| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Blum, C Weickert, E Carrasc. The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619558. |
however, when we assessed whether thyroid hormone replacement could rescue midbrain dopaminergic neurons we found that this treatment accelerated rather than attenuated neurodegeneration. |
2000-01-14 |
2023-08-12 |
mouse |
| M Blum, C Weickert, E Carrasc. The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619558. |
we did not observe that thyroid hormone was able to directly regulate expression of girk2 mrna levels in the midbrain and therefore, speculate that the mechanism by which thyroid hormone accelerates midbrain dopaminergic neurodegeneration is by enhancing the maturation of the striatonigral inputs. |
2000-01-14 |
2023-08-12 |
mouse |
| N le Novère, M Zoli, C Léna, R Ferrari, M R Picciotto, E Merlo-Pich, J P Changeu. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. Neuroreport. vol 10. issue 12. 1999-12-21. PMID:10574359. |
the nicotinic receptor subunit alpha6 is, among other subunits, strongly expressed in the dopaminergic neurons of the mesencephalon. |
1999-12-21 |
2023-08-12 |
Not clear |
| S A Oakman, P L Faris, C Cozzari, B K Hartma. Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579214. |
characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups. |
1999-12-21 |
2023-08-12 |
Not clear |
| B Amini, J W Clark, C C Canavie. Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study. Journal of neurophysiology. vol 82. issue 5. 1999-12-17. PMID:10561403. |
calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study. |
1999-12-17 |
2023-08-12 |
Not clear |
| C Nemoto, T Hida, R Ara. Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study. Brain research. vol 846. issue 1. 1999-12-10. PMID:10536220. |
calretinin and calbindin-d28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study. |
1999-12-10 |
2023-08-12 |
rat |
| C Nemoto, T Hida, R Ara. Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study. Brain research. vol 846. issue 1. 1999-12-10. PMID:10536220. |
we used triple-labeling immunohistochemistry in rat midbrain sections to identify dopaminergic neurons that contain either one or both of the calcium-binding proteins, calretinin (cr) and calbindin-d28k (cb). |
1999-12-10 |
2023-08-12 |
rat |
| C Nemoto, T Hida, R Ara. Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study. Brain research. vol 846. issue 1. 1999-12-10. PMID:10536220. |
midbrain dopaminergic neurons were immunohistochemically labeled for tyrosine hydroxylase (th), cr, and cb. |
1999-12-10 |
2023-08-12 |
rat |
| C Nemoto, T Hida, R Ara. Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study. Brain research. vol 846. issue 1. 1999-12-10. PMID:10536220. |
furthermore, because cr and cb likely contribute to calcium homeostasis by buffering intracellular calcium concentrations, midbrain dopaminergic neurons containing one or both of these calcium-binding proteins may have a higher calcium-buffering capacity than those lacking the two proteins. |
1999-12-10 |
2023-08-12 |
rat |
| Y Tan, E S Williams, D S Zah. Calbindin-D 28kD immunofluorescence in ventral mesencephalic neurons labeled following injections of Fluoro-Gold in nucleus accumbens subterritories: inverse relationship relative to known neurotoxin vulnerabilities. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536262. |
differences in the distributions of the calbindin-d 28kd (cb) and calretinin (cr) might be related to the different vulnerabilities to neurotoxins of dopaminergic neurons in the ventral mesencephalon that project to the core and medial shell of the nucleus accumbens. |
1999-12-10 |
2023-08-12 |
Not clear |
| W Duan, Z Zhang, D M Gash, M P Mattso. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Annals of neurology. vol 46. issue 4. 1999-12-03. PMID:10514095. |
dysfunction and death of midbrain dopaminergic neurons underlies the clinical features of parkinson's disease (pd). |
1999-12-03 |
2023-08-12 |
mouse |
| W Duan, Z Zhang, D M Gash, M P Mattso. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Annals of neurology. vol 46. issue 4. 1999-12-03. PMID:10514095. |
we now report that par-4 levels increase dramatically in midbrain dopaminergic neurons of monkeys and mice exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1999-12-03 |
2023-08-12 |
mouse |
| T A Reader, A R Ase, C Hébert, F Amdis. Distribution of dopamine, its metabolites, and D1 and D2 receptors in heterozygous and homozygous weaver mutant mice. Neurochemical research. vol 24. issue 11. 1999-11-24. PMID:10555787. |
abnormal developmental growth signals, or aberrant cellular responses, may result in defective neurite formation of the midbrain dopaminergic neurons, leading to their postnatal death. |
1999-11-24 |
2023-08-12 |
mouse |
| S Sumitran, J Liu, K A Czech, B Christensson, H Widner, J Holgersso. Human natural antibodies cytotoxic to pig embryonic brain cells recognize novel non-Galalpha1,3Gal-based xenoantigens. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506507. |
transplantation of porcine embryonic brain cells, including dopaminergic neurons, from ventral mesencephalon (vm) is considered a potential treatment for patients with parkinson's disease. |
1999-11-19 |
2023-08-12 |
human |
| H Raab, M Karolczak, I Reisert, C Beye. Ontogenetic expression and splicing of estrogen receptor-alpha and beta mRNA in the rat midbrain. Neuroscience letters. vol 275. issue 1. 1999-11-15. PMID:10554975. |
several studies have shown that estrogen is important for the differentiation of midbrain dopaminergic neurons. |
1999-11-15 |
2023-08-12 |
rat |
| W Le, O M Conneely, Y He, J Jankovic, S H Appe. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537083. |
mutation in the nurr1 gene, a member of the nuclear receptor superfamily, causes selective agenesis of dopaminergic neurons in the midbrain of null mice. |
1999-11-05 |
2023-08-12 |
mouse |
| B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
the weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvgirk2 and k-atp channels. |
1999-10-28 |
2023-08-12 |
mouse |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
cocaine is a highly addictive drug that binds to the dopamine transporter (dat), inhibits the reuptake of dopamine, and initiates multiple actions within midbrain dopaminergic systems. |
1999-10-28 |
2023-08-12 |
human |
| A M Kang, M A Palmatier, K K Kid. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418689. |
the dopamine transporter (dat) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and mptp. |
1999-10-25 |
2023-08-12 |
Not clear |
| K Sakurada, M Ohshima-Sakurada, T D Palmer, F H Gag. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (Cambridge, England). vol 126. issue 18. 1999-10-21. PMID:10457011. |
adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination, including fgf receptors 1, 2 and 3, the sonic hedgehog receptor components smo and ptc, and the region-specific transcription factors ptx3 and nurr1. |
1999-10-21 |
2023-08-12 |
Not clear |