| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
dans from hescs expressed dopaminergic markers, generated action potentials, and released dopamine (da) in vitro. |
2023-12-09 |
2023-12-17 |
human |
| Ichiro Kawahata, Kohji Fukunag. Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069360. |
in particular, fabp3, abundant in nigrostriatal dopaminergic neurons, is responsible for α-synuclein propagation into neurons and intracellular accumulation, affecting the loss of mesencephalic tyrosine hydroxylase protein, a rate-limiting enzyme of dopamine biosynthesis. |
2023-12-09 |
2023-12-17 |
Not clear |
| Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Migue. Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans. Neurotoxicology. 2023-12-09. PMID:38070655. |
we adapted an established dopaminergic neuronal function assay by measuring paralysis in the presence of exogenous dopamine, which revealed clear differences between cat-2 dopamine deficient mutants, wildtype worms, and dat-1 dopamine abundant mutants. |
2023-12-09 |
2023-12-17 |
caenorhabditis_elegans |
| Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Migue. Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans. Neurotoxicology. 2023-12-09. PMID:38070655. |
we show that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopaminergic neurodegeneration morphologies are correlated with functional neuronal outputs. |
2023-12-09 |
2023-12-17 |
caenorhabditis_elegans |
| Antía González-Vila, María Luengo-Mateos, María Silveira-Loureiro, Pablo Garrido-Gil, Nataliia Ohinska, Marco González-Domínguez, Jose Luis Labandeira-García, Cristina García-Cáceres, Miguel López, Olga Barca-May. Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner. Nature communications. vol 14. issue 1. 2023-12-09. PMID:38071352. |
remarkably, the mutants exhibit altered dopamine metabolism, and the pharmacological modulation of dopaminergic signaling partially restores distinct circadian traits in both male and female mutant mice. |
2023-12-09 |
2023-12-17 |
mouse |
| Nidhi Sachan, Saripella Srikrishna, Devendra Kumar Patel, Mahendra Pratap Sing. Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations. Molecular neurobiology. 2023-12-08. PMID:38064103. |
deferoxamine attenuated cypermethrin-induced iron accumulation and number of iron-positive cells and ameliorated the demise of dopaminergic cells and dopamine content. |
2023-12-08 |
2023-12-17 |
Not clear |
| Pinar Eser, Ersoy Kocabicak, Ahmet Bekar, Yasin Teme. The interplay between neuroinflammatory pathways and Parkinson's disease. Experimental neurology. vol 372. 2023-12-08. PMID:38061555. |
parkinson's disease, a progressive neurodegenerative disorder predominantly affecting elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway, culminating in neuronal loss within the substantia nigra pars compacta (snpc) and dopamine depletion. |
2023-12-08 |
2023-12-17 |
Not clear |
| Vesna Sočan, Klemen Dolinar, Mojca Krža. Transporters involved in adult rat cortical astrocyte dopamine uptake: Kinetics, expression and pharmacological modulation. The European journal of neuroscience. 2023-12-06. PMID:38054361. |
in addition, we were interested in the expression of mrna of dopamine transporters as well as dopamine receptors d1 and d2 and in the effect of dopaminergic drugs on the expression of these transporters and receptors. |
2023-12-06 |
2023-12-10 |
rat |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, and although restoring striatal dopamine levels may improve symptoms, no treatment can cure or reverse the disease itself. |
2023-12-05 |
2023-12-10 |
Not clear |
| Reka Csehi, Viktor Molnar, Mariann Fedor, Vivien Zsumbera, Agnes Palasti, Karoly Acsai, Zoltan Grosz, Gyorgy Nemeth, Maria Judit Molna. The improvement of motor symptoms in Huntington's disease during cariprazine treatment. Orphanet journal of rare diseases. vol 18. issue 1. 2023-12-02. PMID:38041194. |
their emergence is related to alterations in striatal dopaminergic neurotransmission: dopamine levels increase in the early stages of the disease, while more advanced stages are characterised by reduced dopamine levels. |
2023-12-02 |
2023-12-10 |
Not clear |
| Rong-Xin Song, Hui-Tao Miao, Shi-Yan Jia, Wen-Guang Li, Ji-Zhen Liu, Wei Zhang, Bao-Rui Xing, Jian-Yong Zhao, Li-Min Zhang, Xiao-Ming L. Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction. Molecular neurobiology. 2023-12-02. PMID:38041715. |
the hsr caused excessive dopaminergic signaling and cognitive dysfunction in the mpfc, a condition that might be ameliorated using a dopamine d1 receptor inhibitor. |
2023-12-02 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
in conclusion, this study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects. |
2023-12-01 |
2023-12-10 |
mouse |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
extensive research has been conducted on dopaminergic neurons, receptors, and dopamine levels as critical factors in cognition and memory in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
recently, a previously overlooked element of the dopaminergic system, the dopamine transporter, has shown significant promise as a more effective target for enhancing cognition while addressing dopaminergic system dysfunction in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
both chemogenetic activation of dopaminergic neurons and treatment with methylphenidate, a dopamine reuptake inhibitor, ameliorated the asd-like behavior of ido2 ko mice. |
2023-12-01 |
2023-12-10 |
mouse |
| Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T Williams, Malcolm G Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J Weber, Lei Wang, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Yulin Zhao, Marina E Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong L. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature methods. 2023-11-30. PMID:38036855. |
dopamine (da) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. |
2023-11-30 |
2023-12-10 |
Not clear |
| Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. |
the observed region-specific changes in the tissue levels of serotonin and in the expression of dopamine and serotonergic metabolism enzymes in rats with an excess of dopamine can indicate important consequences for the pharmacotherapy of drugs that modulate the dopaminergic system. |
2023-11-25 |
2023-11-28 |
rat |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
however, it is not clear whether mobilization of 2-ag specifically from midbrain dopamine neurons is necessary for dopaminergic responses to external stimuli predicting forthcoming reward. |
2023-11-24 |
2023-11-28 |
mouse |
| Laura Dazzi, Fabrizio Sanna, Giuseppe Talani, Valentina Bassareo, Francesca Biggio, Paolo Follesa, Maria Giuseppina Pisu, Patrizia Porcu, Roberta Puliga, Marina Quartu, Mariangela Serra, Maria Pina Serra, Enrico Sann, Elio Acqua. Binge-like administration of alcohol mixed to energy drinks to male adolescent rats severely impacts on mesocortical dopaminergic function in adulthood: A behavioral, neurochemical and electrophysiological study. Neuropharmacology. 2023-11-12. PMID:37952712. |
we did so by measuring: i) physiological sensorimotor gating; ii) voluntary alcohol consumption and dopamine transmission before, during, and after presentation of alcohol; iii) electrophysiological activity of vta dopaminergic neurons and their sensitivity to a challenge with alcohol. |
2023-11-12 |
2023-11-20 |
rat |
| Kyoungjune Pak, Lauri Nummenma. Brain dopamine receptor system is not altered in obesity: Bayesian and frequentist meta-analyses. Human brain mapping. 2023-11-11. PMID:37950852. |
feeding induces dopamine release in the striatum, and a dysfunction of the dopaminergic reward system can lead to overeating, and obesity. |
2023-11-11 |
2023-11-20 |
human |