| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Sakurada, M Ohshima-Sakurada, T D Palmer, F H Gag. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (Cambridge, England). vol 126. issue 18. 1999-10-21. PMID:10457011. |
this uncoupling of tyrosine hydroxylase expression from other dopaminergic markers suggests that the midbrain dopaminergic identity is dictated by a combination of pan-dopaminergic (e.g., shh/fgf-8) and region-specific (nurr1) mechanisms. |
1999-10-21 |
2023-08-12 |
Not clear |
| W F Silverman, A Alfahel-Kakunda, A Dori, J L Barke. Separation of dorsal and ventral dopaminergic neurons from embryonic rat mesencephalon by buoyant density fractionation: disassembling pattern in the ventral midbrain. Journal of neuroscience methods. vol 89. issue 1. 1999-10-18. PMID:10476677. |
separation of dorsal and ventral dopaminergic neurons from embryonic rat mesencephalon by buoyant density fractionation: disassembling pattern in the ventral midbrain. |
1999-10-18 |
2023-08-12 |
rat |
| W F Silverman, A Alfahel-Kakunda, A Dori, J L Barke. Separation of dorsal and ventral dopaminergic neurons from embryonic rat mesencephalon by buoyant density fractionation: disassembling pattern in the ventral midbrain. Journal of neuroscience methods. vol 89. issue 1. 1999-10-18. PMID:10476677. |
the dopaminergic neurons of the ventral mesencephalon, though physically mixed with non-dopamine neurons, are organized into dorsal and ventral 'tiers' with regard to their ontogeny, efferent projections and their relative position in the various mesencephalic sub-nuclei. |
1999-10-18 |
2023-08-12 |
rat |
| M A Alonso-Vanegas, J P Fawcett, C G Causing, F D Miller, A F Sadiko. Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. The Journal of comparative neurology. vol 413. issue 3. 1999-10-18. PMID:10502251. |
characterization of dopaminergic midbrain neurons in a dbh:bdnf transgenic mouse. |
1999-10-18 |
2023-08-12 |
mouse |
| M A Alonso-Vanegas, J P Fawcett, C G Causing, F D Miller, A F Sadiko. Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. The Journal of comparative neurology. vol 413. issue 3. 1999-10-18. PMID:10502251. |
we quantified dopaminergic neuronal profiles at four midbrain coronal levels and compared dbh:bdnf transgenic animals with wild-type mice of the same genetic background. |
1999-10-18 |
2023-08-12 |
mouse |
| M A Alonso-Vanegas, J P Fawcett, C G Causing, F D Miller, A F Sadiko. Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. The Journal of comparative neurology. vol 413. issue 3. 1999-10-18. PMID:10502251. |
analysis of sections immunostained with tyrosine hydroxylase (th) showed that the mean number of dopaminergic neurons in the four selected midbrain sections was 52% greater (one-way analysis of variance, p < 0.0005) in transgenic mice (2,165 +/- 55 s. e.m., n = 4) than in control mice (1,428 +/- 71 s.e.m., n = 4). |
1999-10-18 |
2023-08-12 |
mouse |
| M A Alonso-Vanegas, J P Fawcett, C G Causing, F D Miller, A F Sadiko. Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. The Journal of comparative neurology. vol 413. issue 3. 1999-10-18. PMID:10502251. |
regional analysis of different midbrain areas containing dopaminergic neurons suggested that the increase in cell profile count occurs in a relatively homogeneous manner. |
1999-10-18 |
2023-08-12 |
mouse |
| M B Ghasemzadeh, R C Pierce, P W Kaliva. The monoamine neurons of the rat brain preferentially express a splice variant of alpha1B subunit of the N-type calcium channel. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501220. |
double-label in situ hybridization was used to show expression of this isoform mrna in dopaminergic neurons of the ventral mesencephalon. |
1999-10-14 |
2023-08-12 |
rat |
| J S Rakshi, T Uema, K Ito, D L Bailey, P K Morrish, J Ashburner, A Dagher, I H Jenkins, K J Friston, D J Brook. Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study. Brain : a journal of neurology. vol 122 ( Pt 9). 1999-10-12. PMID:10468504. |
frontal, midbrain and striatal dopaminergic function in early and advanced parkinson's disease a 3d [(18)f]dopa-pet study. |
1999-10-12 |
2023-08-12 |
human |
| L Feng, C Y Wang, H Jiang, C Oho, M Dugich-Djordjevic, L Mei, B L. Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430490. |
in the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. |
1999-10-08 |
2023-08-12 |
Not clear |
