| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A McCutcheon, Lilian A E Weber, Matthew M Nour, Stephanie J Cragg, Philip M McGuir. Psychosis as a disorder of muscarinic signalling: psychopathology and pharmacology. The lancet. Psychiatry. 2024-05-25. PMID:38795721. |
dopaminergic receptor antagonism is a crucial component of all licensed treatments for psychosis, and dopamine dysfunction has been central to pathophysiological models of psychotic symptoms. |
2024-05-25 |
2024-05-31 |
Not clear |
| Fu-Li Zhang, Xiao-Ke Yang, Yu-Ting Qi, Si-Yu Tian, Wei-Hua Huan. Nanoelectrochemistry reveals how presynaptic neurons regulate vesicle release to sustain synaptic plasticity under repetitive stimuli. Chemical science. vol 15. issue 20. 2024-05-24. PMID:38784745. |
herein, nanoelectrochemistry using carbon fiber nanoelectrodes with excellent spatio-temporal resolution was applied for real-time monitoring of presynaptic vesicle release of dopamine inside single synapses of dopaminergic neurons, and exocytotic variations in quantity and kinetics under repetitive electrical stimuli. |
2024-05-24 |
2024-05-27 |
Not clear |
| Bronwyn Bridges, Jake Taylor, John Thomas Webe. Evaluation of the Parkinson's Remote Interactive Monitoring System in a Clinical Setting: Usability Study. JMIR human factors. vol 11. 2024-05-24. PMID:38787603. |
pd is typically treated with levodopa, an oral pill taken to increase dopamine levels, and other dopaminergic agonists. |
2024-05-24 |
2024-05-27 |
Not clear |
| Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Alan Nicol, Rune Brautaset, David I Finkelstein, Christine T O Nguyen, James R Tribble, Pete A William. Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection. Acta neuropathologica communications. vol 12. issue 1. 2024-05-22. PMID:38773545. |
these changes classically include decreased levels of dopamine, accumulation of alpha-synuclein in the brain and retina, and death of dopaminergic nigral neurons and retinal amacrine cells leading to gross neuronal loss. |
2024-05-22 |
2024-05-27 |
mouse |
| Yash Wardhan, Sukriti Vishwas, Arumugam Porselvi, Sachin Kumar Singh, Violina Kakot. Exploring the complex interplay between Parkinson's Disease and BAG proteins. Behavioural brain research. 2024-05-20. PMID:38768687. |
parkinsons disease (pd) is a chronic fast growing neurodegenerative disorder of central nervous system (cns) characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and formation of lewy bodies (lbs) which causes dopamine deficiency within basal ganglia leading to motor and non-motor manifestation. |
2024-05-20 |
2024-05-27 |
Not clear |
| Yujie Yang, Xinyi Li, Jiaying Lu, Jingjie Ge, Mingjia Chen, Ruixin Yao, Mei Tian, Jian Wang, Fengtao Liu, Chuantao Zu. Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism. Neural regeneration research. vol 20. issue 1. 2024-05-20. PMID:38767479. |
nowadays, presynaptic dopaminergic positron emission tomography, which assesses deficiencies in dopamine synthesis, storage, and transport, is widely utilized for early diagnosis and differential diagnosis of parkinsonism. |
2024-05-20 |
2024-05-27 |
Not clear |
| Melisa R Ferreyra, Verónica L Romero, Lucia E Fernández Hubeid, Candelaria Gonzales-Moreno, Michael Aschner, Miriam B Virgolin. Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology. 2024-05-16. PMID:38754108. |
finally, to assess the relationship between ferroptosis and dopamine in a parkinsonian background, we evaluated the ua44 worm strain which overexpresses the alpha-synuclein protein in cherry-labeled dopaminergic neurons. |
2024-05-16 |
2024-05-27 |
caenorhabditis_elegans |
| Francesco Di Carlo, Mauro Pettorruso, Mario Santorelli, Fabrizio Cocciolillo, Giacomo d'Andrea, Marco Di Nicola, Stefano S Sensi, Giovanni Martinotti, Jon E Grant, Giovanni Camardese, Daniela Di Giud. Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder. Journal of gambling studies. 2024-05-16. PMID:38755422. |
the role of dopamine in the pathophysiology of gambling disorder (gd) remains incompletely understood, with disparate research findings concerning presynaptic and postsynaptic structures and dopaminergic synthesis. |
2024-05-16 |
2024-05-27 |
Not clear |
| Lina Ding, Long Wang, Jiaxin Yang, Cuicui Jiang, Xifeng Sun, Huite Huang, Xiuyuan Zhan, Feilong Liu, Qunlin Zhan. (+)-Borneol Protects Dopaminergic Neuronal Loss in Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease Mice: A Study of Dopamine Level using In Vivo Brain Microdialysis. ACS chemical neuroscience. 2024-05-15. PMID:38747405. |
(+)-borneol protects dopaminergic neuronal loss in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinson's disease mice: a study of dopamine level using in vivo brain microdialysis. |
2024-05-15 |
2024-05-27 |
mouse |
| Elizabeth Hubbard, Vivienne Mae Galinato, Pieter Derdeyn, Katrina Bartas, Stephen Vincent Mahler, Kevin T Beie. Neural circuit basis of adolescent THC-induced potentiation of opioid responses in adult mice. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712160. |
last, we show using rabies virus-based circuit mapping that adolescent thc exposure triggers a long-lasting elevation in connectivity from the frontal cortex regions onto ventral tegmental dopamine cells that has the potential to influence dopaminergic response to morphine administration during adulthood. |
2024-05-07 |
2024-05-27 |
mouse |
| Dione Y L Quek, Natasha Taylor, Moran Gilat, Simon J G Lewis, Kaylena A Ehgoetz Marten. Effect of dopamine on limbic network connectivity at rest in Parkinson's disease patients with freezing of gait. Translational neuroscience. vol 15. issue 1. 2024-05-06. PMID:38708096. |
while other studies found that dopaminergic replacement therapy alters functional brain organization in pd, the specific effect of dopamine medication on fronto-striato-limbic functional connectivity in freezers remains unclear. |
2024-05-06 |
2024-05-08 |
Not clear |
| Mélodie Ferrat, Mohammad M Moein, Carmen Cananau, Tetyana Tegnebratt, Paul Saliba, Fredrik Norman, Carsten Steiger, Klas Bratteby, Erik Samén, Kenneth Dahl, Thuy A Tra. GMP production of [ EJNMMI radiopharmacy and chemistry. vol 9. issue 1. 2024-05-02. PMID:38696063. |
dopamine transporter (dat) positron emission tomography (pet) imaging has emerged as a powerful and non-invasive method to quantify dopaminergic function in the living brain. |
2024-05-02 |
2024-05-04 |
Not clear |
| Gerd P Pfeife. DNA Damage and Parkinson's Disease. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673772. |
mitochondrial dysfunction of the respiratory chain, in combination with the presence of redox active dopamine molecules in these cells, will lead to the accumulation of reactive oxygen species (ros) in dopaminergic neurons. |
2024-04-27 |
2024-04-29 |
human |
| Hannah R Stutt, Matthew A Weber, Rachel C Cole, Alexandra S Bova, Xin Ding, Madison S McMurrin, Nandakumar S Narayana. Sex similarities and dopaminergic differences in interval timing. Behavioral neuroscience. vol 138. issue 2. 2024-04-25. PMID:38661668. |
because dopamine powerfully affects interval timing, we also examined sex differences with drugs targeting dopaminergic receptors. |
2024-04-25 |
2024-04-28 |
human |
| Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Leste. Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors. Behavioral neuroscience. vol 138. issue 2. 2024-04-25. PMID:38661670. |
chronic exposure to acea decreased rearing and decreased phasic dopamine release while increasing the dopaminergic response to cocaine. |
2024-04-25 |
2024-04-28 |
mouse |
| Chiara Buoso, Markus Seifert, Martin Lang, Corey M Griffith, Begoña Talavera Andújar, Maria Paulina Castelo Rueda, Christine Fischer, Carolina Doerrier, Heribert Talasz, Alessandra Zanon, Peter P Pramstaller, Emma L Schymanski, Irene Pichler, Guenter Weis. Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease. Neurobiology of disease. 2024-04-22. PMID:38648865. |
in this study, we investigated the interplay between iron, dopamine, and mitochondrial activity in neuroblastoma sh-sy5y cells and human induced pluripotent stem cell (hipsc)-derived dopaminergic neurons differentiated from a healthy control and a pd patient with a mutation in the α-synuclein (snca) gene. |
2024-04-22 |
2024-04-26 |
human |
| Chiara Buoso, Markus Seifert, Martin Lang, Corey M Griffith, Begoña Talavera Andújar, Maria Paulina Castelo Rueda, Christine Fischer, Carolina Doerrier, Heribert Talasz, Alessandra Zanon, Peter P Pramstaller, Emma L Schymanski, Irene Pichler, Guenter Weis. Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease. Neurobiology of disease. 2024-04-22. PMID:38648865. |
in dopaminergic neurons derived from a healthy control individual, dopamine showed comparable effects as observed in sh-sy5y cells. |
2024-04-22 |
2024-04-26 |
human |
| Hao Yang, XiaoLi Yang, SiLu Ya. A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia. Biological cybernetics. 2024-04-21. PMID:38644417. |
more importantly, the spatiotemporal course of dopamine depletion in parkinson's disease patients is well simulated, which states that with the loss of dopaminergic neurons projecting to the striatum, motor dysfunction of parkinson's disease is first observed, whereas cognitive impairment occurs after a period of onset of motor dysfunction. |
2024-04-21 |
2024-04-24 |
Not clear |
| Jose Luis Labandeira-Garcia, Carmen M Labandeira, Maria J Guerra, Ana I Rodriguez-Pere. The role of the brain renin-angiotensin system in Parkinson´s disease. Translational neurodegeneration. vol 13. issue 1. 2024-04-15. PMID:38622720. |
a decrease in the dopaminergic function induces upregulation of the angiotensin type-1 (at1) receptor activity, leading to recovery of dopamine levels. |
2024-04-15 |
2024-04-18 |
Not clear |
| Kallirhoe Kalinderi, Vasileios Papaliagkas, Liana Fidan. GLP-1 Receptor Agonists: A New Treatment in Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612620. |
many data on animal models and preclinical studies show that glp1-r agonists can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration and alleviate motor and non-motor features of pd. |
2024-04-13 |
2024-04-15 |
Not clear |