| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hirofumi Tokuoka, Shin-ichi Muramatsu, Chiho Sumi-Ichinose, Hiroaki Sakane, Masayo Kojima, Yoshinori Aso, Takahide Nomura, Daniel Metzger, Hiroshi Ichinos. Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027820. |
thus, unexpectedly, the reduction of th protein in the striatum, where snc dopaminergic axons innervate densely, was slower than in the snc. |
2012-03-27 |
2023-08-12 |
mouse |
| Susanne Nikolaus, Rolf Larisch, Henning Vosberg, Markus Beu, Andreas Wirrwar, Christina Antke, Konstantin Kley, Maria Angelica De Souza Silva, Joseph P Huston, Hans-Wilhelm Mülle. Pharmacological challenge and synaptic response - assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Reviews in the neurosciences. vol 22. issue 6. 2012-03-27. PMID:22103308. |
pharmacological challenge and synaptic response - assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (spect) and positron emission tomography (pet). |
2012-03-27 |
2023-08-12 |
rat |
| Kai Loewenbrück, Alexander Storc. Stem cell-based therapies in Parkinson's disease: future hope or current treatment option? Journal of neurology. vol 258. issue Suppl 2. 2012-03-25. PMID:21437664. |
parkinson's disease (pd) is one of the most frequent neurodegenerative diseases and represents a major therapeutic challenge because of the so far missing therapeutic means to influence the ongoing loss of dopaminergic innervation to the striatum. |
2012-03-25 |
2023-08-12 |
Not clear |
| D Domenger, D Dea, L Theroux, L Moquin, A Gratton, J Poirie. The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22155743. |
in the striatum, upregulations of gfap, apoe and lrp mrnas at 1 day post-treatment were associated with marked decreases in dopamine (da) levels, loss in tyrosine hydroxylase protein content, as well as to a compensatory increase in dopaminergic metabolism. |
2012-03-25 |
2023-08-12 |
mouse |
| D Macmanus, K R Laurens, E F Walker, J L Brasfield, M Riaz, S Hodgin. Movement abnormalities and psychotic-like experiences in childhood: markers of developing schizophrenia? Psychological medicine. vol 42. issue 1. 2012-03-22. PMID:21740623. |
both involuntary dyskinetic movements and psychotic-like experiences (ples) are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic activity in the striatum. |
2012-03-22 |
2023-08-12 |
Not clear |
| R D Palmite. Dopamine signaling as a neural correlate of consciousness. Neuroscience. vol 198. 2012-03-22. PMID:21839810. |
therefore, i propose that dopaminergic modulation of glutamatergic inputs from the cortex and thalamus onto medium spiny neurons in the striatum contributes to cognition and the expression of consciousness. |
2012-03-22 |
2023-08-12 |
mouse |
| D J Surmeier, L Carrillo-Reid, J Barga. Dopaminergic modulation of striatal neurons, circuits, and assemblies. Neuroscience. vol 198. 2012-03-22. PMID:21906660. |
this review attempts to summarize some of the key advances in this broad area, focusing on dopaminergic modulation of intrinsic excitability and synaptic plasticity in canonical microcircuits in the striatum as well as recent work suggesting that there are neuronal assemblies within the striatum devoted to particular types of computation and possibly action selection. |
2012-03-22 |
2023-08-12 |
Not clear |
| Hideaki Kabuto, Tomoko T Yamanush. Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model. Neurochemical research. vol 36. issue 12. 2012-03-12. PMID:21769642. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (da) depletion in the striatum. |
2012-03-12 |
2023-08-12 |
mouse |
| Sarah A Heimovics, Katrina G Salvante, Keith W Sockman, Lauren V Riter. Individual differences in the motivation to communicate relate to levels of midbrain and striatal catecholamine markers in male European starlings. Hormones and behavior. vol 60. issue 5. 2012-03-09. PMID:21907203. |
results highlight a role for evolutionarily conserved dopaminergic projections from vta to striatum in the motivation to communicate and highlight novel patterns of catecholamine activity in area x, vta, and gct associated with individual differences in sexually-motivated and non-sexually-motivated communication. |
2012-03-09 |
2023-08-12 |
Not clear |
| M Feb. A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams. Journal of neuroendocrinology. vol 23. issue 11. 2012-02-10. PMID:21722215. |
suckling was observed to increase blood-oxygen-level-dependent (bold) signal intensity in the midbrain, striatum and prefrontal cortex, which are areas that receive prominent dopaminergic inputs. |
