| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N R Ferreira, M Mitkovski, W Stühmer, L A Pardo, E A Del Be. Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. Neurotoxicity research. vol 21. issue 3. 2012-06-26. PMID:22048886. |
as dopamine may directly affect k(+) channels, we evaluated whether a nigrostriatal dopaminergic lesion induced by the neurotoxin 6-hydroxydopamine (6-ohda) would alter eag1-k(+) channel expression in the rat basal ganglia and related brain regions. |
2012-06-26 |
2023-08-12 |
rat |
| Min Shi, Amy R Furay, Vesna Sossi, Jan O Aasly, Jeff Armaly, Yu Wang, Zbigniew K Wszolek, Ryan J Uitti, Kazuko Hasegawa, Teruo Yokoyama, Cyrus P Zabetian, James B Leverenz, A Jon Stoessl, Jing Zhan. DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:22019052. |
to determine whether dopaminergic dysfunction in the basal ganglia, as determined by positron emission tomography (pet) scans, correlates with csf levels of dj-1 and αsyn during preclinical stages, luminex assays were used to analyze csf samples from asymptomatic lrrk2 mutation carriers, along with carriers who presented with a clinical diagnosis of pd. |
2012-06-15 |
2023-08-12 |
human |
| Silke Anders, Benjamin Sack, Anna Pohl, Thomas Münte, Peter Pramstaller, Christine Klein, Ferdinand Binkofsk. Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain : a journal of neurology. vol 135. issue Pt 4. 2012-06-08. PMID:22434215. |
neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant parkin or pink1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. |
2012-06-08 |
2023-08-12 |
human |
| Y Iris Chen, Jia-Qian Ren, Ted J Kaptchuk, Kenneth K Kwon. Restoring cerebral dopamine homeostasis by electrical forepaw stimulation: an FMRI study. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22170513. |
as dopamine function is tightly regulated within the basal ganglia circuitry, cortical perturbation would lead to modulation of dopaminergic activity in the striatum. |
2012-05-21 |
2023-08-12 |
rat |
| Hae-Won Shin, Sun Ju Chun. Drug-induced parkinsonism. Journal of clinical neurology (Seoul, Korea). vol 8. issue 1. 2012-05-03. PMID:22523509. |
the pathophysiology of dip is related to drug-induced changes in the basal ganglia motor circuit secondary to dopaminergic receptor blockade. |
2012-05-03 |
2023-08-12 |
Not clear |
| M Giorgi, G Melchiorri, V Nuccetelli, V D'Angelo, A Martorana, R Sorge, V Castelli, G Bernardi, G Sancesari. PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515371. |
our objective was to examine whether expression of phosphodiesterase 10a (pde10a), an isozyme presenting a unique distribution in basal ganglia, is altered after unilateral injection of 6-hydroxydopamine in the medial forebrain bundle, eliminating all midbrain dopaminergic neurons, such that cyclic nucleotide catabolism and steady state could be affected. |
2012-04-09 |
2023-08-12 |
rat |
| C Clément, R Lalonde, C Straziell. Acetylcholinesterase activity in the brain of dystonia musculorum (Dst(dt-J)) mutant mice. Neuroscience research. vol 72. issue 1. 2012-04-09. PMID:21978551. |
neurochemical alterations, notably in dopaminergic and noradrenergic systems, were previously observed in basal ganglia and cerebellum. |
2012-04-09 |
2023-08-12 |
mouse |
| P Jenner, A C McCreary, D K A Schelle. Continuous drug delivery in early- and late-stage Parkinson's disease as a strategy for avoiding dyskinesia induction and expression. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 12. 2012-03-30. PMID:21881838. |
the initiation of dyskinesia involves a priming process dependent on the presence of nigral dopaminergic cell loss leading to alterations in basal ganglia function that underlie the expression of involuntary movements following the administration of each drug dose. |
2012-03-30 |
2023-08-12 |
Not clear |
| Mahmoud M Iravani, Peter Jenne. Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 12. 2012-03-30. PMID:21881839. |
this review assesses some of the mechanisms that underlie dyskinesia induction and expression from presynaptic changes in dopaminergic neurones to postsynaptic alterations in basal ganglia function and examines potential approaches to prevention and treatment. |
2012-03-30 |
2023-08-12 |
Not clear |
| Fabrizio Stocch. Continuous dopaminergic stimulation and novel formulations of dopamine agonists. Journal of neurology. vol 258. issue Suppl 2. 2012-03-25. PMID:21560062. |
there is now accumulating evidence that the combination of progressive pathology of parkinson's disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors are the key contributing factors to the priming of the basal ganglia for induction of motor complications. |
2012-03-25 |
2023-08-12 |
Not clear |
