| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas V Wiecki, Michael J Fran. Neurocomputational models of motor and cognitive deficits in Parkinson's disease. Progress in brain research. vol 183. 2010-12-27. PMID:20696325. |
the loss of dopaminergic neurons innervating the striatum in pd, and the well-established role of dopamine (da) in reinforcement learning (rl), enable neural network models of the basal ganglia (bg) to derive concrete and testable predictions. |
2010-12-27 |
2023-08-12 |
Not clear |
| Nicola Pavese, Vinod Metta, Subrata K Bose, Kallol Ray Chaudhuri, David J Brook. Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain : a journal of neurology. vol 133. issue 11. 2010-11-30. PMID:20884645. |
we used ¹⁸f-dopa and ¹¹c-dasb [n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine] positron emission tomography, markers of dopamine storage capacity and serotonin transporter availability, to investigate whether fatigue in parkinson's disease is associated with dopaminergic and serotonergic dysfunction in basal ganglia and limbic circuits. |
2010-11-30 |
2023-08-12 |
Not clear |
| Emma Thornton, Tuyet T B Tran, Robert Vin. A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death. Neuroscience letters. vol 481. issue 1. 2010-11-08. PMID:20599590. |
the neurotoxin 6-hydroxydopamine (6-ohda) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of parkinson's disease. |
2010-11-08 |
2023-08-12 |
Not clear |
| Peter Redgrave, Manuel Rodriguez, Yoland Smith, Maria C Rodriguez-Oroz, Stephane Lehericy, Hagai Bergman, Yves Agid, Mahlon R DeLong, Jose A Obes. Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. Nature reviews. Neuroscience. vol 11. issue 11. 2010-11-08. PMID:20944662. |
progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of parkinson's disease. |
2010-11-08 |
2023-08-12 |
Not clear |
| Michelle R Ciucci, Lisa Vinney, Emerald J Wahoske, Nadine P Conno. A translational approach to vocalization deficits and neural recovery after behavioral treatment in Parkinson disease. Journal of communication disorders. vol 43. issue 4. 2010-10-20. PMID:20434728. |
parkinson disease is characterized by a complex neuropathological profile that primarily affects dopaminergic neural pathways in the basal ganglia, including pathways that modulate cranial sensorimotor functions such as swallowing, voice and speech. |
2010-10-20 |
2023-08-12 |
rat |
| Dorothy Cowie, Patricia Limousin, Amy Peters, Brian L Da. Insights into the neural control of locomotion from walking through doorways in Parkinson's disease. Neuropsychologia. vol 48. issue 9. 2010-10-20. PMID:20519135. |
in the pd group, dopaminergic medications improved many baseline gait variables but did not affect their sensitivity to door width, suggesting that this visuomotor effect is not mediated by the basal ganglia. |
2010-10-20 |
2023-08-12 |
human |
| Martine van Schouwenburg, Esther Aarts, Roshan Cool. Dopaminergic modulation of cognitive control: distinct roles for the prefrontal cortex and the basal ganglia. Current pharmaceutical design. vol 16. issue 18. 2010-10-08. PMID:20370667. |
dopaminergic modulation of cognitive control: distinct roles for the prefrontal cortex and the basal ganglia. |
2010-10-08 |
2023-08-12 |
Not clear |
| Fabrizio Stocch. Dopamine receptor agonists in the treatment of advanced Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 4. 2010-09-30. PMID:20123558. |
there is now accumulating evidence that the progressive pathology of pd, the change in drug pharmaco-dynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors combine as key contributing factors to the priming of the basal ganglia for induction of motor complications. |
2010-09-30 |
2023-08-12 |
Not clear |
| Takahiro Saito, Mitsuru Nakamura, Teruhiko Shimizu, Keiichi Oda, Kiichi Ishiwata, Kenji Ishii, Kunihiro Iss. Neuroradiologic evidence of pre-synaptic and post-synaptic nigrostriatal dopaminergic dysfunction in idiopathic Basal Ganglia calcification: a case report. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 20. issue 2. 2010-09-29. PMID:19021829. |
neuroradiologic evidence of pre-synaptic and post-synaptic nigrostriatal dopaminergic dysfunction in idiopathic basal ganglia calcification: a case report. |
2010-09-29 |
2023-08-12 |
Not clear |
| Juliana Dushanova, Dolja Philipova, Gloria Nikolov. Beta and gamma frequency-range abnormalities in parkinsonian patients under cognitive sensorimotor task. Journal of the neurological sciences. vol 293. issue 1-2. 2010-08-12. PMID:20392453. |
parkinson's disease (pd) is a neurodegenerative disorder caused by a disruption of dopaminergic neurotransmission in the basal ganglia. |
2010-08-12 |
2023-08-12 |
