| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Limin Mao, John Q Wan. Adult neural stem/progenitor cells in neurodegenerative repair. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 3. 2012-08-20. PMID:12817287. |
in addition to the subventricular zone and hippocampus where active cell division naturally occurs, adult neural progenitors with neurogenic potential exist in the striatum and the vicinity of dopaminergic neurons in the substantia nigra. |
2012-08-20 |
2023-08-12 |
human |
| C Venkateshappa, G Harish, Rajeswara Babu Mythri, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21971758. |
parkinson's disease (pd) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (sn) of the ventral mid brain leading to dopamine depletion in the striatum. |
2012-08-13 |
2023-08-12 |
human |
| Chen Wang, Shu Li, Yuanjun Tang, Shuowen Wang, Yalin Zhang, Guorong Fan, Liqin Li, Yi Zhan. Microdialysis combined with liquid chromatography-tandem mass spectrometry for the determination of levo-tetrahydropalmatine in the rat striatum. Journal of pharmaceutical and biomedical analysis. vol 64-65. 2012-08-03. PMID:22387102. |
levo-tetrahydropalmatine (l-thp), one of the main active alkaloids isolated from rhizoma corydalis, was recently found to elicit profound effects on the dopaminergic system in the striatum, which plays an important role in regulating nociception. |
2012-08-03 |
2023-08-12 |
rat |
| Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsud. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21903118. |
sea0400 protected against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in mptp-treated mice. |
2012-08-01 |
2023-08-12 |
mouse |
| Meret Nora Gaugler, Ozgur Genc, Wojciech Bobela, Safa Mohanna, Mustafa Taleb Ardah, Omar Mukhtar El-Agnaf, Marco Cantoni, Jean-Charles Bensadoun, Ralf Schneggenburger, Graham W Knott, Patrick Aebischer, Bernard Laurent Schneide. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta neuropathologica. vol 123. issue 5. 2012-08-01. PMID:22361813. |
wild-type α-syn causes a reduction of dopamine release in the striatum that exceeds the loss of dopaminergic neurons, axonal fibers, and the reduction in total dopamine. |
2012-08-01 |
2023-08-12 |
human |
| b' Valentina Di Liberto, Johanna M\\xc3\\xa4kel\\xc3\\xa4, Laura Korhonen, Melania Olivieri, Timofey Tselykh, Annika M\\xc3\\xa4lki\\xc3\\xa4, Hai Do Thi, Natale Belluardo, Dan Lindholm, Giuseppa Mud\\xc3\\xb. Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22041555.' |
involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. |
2012-07-27 |
2023-08-12 |
mouse |
| Mercedes Unzeta, Elisenda San. Novel MAO-B inhibitors: potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson's disease. International review of neurobiology. vol 100. 2012-07-24. PMID:21971010. |
parkinson's disease (pd) is a neurodegenerative disease that is characterized by preferential loss of dopaminergic neurons in the substantia nigra pars compacta, leading to declining levels of dopamine in the striatum. |
2012-07-24 |
2023-08-12 |
Not clear |
| Kao Chin Chen, I Hui Lee, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Yen Kuang Yang, Ru-Band Lu, Chwen Cheng Che. Schizotypy trait and striatal dopamine receptors in healthy volunteers. Psychiatry research. vol 201. issue 3. 2012-07-24. PMID:22429746. |
dopaminergic hyperactivity in the striatum has been related to the positive symptoms of schizophrenia, and brain-imaging studies of dopamine uptake in the striatum are thought to be linked to the pathophysiological mechanisms underlying schizophrenia. |
2012-07-24 |
2023-08-12 |
human |
| Alexander Kurz, Caroline May, Oliver Schmidt, Thorsten Müller, Christian Stephan, Helmut E Meyer, Suzana Gispert, Georg Auburger, Katrin Marcu. A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21960009. |
to elucidate the early and late effects of a53t-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2d-dige) and mass spectrometry. |
2012-07-23 |
2023-08-12 |
mouse |
| Laure Chagniel, Christine Robitaille, Manon Lebel, Michel Cy. Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:22037042. |
another fascinating observation was that l-dopa therapy, in combination with intrastriatal infusion of mdl28170, augmented tyrosine hydroxylase levels in the striatum of lesioned rats without affecting the number of dopaminergic cells in the substantia nigra. |
2012-07-23 |
2023-08-12 |
rat |
| Arianna Bellucci, Laura Navarria, Elisa Falarti, Michela Zaltieri, Federica Bono, Ginetta Collo, Maria Grazia Spillantini, Maria Grazia, Cristina Missale, Pierfranco Span. Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease. PloS one. vol 6. issue 12. 2012-07-20. PMID:22163275. |