| Anke M W Linssen, Eric F P M Vuurman, Anke Sambeth, Stephane Nave, Will Spooren, Gabriel Vargas, Luca Santarelli, Wim J Riede. Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate. Psychopharmacology. vol 218. issue 3. 2012-03-19. PMID:21597989. |
the basal ganglia play an important role in motor control, which is dependent on dopaminergic input. |
2012-03-19 |
2023-08-12 |
Not clear |
| Shigeki Moriguchi, Yasushi Yabuki, Kohji Fukunag. Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice. Journal of neurochemistry. vol 120. issue 4. 2012-03-08. PMID:22136399. |
the dopaminergic neurotoxin, mptp-induced neurodegeneration causes an injury of the basal ganglia and is associated with pd-like behaviors. |
2012-03-08 |
2023-08-12 |
mouse |
| Moran Weinberger, William D Hutchison, Mahan Alavi, Mojgan Hodaie, Andres M Lozano, Elena Moro, Jonathan O Dostrovsk. Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 123. issue 2. 2012-02-27. PMID:21843964. |
we tested the hypothesis that pd and dystonia are characterized by different temporal patterns of synchronized oscillations in the gpi, and that the dopaminergic loss in pd makes the basal ganglia more susceptible to oscillatory activity. |
2012-02-27 |
2023-08-12 |
Not clear |
| Satu K Jääskeläine. Pathophysiology of primary burning mouth syndrome. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 123. issue 1. 2012-02-27. PMID:22030140. |
the third subgroup (20-40%) fits the concept of central pain that may be related to hypofunction of dopaminergic neurons in the basal ganglia. |
2012-02-27 |
2023-08-12 |
Not clear |
| Maria Cruz Rodriguez-Oroz, Concepción Marin, Oriol de Fabregue. Continuous dopaminergic stimulation: clinical aspects and experimental bases. The neurologist. vol 17. issue 6 Suppl 1. 2012-02-21. PMID:22045323. |
in addition, these models have facilitated the development of new treatments that may stabilize the motor response and the biochemical alterations in the basal ganglia to provide more efficient forms of continuous dopaminergic stimulation in patients with parkinson disease. |
2012-02-21 |
2023-08-12 |
Not clear |
| Jeff A Beele. Preservation of function in Parkinson's disease: what's learning got to do with it? Brain research. vol 1423. 2012-02-17. PMID:22000081. |
the 'integrative selective gain' framework proposed here integrates dopaminergic mechanisms known to modulate basal ganglia throughput into a single conceptual framework: (1) synaptic weights, the neural instantiation of accumulated experience and skill modulated by dopamine-dependent plasticity and (2) system gain, the operating parameters of the basal ganglia, modulated by dopamine's on-line effects on cell excitability, glutamatergic transmission and the balance between facilitatory and inhibitory pathways. |
2012-02-17 |
2023-08-12 |
Not clear |
| M Vandecasteele, J-M Deniau, L Venanc. Spike frequency adaptation is developmentally regulated in substantia nigra pars compacta dopaminergic neurons. Neuroscience. vol 192. 2012-01-18. PMID:21767612. |
dopaminergic neurons of the substantia nigra pars compacta play a key role in the modulation of basal ganglia and provide a reward-related teaching signal essential for adaptative motor control. |
2012-01-18 |
2023-08-12 |
rat |
| Gilberto Fisone, Erwan Bezar. Molecular mechanisms of l-DOPA-induced dyskinesia. International review of neurobiology. vol 98. 2012-01-18. PMID:21907084. |
parkinson's disease (pd), a common neurodegenerative disorder caused by the loss of the dopaminergic input to the basal ganglia, is commonly treated with l-dopa. |
2012-01-18 |
2023-08-12 |
Not clear |
| Timothy P Gilmour, Brigitte Piallat, Christopher A Lieu, Kala Venkiteswaran, Renuka Ramachandra, Anand N Rao, Andrew C Petticoffer, Matthew A Berk, Thyagarajan Subramania. The effect of striatal dopaminergic grafts on the neuronal activity in the substantia nigra pars reticulata and subthalamic nucleus in hemiparkinsonian rats. Brain : a journal of neurology. vol 134. issue Pt 11. 2012-01-18. PMID:21911417. |
however, the effect of dopaminergic grafts on basal ganglia electrophysiology has not thoroughly been investigated. |
2012-01-18 |
2023-08-12 |
rat |
| Timothy P Gilmour, Brigitte Piallat, Christopher A Lieu, Kala Venkiteswaran, Renuka Ramachandra, Anand N Rao, Andrew C Petticoffer, Matthew A Berk, Thyagarajan Subramania. The effect of striatal dopaminergic grafts on the neuronal activity in the substantia nigra pars reticulata and subthalamic nucleus in hemiparkinsonian rats. Brain : a journal of neurology. vol 134. issue Pt 11. 2012-01-18. PMID:21911417. |
these results suggest that local continuous dopaminergic stimulation exerts a normalizing effect on the downstream parkinsonian basal ganglia firing patterns. |
2012-01-18 |
2023-08-12 |
rat |