| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T L Perry, S Hansen, K Jone. Brain amino acids and glutathione in progressive supranuclear palsy. Neurology. vol 38. issue 6. 1988-06-17. PMID:3368077. |
glutathione, which is significantly decreased in substantia nigra in pd, was increased in this brain region in psp, suggesting that different mechanisms may be responsible for destruction of dopaminergic nigrostriatal neurons in these two disorders. |
1988-06-17 |
2023-08-11 |
human |
| S Nedergaard, J P Bolam, S A Greenfiel. Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature. vol 333. issue 6169. 1988-06-13. PMID:2897080. |
within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. |
1988-06-13 |
2023-08-11 |
Not clear |
| S Nedergaard, J P Bolam, S A Greenfiel. Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature. vol 333. issue 6169. 1988-06-13. PMID:2897080. |
in this study, we show that 5-hydroxytryptamine, which is contained in afferent fibres to the substantia nigra, is present in terminals making direct synaptic contact with dopaminergic neurons and also that it has a site-dependent, receptor-mediated, facilitatory effect on a specific dendritic calcium-dependent potential in nigrostriatal neurons in vitro. |
1988-06-13 |
2023-08-11 |
Not clear |
| E Hirsch, M Ruberg, M M Portier, M Dardenne, Y Agi. Characterization of two antigens in parkinsonian Lewy bodies. Brain research. vol 441. issue 1-2. 1988-06-09. PMID:3359227. |
the g9 antigen was found in the substantia nigra and locus coeruleus, but also in the caudate nucleus, terminal region of the nigrostriatal dopaminergic neurons, and in the cortex and cerebellum, terminal regions of the noradrenergic neurons in the locus coeruleus. |
1988-06-09 |
2023-08-11 |
human |
| E Normand, T Popovici, B Onteniente, D Fellmann, D Piatier-Tonneau, C Auffray, B Bloc. Dopaminergic neurons of the substantia nigra modulate preproenkephalin A gene expression in rat striatal neurons. Brain research. vol 439. issue 1-2. 1988-06-08. PMID:3129123. |
dopaminergic neurons of the substantia nigra modulate preproenkephalin a gene expression in rat striatal neurons. |
1988-06-08 |
2023-08-11 |
rat |
| E Normand, T Popovici, B Onteniente, D Fellmann, D Piatier-Tonneau, C Auffray, B Bloc. Dopaminergic neurons of the substantia nigra modulate preproenkephalin A gene expression in rat striatal neurons. Brain research. vol 439. issue 1-2. 1988-06-08. PMID:3129123. |
the 6-hydroxydopamine lesion which destroyed all dopaminergic neurons in the right substantia nigra, provoked a large increase in the number of ppa mrna copies in enkephalin neurons of the right striatum, and decreased the number of cells expressing the ppa mrna in the left striatum. |
1988-06-08 |
2023-08-11 |
rat |
| R Labatut, M Buda, A Béro. Long-term changes in rat brain tyrosine hydroxylase following reserpine treatment: a quantitative immunochemical analysis. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:2896228. |
in contrast, reserpine did not cause any changes in tyrosine hydroxylase activity in the dopaminergic neurons of the substantia nigra, but provoked a moderate increase in tyrosine hydroxylase protein level. |
1988-06-02 |
2023-08-11 |
rat |
| K Sasaki, H Suda, H Watanabe, S Kaneko, Y Nomura, H Nishino, T On. Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats. Neuroscience letters. vol 86. issue 1. 1988-06-02. PMID:3362431. |
the relation between the habenula and central dopaminergic system was investigated by examining the inhibitory effects of methamphetamine on the firing rate of dopamine neurons in the substantia nigra of habenular lesioned and unlesioned rats. |
1988-06-02 |
2023-08-11 |
rat |
| H J ten Donkelaar, R de Boer-van Huize. Brain stem afferents to the anterior dorsal ventricular ridge in a lizard (Varanus exanthematicus). Anatomy and embryology. vol 177. issue 5. 1988-06-02. PMID:3364750. |
these data strongly suggest direct advr projections from the parabrachial region (related to visceral and taste information) as well as distinct catecholaminergic (presumably dopaminergic: substantia nigra, ventral tegmental area and, noradrenergic: locus coeruleus, respectively) and serotonergic projections (nucleus raphes superior). |
1988-06-02 |
2023-08-11 |
Not clear |
| M A Arian. Striatal D1 dopamine receptor distribution following chemical lesion of the nigrostriatal pathway. Brain research. vol 443. issue 1-2. 1988-05-31. PMID:2965958. |
