| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jürgen L Müller, Caroline Deuticke, Albert Putzhammer, Christian H Röder, Göran Hajak, Jürgen Winkle. Schizophrenia and Parkinson's disease lead to equal motor-related changes in cortical and subcortical brain activation: an fMRI fingertapping study. Psychiatry and clinical neurosciences. vol 57. issue 6. 2004-01-12. PMID:14629703. |
it is hypothesized that dopaminergic depletion in hemiparkinsonism and dopaminergic blockade under neuroleptic agents influence basal ganglia activity in a different way; in particular regarding functional connectivity. |
2004-01-12 |
2023-08-12 |
human |
| Yossi Gilgun-Sherki, Eldad Melamed, Raphael Mechoulam, Daniel Offe. The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. Pharmacology & toxicology. vol 93. issue 2. 2004-01-06. PMID:12899667. |
parkinson's disease is a chronic neurodegenerative disease of the extrapyramidal system associated with dopaminergic neuronal loss in the basal ganglia. |
2004-01-06 |
2023-08-12 |
rat |
| Yuen-Sum Lau, Elizabeth Petroske, Gloria E Meredith, John Q Wan. Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats. Neuropharmacology. vol 45. issue 7. 2003-12-29. PMID:14573391. |
recent studies also indirectly suggest an involvement of nitric oxide synthase (nos) in dopaminergic supersensitivity; however, chronic neuroleptic effects on neuronal nos (nnos) expression in the basal ganglia have not been reported. |
2003-12-29 |
2023-08-12 |
rat |
| Thomas N Chase, Francesco Bibbiani, Justin D O. Striatal glutamatergic mechanisms and extrapyramidal movement disorders. Neurotoxicity research. vol 5. issue 1-2. 2003-11-21. PMID:12832228. |
the nonphysiologic stimulation of striatal dopaminergic receptors, as a result of disease- or drug-related denervation or intermittent excitation, triggers adaptive responses in the basal ganglia which contribute to the appearance of parkinsonian symptoms and later to the dyskinesias and other alterations in motor response associated with dopaminergic therapy. |
2003-11-21 |
2023-08-12 |
Not clear |
| T Johnston, S Dut. Changes in GABA(B) receptor mRNA expression in the rodent basal ganglia and thalamus following lesion of the nigrostriatal pathway. Neuroscience. vol 120. issue 4. 2003-11-10. PMID:12927208. |
loss of striatal dopaminergic innervation in parkinson's disease (pd) is accompanied by widespread alterations in gabaergic activity within the basal ganglia and thalamus. |
2003-11-10 |
2023-08-12 |
rat |
| Ivan Bodis-Wollne. Neuropsychological and perceptual defects in Parkinson's disease. Parkinsonism & related disorders. vol 9 Suppl 2. 2003-10-20. PMID:12915072. |
local, dopaminergic neuronal groups in the retina, basal ganglia and frontal cortical memory system are affected in pd. |
2003-10-20 |
2023-08-12 |
Not clear |
| E C Hirsch, G Höglinger, E Rousselet, T Breidert, K Parain, J Feger, M Ruberg, A Prigent, C Cohen-Salmon, J M Launa. Animal models of Parkinson's disease in rodents induced by toxins: an update. Journal of neural transmission. Supplementum. issue 65. 2003-10-20. PMID:12946051. |
we show that, whereas mptp and 6-hydroxydopamine induce a selective loss of catecholaminergic neurons that in most cases evolves over a short period of time, rotenone infusion by osmotic pumps can induce a chronically progressive degeneration of dopaminergic neurons and also of non-dopaminergic neurons in both the basal ganglia and the brainstem. |
2003-10-20 |
2023-08-12 |
Not clear |
| F Galeffi, L Bianchi, J P Bolam, L Della Cort. The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis. The European journal of neuroscience. vol 18. issue 4. 2003-10-14. PMID:12925011. |
the loss of dopaminergic neurons of the substantia nigra in parkinson's disease and in animal models of parkinson's disease is associated with an imbalance in the activity of the so-called 'direct' and 'indirect' pathways of information flow through the basal ganglia. |
2003-10-14 |
2023-08-12 |
rat |
| Megdad M Zaatre. Anticonvulsant-induced dyskinesia. Expert opinion on drug safety. vol 2. issue 4. 2003-10-08. PMID:12904094. |
similarities with other drug-induced dyskinesias and some animal studies suggest that dopaminergic dysfunction in the basal ganglia is pivotal in the occurrence of dyskinesia. |
2003-10-08 |
2023-08-12 |
human |
| Xi-Bin Liang, Yong Luo, Xian-Yu Liu, Jun Lu, Feng-Qiao Li, Qian Wang, Xiao-Min Wang, Ji-Sheng Ha. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats. Neuroreport. vol 14. issue 8. 2003-09-29. PMID:12821804. |
it suggests that the retrograde nourishment of gdnf to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after ea may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of ea in the treatment of parkinson's disease. |
