| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alagudurai Krishnamoorthy, Riddhi Upadhyay, Murugan Sevana. Chrysin for Neurotrophic and Neurotransmitter Balance in Parkinson's Disease. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427256. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) has a direct impact on the dopaminergic neurons in the substantia nigra pars compacta (snpc), dopamine in the striatum (st), homovanillic acid (hva), neurotrophic factors of the snpc, and st regions leading to parkinson's disease (pd). |
2024-03-01 |
2024-03-03 |
mouse |
| Florina Madalina Mindru, Andrei-Flavius Radu, Adrian Gheorghe Bumbu, Ada Radu, Simona Gabriela Bunga. Insights into the Medical Evaluation of Ekbom Syndrome: An Overview. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396826. |
its pathophysiological mechanism involves uncertain dopaminergic imbalances and dysfunction in the dopamine transporter system. |
2024-02-24 |
2024-02-26 |
Not clear |
| Lingling Zhang, Hao Yan. Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson's disease. Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400887. |
parkinson's disease (pd) is a neurodegenerative disease, the most characteristic pathological feature is the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compactus (snpc) of the mesencephalon, along with reduced dopamine content in the striatum. |
2024-02-24 |
2024-02-27 |
Not clear |
| Mateusz Toś, Anna Grażyńska, Sofija Antoniuk, Joanna Siud. Impulse Control Disorders in Parkinson's Disease and Atypical Parkinsonian Syndromes-Is There a Difference? Brain sciences. vol 14. issue 2. 2024-02-23. PMID:38391755. |
icds are known non-motor symptoms in parkinson's disease (pd) and are associated primarily with the use of dopaminergic treatment (drt) and especially dopamine agonists (da). |
2024-02-23 |
2024-02-25 |
Not clear |
| Hyun Jun Lee, Darlene Mae Ortiz, Leandro Val Sayson, Mikyung Kim, Jae Hoon Cheong, Hee Jin Ki. Ameliorating effects of Acanthopanax koreanum extract and components on nicotine dependence and withdrawal symptoms. Addiction biology. vol 29. issue 2. 2024-02-21. PMID:38380695. |
in addition, alterations in the dopaminergic and drd1-epac-erk-creb pathways were observed using dopamine elisa and western blotting using mouse brains. |
2024-02-21 |
2024-02-23 |
mouse |
| Hadeel Khamis, Ohad Cohe. Coupled action potential and calcium dynamics underlie robust spontaneous firing in dopaminergic neurons. Physical biology. 2024-02-21. PMID:38382117. |
dopaminergic neurons are specialized cells in the substantia nigra, tasked with dopamine secretion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Renata Sadibolova, Emily K DiMarco, Angela Jiang, Benjamin Maas, Stephen B Tatter, Adrian Laxton, Kenneth T Kishida, Devin B Terhun. Sub-second and multi-second dopamine dynamics underlie variability in human time perception. medRxiv : the preprint server for health sciences. 2024-02-19. PMID:38370629. |
fast, phasic, dopaminergic signals were associated with underestimation of temporal intervals, whereas slower, tonic, decreases in dopamine were associated with poorer temporal precision. |
2024-02-19 |
2024-02-21 |
human |
| Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Sing. Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation. Ageing research reviews. 2024-02-18. PMID:38369026. |
post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of nft, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. |
2024-02-18 |
2024-02-21 |
human |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| Xóchitl Flores-Ponce, Adolfo López-Ornelas, Itzel Escobedo-Avila, Mayela Rodríguez-Violante, David Dávila-Ortiz de Montellano, Amín Cervantes-Arriaga, Nancy Monroy-Jaramillo, Aurelio Campos-Romo, Iván Velasc. Establishment of induced pluripotent stem cell lines derived from Parkinson's disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1. Stem cell research. vol 76. 2024-02-15. PMID:38359473. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. |
2024-02-15 |
2024-02-18 |
Not clear |
| Muneshwar Mehra, Gerardo Molina, Md Tarikul Islam, Zahra M Dhanerawala, Eleonora Bano, Edward B Ha. Functionally distinct dopamine domains in the hippocampus. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352351. |
finally, the subcellular scale of dopamine domains suggests specialized postsynaptic pathways for processing and integrating functionally distinct dopaminergic influences. |
