| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carine Chassain, Guy Bielicki, Cécile Keller, Jean-Pierre Renou, Franck Duri. Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse. NMR in biomedicine. vol 23. issue 6. 2010-11-04. PMID:20661872. |
we used in vivo proton ((1)h) magnetic resonance spectroscopy (mrs) to measure the levels of the main excitatory amino acid, glutamate (glu) and also glutamine (gln) and gaba in the striatum and cerebral cortex in the mptp-intoxicated mouse, a model of dopaminergic denervation, before and after dopamine (da) replacement. |
2010-11-04 |
2023-08-12 |
mouse |
| Joanne Clark, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, David K Simo. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808797. |
despite the transient nature of the impact of nac on brain glutathione, the loss of dopaminergic terminals at 1 year associated with snca overexpression was significantly attenuated by nac supplementation, as measured by immunoreactivity for tyrosine hydroxylase in the striatum (p = 0.007; unpaired, two-tailed t-test), with a similar but nonsignificant trend for dopamine transporter (dat) immunoreactivity. |
2010-11-04 |
2023-08-12 |
mouse |
| Toshihiko Aosaki, Masami Miura, Takeo Suzuki, Kinya Nishimura, Masao Masud. Acetylcholine-dopamine balance hypothesis in the striatum: an update. Geriatrics & gerontology international. vol 10 Suppl 1. 2010-10-21. PMID:20590830. |
the imbalance between cholinergic activity and dopaminergic activity in the striatum causes a variety of neurological disorders, such as parkinson's disease. |
2010-10-21 |
2023-08-12 |
Not clear |
| Toshihiko Aosaki, Masami Miura, Takeo Suzuki, Kinya Nishimura, Masao Masud. Acetylcholine-dopamine balance hypothesis in the striatum: an update. Geriatrics & gerontology international. vol 10 Suppl 1. 2010-10-21. PMID:20590830. |
during sensorimotor learning, the arrival of a conditioned stimulus reporting a reward evokes a pause response in the firing of the tonically active cholinergic interneurons in targeted areas of the striatum, whereas the same stimulus triggers an increase in the firing frequency of the dopaminergic neurons in the substantia nigra pars compacta. |
2010-10-21 |
2023-08-12 |
Not clear |
| J H Sun, Q Gao, J Zhang, L H Bao, H M Dong, N Liang, G B Li, Z H Li, Y M Ga. Ephrinb3 induces mesostriatal dopaminergic projection to the striatum. Biochemical and biophysical research communications. vol 400. issue 2. 2010-10-13. PMID:20719236. |
ephrinb3 induces mesostriatal dopaminergic projection to the striatum. |
2010-10-13 |
2023-08-12 |
Not clear |
| Manolis Markianos, Marios Panas, Nikos Kalfakis, John Hatzimanolis, Dimitrios Vassilopoulo. Neuroendocrine evidence of normal hypothalamus-pituitary dopaminergic function in Huntington's disease. Neuro endocrinology letters. vol 31. issue 3. 2010-10-08. PMID:20588235. |
in addition to neuronal loss in striatum and cerebral cortex that characterizes huntington's disease (hd), hypothalamic atrophy has also been found only in certain areas, probably not including dopaminergic functions. |
2010-10-08 |
2023-08-12 |
Not clear |
| Gunnar Hargus, Oliver Cooper, Michela Deleidi, Adam Levy, Kristen Lee, Elizabeth Marlow, Alyssa Yow, Frank Soldner, Dirk Hockemeyer, Penelope J Hallett, Teresia Osborn, Rudolf Jaenisch, Ole Isacso. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 36. 2010-10-07. PMID:20798034. |
we differentiated ips cells from patients with parkinson's disease (pd) into dopaminergic (da) neurons and show that these da neurons can be transplanted without signs of neurodegeneration into the adult rodent striatum. |
2010-10-07 |
2023-08-12 |
human |
| Chun-Jung Lin, Ying Tai, Miao-Tzu Huang, Yuan-Feen Tsai, Hao-Jui Hsu, Kai-Yuan Tzen, Horng-Huei Lio. Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents. Journal of neurochemistry. vol 114. issue 3. 2010-10-06. PMID:20477935. |
mptp-induced dopaminergic toxicity was examined by measuring dopamine levels in the brain striatum and by positron emission tomography scanning. |
2010-10-06 |
2023-08-12 |
mouse |
| Ali Jahanshahi, Rinske Vlamings, Ahmet Hilmi Kaya, Lee Wei Lim, Marcus L F Janssen, Sonny Tan, Veerle Visser-Vandewalle, Harry W M Steinbusch, Yasin Teme. Hyperdopaminergic status in experimental Huntington disease. Journal of neuropathology and experimental neurology. vol 69. issue 9. 2010-10-05. PMID:20720506. |
huntington disease has been linked to increased dopaminergic neurotransmission in the striatum, and clinical studies have demonstrated that the associated chorea can be treated with dopamine antagonist or dopamine-depleting drugs. |
2010-10-05 |
2023-08-12 |
rat |