by using the proximity ligation assay, a technique which allows the "in situ" visualization of protein-protein interactions, we studied the occurrence of alterations in the distribution of dat/α-synuclein complexes in the syn120 transgenic mouse model, showing insoluble α-synuclein aggregates into dopaminergic neurons of the nigrostriatal system, reduced striatal da levels and an altered distribution of synaptic proteins in the striatum. |
2012-07-20 |
2023-08-12 |
mouse |
| Shota Kobayashi, Akiko Muroyama, Hiroaki Matsushima, Ikuo Yoshimura, Yasuhide Mitsumot. Oral administration of coenzyme Q₁₀ reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 1. 2012-07-19. PMID:21598008. |
oral administration of coenzyme q₁₀ reduces mptp-induced loss of dopaminergic nerve terminals in the striatum in mice. |
2012-07-19 |
2023-08-12 |
mouse |
| A M Smith, K A Wellmann, T M Lundblad, M L Carter, S Barron, L P Dwoski. Lobeline attenuates neonatal ethanol-mediated changes in hyperactivity and dopamine transporter function in the prefrontal cortex in rats. Neuroscience. vol 206. 2012-07-18. PMID:22119644. |
in the current study, lobeline, which interacts with proteins in dopaminergic presynaptic terminals, was evaluated for its ability to attenuate neonatal ethanol-induced locomotor hyperactivity and alterations in dopamine transporter (dat) function in striatum and prefrontal cortex (pfc). |
2012-07-18 |
2023-08-12 |
rat |
| Miguel Schwartz, Sergiu Sabeta. An approach to the continuous dopaminergic stimulation in Parkinson's disease. The Israel Medical Association journal : IMAJ. vol 14. issue 3. 2012-07-10. PMID:22675859. |
treatment with long-acting dopaminergic agents, or providing a more continuous dopaminergic effect in the striatum, has been associated with fewer clinical motor complications. |
2012-07-10 |
2023-08-12 |
Not clear |
| E Gramage, Y B Martín, P Ramanah, C Pérez-García, G Herradó. Midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: functional differences between pleiotrophin and midkine. Neuroscience. vol 190. 2012-07-05. PMID:21704677. |
midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: functional differences between pleiotrophin and midkine. |
2012-07-05 |
2023-08-12 |
mouse |
| Lixiang Ma, Baoyang Hu, Yan Liu, Scott Christopher Vermilyea, Huisheng Liu, Lu Gao, Yan Sun, Xiaoqing Zhang, Su-Chun Zhan. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell stem cell. vol 10. issue 4. 2012-07-03. PMID:22424902. |
transplantation of these human forebrain gaba neurons and their progenitors, but not spinal gaba cells, into the striatum of quinolinic acid-lesioned mice results in generation of large populations of darpp32(+) gaba neurons, which project to the substantia nigra as well as receiving glutamatergic and dopaminergic inputs, corresponding to correction of motor deficits. |
2012-07-03 |
2023-08-12 |
mouse |
| Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima, Kazushige Sakaguch. Ephrin-A1-mediated dopaminergic neurogenesis and angiogenesis in a rat model of Parkinson's disease. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363788. |
clustered ephrin-a1-fc transformed the subventricular niche, increasing bromodeoxyuridine-positive cells in the subventricular area, and the cells then migrated to the striatum and differentiated to dopaminergic neurons and astrocytes. |
2012-06-29 |
2023-08-12 |
rat |
| Daniela Hernandez, Ciara A Torres, Wanda Setlik, Carolina Cebrián, Eugene V Mosharov, Guomei Tang, Hsiao-Chun Cheng, Nikolai Kholodilov, Olga Yarygina, Robert E Burke, Michael Gershon, David Sulze. Regulation of presynaptic neurotransmission by macroautophagy. Neuron. vol 74. issue 2. 2012-06-29. PMID:22542182. |
evoked dopamine secretion was enhanced and recovery was accelerated in transgenic mice in which macroautophagy deficiency was restricted to dopaminergic neurons; rapamycin failed to decrease evoked dopamine release in the striatum of these mice. |
2012-06-29 |
2023-08-12 |
mouse |
| Fumihito Yoshi. [Pain and sensory disturbance in Parkinson disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 4. 2012-06-21. PMID:22481509. |
the importance of dopaminergic deficits as a causal factor in pd-related pain is supported by the normalization of these abnormalities after l-dopa administration, which suggests that the human striatum plays a central role in processing nociceptive information. |
2012-06-21 |
2023-08-12 |
human |
| Ricardo Pardal, José López-Barne. Neural stem cells and transplantation studies in Parkinson's disease. Advances in experimental medicine and biology. vol 741. 2012-06-15. PMID:22457112. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is primarily caused by the selective degeneration of specific neuronal populations, particularly dopaminergic neurons within the substantia nigra projecting to the striatum (nigrostriatal neurons). |
2012-06-15 |
2023-08-12 |
Not clear |