| J C Stoof, A Winogrodzka, F L van Muiswinkel, E C Wolters, P Voorn, H J Groenewegen, J Booij, B Drukarc. Leads for the development of neuroprotective treatment in Parkinson's disease and brain imaging methods for estimating treatment efficacy. European journal of pharmacology. vol 375. issue 1-3. 1999-10-08. PMID:10443566. |
patients suffering from parkinson's disease display severe and progressive deficits in motor behavior, predominantly as a consequence of the degeneration of dopaminergic neurons, located in the mesencephalon and projecting to striatal regions. |
1999-10-08 |
2023-08-12 |
Not clear |
| J D Broome, K V Wills, P A Lapchak, B Ghetti, L L Camp, S A Baye. Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: a quantitative immunocytochemical study. Brain research. Developmental brain research. vol 116. issue 1. 1999-10-07. PMID:10446341. |
the weaver mouse (wv/wv) has natural and spontaneous midbrain dopaminergic cell death which gives a unique opportunity to examine the effects of gdnf. |
1999-10-07 |
2023-08-12 |
mouse |
| J D Broome, K V Wills, P A Lapchak, B Ghetti, L L Camp, S A Baye. Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: a quantitative immunocytochemical study. Brain research. Developmental brain research. vol 116. issue 1. 1999-10-07. PMID:10446341. |
the results demonstrate that gdnf does protect weaver dopaminergic midbrain neurons from the lethal action of the weaver gene and the effect is positively correlated to dosage. |
1999-10-07 |
2023-08-12 |
mouse |
| H Takashima, M Tsujihata, M Kishikawa, W J Free. Bromocriptine protects dopaminergic neurons from levodopa-induced toxicity by stimulating D(2)receptors. Experimental neurology. vol 159. issue 1. 1999-10-07. PMID:10486178. |
neuroprotective properties of bromocriptine, a d(2) receptor agonist, were investigated using the in vitro neurotoxicity of levodopa for dopaminergic neurons from rat embryonic ventral mesencephalon. |
1999-10-07 |
2023-08-12 |
rat |
| M Di Mascio, G Di Giovanni, V Di Matteo, E Esposit. Decreased chaos of midbrain dopaminergic neurons after serotonin denervation. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392846. |
decreased chaos of midbrain dopaminergic neurons after serotonin denervation. |
1999-10-06 |
2023-08-12 |
rat |
| S J Lokwan, P G Overton, M S Berry, D Clar. Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392847. |
stimulation of the medial prefrontal cortex in the rat produces events in midbrain dopaminergic neurons which resemble natural bursts, and which are closely time-locked to the stimulation, albeit with a very long latency. |
1999-10-06 |
2023-08-12 |
rat |
| J Wagner, P Akerud, D S Castro, P C Holm, J M Canals, E Y Snyder, T Perlmann, E Arena. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nature biotechnology. vol 17. issue 7. 1999-09-29. PMID:10404157. |
induction of a midbrain dopaminergic phenotype in nurr1-overexpressing neural stem cells by type 1 astrocytes. |
1999-09-29 |
2023-08-12 |
Not clear |
| M Michikaw. [cDNA cloning of ju-myo protein (JP) and elucidation of the molecular mechanisms by which it exerts neurotrophic effects on neurons]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 36. issue 2. 1999-09-20. PMID:10363526. |
here we show that jp can exert neurotrophic activities on postmitotic fetal rat neurons isolated from cerebral cortical and dopaminergic neurons isolated from the midbrain: it enhanced survival of map2-positive cells and tyrosine hydroxylase immunoreactive neurons by approximately 2-fold over the control group. |
1999-09-20 |
2023-08-12 |
rat |
| M Vidailhet, C Dupel, S Lehéricy, P Remy, D Dormont, M Serdaru, P Jedynak, H Veber, Y Samson, C Marsault, Y Agi. Dopaminergic dysfunction in midbrain dystonia: anatomoclinical study using 3-dimensional magnetic resonance imaging and fluorodopa F 18 positron emission tomography. Archives of neurology. vol 56. issue 8. 1999-09-15. PMID:10448804. |
dopaminergic dysfunction in midbrain dystonia: anatomoclinical study using 3-dimensional magnetic resonance imaging and fluorodopa f 18 positron emission tomography. |
1999-09-15 |
2023-08-12 |
Not clear |
| S Shimazu, H Katsuki, A Akaik. Deprenyl rescues dopaminergic neurons in organotypic slice cultures of neonatal rat mesencephalon from N-methyl-D-aspartate toxicity. European journal of pharmacology. vol 377. issue 1. 1999-09-08. PMID:10448922. |
deprenyl rescues dopaminergic neurons in organotypic slice cultures of neonatal rat mesencephalon from n-methyl-d-aspartate toxicity. |
1999-09-08 |
2023-08-12 |
rat |