2003-09-29 |
2023-08-12 |
rat |
| Keun-Ah Cheon, Young Hoon Ryu, Young-Kee Kim, Kee Namkoong, Chan-Hyung Kim, Jong Doo Le. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 2. 2003-09-26. PMID:12552351. |
in this study, we investigated dopamine transporter (dat) density in children with adhd using iodine-123 labelled n-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ([(123)i]ipt) single-photon emission tomography (spet) and postulated that an alteration in dat density in the basal ganglia is responsible for dopaminergic dysfunction in children with adhd. |
2003-09-26 |
2023-08-12 |
Not clear |
| J Srinivasan, W J Schmid. Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. The European journal of neuroscience. vol 17. issue 12. 2003-09-24. PMID:12823465. |
based on the present findings and existing reports, it can be concluded that noradrenergic neurons of locus coeruleus have neuromodulatory and neuroprotective properties on the dopaminergic neurons of basal ganglia and that noradrenergic degeneration may contribute to the aetiology and pathophysiology of parkinson's disease. |
2003-09-24 |
2023-08-12 |
rat |
| Peter Jenne. Pharmacology of dopamine agonists in the treatment of Parkinson's disease. Neurology. vol 58. issue 4 Suppl 1. 2003-09-15. PMID:11909980. |
continuous dopaminergic stimulation appears less likely to prime basal ganglia for involuntary movements compared with drugs, such as l-dopa, that produce pulsatile stimulation. |
2003-09-15 |
2023-08-12 |
Not clear |
| B B Carlson, S Behrstock, A J Tobin, J D Salamon. Brain implantations of engineered GABA-releasing cells suppress tremor in an animal model of Parkinsonism. Neuroscience. vol 119. issue 4. 2003-09-05. PMID:12831853. |
traditional approaches in the treatment of parkinson's disease have typically been directed at restoring dopaminergic tone in the neostriatum of the basal ganglia. |
2003-09-05 |
2023-08-12 |
Not clear |
| M Fedrowitz, S Lindemann, W Löscher, M Gerner. Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710993. |
for further evaluation as to whether this striatal imbalance has functional consequences within basal ganglia structures, the spontaneous extracellular single unit activity of gabaergic neurons located in the striatum and, downstream to the dopaminergic nigrostriatal system, the substantia nigra pars reticulata (snr) was recorded bilaterally in anesthetized ci2 rats. |
2003-08-08 |
2023-08-12 |
rat |
| Harald Prüss, Mareike Wenzel, Dirk Eulitz, Achim Thomzig, Andreas Karschin, Rüdiger W Ve. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain research. Molecular brain research. vol 110. issue 2. 2003-07-28. PMID:12591157. |
these two structures are among the key players in regulating dopaminergic and cholinergic neurotransmission within the striatum, and therefore are of major importance for the output of the basal ganglia. |
2003-07-28 |
2023-08-12 |
rat |
| M D Julian, A B Martin, B Cuellar, F Rodriguez De Fonseca, M Navarro, R Moratalla, L M Garcia-Segur. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763090. |
neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. |
2003-07-28 |
2023-08-12 |
rat |
| M D Julian, A B Martin, B Cuellar, F Rodriguez De Fonseca, M Navarro, R Moratalla, L M Garcia-Segur. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763090. |
in conclusion, these data provide a neuroanatomical basis to explain functional interactions between endocannabinoid and dopaminergic systems in the basal ganglia. |
2003-07-28 |
2023-08-12 |
rat |
| Louise Normandin, Alan S Hazel. Manganese neurotoxicity: an update of pathophysiologic mechanisms. Metabolic brain disease. vol 17. issue 4. 2003-07-03. PMID:12602514. |
increasing evidence suggests that astrocytes are a site of early dysfunction and damage; chronic exposure to manganese leads to selective dopaminergic dysfunction, neuronal loss, and gliosis in basal ganglia structures together with characteristic astrocytic changes known as alzheimer type ii astrocytosis. |
2003-07-03 |
2023-08-12 |
Not clear |
| A Tofighy, A Abbott, D Centonze, A J Cooper, E Noor, S M Pearce, M Puntis, I M Stanford, M A Wigmore, M G Lace. Excitation by dopamine of rat subthalamic nucleus neurones in vitro-a direct action with unconventional pharmacology. Neuroscience. vol 116. issue 1. 2003-06-24. PMID:12535949. |
this nucleus has a pivotal role in basal ganglia function and voluntary movement control and the possibility that dopamine, and dopaminergic medication used in parkinson's disease, might directly influence its activity is of considerable interest. |
2003-06-24 |
2023-08-12 |
rat |