human |
| Takatoshi Hikida, Kensuke Kimura, Norio Wada, Kazuo Funabiki, Shigetada Nakanish. Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior. Neuron. vol 66. issue 6. 2010-08-06. PMID:20620875. |
in the basal ganglia, convergent input and dopaminergic modulation of the direct striatonigral and the indirect striatopallidal pathways are critical in rewarding and aversive learning and drug addiction. |
2010-08-06 |
2023-08-12 |
Not clear |
| Gregory P Crucian, Sheyan Armaghani, Avan Armaghani, Paul S Foster, David W Burks, Barry Skoblar, Valeria Drago, Kenneth M Heilma. Visual-spatial disembedding in Parkinson's disease. Journal of clinical and experimental neuropsychology. vol 32. issue 2. 2010-07-21. PMID:19484649. |
lack of improvement with dopaminergic treatment suggests deficits in other neurotransmitter-neuromodulatory systems or degenerative processes in the frontal-striatal networks, cortex, or basal ganglia. |
2010-07-21 |
2023-08-12 |
human |
| G Ambrosi, M-T Armentero, G Levandis, P Bramanti, G Nappi, F Blandin. Effects of early and delayed treatment with an mGluR5 antagonist on motor impairment, nigrostriatal damage and neuroinflammation in a rodent model of Parkinson's disease. Brain research bulletin. vol 82. issue 1-2. 2010-07-19. PMID:20100549. |
the loss of nigrostriatal dopaminergic neurons that characterizes parkinson's disease (pd) causes complex functional alterations in the basal ganglia circuit. |
2010-07-19 |
2023-08-12 |
rat |
| M T Eckart, M C Huelse-Matia, D Loer, R K W Schwartin. Acquisition and performance in a rat sequential reaction time task is not affected by subtotal ventral striatal 6-OHDA lesions. Neuroscience letters. vol 476. issue 1. 2010-07-19. PMID:20371375. |
based on findings of experiments with humans, non-human primates and rodents, it is commonly accepted that dopaminergic basal ganglia processes play a crucial role in procedural and sequential learning. |
2010-07-19 |
2023-08-12 |
human |
| Jason M Williams, Dejan Milatovic, John C Gore, Michael Aschner, Malcolm J Aviso. Chronic exposure to manganese alters brain responses to amphetamine: a pharmacological magnetic resonance imaging study. Toxicological sciences : an official journal of the Society of Toxicology. vol 114. issue 2. 2010-06-21. PMID:20061340. |
the parkinsonian symptoms and increased mn accumulation in dopaminergic (daergic) neurons of the basal ganglia implicate impaired dopamine signaling in the neurotoxic effects of chronic manganese overexposure. |
2010-06-21 |
2023-08-12 |
rat |
| Mark D Humphries, Tony J Prescot. The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Progress in neurobiology. vol 90. issue 4. 2010-06-14. PMID:19941931. |
dopamine's key role in learning is reviewed within the three current major computational frameworks; we also show that the shell-based basal ganglia sub-circuits are well placed to generate the phasic burst and dip responses of dopaminergic neurons. |
2010-06-14 |
2023-08-12 |
Not clear |
| Mark D Humphries, Tony J Prescot. The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Progress in neurobiology. vol 90. issue 4. 2010-06-14. PMID:19941931. |
the ventral basal ganglia are revealed as a constellation of multiple functional systems for the learning and selection of flexible behaviours and of behavioural strategies, sharing the common operations of selection-by-disinhibition and of dopaminergic modulation. |
2010-06-14 |
2023-08-12 |
Not clear |
| Giselle M Petzinger, Beth E Fisher, Jon-Eric Van Leeuwen, Marta Vukovic, Garnik Akopian, Charlie K Meshul, Daniel P Holschneider, Angelo Nacca, John P Walsh, Michael W Jakowe. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187247. |
the data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. |
2010-06-14 |
2023-08-12 |
Not clear |
| Andreas Plaitakis, Helen Latsoudis, Konstantinos Kanavouras, Beate Ritz, Jeff M Bronstein, Irene Skoula, Vasileios Mastorodemos, Spyridon Papapetropoulos, Nikolas Borompokas, Ioannis Zaganas, Georgia Xiromerisiou, George M Hadjigeorgiou, Cleanthe Spanak. Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset. European journal of human genetics : EJHG. vol 18. issue 3. 2010-05-18. PMID:19826450. |
parkinson's disease (pd), a common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and their terminations in the basal ganglia, is thought to be related to genetic and environmental factors. |
2010-05-18 |
2023-08-12 |
human |
| Christian R Lee, James M Teppe. Basal ganglia control of substantia nigra dopaminergic neurons. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411769. |
basal ganglia control of substantia nigra dopaminergic neurons. |
2010-05-14 |
2023-08-12 |
Not clear |