| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maki Okada, Ryuji Nakao, Rie Hosoi, Ming-Rong Zhang, Toshimitsu Fukumura, Kazutoshi Suzuki, Osamu Inou. Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20407462. |
to measure dopaminergic metabolism, we used microdialysis with radiometric detection to monitor l-[β-(11)c]dopa metabolites in the extracellular space of the rat striatum. |
2011-02-03 |
2023-08-12 |
rat |
| Wanida Tripanichkul, Orapin Gerdprasert, Em-orn Jaroensuppaperc. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. The International journal of neuroscience. vol 120. issue 7. 2011-02-03. PMID:20583901. |
estrogen reduces bdnf level, but maintains dopaminergic cell density in the striatum of mptp mouse model. |
2011-02-03 |
2023-08-12 |
mouse |
| Wanida Tripanichkul, Orapin Gerdprasert, Em-orn Jaroensuppaperc. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. The International journal of neuroscience. vol 120. issue 7. 2011-02-03. PMID:20583901. |
degeneration of dopaminergic (da) axons in the striatum triggers upregulation of striatal trophic activity and striatal da neuronal number in animal models of parkinson's disease (pd). |
2011-02-03 |
2023-08-12 |
mouse |
| Bai-Yun Zeng, Mahmoud M Iravani, Michael J Jackson, Sarah Rose, André Parent, Peter Jenne. Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20713157. |
hyperinnervation of the striatum by serotoninergic (5-ht) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. |
2011-01-25 |
2023-08-12 |
rat |
| Teresa C Moloney, Gemma E Rooney, Frank P Barry, Linda Howard, Eilís Dow. Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain. Brain research. vol 1359. 2011-01-25. PMID:20732313. |
quantitative tyrosine hydroxylase immunohistochemical staining revealed that gdnf-transduced mscs were capable of inducing a pronounced local trophic effect in the denervated striatum which was evident by sprouting from the remaining dopaminergic terminals towards the neurotrophic milieu created by the transplanted cells. |
2011-01-25 |
2023-08-12 |
rat |
| Renju Kuriakose, A Jon Stoess. Imaging the nigrostriatal system to monitor disease progression and treatment-induced complications. Progress in brain research. vol 184. 2011-01-21. PMID:20887875. |
dopaminergic hypofunction in the striatum follows a negative exponential pattern with the fastest rate of decline in early disease. |
2011-01-21 |
2023-08-12 |
Not clear |
| Patrik Brundin, Roger A Barker, Malin Parma. Neural grafting in Parkinson's disease Problems and possibilities. Progress in brain research. vol 184. 2011-01-21. PMID:20887880. |
clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with pd, provided proof-of-principle that long-lasting therapeutic benefits can be achieved. |
2011-01-21 |
2023-08-12 |
human |
| C A Haaxma, R C G Helmich, G F Borm, A C Kappelle, M W I M Horstink, B R Bloe. Side of symptom onset affects motor dysfunction in Parkinson's disease. Neuroscience. vol 170. issue 4. 2011-01-18. PMID:20723583. |
here, we test the hypothesis that this neurochemical asymmetry renders the right striatum relatively more vulnerable to the effects of dopaminergic denervation in parkinson's disease (pd). |
2011-01-18 |
2023-08-12 |
human |
| Hironori Yokoyama, Ryohei Yano, Hayato Kuroiwa, Tatsuya Tsukada, Hiroto Uchida, Hiroyuki Kato, Jiro Kasahara, Tsutomu Arak. Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 25. issue 2. 2011-01-13. PMID:20424905. |
our western blot analysis and immunohistochemical study showed that the post-treatment with zonisamide prevented significantly dopaminergic cell damage, the depletion of tyrosine-hydroxylase (th) protein levels and the proliferation of microglia in the striatum and/or substantia nigra 8 days after mptp treatment. |
2011-01-13 |
2023-08-12 |
mouse |
| Anupom Borah, Kochupurackal P Mohanakuma. Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism. Brain research. vol 1344. 2011-01-10. PMID:20470760. |
the present study evaluated the ability of salicylic acid (sa) to attenuate long-term l-dopa-induced 6-hydroxydopamine (6-ohda) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. |
2011-01-10 |
2023-08-12 |
mouse |
| Grit Lessner, Oliver Schmitt, Stefan J-P Haas, Stefan Mikkat, Michael Kreutzer, Andreas Wree, Michael O Glocke. Differential proteome of the striatum from hemiparkinsonian rats displays vivid structural remodeling processes. Journal of proteome research. vol 9. issue 9. 2011-01-04. PMID:20666516. |
