| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke-chun Yang, Guo-zhang Jin, Jie W. Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498417. |
although alpha4beta2- and alpha7-nachrs are the two major functional nachr types in the cns, alpha6*-nachrs are abundantly expressed in the midbrain dopaminergic (daergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. |
2009-07-31 |
2023-08-12 |
mouse |
| Hideaki Shimada, Naoko Yoshimura, Akiko Tsuji, Takahiro Kunisad. Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20. Journal of bioscience and bioengineering. vol 107. issue 4. 2009-07-29. PMID:19332307. |
derivation of midbrain dopaminergic (da) neurons from human embryonic stem (hes) cells has been of particular interest because of the clinical potential for da neuron transplantation in patients with parkinson's disease (pd). |
2009-07-29 |
2023-08-12 |
mouse |
| Christopher D Herzog, Lamar Brown, Dawn Gammon, Brian Kruegel, Richard Lin, Alistair Wilson, Ariadne Bolton, Marie Printz, Mehdi Gasmi, Kathie M Bishop, Jeffrey H Kordower, Raymond T Bartu. Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease. Neurosurgery. vol 64. issue 4. 2009-07-23. PMID:19349823. |
parkinson's disease is characterized by profound motor deficits that result mainly as a consequence of degeneration of midbrain dopaminergic neurons. |
2009-07-23 |
2023-08-12 |
human |
| Ada Ledonne, Luca Sebastianelli, Mauro Federici, Giorgio Bernardi, Nicola Biagio Mercur. The anorexic agents, sibutramine and fenfluramine, depress GABA(B)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells. British journal of pharmacology. vol 156. issue 6. 2009-07-20. PMID:19298257. |
accumulating evidence supports key roles for the dopaminergic neurons of the ventral midbrain in regulating feeding behaviour. |
2009-07-20 |
2023-08-12 |
rat |
| Xinhua Zhang, Zheng Zhou, Dakui Wang, Aiqun Li, Yanqing Yin, Xiaosong Gu, Fei Ding, Xuechu Zhen, Jiawei Zho. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535588. |
moreover, intraperitoneal administration of skf83959 reversed l-methyl-4-phenyl-l,2,3,6-tetrahydropypridine (mptp)-induced reduction in fgf-2 expression in both the striatum and ventral midbrain and resulted in marked protection of dopaminergic neurons from mptp-induced neurotoxicity. |
2009-07-17 |
2023-08-12 |
Not clear |
| Serge Guerreiro, Aurélie Ponceau, Damien Toulorge, Elodie Martin, Daniel Alvarez-Fischer, Etienne C Hirsch, Patrick P Miche. Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302482. |
protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization. |
2009-07-16 |
2023-08-12 |
Not clear |
| Serge Guerreiro, Aurélie Ponceau, Damien Toulorge, Elodie Martin, Daniel Alvarez-Fischer, Etienne C Hirsch, Patrick P Miche. Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302482. |
high plasma levels of the end product of purine metabolism uric acid (ua) predict a reduced risk of developing parkinson's disease suggesting that ua may operate as a protective factor for midbrain dopaminergic neurons. |
2009-07-16 |
2023-08-12 |
Not clear |
| Vimal Parkash, Päivi Lindholm, Johan Peränen, Nisse Kalkkinen, Esko Oksanen, Mart Saarma, Veli-Matti Leppänen, Adrian Goldma. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. Protein engineering, design & selection : PEDS. vol 22. issue 4. 2009-07-14. PMID:19258449. |
cdnf protects and repairs midbrain dopaminergic neurons in vivo; manf supports their survival in culture and is also cytoprotective against endoplasmic reticulum (er) stress. |
2009-07-14 |
2023-08-12 |
Not clear |
| Takashi Tanida, Katsuhiko Warita, Kana Ishihara, Shiho Fukui, Tomoko Mitsuhashi, Teruo Sugawara, Yoshiaki Tabuchi, Takashi Nanmori, Wang-Mei Qi, Tetsurou Inamoto, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hosh. Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. Toxicology letters. vol 189. issue 1. 2009-07-14. PMID:19481886. |
fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. |
2009-07-14 |
2023-08-12 |
mouse |
| Takashi Tanida, Katsuhiko Warita, Kana Ishihara, Shiho Fukui, Tomoko Mitsuhashi, Teruo Sugawara, Yoshiaki Tabuchi, Takashi Nanmori, Wang-Mei Qi, Tetsurou Inamoto, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hosh. Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. Toxicology letters. vol 189. issue 1. 2009-07-14. PMID:19481886. |
