2023-12-19 |
Not clear |
| Rana Alnasser Alsukhni, Ekawat Vichayanrat, Shiwen Koay, Laura May Davis, Gordon Ingle, Patricia McNamara, Jalesh N Panicker, Kailash P Bhatia, Christopher Mathias, Jamshed Bomanji, Valeria Iodic. Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement. European journal of neurology. 2023-12-12. PMID:38085264. |
a possibility is to evaluate the nigrostriatal dopaminergic degeneration by imaging of dopamine transporter with datscan brain imaging. |
2023-12-12 |
2023-12-17 |
Not clear |
| Osama A Mohammed, Mohammed S Elballal, Ahmed A El-Husseiny, Emad Gamil Khidr, Manar Mohammed El Tabaa, Ola Elazazy, Mai A Abd-Elmawla, Ahmed E Elesawy, Henwa M Ibrahim, Ahmed I Abulsoud, Walaa A El-Dakroury, Sherif S Abdel Mageed, Mahmoud A Elrebehy, Yousra Nomier, Mustafa Ahmed Abdel-Reheim, Hussein M El-Husseiny, Abdulla M A Mahmoud, Sameh Saber, Ahmed S Doghis. Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease. Pathology, research and practice. vol 253. 2023-12-11. PMID:38081104. |
the occurrence of striatal dopamine insufficiency can be attributed to a notable decline in dopaminergic neurons inside the substantia nigra pars compacta. |
2023-12-11 |
2023-12-17 |
Not clear |
| Osama A Mohammed, Mohammed S Elballal, Ahmed A El-Husseiny, Emad Gamil Khidr, Manar Mohammed El Tabaa, Ola Elazazy, Mai A Abd-Elmawla, Ahmed E Elesawy, Henwa M Ibrahim, Ahmed I Abulsoud, Walaa A El-Dakroury, Sherif S Abdel Mageed, Mahmoud A Elrebehy, Yousra Nomier, Mustafa Ahmed Abdel-Reheim, Hussein M El-Husseiny, Abdulla M A Mahmoud, Sameh Saber, Ahmed S Doghis. Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease. Pathology, research and practice. vol 253. 2023-12-11. PMID:38081104. |
while current therapy approaches for pd aim to preserve dopaminergic neurons or replenish dopamine levels in the brain, it is important to acknowledge that achieving complete remission of the condition remains elusive. |
2023-12-11 |
2023-12-17 |
Not clear |
| Laura Kubens, Ann-Kathrin Weishaupt, Vivien Michaelis, Isabelle Rohn, Fabian Mohr, Julia Bornhors. Exposure to the environmentally relevant fungicide Maneb: Studying toxicity in the soil nematode Caenorhabditis elegans. Environment international. vol 183. 2023-12-10. PMID:38071851. |
nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (gaba) was observed as well as morphological changes in the dopaminergic neurons upon maneb exposure, which underlines the assumption of the neurotoxic potential of maneb. |
2023-12-10 |
2023-12-17 |
caenorhabditis_elegans |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
ventral midbrain (vm) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of parkinson's disease (pd). |
2023-12-10 |
2023-12-17 |
human |