here, we analyzed proteome changes of the striatum three months after 6-ohda lesions of the nigral dopaminergic cell population. |
2011-01-04 |
2023-08-12 |
rat |
| Christelle Baunez, Paolo Gubellin. Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease. Progress in brain research. vol 183. 2010-12-27. PMID:20696323. |
loss of the dopaminergic input to the striatum, characterizing parkinson's disease, leads to the hyper-activity of two key nuclei of the basal ganglia (bg): the subthalamic nucleus (stn) and the internal segment of the globus pallidus (gpi). |
2010-12-27 |
2023-08-12 |
Not clear |
| Thomas V Wiecki, Michael J Fran. Neurocomputational models of motor and cognitive deficits in Parkinson's disease. Progress in brain research. vol 183. 2010-12-27. PMID:20696325. |
the loss of dopaminergic neurons innervating the striatum in pd, and the well-established role of dopamine (da) in reinforcement learning (rl), enable neural network models of the basal ganglia (bg) to derive concrete and testable predictions. |
2010-12-27 |
2023-08-12 |
Not clear |
| Douglas J Lansk. Chapter 33: the history of movement disorders. Handbook of clinical neurology. vol 95. 2010-12-16. PMID:19892136. |
parkinsonism: pathologic changes in parkinson's disease were recognized in the substantia nigra by blocq and marinescu in the late 19th century, and around 1920 trértiakoff established lewy bodies in the substantia nigra as a pathologic hallmark while the vogts instead emphasized pathologic changes in the striatum; it was only in the mid-1960s that a nigrostriatal dopaminergic pathway was demonstrated and found to be critical to pathogenesis. |
2010-12-16 |
2023-08-12 |
monkey |
| Daniel P Eisenberg, Philip D Kohn, Erica B Baller, Joel A Bronstein, Joseph C Masdeu, Karen F Berma. Seasonal effects on human striatal presynaptic dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048126. |
past studies in rodents have demonstrated circannual variation in central dopaminergic activity as well as a host of compelling interactions between melatonin--a scotoperiod-responsive neurohormone closely tied to seasonal adaptation--and dopamine in the striatum and in midbrain neuronal populations with striatal projections. |
2010-12-08 |
2023-08-12 |
human |
| Xiomara A Perez, Tanuja Bordia, J Michael McIntosh, Maryka Qui. α6ß2* and α4ß2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease. Molecular pharmacology. vol 78. issue 5. 2010-12-07. PMID:20732972. |
nicotinic receptors (nachrs) are important modulators of dopaminergic transmission in striatum, a region critical to parkinson's disease. |
2010-12-07 |
2023-08-12 |
Not clear |
| Li Qian, Patrick M Flood, Jau-Shyong Hon. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571837. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2010-11-30 |
2023-08-12 |
Not clear |
| Mohammad Moshahid Khan, Md Nasrul Hoda, Tauheed Ishrat, Ajmal Ahmad, Mohammad Badruzzaman Khan, Gulrana Khuwaja, Syed Shadab Raza, Mohammed M Safhi, Fakhrul Isla. Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease. Behavioural pharmacology. vol 21. issue 5-6. 2010-11-24. PMID:20657266. |
an increase in the number of dopaminergic d2 receptors and decrease in the level of dopamine and its metabolite 3,4-dihydroxyphenyl acetic acid in the striatum were observed after mptp injection, and restored significantly after pyc pretreatment. |
2010-11-24 |
2023-08-12 |
mouse |
| Payam Piray, Mohammad Mahdi Keramati, Amir Dezfouli, Caro Lucas, Azarakhsh Mokr. Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: a computational approach. Neural computation. vol 22. issue 9. 2010-11-22. PMID:20569176. |
here, modeling striatal-midbrain dopaminergic circuit, we propose a reinforcement learning model for addiction based on the actor-critic model of striatum. |
2010-11-22 |
2023-08-12 |
Not clear |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
postmortem stereological cell counts of dopaminergic neurons in the ventral midbrain, and intensity measurements of dat and tyrosine hydroxylase (th) immunoreactivity in the striatum were performed and correlated with striatal and ventral midbrain pet data. |
2010-11-12 |
2023-08-12 |
monkey |