2012-02-10 |
2023-08-12 |
rat |
| b' A Anastas\\xc3\\xada, J Wojnacki, G A de Erausquin, D H Masc\\xc3\\xb. Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson\'s disease. Neuroscience. vol 195. 2012-02-06. PMID:21871541.' |
we previously reported that ecs protects the integrity of the rat nigrostriatal dopaminergic system against 6-hydroxydopamine (6-ohda)-induced toxicity; in order to shed light into its neuroprotective mechanism, we studied glial cell-line derived neurotrophic factor (gdnf) levels (the most efficient tf for dopaminergic neurons) in the substantia nigra (sn) and striatum of 6-ohda-injected animals with or without ecs treatment. |
2012-02-06 |
2023-08-12 |
human |
| Krishnan Sriram, Gary X Lin, Amy M Jefferson, Jenny R Roberts, Ronnee N Andrews, Michael L Kashon, James M Antonin. Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. Toxicology. vol 291. issue 1-3. 2012-02-06. PMID:22085607. |
trace element analysis revealed selective mn accumulation in dopaminergic brain areas, striatum (str) and midbrain (mb), following exposure to the two fumes. |
2012-02-06 |
2023-08-12 |
rat |
| Afsaneh Gaillard, Mohamed Jabe. Rewiring the brain with cell transplantation in Parkinson's disease. Trends in neurosciences. vol 34. issue 3. 2012-01-23. PMID:21316770. |
here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of pd. |
2012-01-23 |
2023-08-12 |
Not clear |
| Maria Hadjiconstantinou, Norton H Nef. Nicotine and endogenous opioids: neurochemical and pharmacological evidence. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21108953. |
striatum is rich in opioid peptides and opioid receptors, and striatal opioidergic neurons are engaged in a bidirectional communication with midbrain dopaminergic neurons, closely regulating each other's activity. |
2012-01-18 |
2023-08-12 |
Not clear |
| Y Masamizu, T Okada, K Kawasaki, H Ishibashi, S Yuasa, S Takeda, I Hasegawa, K Nakahar. Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9. Neuroscience. vol 193. 2012-01-18. PMID:21782903. |
injections of either aav8-egfp or aav9-egfp into the marmoset striatum resulted in egfp expression in local striatal neurons as a result of local infection, as well as expression in dopaminergic neurons of the substantia nigra via retrograde transport along nigrostriatal axonal projections. |
2012-01-18 |
2023-08-12 |
monkey |
| Zhifeng Qi, Weiwei Yang, Yujun Liu, Tao Cui, Hua Gao, Chunli Duan, Lingling Lu, Chunli Zhao, Huanying Zhao, Hui Yan. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochemistry international. vol 59. issue 5. 2012-01-12. PMID:21672589. |
reduced pp2a activity and increased phosphorylation of pp2a at y307 (inactive form of pp2a) were observed in pink1-knockdown dopaminergic cells and striatum tissues. |
2012-01-12 |
2023-08-12 |
mouse |
| Andreas Ratzka, Olga Baron, Claudia Groth. FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. PloS one. vol 6. issue 8. 2011-12-30. PMID:21876757. |
in the central nervous system dopaminergic neurons of the substantia nigra and their axonal projections into the striatum progressively degenerate in parkinson's disease. |
2011-12-30 |
2023-08-12 |
mouse |
| Gennaro Giordano, Toby B Cole, Clement E Furlong, Lucio G Cost. Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role? Toxicology and applied pharmacology. vol 256. issue 3. 2011-12-27. PMID:21354197. |
these results indicate that pon2 is expressed in the brain, and that higher levels are found in dopaminergic regions such as the striatum, suggesting that this enzyme may provide protection against oxidative stress-mediated neurotoxicity. |
2011-12-27 |
2023-08-12 |
mouse |
| Toshio Obata, Masahiro Aomin. Protective effect of tamoxifen, a synthetic non-steroidal antiestrogen, on phenelzine and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Research communications in molecular pathology and pharmacology. vol 122-123. issue 1-6. 2011-12-13. PMID:22032091. |
the present study examined whether tamoxifen could suppress antidepressant drug phenelzine can increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (mpp+)-induced hydroxyl radical (*oh) generation in the extracellular fluid of rat striatum, using in vivo microdialysis system. |
2011-12-13 |
2023-08-12 |
rat |
| Ahmed Hasbi, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Molecular brain. vol 4. 2011-11-30. PMID:21663703. |
dopamine d1 and d2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of d1-d2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. |
2011-11-30 |
2023-08-12 |
Not clear |