| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujira Mukda, Oranich Vimolratana, Piyarat Govitrapon. Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum. Neuroscience letters. vol 488. issue 2. 2011-04-25. PMID:21078367. |
we found that chronic amphetamine administration in postnatal rats produces dopaminergic deficits in the striatum, including decreases in the levels of vmat-2 and phosphorylated tyrosine hydroxylase. |
2011-04-25 |
2023-08-12 |
rat |
| Nicole A Northrop, Laura P Smith, Bryan K Yamamoto, David J Eyerma. Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159748. |
in addition, the subsequent long-term decreases in markers of dopaminergic and serotonergic terminals, including da reuptake transporter (dat), serotonin reuptake transporter (sert), vesicular monoamine transporter-2, vesicular da, and vesicular 5-ht content in the rat striatum, were measured. |
2011-04-21 |
2023-08-12 |
rat |
| Chi-Bong Choi, Sang-Young Kim, Sung-Ho Lee, Geon-Ho Jahng, Hwi-Yool Kim, Bo-Young Choe, Kyung-Nam Ryu, Dal-Mo Yang, Sung-Vin Yim, Woo-Suk Cho. Assessment of metabolic changes in the striatum of a MPTP-intoxicated canine model: in vivo ¹H-MRS study of an animal model for Parkinson's disease. Magnetic resonance imaging. vol 29. issue 1. 2011-04-12. PMID:20980117. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta, which projects to the striatum. |
2011-04-12 |
2023-08-12 |
Not clear |
| Hamid Y Qureshi, Hemant K Paude. Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21127069. |
in parkinson disease (pd) brain, a progressive loss of dopaminergic neurons leads to dopamine depletion in the striatum and reduced motor function. |
2011-04-11 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Maryna Baydyuk, Madeline T Nguyen, Baoji X. Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. Experimental neurology. vol 228. issue 1. 2011-03-30. PMID:21192928. |
the neuronal loss was accompanied by a decrease in dopaminergic axonal terminals in the striatum and by gliosis in both the snc and striatum. |
2011-03-30 |
2023-08-12 |
mouse |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
gfrα1 is expressed in the striatum, a target of the dopaminergic projection of the substantia nigra. |
2011-03-22 |
2023-08-12 |
mouse |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
to determine whether post-synaptic expression of gfrα1 in striatum in trans has effects on the development or adult responses to injury of dopamine neurons, we have created transgenic mice in which gfrα1 expression is selectively increased in striatum and other forebrain targets of the dopaminergic projection. |
2011-03-22 |
2023-08-12 |
mouse |
| Hyo Geun Kim, Mi Sun Ju, Dong-Hyun Kim, Jongki Hong, Seung-Hun Cho, Ki-Ho Cho, Wansu Park, Eunjoo H Lee, Sun Yeou Kim, Myung Sook O. Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease. Basic & clinical pharmacology & toxicology. vol 107. issue 6. 2011-03-10. PMID:20629656. |
ameliorated pd-like behavioural symptoms (bradykinesia) and reduced dopaminergic neuronal damage in the snpc and striatum as measured by immunocytochemistry. |
2011-03-10 |
2023-08-12 |
Not clear |
| F M Gómez, J E Ortega, I Horrillo, J J Mean. Relationship between non-functional masticatory activity and central dopamine in stressed rats. Journal of oral rehabilitation. vol 37. issue 11. 2011-03-03. PMID:21039747. |
to clarify the relationship between central dopaminergic activity and stress-induced parafunctional masticatory behaviour, using microdialysis in vivo, we assessed the changes in extracellular dopamine concentrations in both prefrontal cortex and striatum of rats subjected to a mild tail pinch. |
2011-03-03 |
2023-08-12 |
rat |
| Yunmin Ding, Lisa Won, Jonathan P Britt, Sean Austin O Lim, Daniel S McGehee, Un Jung Kan. Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 2. 2011-02-24. PMID:21187382. |
using two pd models, the traditional 6-hydroxydopamine toxic lesion and a genetic model with nigrostriatal dopaminergic deficits, we found that acute dopamine challenge induces erk activation in medium spiny neurons in denervated striatum. |
