| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Quirion, J Richar. Differential effects of selective lesions of cholinergic and dopaminergic neurons on serotonin-type 1 receptors in rat brain. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3145578. |
high densities of [3h]5-ht1 binding sites are especially located in areas enriched with cholinergic and dopaminergic innervation, such as the substantia innominata/ventral pallidum, striatum, septal nuclei, hippocampus and substantia nigra. |
1989-02-21 |
2023-08-11 |
rat |
| R Quirion, J Richar. Differential effects of selective lesions of cholinergic and dopaminergic neurons on serotonin-type 1 receptors in rat brain. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3145578. |
lesions of the nigrostriatal dopaminergic projection did not modify [3h]5-ht1 binding in the substantia nigra and the striatum, suggesting that 5-ht1 receptors are not closely associated with dopaminergic cell bodies and nerve terminals in this pathway. |
1989-02-21 |
2023-08-11 |
rat |
| W J Friedman, C F Dreyfus, B McEwen, I B Blac. Presynaptic transmitters and depolarizing influences regulate development of the substantia nigra in culture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 10. 1989-01-03. PMID:2461433. |
development of the dopaminergic phenotype in the mouse substantia nigra (sn) was studied by monitoring tyrosine hydroxylase (th), the rate-limiting enzyme in ca biosynthesis in vivo and in culture. |
1989-01-03 |
2023-08-11 |
mouse |
| E S Nisenbaum, W B Orr, T W Berge. Evidence for two functionally distinct subpopulations of neurons within the rat striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 11. 1988-12-22. PMID:3183715. |
finally, type ii neurons display at least a 5 times greater sensitivity to iontophoretically applied da than type i cells, suggesting that the 2 cell populations also are affected differentially by dopaminergic input from the substantia nigra. |
1988-12-22 |
2023-08-11 |
rat |
| T J Mahali. Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: an ultrastructural study. Synapse (New York, N.Y.). vol 2. issue 5. 1988-12-21. PMID:2460962. |
the results of many anatomical, physiological, and pharmacological studies suggest that substance p-containing neurons of the striatum project to the substantia nigra, and that substance p influences the activity of dopaminergic nigrostriatal neurons. |
1988-12-21 |
2023-08-11 |
rat |
| S Denis-Donini, M Esteno. Interneurons versus efferent neurons: heterogeneity in their neurite outgrowth response to glia from several brain regions. Developmental biology. vol 130. issue 1. 1988-12-21. PMID:3181629. |
we have studied in vitro the morphology of two populations of dopaminergic neurons from mouse embryos: the periglomerular interneurons from the olfactory bulb (dobi) and the efferent neurons from the substantia nigra (denn). |
1988-12-21 |
2023-08-11 |
mouse |
| D Samuel, U Kumar, A Nieoullo. gamma-Aminobutyric acid function in the rat striatum is under the double influence of nigrostriatal dopaminergic and thalamostriatal inputs: two modes of regulation? Journal of neurochemistry. vol 51. issue 6. 1988-12-20. PMID:3141584. |
glutamic acid decarboxylase (gad), gamma-[3h]-aminobutyric acid [( 3h]gaba) high-affinity uptake into synaptosomes, and endogenous gaba content were measured in the rat striatum 2-3 weeks following 6-hydroxydopamine injection in the ipsilateral substantia nigra to destroy the nigrostriatal dopaminergic pathway and after kainic acid injection into the centromedial-parafascicular complex of the ipsilateral thalamus to lesion the thalamostriatal input. |
1988-12-20 |
2023-08-11 |
rat |
| L T Meltzer, C L Christofferse. Effects of intraperitoneal administration of apomorphine and the isomers of 3-(1-propyl-3-piperidinyl)phenol on the firing activity of substantia nigra dopamine neurons: comparison of agonist efficacies and development of acute tolerance. Neuropharmacology. vol 27. issue 9. 1988-12-16. PMID:3185867. |
the effects of intraperitoneal administration of apomorphine, (+)-3-ppp, and (-)-3-ppp on slow-(less than 4 spikes/sec) and fast-(greater than 4 spikes/sec) firing dopaminergic neurons in the substantia nigra zona compacta of rats anesthetized with chloral hydrate were assessed. |
1988-12-16 |
2023-08-11 |
rat |
| A Studer, E Sundström, G Jonsson, W Schult. Acute electrophysiological and neurochemical effects of administration of MPTP in mice. Neuropharmacology. vol 27. issue 9. 1988-12-16. PMID:3263584. |
injections of mptp (30-60 mg/kg s.c.) reduced the impulse rate by 12-45% in all dopaminergic neurones tested in the pars compacta of the substantia nigra. |
