| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R L Rodnitzk. Can calcium antagonists provide a neuroprotective effect in Parkinson's disease? Drugs. vol 57. issue 6. 1999-09-03. PMID:10400399. |
the common calcium antagonists in use for the treatment of cardiovascular diseases have the potential to modify calcium neurotoxicity in pd since they block l-type calcium channels which are predominantly responsible for regulating intracellular calcium in midbrain dopaminergic cells. |
1999-09-03 |
2023-08-12 |
human |
| A Migheli, R Piva, S Casolino, C Atzori, S R Dlouhy, B Ghett. A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. The American journal of pathology. vol 155. issue 2. 1999-08-31. PMID:10433930. |
a missense mutation in the gene coding for the g-protein-activated inwardly rectifying potassium (girk) channel, girk2, is responsible for apoptosis in the external germinal layer (egl) of the cerebellum and a nonapoptotic death of midbrain dopaminergic neurons in the weaver (wv) mouse. |
1999-08-31 |
2023-08-12 |
mouse |
| H Slovin, M Abeles, E Vaadia, I Haalman, Y Prut, H Bergma. Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys. Journal of neurophysiology. vol 81. issue 2. 1999-08-17. PMID:10036286. |
the behavioral and saccadic deficits probably result from the marked reduction of dopaminergic neurons in the midbrain. |
1999-08-17 |
2023-08-12 |
monkey |
| M M Arroyo-Jim nez, J P Bourgeois, L M Marubio, A M Le Sourd, O P Ottersen, E Rinvik, A Fairén, J P Changeu. Ultrastructural localization of the alpha4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 15. 1999-08-16. PMID:10414976. |
at the electron microscope level, the neurons in the snpc exhibited alpha4-subunit-li in association with a minority of postsynaptic densities, suggesting that the alpha4-subunit may be a component of functional nachrs mediating synaptic transmission between midbrain cholinergic neurons and mesencephalic dopaminergic neurons. |
1999-08-16 |
2023-08-12 |
rat |
| H Sei, Y Morit. Why does arterial blood pressure rise actively during REM sleep? The journal of medical investigation : JMI. vol 46. issue 1-2. 1999-08-10. PMID:10408152. |
furthermore, the midbrain dopaminergic system has been recently found to be involved in increases in rem-associated ap. |
1999-08-10 |
2023-08-12 |
rat |
| T C Napier, I Mitrovi. Opioid modulation of ventral pallidal inputs. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415650. |
subthreshold opioids also attenuated inhibitory responses to stimulating midbrain dopaminergic cells. |
1999-08-10 |
2023-08-12 |
rat |
| P Grillner, A Bonci, T H Svensson, G Bernardi, N B Mercur. Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366013. |
our data indicate that presynaptically located m3 receptors modulate the excitatory transmission to midbrain dopaminergic neurons via a n-ethylmaleimide-insensitive g-protein which activates mechanisms neither linked to n-, p-, q-type calcium channels nor to barium- and 4-aminopyridine-sensitive potassium channels. |
1999-08-02 |
2023-08-12 |
rat |
| E C Hirsc. Mechanism and consequences of nerve cell death in Parkinson's disease. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370907. |
parkinson's disease is characterized by a selective vulnerability of sub-populations of dopaminergic neurons in the mesencephalon. |
1999-08-02 |
2023-08-12 |
human |
| F C Dalman, K L O'Malle. kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 14. 1999-08-02. PMID:10407016. |
kappa-opioid tolerance and dependence in cultures of dopaminergic midbrain neurons. |
1999-08-02 |
2023-08-12 |
Not clear |
| E Fedele, G Fontana, C Munari, M Cossu, M Raiter. Native human neocortex release-regulating dopamine D2 type autoreceptors are dopamine D2 subtype. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383624. |
