| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David C Dorman, Melanie F Struve, Marianne W Marshall, Carl U Parkinson, R Arden James, Brian A Won. Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation. Toxicological sciences : an official journal of the Society of Toxicology. vol 92. issue 1. 2006-08-30. PMID:16624849. |
high-dose human exposure to manganese results in manganese accumulation in the basal ganglia and dopaminergic neuropathology. |
2006-08-30 |
2023-08-12 |
human |
| Richard Levy, Bruno Duboi. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral cortex (New York, N.Y. : 1991). vol 16. issue 7. 2006-07-27. PMID:16207933. |
in both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired. |
2006-07-27 |
2023-08-12 |
Not clear |
| Sara González, Camila Scorticati, Moisés García-Arencibia, Rosario de Miguel, José A Ramos, Javier Fernández-Rui. Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain research. vol 1073-1074. 2006-07-19. PMID:16412990. |
there is also degeneration of other dopaminergic pathways out of the basal ganglia, but this does not appear to interfere significantly with the hypokinetic profile of these rats. |
2006-07-19 |
2023-08-12 |
rat |
| T E Hazy, M J Frank, R C O'Reill. Banishing the homunculus: making working memory work. Neuroscience. vol 139. issue 1. 2006-06-30. PMID:16343792. |
it is capable of developing human-like performance largely on its own by taking advantage of powerful reinforcement learning mechanisms, based on the midbrain dopaminergic system and its activation via the basal ganglia and amygdala. |
2006-06-30 |
2023-08-12 |
Not clear |
| Roger L Albin, Jonathan W Min. Recent advances in Tourette syndrome research. Trends in neurosciences. vol 29. issue 3. 2006-05-05. PMID:16430974. |
recent anatomical and neuroimaging studies have provided evidence for abnormal basal ganglia and dopaminergic function in ts. |
2006-05-05 |
2023-08-12 |
Not clear |
| I G Sil'ki. [Role of the basal ganglia in the occurrence of paradoxical sleep dreams (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 56. issue 1. 2006-05-03. PMID:16583673. |
this disinhibition is promoted by activation of dopaminergic cells by pedunculopontine neurons, subsequent rise in dopamine concentration in the input basal ganglia structure. |
2006-05-03 |
2023-08-12 |
Not clear |
| Hélène N David, Marc Ansseau, Jacques H Abrain. Dopamine-glutamate reciprocal modulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of "intact" animals. Brain research. Brain research reviews. vol 50. issue 2. 2006-04-12. PMID:16278019. |
functional interactions between dopaminergic neurotransmission and glutamatergic neurotransmission are well known to play a crucial integrative role in the striatum, the major input structure of the basal ganglia now widely recognized to contribute to the control of motor activity and movements but also to the processing of cognitive and limbic functions. |
2006-04-12 |
2023-08-12 |
rat |
| Clifford W Shults, Edward Rockenstein, Leslie Crews, Anthony Adame, Michael Mante, Gabriel Larrea, Makoto Hashimoto, David Song, Takeshi Iwatsubo, Kyoko Tsuboi, Eliezer Maslia. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 46. 2006-03-10. PMID:16291942. |
accumulation of halpha-syn in oligodendrocytes also leads to prominent neurodegenerative changes in the neocortex with decreased dendritic density and to loss of dopaminergic fibers in the basal ganglia. |
2006-03-10 |
2023-08-12 |
mouse |
| J Baufreton, Z-T Zhu, M Garret, B Bioulac, S W Johnson, A I Taupigno. Dopamine receptors set the pattern of activity generated in subthalamic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 13. 2006-03-07. PMID:16260646. |
as parkinson's disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine-depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. |
2006-03-07 |
2023-08-12 |
rat |
| Kuei Y Tseng, Lucila Kargieman, Sebastian Gacio, Luis A Riquelme, M Gustavo Mure. Consequences of partial and severe dopaminergic lesion on basal ganglia oscillatory activity and akinesia. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307600. |
consequences of partial and severe dopaminergic lesion on basal ganglia oscillatory activity and akinesia. |
2006-01-17 |
2023-08-12 |
rat |