the cellular pattern of d1 dopaminergic binding was assessed using in vitro autoradiographic localization of [3h]sch 23390 or [125i]sch 23982, selective d1 receptor antagonists, 1 week following unilateral infusion of the neurotoxin 6-hydroxydopamine (6-ohda) into the substantia nigra. |
1988-05-31 |
2023-08-11 |
rat |
| S R Vincen. Distributions of tyrosine hydroxylase-, dopamine-beta-hydroxylase-, and phenylethanolamine-N-methyltransferase-immunoreactive neurons in the brain of the hamster (Mesocricetus auratus). The Journal of comparative neurology. vol 268. issue 4. 1988-05-26. PMID:2895779. |
th-immunoreactive cell groups in the olfactory bulb, hypothalamus, substantia nigra, and ventral tegmental area of the hamster appeared to correspond to the dopaminergic cells groups described in the rat and other species. |
1988-05-26 |
2023-08-11 |
rat |
| P N Izzo, J P Bola. Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat. The Journal of comparative neurology. vol 269. issue 2. 1988-05-26. PMID:3281983. |
the topography of the cholinergic afferents of these cells is distinctly different from that of other boutons derived from local neurons and from boutons that form asymmetrical synaptic specializations, but it is similar to that of the dopaminergic boutons originating from neurons in the substantia nigra. |
1988-05-26 |
2023-08-11 |
rat |
| M F Pozza, E Küng, S Bischoff, H R Olp. The neurotensin analog xenopsin excites nigral dopamine neurons. European journal of pharmacology. vol 145. issue 3. 1988-05-03. PMID:3350051. |
the electrophysiological effects of neurotensin (nt), its analog xenopsin, and the fragment nt-(1-8) on the activity of dopaminergic neurons in rat substantia nigra slices were compared. |
1988-05-03 |
2023-08-11 |
rat |
| R G Wiley, F Stirp. Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS. Brain research. vol 438. issue 1-2. 1988-04-18. PMID:2449931. |
histofluorescence confirmed loss of dopaminergic neurons from the ipsilateral substantia nigra after modeccin or volkensin but not abrin injections. |
1988-04-18 |
2023-08-11 |
rat |
| E Melamed, D Soffer, J Rosenthal, E Pikarsky, A Reche. Effect of intrastriatal and intranigral administration of synthetic neuromelanin on the dopaminergic neurotoxicity of MPTP in rodents. Neuroscience letters. vol 83. issue 1-2. 1988-04-12. PMID:3502019. |
therefore, the presence of nm in human and primate but not in rodent substantia nigra, theoretically may be responsible for the species-selective dopaminergic (da) toxicity of mptp. |
1988-04-12 |
2023-08-11 |
mouse |
| C M Waters, S P Hunt, P Jenner, C D Marsde. An immunohistochemical study of the acute and long-term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the marmoset. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893993. |
detection of catecholaminergic neurons using antibodies directed against the enzyme tyrosine hydroxylase revealed a profound (80%) loss of dopaminergic cells from the substantia nigra one month after initiation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment. |
1988-04-05 |
2023-08-11 |
marmoset |
| C M Waters, S P Hunt, P Jenner, C D Marsde. An immunohistochemical study of the acute and long-term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the marmoset. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893993. |
at longer survival times the substantia nigra was less damaged, with a proliferation of glia in the pars compacta and a loss of approximately 20% of the dopaminergic perikarya. |
1988-04-05 |
2023-08-11 |
marmoset |
| P B Clarke, D W Hommer, A Pert, L R Skirbol. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:3437988. |
subsequent experiments employed anaesthetized rats; kainate was microinfused into tegmental sites in order to stimulate local cholinergic perikarya, and concurrently, extracellular recordings were made of single dopaminergic neurons in the substantia nigra. |
1988-04-05 |
2023-08-11 |
rat |
| P B Clarke, D W Hommer, A Pert, L R Skirbol. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:3437988. |
consistent with our anatomical findings, unilateral microinfusion of kainic acid in or near the pedunculopontine nucleus increased the firing rate of dopaminergic neurons situated remotely in the ipsilateral substantia nigra. |
1988-04-05 |
2023-08-11 |
rat |
| T B Mulder, J B de Vries, D Dijkstra, J W Wiechers, C J Grol, A S Hor. Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 5. 1988-03-30. PMID:2830544. |
the binding of [3h]dp-7-atn to the homogenates of the dopaminergic cell bodies in the substantia nigra revealed a bmax of 542.4 +/- 40.1 fmol/mg protein and a kd of 11.1 +/- 1.3 nm. |
1988-03-30 |
2023-08-11 |
rat |