it is concluded that in human brain, as well as in rat brain, the release of da in the terminal region of midbrain dopaminergic neurons is regulated through autoreceptors of the d2 subtype. |
1999-07-30 |
2023-08-12 |
human |
| M Saarma, H Sariol. Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383122. |
glial cell line-derived neurotrophic factor (gdnf) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of parkinson's disease. |
1999-07-29 |
2023-08-12 |
chicken |
| M Di Mascio, G Di Giovanni, V Di Matteo, E Esposit. Reduced chaos of interspike interval of midbrain dopaminergic neurons in aged rats. Neuroscience. vol 89. issue 4. 1999-07-22. PMID:10362290. |
reduced chaos of interspike interval of midbrain dopaminergic neurons in aged rats. |
1999-07-22 |
2023-08-12 |
rat |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
double-labeling studies combining dat and tyrosine hydroxylase (th) immunostaining in the ventral mesencephalon showed two subpopulations of dopaminergic neurons differentiated by the presence or absence of dat-immunoreactivity in the a9 and a10 cell groups. |
1999-07-20 |
2023-08-12 |
human |
| W F Silverman, J M Krum, N Mani, J M Rosenstei. Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience. vol 90. issue 4. 1999-07-16. PMID:10338318. |
we conclude that, in explants of the ventral mesencephalon, exogenously applied vascular endothelial growth factor is mitogenic for endothelial cells and astrocytes, and promotes growth/survival of neurons in general and dopaminergic neurons in particular. |
1999-07-16 |
2023-08-12 |
rat |
| M Lindskog, P Svenningsson, B B Fredholm, P Greengard, G Fison. Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms. Neuroscience. vol 88. issue 4. 1999-07-15. PMID:10336115. |
these cells receive glutamatergic input from the cortex, thalamus and limbic areas and dopaminergic input from the mesencephalon. |
1999-07-15 |
2023-08-12 |
Not clear |
| P Akerud, J Alberch, S Eketjäll, J Wagner, E Arena. Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. Journal of neurochemistry. vol 73. issue 1. 1999-07-08. PMID:10386956. |
our goal in the present work was to compare their function and define whether nonoverlapping biological activities on midbrain dopaminergic neurons exist. |
1999-07-08 |
2023-08-12 |
Not clear |
| P Akerud, J Alberch, S Eketjäll, J Wagner, E Arena. Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. Journal of neurochemistry. vol 73. issue 1. 1999-07-08. PMID:10386956. |
we therefore examined their function in ventral mesencephalon cultures and found that ntn promoted survival comparable with gdnf, but only gdnf induced sprouting and hypertrophy of developing dopaminergic neurons. |
1999-07-08 |
2023-08-12 |
Not clear |
| C A Heidbreder, T Oertle, J Feldo. Dopamine and serotonin imbalances in the left anterior cingulate and pyriform cortices following the repeated intermittent administration of cocaine. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199606. |
these results demonstrate that cocaine produces alterations in specific dopaminergic and serotonergic pathways that arise from the mesencephalon and project towards both the anterior cingulate and pyriform cortices. |
1999-07-07 |
2023-08-12 |
Not clear |
| M Hironishi, E Ueyama, E Senb. Systematic expression of immediate early genes and intensive astrocyte activation induced by intrastriatal ferrous iron injection. Brain research. vol 828. issue 1-2. 1999-06-30. PMID:10320734. |
when fecl2 was injected into the ventral midbrain, rats showed a characteristic behavior which indicated ipsilateral dopaminergic hyperactivity. |
1999-06-30 |
2023-08-12 |
rat |
| N Liu, H Bake. Activity-dependent Nurr1 and NGFI-B gene expression in adult mouse olfactory bulb. Neuroreport. vol 10. issue 4. 1999-06-29. PMID:10208542. |
previous studies showed that nurr1 is essential to development of the dopamine phenotype in midbrain, but not for dopaminergic neurons intrinsic to the olfactory bulb (ob). |
1999-06-29 |
2023-08-12 |
mouse |