| Paul S Frankel, Amanda J Hoonakker, Glen R Hanson, Lloyd Bush, Kristen A Keefe, Mario E Alburge. Differential neurotensin responses to low and high doses of methamphetamine in the terminal regions of striatal efferents. European journal of pharmacology. vol 522. issue 1-3. 2006-01-10. PMID:16199030. |
neurotensin is a neuropeptide associated with basal ganglia dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
Not clear |
| Jordi Bové, Jordi Serrats, Guadalupe Mengod, Roser Cortés, Eduardo Tolosa, Concepció Mari. Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways. Experimental brain research. vol 165. issue 3. 2005-12-01. PMID:15968457. |
in parkinson's disease (pd), the striatal dopamine depletion and the following overactivation of the indirect pathway of the basal ganglia leads to very early disinhibition of the subthalamic nucleus (stn) that may contribute to the progression of pd by glutamatergic overstimulation of the dopaminergic neurons in the substantia nigra. |
2005-12-01 |
2023-08-12 |
rat |
| Yuting Tang, Keith T Demares. Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells. Journal of receptor and signal transduction research. vol 25. issue 3. 2005-11-22. PMID:16194932. |
adenosine a(2a) receptor (a(2a)r) colocalizes with dopamine d(2) receptor (d(2)r) in the basal ganglia and modulates d(2)r-mediated dopaminergic activities. |
2005-11-22 |
2023-08-12 |
mouse |
| Carsten Scheller, Sieghart Sopper, Meta Jenuwein, Eva Neuen-Jacob, Thomas Tatschner, Edna Grünblatt, Volker ter Meulen, Peter Riederer, Eleni Koutsilier. Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16190867. |
movement disorders are a common neurological complication of immunodeficiency virus infection and are thought to result from dopaminergic dysfunction in the basal ganglia. |
2005-11-02 |
2023-08-12 |
monkey |
| I G Sil'ki. [Possible mechanisms of involvement of the subthalamic nucleus and structures interconnected with this nucleus in movement disorders evoked by dopamine depletion]. Uspekhi fiziologicheskikh nauk. vol 36. issue 2. 2005-11-01. PMID:15909665. |
it is assumed that high-frequency stimulation of the stn can reduce or eliminate parkinsonian symptoms not only owing to inhibition of activity of gabaergic neurons in the output basal ganglia nuclei, projected into the thalamus or pedunculopontine nucleus, but also due to excitation of glutamatergic or cholinergic neurons in the output nuclei, and due to potentiation of excitatory inputs to preserved dopaminergic neurons and subsequent rise in dopamine concentration. |
2005-11-01 |
2023-08-12 |
Not clear |
| A J Lawrence, C L Parish, F Chen, D J Lodge, E V Krstew, K Card, D I Finkelstein, M K Horn. Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16000149. |
following chronic antalarmin the density of dopaminergic terminals within the basal ganglia and amygdaloid complex were reduced, as was dopamine transporter binding within the striatum. |
2005-10-27 |
2023-08-12 |
rat |
| A J Lawrence, C L Parish, F Chen, D J Lodge, E V Krstew, K Card, D I Finkelstein, M K Horn. Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16000149. |
thus, chronic antalarmin treatment modulates dopaminergic pathways and implies that chronic treatment with drugs of this class may ultimately alter postsynaptic signaling mechanisms within the basal ganglia. |
2005-10-27 |
2023-08-12 |
rat |
| Jan Lewerenz, Bartosz Zurowski, Lars Jenicke, Tobias Bäumer, Andrew J Lees, Alexander Müncha. Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15838851. |
we suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension. |
2005-10-19 |
2023-08-12 |
Not clear |
| Takashi Ohru. Preventive strategies for aspiration pneumonia in elderly disabled persons. The Tohoku journal of experimental medicine. vol 207. issue 1. 2005-09-14. PMID:16082150. |
similarly, since the production of substance p is regulated by dopaminergic neurons in the cerebral basal ganglia, treatment with dopamine analogs or potentiating drugs such as amantadine can reduce the incidence of pneumonia. |
2005-09-14 |
2023-08-12 |
human |
| L E Bartlett, I Mende. Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson's disease. Cell transplantation. vol 14. issue 2-3. 2005-08-19. PMID:15881421. |
this limitation may be due to an incomplete restoration of the dopaminergic input to other basal ganglia structures such as the external segment of the globus pallidus (gpe, homologue of the rodent gp), which normally receives dopaminergic input from the substantia nigra (sn). |
2005-08-19 |
2023-08-12 |
rat |