| Robert A Hodgson, Paul J Bedard, Geoffrey B Varty, Tatiana M Kazdoba, Therese Di Paolo, Michael E Grzelak, Annamarie J Pond, Abdallah Hadjtahar, Nancy Belanger, Laurent Gregoire, Aurelie Dare, Bernard R Neustadt, Andrew W Stamford, John C Hunte. Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders. Experimental neurology. vol 225. issue 2. 2010-10-01. PMID:20655910. |
parkinson's disease (pd) and extrapyramidal syndrome (eps) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine d(2) receptors by antipsychotics, respectively. |
2010-10-01 |
2023-08-12 |
monkey |
| Takahiro Saito, Mitsuru Nakamura, Teruhiko Shimizu, Keiichi Oda, Kiichi Ishiwata, Kenji Ishii, Kunihiro Iss. Neuroradiologic evidence of pre-synaptic and post-synaptic nigrostriatal dopaminergic dysfunction in idiopathic Basal Ganglia calcification: a case report. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 20. issue 2. 2010-09-29. PMID:19021829. |
the results showed that widespread hypometabolism was evident in the frontal, temporal, and parietal cortices while the decline in dopaminergic function was severe in the bilateral striatum. |
2010-09-29 |
2023-08-12 |
Not clear |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
additionally, acetylcholine-containing interneurons in the striatum also constitute an important neural substrate to provide further cholinergic modulation of forebrain striatal dopaminergic transmission. |
2010-09-22 |
2023-08-12 |
Not clear |
| Marta Imbesi, Ahmet Dirim Arslan, Sevim Yildiz, Rajiv Sharma, David Gavin, Nguwah Tun, Hari Manev, Tolga U. The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal 'clock' gene expression in striatal neurons in vitro. Journal of pineal research. vol 46. issue 1. 2010-09-21. PMID:18798788. |
melatonin-mediated changes in clock gene expression have been reported in brain regions, including the striatum, that are crucial for the development of dopaminergic behaviors and mood. |
2010-09-21 |
2023-08-12 |
Not clear |
| Karl B Scheidweiler, Bruce Ladenheim, Jean Lud Cadet, Marilyn A Huesti. Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatum. Neurotoxicity research. vol 18. issue 2. 2010-09-20. PMID:19851718. |
mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (mdma) in striatum. |
2010-09-20 |
2023-08-12 |
mouse |
| Mohamed R Ahmed, Amandine Berthet, Evgeny Bychkov, Gregory Porras, Qin Li, Bernard H Bioulac, Yonatan T Carl, Bertrand Bloch, Seunghyi Kook, Incarnation Aubert, Sandra Dovero, Evelyne Doudnikoff, Vsevolod V Gurevich, Eugenia V Gurevich, Erwan Bezar. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Science translational medicine. vol 2. issue 28. 2010-09-20. PMID:20410529. |
parkinson's disease is caused primarily by degeneration of brain dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine in the striatum. |
2010-09-20 |
2023-08-12 |
rat |
| Jaime Barral, Elvira Galarraga, Dagoberto Tapia, Edén Flores-Barrera, Arturo Reyes, José Barga. Dopaminergic modulation of spiny neurons in the turtle striatum. Cellular and molecular neurobiology. vol 30. issue 5. 2010-09-16. PMID:20140492. |
dopaminergic modulation of spiny neurons in the turtle striatum. |
2010-09-16 |
2023-08-12 |
Not clear |
| Jaime Barral, Elvira Galarraga, Dagoberto Tapia, Edén Flores-Barrera, Arturo Reyes, José Barga. Dopaminergic modulation of spiny neurons in the turtle striatum. Cellular and molecular neurobiology. vol 30. issue 5. 2010-09-16. PMID:20140492. |
spiny neurons of the turtle resembled those found in the mammalian and avian striatum and express dopaminergic d(1) and d(2) class receptors. |
2010-09-16 |
2023-08-12 |
Not clear |
| Jaime Barral, Elvira Galarraga, Dagoberto Tapia, Edén Flores-Barrera, Arturo Reyes, José Barga. Dopaminergic modulation of spiny neurons in the turtle striatum. Cellular and molecular neurobiology. vol 30. issue 5. 2010-09-16. PMID:20140492. |
because the striatum of the turtle receives a dense dopaminergic innervation from tegmental dopaminergic neurons we investigated the postsynaptic actions of selective dopamine receptor agonists in the excitability of spiny neurons. |
2010-09-16 |
2023-08-12 |
Not clear |
| Andreas Heinz, Florian Schlagenhau. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophrenia bulletin. vol 36. issue 3. 2010-09-16. PMID:20453041. |
it was hypothesized that increased firing (chaotic or stress associated) of dopaminergic neurons in the striatum of schizophrenia patients attributes incentive salience to otherwise irrelevant stimuli. |
2010-09-16 |
2023-08-12 |
Not clear |
| Shin-ichi Muramats. [Cell therapy for Parkinson disease]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030240. |
since grafts were transplanted ectopically into the striatum instead of the substantia nigra in most current protocols, surviving dopaminergic neurons would not have to be the same subtype as the nigral cells. |
2010-09-02 |
2023-08-12 |
Not clear |