| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kareem A Zaghloul, Justin A Blanco, Christoph T Weidemann, Kathryn McGill, Jurg L Jaggi, Gordon H Baltuch, Michael J Kahan. Human substantia nigra neurons encode unexpected financial rewards. Science (New York, N.Y.). vol 323. issue 5920. 2009-04-01. PMID:19286561. |
emerging research suggests that midbrain dopaminergic neurons encode these unexpected outcomes. |
2009-04-01 |
2023-08-12 |
human |
| A V Droblenkov, N R Karelina, V A Lebede. [Rat mesoaccumbocingulate dopaminergic system and brain emotional functions]. Morfologiia (Saint Petersburg, Russia). vol 134. issue 6. 2009-03-24. PMID:19241878. |
the affective function of the rat anterior cingulate fields after the administration of psychoactive drugs, as well as the formation of dependence on them, is associated with the distribution of the dopaminergic endings of midbrain neurons in the nucleus accumbens and at the anterior cingulate fields, in particular, in the pregenual part. |
2009-03-24 |
2023-08-12 |
rat |
| Kaia Kala, Maarja Haugas, Kersti Lilleväli, Jordi Guimera, Wolfgang Wurst, Marjo Salminen, Juha Partane. Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons. Development (Cambridge, England). vol 136. issue 2. 2009-03-18. PMID:19088086. |
surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the gabaergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. |
2009-03-18 |
2023-08-12 |
mouse |
| Kairong Li, Bing Xue, Yue Wang, Xuan Wang, Haomin Wang, Xiaomin Wan. Ventral mesencephalon astrocytes are more efficient than those of other regions in inducing dopaminergic neurons through higher expression level of TGF-beta3. Journal of molecular neuroscience : MN. vol 37. issue 3. 2009-03-16. PMID:18982456. |
ventral mesencephalon astrocytes are more efficient than those of other regions in inducing dopaminergic neurons through higher expression level of tgf-beta3. |
2009-03-16 |
2023-08-12 |
Not clear |
| Kairong Li, Bing Xue, Yue Wang, Xuan Wang, Haomin Wang, Xiaomin Wan. Ventral mesencephalon astrocytes are more efficient than those of other regions in inducing dopaminergic neurons through higher expression level of TGF-beta3. Journal of molecular neuroscience : MN. vol 37. issue 3. 2009-03-16. PMID:18982456. |
ventral mesencephalon (vm) astrocytes were also detected being instructive for vm dopaminergic (da) neurogenesis, but the underling mechanisms are still unclear. |
2009-03-16 |
2023-08-12 |
Not clear |
| Jaana M Jurvansuu, Adrian Goldma. Recent inventions on receptor tyrosine kinase RET modulation. Recent patents on biotechnology. vol 2. issue 1. 2009-03-16. PMID:19075852. |
therefore, the neuroprotective capacity of ret activation to override the apoptotic program in neurodegenerative diseases, like in dying midbrain dopaminergic neurons in parkinson's disease, is of great interest. |
2009-03-16 |
2023-08-12 |
Not clear |
| Hui-Li Zou, Chang-Jun Su, Ming Shi, Guang-Yu Zhao, Zhu-Yi Li, Chao Guo, Yu-Qiang Din. Expression of the LIM-homeodomain gene Lmx1a in the postnatal mouse central nervous system. Brain research bulletin. vol 78. issue 6. 2009-03-13. PMID:19111912. |
the lim-homeodomain transcription factor lmx1a plays critical roles in roof plate formation as well as in the cell fate determination of midbrain dopaminergic neurons during embryonic development, but its function in the adult brain remains unknown. |
2009-03-13 |
2023-08-12 |
mouse |
| Hui-Li Zou, Chang-Jun Su, Ming Shi, Guang-Yu Zhao, Zhu-Yi Li, Chao Guo, Yu-Qiang Din. Expression of the LIM-homeodomain gene Lmx1a in the postnatal mouse central nervous system. Brain research bulletin. vol 78. issue 6. 2009-03-13. PMID:19111912. |
lmx1a-expressing neurons in the ventral midbrain were dopaminergic as evidenced by co-expression with tyrosine hydroxylase in these regions. |
2009-03-13 |
2023-08-12 |
mouse |
| B H Meurers, C Zhu, P O Fernagut, F Richter, Y C Hsia, S M Fleming, M Oh, D Elashoff, C D Dicarlo, R L Seaman, M F Chessele. Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo. Neurobiology of disease. vol 33. issue 2. 2009-03-09. PMID:19013527. |
mitochondrial complex i inhibition has been implicated in the degeneration of midbrain dopaminergic (da) neurons in parkinson's disease. |
2009-03-09 |
2023-08-12 |
rat |
| A Guyon, D Skrzydelski, C Rovère, E Apartis, W Rostène, P Kitabgi, S Mélik Parsadaniantz, J L Naho. Stromal-cell-derived factor 1alpha /CXCL12 modulates high-threshold calcium currents in rat substantia nigra. The European journal of neuroscience. vol 28. issue 5. 2009-03-05. PMID:18671738. |
we therefore investigated the effects of cxcl12 on da release from cultured dopaminergic neurons from the rat mesencephalon. |