2011-02-24 |
2023-08-12 |
mouse |
| Jacquelyn A Brown, Ryan J Emnett, Crystal R White, Carla M Yuede, Sara B Conyers, Karen L O'Malley, David F Wozniak, David H Gutman. Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice. Human molecular genetics. vol 19. issue 22. 2011-02-17. PMID:20826448. |
moreover, we demonstrate a cell-autonomous defect in nf1+/- dopaminergic neuron growth cone areas and neurite extension in vitro, which results in decreased dopaminergic cell projections to the striatum in nf1 opg mice in vivo. |
2011-02-17 |
2023-08-12 |
mouse |
| Josep Gamez, Carles Lorenzo-Bosquet, Gemma Cuberas-Borrós, Francesc Carmona, Jorge Hernández-Vara, Joaquin Castilló, Joan Castell-Cones. Does reduced [(123)I]-FP-CIT binding in Huntington's disease suggest pre-synaptic dopaminergic involvement? Clinical neurology and neurosurgery. vol 112. issue 10. 2011-02-08. PMID:20724066. |
to evaluate the usefulness of spect in assessing damage to the pre-synaptic dopaminergic system in huntington's disease (hd) using [(123)i]-fp-cit (datscan), a selective radioligand with regulatory approval as the diagnostic test for investigating functional dopaminergic neuron loss in the striatum in parkinson's disease. |
2011-02-08 |
2023-08-12 |
Not clear |
| Kurt A Jellinge. Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20965169. |
recent neurochemical studies in postmortem brains of patients with parkinson's disease (pd), pd with dementia (pdd) and age-matched controls revealed significant decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in striatum, confirming previous studies indicating substantial loss of dopaminergic neurons and terminals. |
2011-02-04 |
2023-08-12 |
mouse |
| Syed Z Imam, Qing Zhou, Ayako Yamamoto, Anthony J Valente, Syed F Ali, Mona Bains, James L Roberts, Philipp J Kahle, Robert A Clark, Senlin L. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209200. |
under oxidative and dopaminergic stress, c-abl was activated in cultured neuronal cells and in striatum of adult c57bl/6 mice. |
2011-02-04 |
2023-08-12 |
mouse |
| Maki Okada, Ryuji Nakao, Rie Hosoi, Ming-Rong Zhang, Toshimitsu Fukumura, Kazutoshi Suzuki, Osamu Inou. Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20407462. |
to measure dopaminergic metabolism, we used microdialysis with radiometric detection to monitor l-[β-(11)c]dopa metabolites in the extracellular space of the rat striatum. |
2011-02-03 |
2023-08-12 |
rat |
| Wanida Tripanichkul, Orapin Gerdprasert, Em-orn Jaroensuppaperc. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. The International journal of neuroscience. vol 120. issue 7. 2011-02-03. PMID:20583901. |
estrogen reduces bdnf level, but maintains dopaminergic cell density in the striatum of mptp mouse model. |
2011-02-03 |
2023-08-12 |
mouse |
| Wanida Tripanichkul, Orapin Gerdprasert, Em-orn Jaroensuppaperc. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. The International journal of neuroscience. vol 120. issue 7. 2011-02-03. PMID:20583901. |
degeneration of dopaminergic (da) axons in the striatum triggers upregulation of striatal trophic activity and striatal da neuronal number in animal models of parkinson's disease (pd). |
2011-02-03 |
2023-08-12 |
mouse |
| Bai-Yun Zeng, Mahmoud M Iravani, Michael J Jackson, Sarah Rose, André Parent, Peter Jenne. Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20713157. |
hyperinnervation of the striatum by serotoninergic (5-ht) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. |
2011-01-25 |
2023-08-12 |
rat |
| Teresa C Moloney, Gemma E Rooney, Frank P Barry, Linda Howard, Eilís Dow. Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain. Brain research. vol 1359. 2011-01-25. PMID:20732313. |
quantitative tyrosine hydroxylase immunohistochemical staining revealed that gdnf-transduced mscs were capable of inducing a pronounced local trophic effect in the denervated striatum which was evident by sprouting from the remaining dopaminergic terminals towards the neurotrophic milieu created by the transplanted cells. |
2011-01-25 |
2023-08-12 |
rat |