| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B P Draye. Imaging of the aging brain. Part II. Pathologic conditions. Radiology. vol 166. issue 3. 1988-03-16. PMID:3277248. |
parkinsonian disorders are characterized by generalized brain atrophy and dopaminergic site (e.g., putamen, pars compacta of the substantia nigra) iron or pigmentary accumulation best visualized in disease that responds poorly to dopamine replacement therapy. |
1988-03-16 |
2023-08-11 |
Not clear |
| J P Bolam, T F Freund, A Björklund, S B Dunnett, A D Smit. Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host neostriatum. Experimental brain research. vol 68. issue 1. 1988-02-12. PMID:2446902. |
these synapses were similar to the types of synapses found contacting dopaminergic neurons in the substantia nigra contralateral to the graft or the substantia nigra of a control rat. |
1988-02-12 |
2023-08-11 |
rat |
| T L Perry, V W Yong, S Hansen, K Jones, C Bergeron, J G Foulks, J M Wrigh. Alpha-tocopherol and beta-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of the neurological sciences. vol 81. issue 2-3. 1988-02-12. PMID:3121800. |
because the mechanisms of neuronal damage in both idiopathic pd and in the mptp model of pd may involve free radical formation in the substantia nigra, antioxidants might protect dopaminergic neurons. |
1988-02-12 |
2023-08-11 |
mouse |
| C R Gerfen, M Herkenham, J Thibaul. The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:2891799. |
mesostriatal projections, which arise from dopaminergic and non-dopaminergic neurons in the ventral tegmental area, substantia nigra, and retrorubral area, are compartmentally organized in the striatum. |
1988-01-28 |
2023-08-11 |
Not clear |
| E Y Eaker, G B Bixler, A J Dunn, W V Moreshead, J R Mathia. Chronic alterations in jejunal myoelectric activity in rats due to MPTP. The American journal of physiology. vol 253. issue 6 Pt 1. 1988-01-27. PMID:3501248. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), after conversion to a toxic metabolite via the monoamine oxidase system, can induce parkinson's disease by destroying dopaminergic neurons in the substantia nigra in humans and primates. |
1988-01-27 |
2023-08-11 |
rat |
| C Gauchy, M L Kemel, M Desban, R Romo, J Glowinski, M J Besso. The role of dopamine released from distal and proximal dendrites of nigrostriatal dopaminergic neurons in the control of GABA transmission in the thalamic nucleus ventralis medialis in the cat. Neuroscience. vol 22. issue 3. 1988-01-20. PMID:3683856. |
amphetamine was applied in the pars reticulata or pars compacta of the substantia nigra in order to determine the role of dopamine released from distal or proximal dendrites of dopaminergic cells in the control of gabaergic transmission in the nucleus ventralis medialis of the thalamus. |
1988-01-20 |
2023-08-11 |
cat |
| M Kubota, H Namba, K Sunami, A Yamaura, H Makino, S Murano, T Nishikawa, T Oheda, Y Saito, S Yoshid. The effects of mazindol on local cerebral glucose utilization in rats. Neuropharmacology. vol 26. issue 9. 1987-12-07. PMID:3670561. |
these 10 areas included regions rich in dopaminergic receptors (substantia nigra, globus pallidus), and also regions with few dopaminergic receptors (cerebral cortex, thalamus, cerebellum). |
1987-12-07 |
2023-08-11 |
rat |
| M P Abbracchio, F Colombo, M Di Luca, P Zaratin, F Cattaben. Adenosine modulates the dopaminergic function in the nigro-striatal system by interacting with striatal dopamine dependent adenylate cyclase. Pharmacological research communications. vol 19. issue 4. 1987-10-29. PMID:2889222. |
two experimental approaches leading to supersensitivity of striatal dopaminergic receptors, (i.e., 6-hydroxy-dopamine injection in substantia nigra and reserpine administration) also induced upregulation of adenosine-dependent adenylate cyclase in striatum, and altered r-pia modulation of dopamine-sensitive adenylate cyclase. |
1987-10-29 |
2023-08-11 |
rat |
| N König, V Han, E Lieth, J Laude. Effects of coculture on the morphology of identified raphe and substantia nigra neurons from the embryonic rat brain. Journal of neuroscience research. vol 17. issue 4. 1987-10-21. PMID:2887662. |
to test the hypothesis that embryonic 5-ht and catecholamine neurons may influence the differentiation of their target cells or source neurons, we have produced dissociated cell cultures from embryonic day 14 (e14) rat rhombencephalon (containing the serotonergic rn) and mesencephalon (containing the dopaminergic substantia nigra, sn). |
1987-10-21 |
2023-08-11 |
rat |
| M Eghbali, C Santoro, W Paredes, E L Gardner, R S Zuki. Visualization of multiple opioid-receptor types in rat striatum after specific mesencephalic lesions. Proceedings of the National Academy of Sciences of the United States of America. vol 84. issue 18. 1987-10-15. PMID:2819882. |
dopaminergic terminals projecting from the substantia nigra to the corpus striatum were destroyed by unilateral injection of 6-hydroxydopamine into the substantia nigra. |
1987-10-15 |
2023-08-11 |
