| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Lagrue, B Abert, L Nadal, L Tabone, S Bodard, F Medja, A Lombes, S Chalon, P Castelna. MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood. Metabolic brain disease. vol 24. issue 2. 2009-09-14. PMID:19319673. |
the basal ganglia, which are interconnected in the striato-nigral dopaminergic network, are affected in several childhood diseases including leigh syndrome (ls). |
2009-09-14 |
2023-08-12 |
mouse |
| Gregg D Stanwood, Duncan B Leitch, Valentina Savchenko, Jane Wu, Vanessa A Fitsanakis, Douglas J Anderson, Jeannette N Stankowski, Michael Aschner, BethAnn McLaughli. Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. Journal of neurochemistry. vol 110. issue 1. 2009-08-21. PMID:19457100. |
manganese exposure is cytotoxic and alters dopaminergic and gabaergic neurons within the basal ganglia. |
2009-08-21 |
2023-08-12 |
mouse |
| Irene Ceballos-Picot, Lionel Mockel, Marie-Claude Potier, Luce Dauphinot, Thomas L Shirley, Raoul Torero-Ibad, Julia Fuchs, H A Jinna. Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis. Human molecular genetics. vol 18. issue 13. 2009-08-13. PMID:19342420. |
hypoxanthine-guanine phosphoribosyltransferase (hprt) deficiency results in lesch-nyhan disease (lnd), where affected individuals exhibit a characteristic neurobehavioral disorder that has been linked with dysfunction of dopaminergic pathways of the basal ganglia. |
2009-08-13 |
2023-08-12 |
human |
| Jarom E Hanson, Elisabeth Birdsall, Kristi S Seferian, Marcus A Crosby, Kristen A Keefe, James W Gibb, Glen R Hanson, Annette E Fleckenstei. Methamphetamine-induced dopaminergic deficits and refractoriness to subsequent treatment. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326567. |
thus, this study describes a model of resistance, possibly explained by: 1) the existence of dopaminergic neurons that are a priori refractory to deficits caused by methamphetamine; 2) the existence of dopaminergic neurons made persistently resistant consequent to a neurotoxic methamphetamine exposure; and/or 3) altered activation of post-synaptic basal ganglia systems necessary for the elaboration of methamphetamine-induced dopamine neurotoxicity. |
2009-07-07 |
2023-08-12 |
rat |
| Simon J G Lewis, Roger A Barke. Understanding the dopaminergic deficits in Parkinson's disease: insights into disease heterogeneity. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 16. issue 5. 2009-06-25. PMID:19285870. |
this paper describes how dopaminergic disruption within basal ganglia circuitry accounts for some of the major features of the disease and examines how the limited repertoire of the output nuclei within these pathways could allow for an element of "cross-talk" between competing inputs. |
2009-06-25 |
2023-08-12 |
Not clear |
| Florian Kempf, Christof Brücke, Farid Salih, Thomas Trottenberg, Andreas Kupsch, Gerd-Helge Schneider, Louise M F Doyle Gaynor, Karl-Titus Hoffmann, Jan Vesper, Johannes Wöhrle, Dirk-Matthias Altenmüller, Joachim K Krauss, Paolo Mazzone, Vincenzo Di Lazzaro, Jérôme Yelnik, Andrea A Kühn, Peter Brow. Gamma activity and reactivity in human thalamic local field potentials. The European journal of neuroscience. vol 29. issue 5. 2009-06-09. PMID:19291224. |
depth recordings in patients with parkinson's disease on dopaminergic therapy have revealed a tendency for oscillatory activity in the basal ganglia that is sharply tuned to frequencies of approximately 70 hz and increases with voluntary movement. |
2009-06-09 |
2023-08-12 |
human |
| F Steigerwald, M Pötter, J Herzog, M Pinsker, F Kopper, H Mehdorn, G Deuschl, J Volkman. Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state. Journal of neurophysiology. vol 100. issue 5. 2009-04-20. PMID:18701754. |
essential tremor is a movement disorder without any known basal ganglia pathology and with normal dopaminergic brain function. |
2009-04-20 |
2023-08-12 |
human |
| N Kickler, E Lacombe, C Chassain, F Durif, A Krainik, R Farion, P Provent, C Segebarth, C Rémy, M Savast. Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study. NMR in biomedicine. vol 22. issue 2. 2009-04-16. PMID:19130495. |
degeneration of the dopaminergic neurons of the substantia nigra pars compacta in parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. |
2009-04-16 |
2023-08-12 |
rat |
| D Mongeon, P Blanchet, J Messie. Impact of Parkinson's disease and dopaminergic medication on proprioceptive processing. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:18996173. |
furthermore, the diversity of effects of medication on accuracy of reaching to proprioceptively-defined targets supports the idea that dysfunction of dopaminergic circuits within the basal ganglia is not primarily responsible for the proprioceptive processing deficits of pd patients. |
2009-04-15 |
2023-08-12 |
human |
| Jeannette Henning, Ulf Strauss, Andreas Wree, Jan Gimsa, Arndt Rolfs, Reiner Benecke, Ulrike Gims. Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease. Neuroscience research. vol 62. issue 4. 2009-04-14. PMID:18824050. |
