| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Celine Ullrich, Nina Daschil, Christian Humpe. Organotypic vibrosections: novel whole sagittal brain cultures. Journal of neuroscience methods. vol 201. issue 1. 2012-06-12. PMID:21835204. |
dopaminergic nerve fibers extended from the mesencephalon, but in the striato-nigral tract and in the striatum only strong dense varicosities were found. |
2012-06-12 |
2023-08-12 |
rat |
| Barbara Picconi, Giovanni Piccoli, Paolo Calabres. Synaptic dysfunction in Parkinson's disease. Advances in experimental medicine and biology. vol 970. 2012-06-12. PMID:22351072. |
the impairment of these two forms of synaptic plasticity in the nucleus striatum could account for the onset and the progression of motor and cognitive symptoms of parkinson's disease (pd), characterized by the massive degeneration of dopaminergic neurons. |
2012-06-12 |
2023-08-12 |
Not clear |
| Barbara Picconi, Giovanni Piccoli, Paolo Calabres. Synaptic dysfunction in Parkinson's disease. Advances in experimental medicine and biology. vol 970. 2012-06-12. PMID:22351072. |
a series of cellular and synaptic alterations occur in the striatum of experimental parkinsonism in response to the massive dopaminergic loss. |
2012-06-12 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F Oo, W Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E Burk. Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782946. |
however, in both aged mice and in transgenic mice with increased expression of human α-synuclein we observe decreased phenotypic expression of the catecholamine synthetic enzyme tyrosine hydroxylase (th) in dopaminergic axons and terminals in the striatum. |
2012-06-11 |
2023-08-12 |
mouse |
| Javier Bernácer, Lucía Prensa, José Manuel Giménez-Amay. Distribution of GABAergic interneurons and dopaminergic cells in the functional territories of the human striatum. PloS one. vol 7. issue 1. 2012-06-11. PMID:22272358. |
distribution of gabaergic interneurons and dopaminergic cells in the functional territories of the human striatum. |
2012-06-11 |
2023-08-12 |
human |
| S Walsh, D P Finn, E Dow. Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat. Neuroscience. vol 175. 2012-06-01. PMID:21145947. |
following terminal lesion, dopaminergic deafferentation of the striatum was evident from 6 h post-lesion and was accompanied by microglial and astroglial activation. |
2012-06-01 |
2023-08-12 |
human |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Andreas Heuer, Gaynor A Smith, Mariah J Lelos, Emma L Lane, Stephen B Dunnet. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22146593. |
in the present study we examine the consequences of injection of the toxin at three sites along the nigrostriatal tract (substantia nigra, medial forebrain bundle, and striatum) on a broad range of simple motor tasks, and on the dopaminergic pathology. |
2012-05-24 |
2023-08-12 |
mouse |
| Deniz Kahraman, Carsten Eggers, Harald Schicha, Lars Timmermann, Matthias Schmid. Visual assessment of dopaminergic degeneration pattern in 123I-FP-CIT SPECT differentiates patients with atypical parkinsonian syndromes and idiopathic Parkinson's disease. Journal of neurology. vol 259. issue 2. 2012-05-21. PMID:21750954. |
according to predefined visual patterns of dopaminergic degeneration the results were graded as normal (grade 5) or abnormal (grade 1-4), distinguishing a posterior-anterior degeneration pattern ("egg shape") from a global and severe degeneration pattern ("burst striatum"). |
2012-05-21 |
2023-08-12 |
Not clear |
| Y Iris Chen, Jia-Qian Ren, Ted J Kaptchuk, Kenneth K Kwon. Restoring cerebral dopamine homeostasis by electrical forepaw stimulation: an FMRI study. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22170513. |
as dopamine function is tightly regulated within the basal ganglia circuitry, cortical perturbation would lead to modulation of dopaminergic activity in the striatum. |
2012-05-21 |
2023-08-12 |
rat |
| Monica S Guzman, Xavier De Jaeger, Sanda Raulic, Ivana A Souza, Alex X Li, Susanne Schmid, Ravi S Menon, Raul R Gainetdinov, Marc G Caron, Robert Bartha, Vania F Prado, Marco A M Prad. Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission. PLoS biology. vol 9. issue 11. 2012-05-17. PMID:22087075. |