rat |
| M L Porceddu, O Giorgi, G De Montis, S Mele, L Cocco, E Ongini, G Biggi. 6-Hydroxydopamine-induced degeneration of nigral dopamine neurons: differential effect on nigral and striatal D-1 dopamine receptors. Life sciences. vol 41. issue 6. 1987-09-21. PMID:2956472. |
the results indicate that: within the substantia nigra a fraction (30%) of d-1 dopamine receptors coupled to the adenylate cyclase is located on cell bodies and/or dendrites of dopaminergic neurons; striatal d-1 dopamine receptors are tonically innervated by nigrostriatal afferent fibers. |
1987-09-21 |
2023-08-11 |
rat |
| R B Innis, G K Aghajania. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain research. vol 411. issue 1. 1987-08-28. PMID:2955848. |
pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. |
1987-08-28 |
2023-08-11 |
rat |
| C M Waters, S P Hunt, P Jenner, C D Marsde. Localization of neurotensin receptors in the forebrain of the common marmoset and the effects of treatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. vol 412. issue 2. 1987-08-28. PMID:3038264. |
the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine selectively destroyed over 80% of the dopaminergic neurons of the marmoset substantia nigra and almost 60% of those in the adjacent ventral tegmental area. |
1987-08-28 |
2023-08-11 |
marmoset |
| C M Waters, S P Hunt, P Jenner, C D Marsde. Localization of neurotensin receptors in the forebrain of the common marmoset and the effects of treatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. vol 412. issue 2. 1987-08-28. PMID:3038264. |
the subsequent loss of a large proportion of neurotensin receptors from marmoset substantia nigra and striatum suggests their presence on the dopaminergic nigrostriatal pathway. |
1987-08-28 |
2023-08-11 |
marmoset |
| B A McMillen, S M Scott, H L Williams, M K Sangher. Effects of gepirone, an aryl-piperazine anxiolytic drug, on aggressive behavior and brain monoaminergic neurotransmission. Naunyn-Schmiedeberg's archives of pharmacology. vol 335. issue 4. 1987-07-30. PMID:2439924. |
in contrast to buspirone, which markedly increased dopaminergic impulse flow, gepirone inhibited the firing of most cells recorded from the substantia nigra zona compacta in doses of 2.3-10 mg/kg i.v. |
1987-07-30 |
2023-08-11 |
mouse |
| L C Cork, C A Kitt, R G Struble, J W Griffin, D L Pric. Animal models of degenerative neurological disease. Progress in clinical and biological research. vol 229. 1987-07-24. PMID:3601987. |
these clinical findings are attributed to regeneration of dopaminergic neurons of the substantia nigra, a cell group showing abnormal accumulations of neurofilament antigens in the form of lewy bodies. |
1987-07-24 |
2023-08-11 |
human |
| L C Cork, C A Kitt, R G Struble, J W Griffin, D L Pric. Animal models of degenerative neurological disease. Progress in clinical and biological research. vol 229. 1987-07-24. PMID:3601987. |
intoxication of macaques with 1-methyl-4-]henyl-1,2,3,6,tetrahydropyridine (mptp) produces a parkinsonian syndrome due to selective injury of dopaminergic neurons in the substantia nigra and associated denervation of the striatum. |
1987-07-24 |
2023-08-11 |
human |
| R M Beckstea. Striatal substance P cell clusters coincide with the high density terminal zones of the discontinuous nigrostriatal dopaminergic projection system in the cat: a study by combined immunohistochemistry and autoradiographic axon-tracing. Neuroscience. vol 20. issue 2. 1987-06-26. PMID:2438592. |
a portion of the nigrostriatal projection that originates from presumably dopaminergic neurons in the caudal pars compacta of the substantia nigra and the suprajacent pars dorsalis (retrorubral area), was shown by [3h]amino acid autoradiographic tracing to distribute nonhomogeneously in the head of the caudate nucleus, such that zones of high density termination are in register with the archipelago of substance p cell clusters revealed immunohistochemically in the same and adjacent tissue sections of the cat's brain. |
1987-06-26 |
2023-08-11 |
cat |
| D L Price, L C Cork, R G Struble, C A Kitt, L C Walker, R E Powers, P J Whitehouse, J W Griffi. Dysfunction and death of neurons in human degenerative neurological diseases and in animal models. Ciba Foundation symposium. vol 126. 1987-06-26. PMID:3556088. |
slow movements, tremor and rigidity, are attributed, in part, to degeneration of dopaminergic neurons of the substantia nigra. |
1987-06-26 |
2023-08-11 |
human |
| R N Kalaria, M J Mitchell, S I Hari. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proceedings of the National Academy of Sciences of the United States of America. vol 84. issue 10. 1987-06-18. PMID:3495000. |
since mptp causes selective dopaminergic neurotoxicity when infused directly into rat substantia nigra, we hypothesized that systemic mptp may be metabolized by monoamine oxidase and/or other enzymes in rat brain capillaries and possibly other peripheral organs and thus prevented from reaching its neuronal sites of toxicity. |
1987-06-18 |
2023-08-11 |
mouse |