2024-02-14 |
2024-02-16 |
mouse |
| Josep Carbonell-Roig, Alina Aaltonen, Veronica Cartocci, Avery McGuirt, Eugene Mosharov, Jan Kehr, Ori J Lieberman, David Sulzer, Anders Borgkvist, Emanuela Santin. Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352367. |
the loss of normal dopamine neurotransmission is due to a defective nicotinic receptor signaling that regulates calcium dynamics in dopaminergic axons. |
2024-02-14 |
2024-02-16 |
mouse |
| Pingping Song, Dimitri Krain. Protocol to investigate Parkinson's patient-derived dopaminergic neurons by live-cell microscopy and oxidized dopamine assays. STAR protocols. vol 5. issue 1. 2024-02-11. PMID:38341851. |
protocol to investigate parkinson's patient-derived dopaminergic neurons by live-cell microscopy and oxidized dopamine assays. |
2024-02-11 |
2024-02-14 |
human |
| Victor Blokhin, Ekaterina N Pavlova, Elena A Katunina, Marina R Nodel, Galina V Kataeva, Elina R Moskalets, Tatiana S Pronina, Michael V Ugrumo. Dopamine Synthesis in the Nigrostriatal Dopaminergic System in Patients at Risk of Developing Parkinson's Disease at the Prodromal Stage. Journal of clinical medicine. vol 13. issue 3. 2024-02-10. PMID:38337569. |
dopamine synthesis in the nigrostriatal dopaminergic system in patients at risk of developing parkinson's disease at the prodromal stage. |
2024-02-10 |
2024-02-12 |
Not clear |
| Miguel Siqueira Campos Junior, Andréia Gomes Bezerra, Daniela Fernández Curado, Renata Pauluci Gregório, José Carlos Fernandes Galduró. Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial. Pharmacology, biochemistry, and behavior. 2024-02-10. PMID:38340989. |
several studies have demonstrated that ach modulates the dopaminergic circuit in the nucleus accumbens, and its blockade appears to be associated with the inhibition of the reinforced effect or the increase in dopamine caused by cocaine use. |
2024-02-10 |
2024-02-14 |
Not clear |
| Niklas Reich, Michael Mannino, Steven Kotle. Using caffeine as a chemical means to induce flow states. Neuroscience and biobehavioral reviews. 2024-02-08. PMID:38331128. |
caffeine may facilitate flow through various effects, including: i) upregulation of dopamine d1/d2 receptor affinity in reward-associated brain areas, leading to greater energetic arousal and 'wanting'; ii) protection of dopaminergic neurons; iii) increases in norepinephrine release and alertness, which offset sleep-deprivation and hypoarousal; iv) heightening of parasympathetic high frequency heart rate variability, resulting in improved cortical stress appraisal, v) modification of striatal endocannabinoid-cb1 receptor-signalling, leading to enhanced stress tolerance; and vi) changes in brain network activity in favour of executive function and flow. |
2024-02-08 |
2024-02-11 |
Not clear |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
since dopamine transporter (dat) gene is known as a marker for dopaminergic neurons, we inserted chr2-mcherry into the downstream of the dat gene locus of the rat genome by clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (crispr-cas9) genome editing and created dat-chr2-mcherry knock-in rats. |
2024-02-07 |
2024-02-10 |
rat |
| Larissa Pereira Dantas da Silva, Erika da Cruz Guedes, Isabel Cristina Oliveira Fernandes, Lucas Aleixo Leal Pedroza, Gustavo José da Silva Pereira, Priscila Guber. Exploring Caenorhabditis elegans as Parkinson's Disease Model: Neurotoxins and Genetic Implications. Neurotoxicity research. vol 42. issue 1. 2024-02-06. PMID:38319410. |
c. elegans has a conserved neurotransmission system during evolution; it produces dopamine, through the eight dopaminergic neurons; it can be used to study the effect of neurotoxins and also has strains that express human α-synuclein. |
2024-02-06 |
2024-02-09 |
human |
| Larissa Pereira Dantas da Silva, Erika da Cruz Guedes, Isabel Cristina Oliveira Fernandes, Lucas Aleixo Leal Pedroza, Gustavo José da Silva Pereira, Priscila Guber. Exploring Caenorhabditis elegans as Parkinson's Disease Model: Neurotoxins and Genetic Implications. Neurotoxicity research. vol 42. issue 1. 2024-02-06. PMID:38319410. |
here, we identified that nematodes exposed to the neurotoxins, such as 6-ohda, mptp, paraquat, and rotenone, had a progressive loss of dopaminergic neurons, dopamine deficits, and decreased survival rate. |
2024-02-06 |
2024-02-09 |
human |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |