| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Y Deutch, S Y Tam, A S Freeman, M B Bowers, R H Rot. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:3569414. |
in contrast, levels of both metabolites decreased in the striatum and tended to decrease in the substantia nigra, source of the striatal dopaminergic innervation. |
1987-05-28 |
2023-08-11 |
rat |
| A Y Deutch, S Y Tam, A S Freeman, M B Bowers, R H Rot. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:3569414. |
since the firing rate of both a10 (ventral tegmental area) and a9 (substantia nigra) dopamine neurons has previously been shown to be increased by phencyclidine, these data suggest that phencyclidine results in a differential regulation of presynaptic release of dopamine in mesolimbic/cortical as opposed to nigrostriatal dopaminergic regions. |
1987-05-28 |
2023-08-11 |
rat |
| J O Rinn. Muscarinic and dopaminergic receptors in the aging human brain. Brain research. vol 404. issue 1-2. 1987-05-26. PMID:3567563. |
the binding of the dopaminergic ligands was determined in the caudate nucleus, putamen, pallidum and substantia nigra. |
1987-05-26 |
2023-08-11 |
human |
| G A Ricaurte, I Irwin, L S Forno, L E DeLanney, E Langston, J W Langsto. Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra. Brain research. vol 403. issue 1. 1987-05-20. PMID:3493827. |
aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra. |
1987-05-20 |
2023-08-11 |
mouse |
| D M Mann, P O Yates, B Marcyniu. Dopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age. Journal of neurology, neurosurgery, and psychiatry. vol 50. issue 3. 1987-05-18. PMID:2951499. |
in 15 patients with alzheimer's disease and in 10 with down's syndrome at middle age, there was severe atrophy, neurofibrillary degeneration and loss of pigmented dopaminergic nerve cells from ventral tegmental area (a10) whereas nerve cells in neighbouring substantia nigra (a9) were much less affected in all three respects. |
1987-05-18 |
2023-08-11 |
Not clear |
| J F Plantjé, H W Steinbusch, J Schipper, F A Dijcks, P F Verheijden, J C Stoo. D-2 dopamine-receptors regulate the release of [3H]dopamine in rat cortical regions showing dopamine immunoreactive fibers. Neuroscience. vol 20. issue 1. 1987-05-11. PMID:2951613. |
therefore it is our conclusion that d-2 receptors regulate the release of dopamine from dopaminergic neurons originating in the ventral tegmental area as well as in the substantia nigra. |
1987-05-11 |
2023-08-11 |
rat |
| L Kerkerian, N Dusticier, A Nieoullo. Modulatory effect of dopamine on high-affinity glutamate uptake in the rat striatum. Journal of neurochemistry. vol 48. issue 4. 1987-04-22. PMID:2880932. |
interestingly enough, lesion of dopaminergic neurons by substantia nigra injection of 6-hydroxydopamine (6-ohda) did not cause any significant change either in basal hagu or in the effect of cortical stimulation. |
1987-04-22 |
2023-08-11 |
rat |
| M Savasta, A Dubois, J Benavides, B Scatto. Different neuronal location of [3H]SCH 23390 binding sites in pars reticulata and pars compacta of the substantia nigra in the rat. Neuroscience letters. vol 72. issue 3. 1987-04-08. PMID:2950341. |
the precise neuronal localization of d1 receptors in the substantia nigra has been studied autoradiographically in the rat by measuring the alterations of [3h]sch 23390 binding site densities in this brain area after 6-hydroxydopamine (6-ohda) induced destruction of nigrostriatal dopaminergic neurons and after ibotenate-induced lesion of striatal afferents. |
1987-04-08 |
2023-08-11 |
rat |
| M Savasta, A Dubois, J Benavides, B Scatto. Different neuronal location of [3H]SCH 23390 binding sites in pars reticulata and pars compacta of the substantia nigra in the rat. Neuroscience letters. vol 72. issue 3. 1987-04-08. PMID:2950341. |
these results suggest that d1 receptors in the pars compacta or pars lateralis of the substantia nigra are located on the dopaminergic perikarya whereas those d1 receptors present in the pars reticulata of the substantia nigra lie on the terminals of nigral afferents of striatal origin. |
1987-04-08 |
2023-08-11 |
rat |
| M Pritzel, O Isacson, P Brundin, L Wiklund, A Björklun. Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats. Experimental brain research. vol 65. issue 1. 1987-03-19. PMID:2433142. |
the results provide evidence that intrastriatal grafts of fetal striatal tissue receive extensive dopaminergic afferents from the host substantia nigra, and that they may be capable of establishing connections also with thalamus, neocortex and globus pallidus of the host, as well as with the spared portions of the host caudate-putamen. |
1987-03-19 |
2023-08-11 |
rat |
| P K Sonsalla, J W Gibb, G R Hanso. Nigrostriatal dopamine actions on the D2 receptors mediate methamphetamine effects on the striatonigral substance P system. Neuropharmacology. vol 25. issue 11. 1987-02-11. PMID:2432440. |
multiple administrations of methamphetamine to rats produced elevated concentrations of substance p-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. |
1987-02-11 |
2023-08-11 |
rat |
| C R Galliste. The role of the dopaminergic projections in MFB self-stimulation. Behavioural brain research. vol 22. issue 2. 1987-02-10. PMID:3491613. |
2-deoxy-[14c]glucose autoradiography in self-stimulating animals or animals receiving automatically administered rewarding stimulation after treatment with reward-blocking doses of pimozide reveals activation of a descending myelinated system but no stimulation-produced activation of an ascending dopaminergic projection system, even though the autoradiographic method reveals the mild elevations and depressions of activity in dopaminergic terminal fields consequent upon injections of neuroleptics and amphetamine, respectively, and the strong activation of the nigrostriatal projection produced by stimulating directly in the substantia nigra. |
1987-02-10 |
2023-08-11 |
Not clear |
| A Y Deutch, M Goldstein, R H Rot. The ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. Neuroscience letters. vol 71. issue 3. 1987-01-28. PMID:2879262. |
the ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. |
1987-01-28 |
2023-08-11 |
Not clear |
| A Y Deutch, M Goldstein, R H Rot. The ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. Neuroscience letters. vol 71. issue 3. 1987-01-28. PMID:2879262. |
the efferent projections of the dopaminergic neurons in the zona reticulata of the substantia nigra were examined using a combined retrograde tracer-immunohistochemical method. |
1987-01-28 |
2023-08-11 |
Not clear |
| R Barke. Substance P and Parkinson's disease: a causal relationship? Journal of theoretical biology. vol 120. issue 3. 1987-01-22. PMID:2431225. |
here i present evidence to show that pd may result from a primary loss of active tachykinin, probably substance p (sp) in the substantia nigra (sn), and that this loss leads to a secondary degeneration of the dopaminergic neurones. |
1987-01-22 |
2023-08-11 |
Not clear |
| F J White, R Y Wan. Effects of tiaspirone (BMY-13859) and a chemical congener (BMY-13980) on A9 and A10 dopamine neurons in the rat. Neuropharmacology. vol 25. issue 9. 1986-12-12. PMID:2877417. |
two new potential antipsychotic drugs, bmy-13980 and bmy-13859 were compared for the ability to influence the electrophysiological activity of dopaminergic neurons in the substantia nigra zona compacta (a9 da cells) and ventral tegmental area (a10 da cells) in the brain of the rat. |
1986-12-12 |
2023-08-11 |
rat |
| M Gupta, B K Gupta, R Thomas, V Bruemmer, J R Sladek, D L Felte. Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults. Neuroscience letters. vol 70. issue 3. 1986-12-09. PMID:3490639. |
we present here evidence that mptp treatment in aged 21-month-old mice produced a marked reduction in the presence and intensity of fluorescence in noradrenergic neurons of the locus coeruleus and in dopaminergic neurons of the ventral tegmental area in addition to extensive damage to the substantia nigra. |
1986-12-09 |
2023-08-11 |
mouse |
| S Mazzari, C Aldinio, M Beccaro, G Toffano, R Schwarc. Intracerebral quinolinic acid injection in the rat: effects on dopaminergic neurons. Brain research. vol 380. issue 2. 1986-11-18. PMID:2944562. |
at the later timepoints examined (6 h, 4 and 11 days after quin), dopaminergic parameters are increased in the injected striatum only while no changes can be detected in the homolateral substantia nigra. |
1986-11-18 |
2023-08-11 |
rat |
| W G Erwin, T F Turc. Current concepts in clinical therapeutics: Parkinson's disease. Clinical pharmacy. vol 5. issue 9. 1986-11-03. PMID:3530616. |
the clinical features of parkinsonism result from a depletion in dopaminergic transmission in the corpus striatum; the dopamine deficiency is caused by a loss of melanin-containing nerve cells within the substantia nigra and locus ceruleus. |
1986-11-03 |
2023-08-11 |
Not clear |
| S K Kulkarni, A K Mehta, K O Aley, V K Shukl. MPTP: a pharmacological tool to study parkinsonism. Methods and findings in experimental and clinical pharmacology. vol 8. issue 8. 1986-10-22. PMID:3489146. |
mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is reported to selectively degenerate dopaminergic cells of the zona compacta of the substantia nigra and produce parkinson's-like symptoms in man and animals. |
1986-10-22 |
2023-08-11 |
Not clear |