| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
these results suggest that naloxone at least in part interferes with the binding of lps to cell membranes to inhibit microglia activation and protect dopaminergic neurons as well as other neurons in the midbrain cultures from inflammatory damage. |
2000-06-21 |
2023-08-12 |
rat |
| S Nakamura, Y Ito, R Shirasaki, F Murakam. Local directional cues control growth polarity of dopaminergic axons along the rostrocaudal axis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818146. |
here, we examined the mechanism that guides midbrain dopaminergic axons rostrally, using flat whole-mount preparations of embryonic rat brain both in vivo and in vitro. |
2000-06-15 |
2023-08-12 |
rat |
| S Nakamura, Y Ito, R Shirasaki, F Murakam. Local directional cues control growth polarity of dopaminergic axons along the rostrocaudal axis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818146. |
at embryonic day 11 (e11) and early stage e12, dopaminergic neurons in the ventral midbrain extended short axons dorsally. |
2000-06-15 |
2023-08-12 |
rat |
| P Lingor, K Unsicker, K Krieglstei. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785444. |
gdnf and nt-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. |
2000-06-13 |
2023-08-12 |
rat |
| P Hou, A Di, P Huang, C B Hansen, D J Nelso. Impermeability of the GIRK2 weaver channel to divalent cations. American journal of physiology. Cell physiology. vol 278. issue 5. 2000-06-12. PMID:10794678. |
the mutant channel subunit (girk2wv) causes the pleiotropic weaver disease in mice, which is characterized by the selective vulnerability of cerebellar granule cells and purkinje cells, as well as dopaminergic neurons in the mesencephalon, to cell death. |
2000-06-12 |
2023-08-12 |
mouse |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
pharmacological identification of the k(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. |
2000-05-25 |
2023-08-12 |
rat |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
hypoglycemia (zero glucose) initially depolarized the membrane and increased the spontaneous firing of rat midbrain dopaminergic neurones (more than 50%) intracellularly recorded in an in vitro slice preparation. |
2000-05-25 |
2023-08-12 |
rat |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
our data suggest that midbrain dopaminergic cells respond to glucose deprivation with a hyperpolarization generated by the opening of several k(+) channels (sulphonylurea-sensitive, charybdotoxin-sensitive and sulphonylurea and charybdotoxin-insensitive) and by the activation of the na(+)/k(+) atpase pump after the hypoglycemic period. |
2000-05-25 |
2023-08-12 |
rat |
| P Liberini, S Parola, P F Spano, L Antonin. Olfaction in Parkinson's disease: methods of assessment and clinical relevance. Journal of neurology. vol 247. issue 2. 2000-05-19. PMID:10751109. |
moreover, indirect evidence suggests that dysfunction of the dopaminergic pathways from mesencephalon to the piriform cortex may play a role in olfactory impairment in pd. |
2000-05-19 |
2023-08-12 |
Not clear |
| F Xu, R R Gainetdinov, W C Wetsel, S R Jones, L M Bohn, G W Miller, Y M Wang, M G Caro. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nature neuroscience. vol 3. issue 5. 2000-05-18. PMID:10769386. |
thus altering net expression significantly modulates midbrain dopaminergic function, an effect that may be an important component of the actions of antidepressants and psychostimulants. |
2000-05-18 |
2023-08-12 |
mouse |
| X Zhou, W Zhang, T Ba. [Expression of glial cells line-derived neurotrophic factor in the central nervous system of rat]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 29. issue 3. 2000-04-25. PMID:10684095. |
glial cell line-derived neurotrophic factor (gdnf) iss a distant member of the transforming growth factor-beta, originally isolated by virtue of its ability to induce dopamine uptake and cell survival in cultures of embryonic ventral midbrain dopaminergic neurons, and more recently it has been shown to be a potent neurotrophic factor for motor neurons. |
2000-04-25 |
2023-08-12 |
rat |
| A Hartmann, S Hunot, P P Michel, M P Muriel, S Vyas, B A Faucheux, A Mouatt-Prigent, H Turmel, A Srinivasan, M Ruberg, G I Evan, Y Agid, E C Hirsc. Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10688892. |
using caspase-3 immunohistochemistry on the postmortem human brain, we observed a positive correlation between the degree of neuronal loss in dopaminergic (da) cell groups affected in the mesencephalon of pd patients and the percentage of caspase-3-positive neurons in these cell groups in control subjects and a significant decrease of caspase-3-positive pigmented neurons in the substantia nigra pars compacta of pd patients compared with controls that also could be observed in an animal model of pd. |
2000-04-25 |
2023-08-12 |
human |
| E Koga, T Momiyam. Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones. The Journal of physiology. vol 523 Pt 1. 2000-04-18. PMID:10673553. |
the effects of dopamine (da) on non-nmda glutamatergic transmission onto dopaminergic neurones in the ventral tegmental area (vta) were examined in rat midbrain slices using the whole-cell patch-clamp technique. |
2000-04-18 |
2023-08-12 |
rat |
| J N Kay, M Blu. Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. Developmental neuroscience. vol 22. issue 1-2. 2000-04-11. PMID:10657698. |
differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. |
2000-04-11 |
2023-08-12 |
mouse |
| R A Barker, E Ratcliffe, A Richards, S B Dunnet. Fetal porcine dopaminergic cell survival in vitro and its relationship to embryonic age. Cell transplantation. vol 8. issue 6. 2000-03-30. PMID:10701488. |
this is especially the case for the developing dopaminergic neurons in the embryonic ventral mesencephalon, which are used for neural grafts in parkinson's disease (pd). |
2000-03-30 |
2023-08-12 |
mouse |
| S Shimazu, H Katsuki, C Takenaka, M Tomita, T Kume, S Kaneko, A Akaik. sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666505. |
when challenged with 100-microm n-methyl-d-aspartate (nmda) for 24 h, dopaminergic neurons in midbrain slice cultures degenerated, and this was prevented by (5r, 10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,b]-cyclohepten-5, 10-imine (mk-801; 1-10 microm). |
2000-03-16 |
2023-08-12 |
Not clear |
| S Shimazu, H Katsuki, C Takenaka, M Tomita, T Kume, S Kaneko, A Akaik. sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666505. |
these results indicate that sigma receptor ligands attenuate the cytotoxic effects of nmda on midbrain dopaminergic neurons, possibly via inhibition of nmda receptor functions. |
2000-03-16 |
2023-08-12 |
Not clear |
| R H Baloh, M G Tansey, E M Johnson, J Milbrand. Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists. The Journal of biological chemistry. vol 275. issue 5. 2000-03-02. PMID:10652334. |
the glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) (gdnf, neurturin, artemin, and persephin) are critical regulators of neurodevelopment and support the survival of midbrain dopaminergic and spinal motor neurons in vitro and in animal disease models making them attractive therapeutic candidates for treatment of neurodegenerative diseases. |
2000-03-02 |
2023-08-12 |
Not clear |
| N Kubis, B A Faucheux, G Ransmayr, P Damier, C Duyckaerts, D Henin, B Forette, Y Le Charpentier, J J Hauw, Y Agid, E C Hirsc. Preservation of midbrain catecholaminergic neurons in very old human subjects. Brain : a journal of neurology. vol 123 ( Pt 2). 2000-02-25. PMID:10648443. |
parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. |
2000-02-25 |
2023-08-12 |
human |
| C Beyer, M Karolcza. Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658191. |
estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on camp/protein kinase a signalling. |
2000-02-25 |
2023-08-12 |
mouse |