however, dopaminergic sensitivity of medium spiny neurons (msn) and the behavioural outputs in response to direct dopaminergic agonists were enhanced, likely due to increased expression/function of dopamine receptors in the striatum. |
2012-05-17 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Miriam A Vogt, Heide Hörtnagl, Peter Gass, Rainer Hellwe. Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice. European journal of pharmacology. vol 677. issue 1-3. 2012-05-17. PMID:22206815. |
neurochemical analyses revealed a highly significant effect on dopaminergic metabolites in the striatum as well as a moderate transient modulation of the serotonergic system in the hippocampus. |
2012-05-17 |
2023-08-12 |
mouse |
| Hwei-Hsien Chen, Shiau-Chin Lin, Ming-Huan Cha. Protective and restorative effects of magnolol on neurotoxicity in mice with 6-hydroxydopamine-induced hemiparkinsonism. Neuro-degenerative diseases. vol 8. issue 5. 2012-05-08. PMID:21494012. |
one week after termination of the 7-day subchronic pretreatment, magnolol also remarkably prevented the dopaminergic neuronal loss as identified by th immunohistochemistry staining in striatum, associated with rotational behavioral protection in 6-ohda-lesioned mice. |
2012-05-08 |
2023-08-12 |
mouse |
| Hae-Won Shin, Sun Ju Chun. Drug-induced parkinsonism. Journal of clinical neurology (Seoul, Korea). vol 8. issue 1. 2012-05-03. PMID:22523509. |
since these effects are limited to postsynaptic dopaminergic receptors, it is expected that presynaptic dopaminergic neurons in the striatum will be intact. |
2012-05-03 |
2023-08-12 |
Not clear |
| Min Jeong Kang, Sang Sun Lee, Hyun Chul Ko. Prooxidant properties of ascorbic acid in the nigrostriatal dopaminergic system of C57BL/6 mice. Toxicology. vol 294. issue 1. 2012-04-25. PMID:22285708. |
taken together, our data suggest that repeated aa injection induces dopaminergic neurotoxicity through generation of oxidative stress, and that this toxicity is related to the decline of gsh in both the snpc and striatum. |
2012-04-25 |
2023-08-12 |
mouse |
| Meaghan Morris, Akihiko Koyama, Eliezer Masliah, Lennart Muck. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PloS one. vol 6. issue 12. 2012-04-23. PMID:22206005. |
tau reduction also did not prevent 6-ohda-induced loss of dopaminergic terminals in the striatum. |
2012-04-23 |
2023-08-12 |
mouse |
| Minyoung Oh, Jae Seung Kim, Ji Young Kim, Kwang-Ho Shin, Seol Hoon Park, Hye Ok Kim, Dae Hyuk Moon, Seung Jun Oh, Sun Ju Chung, Chong Sik Le. Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 53. issue 3. 2012-04-23. PMID:22323779. |
parkinson disease (pd), progressive supranuclear palsy (psp), and multiple-system atrophy (msa) are known to affect dopaminergic neurons of the brain stem and striatum with different preferential involvement. |
2012-04-23 |
2023-08-12 |
Not clear |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum, and tyrosine hydroxylase (th) immunoreactivity and 4',6-diamidino-2-phenylindole (dapi)/fluoro-jade b staining in the substantia nigra were measured to assess dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
rat |
| Carrie K Jones, Michael Bubser, Analisa D Thompson, Jonathan W Dickerson, Nathalie Turle-Lorenzo, Marianne Amalric, Anna L Blobaum, Thomas M Bridges, Ryan D Morrison, Satyawan Jadhav, Darren W Engers, Kimberly Italiano, Jacob Bode, J Scott Daniels, Craig W Lindsley, Corey R Hopkins, P Jeffrey Conn, Colleen M Niswende. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 340. issue 2. 2012-04-06. PMID:22088953. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder associated with severe motor impairments caused by the loss of dopaminergic innervation of the striatum. |
2012-04-06 |
2023-08-12 |
rat |
| Lisa R Beutler, Kiara C Eldred, Albert Quintana, C Dirk Keene, Shannon E Rose, Nadia Postupna, Thomas J Montine, Richard D Palmite. Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132236. |
the striatum is composed predominantly of medium spiny neurons (msns) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. |
2012-04-02 |
2023-08-12 |
mouse |