2009-03-05 |
2023-08-12 |
rat |
| Weidong Le, Tianhong Pan, Maosheng Huang, Pingyi Xu, Wenjie Xie, Wen Zhu, Xiong Zhang, Hao Deng, Joseph Jankovi. Decreased NURR1 gene expression in patients with Parkinson's disease. Journal of the neurological sciences. vol 273. issue 1-2. 2009-02-06. PMID:18684475. |
nurr1 is a transcription factor essential for the development, survival, and functional maintenance of midbrain dopaminergic (daergic) neurons and nurr1 is a potential susceptibility gene for parkinson's disease (pd). |
2009-02-06 |
2023-08-12 |
human |
| Anna Castañé, Francesc Artigas, Analía Bortolozz. The absence of 5-HT(1A) receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex. Psychopharmacology. vol 200. issue 2. 2009-01-29. PMID:18594799. |
projection pyramidal neurons and local gabaergic interneurons in mpfc express 5-ht(1a) receptors, whose activation modulates dopaminergic (da) and serotonergic (5-ht) activity in midbrain and the cortical release of both monoamines. |
2009-01-29 |
2023-08-12 |
mouse |
| Xuefei Wu, Po See Chen, Shannon Dallas, Belinda Wilson, Michelle L Block, Chao-Chuan Wang, Harriet Kinyamu, Nick Lu, Xi Gao, Yan Leng, De-Maw Chuang, Wanqin Zhang, Ru Band Lu, Jau-Shyong Hon. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18611290. |
parkinson's disease (pd) is characterized by the selective and progressive loss of dopaminergic (da) neurons in the midbrain substantia nigra. |
2009-01-26 |
2023-08-12 |
Not clear |
| David L Carbone, Katriana A Popichak, Julie A Moreno, Stephen Safe, Ronald B Tjalken. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular pharmacology. vol 75. issue 1. 2009-01-26. PMID:18840677. |
the progressive debilitation of motor functions in parkinson's disease (pd) results from degeneration of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. |
2009-01-26 |
2023-08-12 |
Not clear |
| Ignacio Cruz-Muros, Domingo Afonso-Oramas, Pedro Abreu, Manuel Rodríguez, M Carmen González, Tomás González-Hernánde. Deglycosylation and subcellular redistribution of VMAT2 in the mesostriatal system during normal aging. Neurobiology of aging. vol 29. issue 11. 2009-01-23. PMID:17582657. |
these changes may be responsible for the loss of vmat2 activity during aging and may contribute to the high susceptibility of aged midbrain dopaminergic cells to degeneration. |
2009-01-23 |
2023-08-12 |
rat |
| José-Manuel Baizabal, Luis Covarrubia. The embryonic midbrain directs neuronal specification of embryonic stem cells at early stages of differentiation. Developmental biology. vol 325. issue 1. 2009-01-23. PMID:18929554. |
using this experimental design, we show that the transition from escs to embryoid body (eb) precursors is necessary to differentiate into lmx1a(+)/ptx3(+)/th(+) dopaminergic neurons around the ventral midline of the midbrain. |
2009-01-23 |
2023-08-12 |
Not clear |
| José-Manuel Baizabal, Luis Covarrubia. The embryonic midbrain directs neuronal specification of embryonic stem cells at early stages of differentiation. Developmental biology. vol 325. issue 1. 2009-01-23. PMID:18929554. |
finally, exposure to fgf8 and shh in vitro promotes commitment of some esc-derived npcs to differentiate into putative lmx1a(+) dopaminergic neurons in the midbrain. |
2009-01-23 |
2023-08-12 |
Not clear |
| Emma R Andersson, Nilima Prakash, Lukas Cajanek, Eleonora Minina, Vitezslav Bryja, Lenka Bryjova, Terry P Yamaguchi, Anita C Hall, Wolfgang Wurst, Ernest Arena. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PloS one. vol 3. issue 10. 2009-01-21. PMID:18953410. |
wnt5a regulates ventral midbrain morphogenesis and the development of a9-a10 dopaminergic cells in vivo. |
2009-01-21 |
2023-08-12 |
mouse |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
using the pd animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) intoxication in mice, we showed that dmt1 expression increases in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress, and dopaminergic cell loss. |
2009-01-07 |
2023-08-12 |
mouse |
| Ashley E Brady, Carrie K Jones, Thomas M Bridges, J Phillip Kennedy, Analisa D Thompson, Justin U Heiman, Micah L Breininger, Patrick R Gentry, Huiyong Yin, Satyawan B Jadhav, Jana K Shirey, P Jeffrey Conn, Craig W Lindsle. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18772318. |
this is consistent with the hypothesis that m(4) plays an important role in regulating midbrain dopaminergic activity and raises the possibility that positive allosteric modulation of m(4) may mimic some of the antipsychotic-like effects of less selective machr agonists. |
2009-01-05 |
2023-08-12 |
rat |