we therefore investigated the effects of fetal and neonatal exposure to three typical eds - bisphenol a (bpa), di-(2-ethylhexyl)-phthalate (dehp), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) - on the midbrain dopaminergic system associated with functions - including motor activity, emotion, and cognition - affected by neuropsychiatric diseases such as attention-deficit/hyperactivity disorder. |
2009-07-14 |
2023-08-12 |
mouse |
| Takashi Tanida, Katsuhiko Warita, Kana Ishihara, Shiho Fukui, Tomoko Mitsuhashi, Teruo Sugawara, Yoshiaki Tabuchi, Takashi Nanmori, Wang-Mei Qi, Tetsurou Inamoto, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hosh. Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. Toxicology letters. vol 189. issue 1. 2009-07-14. PMID:19481886. |
the numbers of th- and/or fos-ir neurons and the intensity of th-immunoreactivity within midbrain dopaminergic nuclei (a9, a10, and a8) of each sole administration group significantly differed from controls at 2, 4, and 6 weeks of age. |
2009-07-14 |
2023-08-12 |
mouse |
| Jian Wang, Haiyan Lou, Courtney J Pedersen, Amanda D Smith, Ruth G Pere. 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19289463. |
together the data support a role for 14-3-3zeta as an endogenous activator of th in midbrain dopaminergic neurons and furthermore, identify mitochondria as a potential novel site for dopamine synthesis, with implications for parkinson disease. |
2009-07-07 |
2023-08-12 |
Not clear |
| Toshihiko Aosaki, Masami Miura, Masao Masud. [Physiological interaction between acetylcholine and dopamine in the striatum]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 4. 2009-07-01. PMID:19378806. |
simultaneous recordings of striatal cholinergic interneurons and midbrain dopaminergic neurons during the task revealed that the pause response was well synchronized with the increase in the firing frequency of the dopaminergic neurons. |
2009-07-01 |
2023-08-12 |
Not clear |
| G H Doherty, C Oldreive, J Harve. Neuroprotective actions of leptin on central and peripheral neurons in vitro. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18550292. |
thus we established primary neuronal cultures of dopaminergic midbrain neurons and trigeminal sensory neurons and induced cell death via either toxic insult or growth factor withdrawal. |
2009-06-29 |
2023-08-12 |
Not clear |
| G H Doherty, C Oldreive, J Harve. Neuroprotective actions of leptin on central and peripheral neurons in vitro. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18550292. |
specifically, leptin protects dopaminergic midbrain neurons from the apoptotic stimuli, tumor necrosis factor alpha (tnf-alpha) and 6-hydroxydopamine (6-ohda). |
2009-06-29 |
2023-08-12 |
Not clear |
| Mati Joshua, Avital Adler, Yifat Prut, Eilon Vaadia, Jeffery R Wickens, Hagai Bergma. Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. Neuron. vol 62. issue 5. 2009-06-26. PMID:19524528. |
synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. |
2009-06-26 |
2023-08-12 |
monkey |
| Jacob Eriksen, Søren G F Rasmussen, Trine Nygaard Rasmussen, Christian Bjerggaard Vaegter, Joo Hwan Cha, Mu-Fa Zou, Amy Hauck Newman, Ulrik Gethe. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474307. |
here we use novel fluorescently tagged cocaine analogs to visualize dat and dat trafficking in cultured live midbrain dopaminergic neurons. |
2009-06-23 |
2023-08-12 |
human |
| Julia Fuchs, Jakob C Mueller, Peter Lichtner, Claudia Schulte, Marita Munz, Daniela Berg, Ullrich Wüllner, Thomas Illig, Manu Sharma, Thomas Gasse. The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiology of aging. vol 30. issue 5. 2009-06-22. PMID:17905480. |
parkinson's disease (pd) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta. |
2009-06-22 |
2023-08-12 |
Not clear |
| D E Vaillancourt, M B Spraker, J Prodoehl, I Abraham, D M Corcos, X J Zhou, C L Comella, D M Littl. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology. vol 72. issue 16. 2009-06-22. PMID:19129507. |
in the midbrain of patients with parkinson disease (pd), there is a selective loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (sn). |
2009-06-22 |
2023-08-12 |
mouse |
| Mei Cui, Radha Aras, Whitney V Christian, Phillip M Rappold, Mamata Hatwar, Joseph Panza, Vernice Jackson-Lewis, Jonathan A Javitch, Nazzareno Ballatori, Serge Przedborski, Kim Tie. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 19. 2009-06-22. PMID:19416912. |
here, we show that the organic cation transporter 3 (oct3) is expressed in nondopaminergic cells adjacent to both the soma and terminals of midbrain dopaminergic neurons. |
2009-06-22 |
2023-08-12 |
mouse |