1988-12-16 |
2023-08-11 |
mouse |
| R Labatut, F Richard, B Milne, L Quintin, D Lecestre, J F Pujo. Long-term effects of RU24722 on tyrosine hydroxylase of the rat brain. Journal of neurochemistry. vol 51. issue 5. 1988-11-22. PMID:2902195. |
ru24722 induced increases in tyrosine hydroxylase activities and specific protein content in noradrenergic cells of the locus ceruleus and decreased all these parameters in dopaminergic neurons of the substantia nigra and ventral tegmental area. |
1988-11-22 |
2023-08-11 |
rat |
| K T Kao, D A Powel. Lesions of the substantia nigra retard Pavlovian eye-blink but not heart rate conditioning in the rabbit. Behavioral neuroscience. vol 102. issue 4. 1988-11-15. PMID:3166726. |
these results suggest that interruption of the nigro-striatal dopaminergic pathway retards pavlovian somatomotor learning without affecting concurrent autonomic learning, although the latter may depend on an intact ascending ne pathway to the hypothalamus, which passes through the tegmentum and thus is also destroyed in some cases by substantia nigra lesions. |
1988-11-15 |
2023-08-11 |
rabbit |
| F Gra. [The neuropathology of Parkinson syndrome]. Revue neurologique. vol 144. issue 4. 1988-10-14. PMID:2843979. |
parkinsonism is due to an alteration of the dopaminergic nigro-striatal pathway the main morphological basis of which is a lesion of the substantia nigra (sn). |
1988-10-14 |
2023-08-11 |
Not clear |
| T H McNeill, S A Brown, J A Rafols, I Shoulso. Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease. Brain research. vol 455. issue 1. 1988-10-14. PMID:3416180. |
loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of parkinson's disease (pd) and results in a partial deafferentation to the striatum. |
1988-10-14 |
2023-08-11 |
Not clear |
| K L Leender. Parkinson's disease and PET tracer studies. Journal of neural transmission. Supplementum. vol 27. 1988-09-16. PMID:3136228. |
although the cause of parkinson's disease is still unknown it has become clear that dopaminergic cell loss in the substantia nigra is a prominent feature of the disease. |
1988-09-16 |
2023-08-11 |
human |
| H Nabatame, M Sasa, S Takaori, M Kameyam. Muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra. Japanese journal of pharmacology. vol 46. issue 4. 1988-09-09. PMID:3404769. |
muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra. |
1988-09-09 |
2023-08-11 |
rat |
| S E Bachus, K Gal. Differential effects of chronic treatment with chlorpromazine versus cocaine on behavioral responsiveness to nigral GABA receptor stimulation. Psychopharmacology. vol 95. issue 1. 1988-08-10. PMID:2838860. |
it therefore appears that changes in the responsiveness of neural outputs from, or distal to, substantia nigra may contribute to the enhanced behavioral effects of dopaminergic stimulants caused by chronic exposure to dopaminergic antagonists, but that the critical neural changes responsible for cocaine sensitization probably do not occur at, or distal to, the nigral outflow from the basal ganglia. |
1988-08-10 |
2023-08-11 |
rat |
| S A Greenfield, J J Jack, A T Last, M Frenc. An electrophysiological action of acetylcholinesterase independent of its catalytic site. Experimental brain research. vol 70. issue 2. 1988-07-29. PMID:3384044. |
acetylcholinesterase (ache) is released from the cell bodies and/or dendrites of dopaminergic neurones in the substantia nigra. |
1988-07-29 |
2023-08-11 |
Not clear |
| H T Chan. Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials. Brain research. vol 448. issue 2. 1988-07-22. PMID:2454145. |
the synaptic relationships between substance p-containing terminals and dopaminergic neurons (immunoreactive for tyrosine hydroxylase) in the substantia nigra were studied at both light and electron microscopic levels using a pre-embedding double-labeling immunocytochemical method. |
1988-07-22 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
peripheral injection of the dopaminergic stimulant methamphetamine induced a short (lasting approximately 20 min) 4-5 fold increase in gaba release in the intact globus pallidus and a longer (lasting longer than 80 min) increase in the substantia nigra. |
1988-07-18 |
2023-08-11 |
rat |
| b' F Artigas, E Mart\\xc3\\xadnez, L Cam\\xc3\\xb3n, E Rodr\\xc3\\xadguez Farr\\xc3\\xa. Synthesis and utilization of neurotransmitters: actions of subconvulsant doses of hexachlorocyclohexane isomers on brain monoamines. Toxicology. vol 49. issue 1. 1988-06-30. PMID:2453940.' |
also, the activity of dopaminergic neurons is increased in the substantia nigra. |
1988-06-30 |
2023-08-11 |
Not clear |