in rat models of parkinson's disease, injections of 6-hydroxydopamine (6-ohda) into different areas of the basal ganglia result in dopaminergic neurodegeneration in the substantia nigra. |
2009-04-14 |
2023-08-12 |
rat |
| Peter Jenne. Molecular mechanisms of L-DOPA-induced dyskinesia. Nature reviews. Neuroscience. vol 9. issue 9. 2009-04-09. PMID:18714325. |
the subsequent response of the abnormal basal ganglia to dopaminergic drugs determines the manner and timing of dyskinesia expression. |
2009-04-09 |
2023-08-12 |
Not clear |
| Fabrizio Stocch. The hypothesis of the genesis of motor complications and continuous dopaminergic stimulation in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 1. 2009-03-31. PMID:19131046. |
there is now accumulating evidence that several factors - the progressive pathology of parkinson's disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors - are key contributors to the priming of the basal ganglia for induction of motor complications. |
2009-03-31 |
2023-08-12 |
Not clear |
| José L Lanciego, Icíar P López, Alberto J Rico, María S Aymerich, Mónica Pérez-Manso, Lorena Conte, Carolina Combarro, Elvira Roda, Carmen Molina, Nancy Gonzalo, María Castle, Teresa Tuñón, Elena Erro, Pedro Barroso-Chine. The search for a role of the caudal intralaminar nuclei in the pathophysiology of Parkinson's disease. Brain research bulletin. vol 78. issue 2-3. 2009-03-23. PMID:18790023. |
although the anatomical basis sustaining the thalamic modulation of basal ganglia circuits has long been characterized, the functional significance of these transverse circuits still remain to be properly accommodated within the basal ganglia model, both under normal conditions as well as in situations of dopaminergic depletion. |
2009-03-23 |
2023-08-12 |
Not clear |
| Anthony H V Schapir. Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease. Neurology. vol 72. issue 7 Suppl. 2009-03-12. PMID:19221314. |
the basis for this may lie in the support of basal ganglia compensatory mechanisms and the restoration of normal dopaminergic transmission. |
2009-03-12 |
2023-08-12 |
human |
| Patryk A Lauren. The emergence of saliency and novelty responses from Reinforcement Learning principles. Neural networks : the official journal of the International Neural Network Society. vol 21. issue 10. 2009-03-03. PMID:18938058. |
thus, reinforcement learning principles can be used to understand not just reward-related activity of the dopaminergic neurons of the basal ganglia, but also some of their apparently non-reward-related activity. |
2009-03-03 |
2023-08-12 |
Not clear |
| Omar M E Abdel-Sala. Drugs used to treat Parkinson's disease, present status and future directions. CNS & neurological disorders drug targets. vol 7. issue 4. 2009-02-19. PMID:18991661. |
in pd, motor symptoms result from the degeneration and loss of pigmented dopaminergic neurons of the substantia nigra pars compacta of the basal ganglia. |
2009-02-19 |
2023-08-12 |
Not clear |
| Rosaria Greco, Cristina Tassorelli, Marie Therèse Armentero, Giorgio Sandrini, Giuseppe Nappi, Fabio Blandin. Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia. Brain research. vol 1238. 2009-02-09. PMID:18761334. |
experimental evidence shows that dopaminergic transmission within the basal ganglia is involved in the modulation of nociceptive information. |
2009-02-09 |
2023-08-12 |
rat |
| P Crenna, I Carpinella, L Lopiano, A Marzegan, M Rabuffetti, M Rizzone, M Lanotte, M Ferrari. Influence of basal ganglia on upper limb locomotor synergies. Evidence from deep brain stimulation and L-DOPA treatment in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:18952669. |
the evidence that locomotor automatisms of the upper and lower limbs display uncorrelated impairment upon dysfunction of the basal ganglia, as well as different susceptibility to electrophysiological and pharmacological interventions, points to the presence of heterogeneously distributed, possibly partially independent, supraspinal control channels, whereby stn and dopaminergic systems have relatively weaker influence on the executive structures involved in the arm swing and preferential action on those for lower limb movements. |
2009-02-02 |
2023-08-12 |
Not clear |
| Vincenzo Di Matteo, Massimo Pierucci, Ennio Esposito, Giuseppe Crescimanno, Arcangelo Benigno, Giuseppe Di Giovann. Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders. Progress in brain research. vol 172. 2009-01-15. PMID:18772045. |
several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. |
2009-01-15 |
2023-08-12 |
Not clear |
| Ann Massie, Lieselotte Cnops, Ilse Smolders, Robert McCullumsmith, Ron Kooijman, Shin Kwak, Lutgarde Arckens, Yvette Michott. High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain. The Journal of comparative neurology. vol 511. issue 2. 2008-12-22. PMID:18770868. |
relatively high levels of eaat4 protein were also detected in the hippocampal principal cells, in the glutamatergic, gamma-aminobutyric acid (gaba)ergic, dopaminergic and most likely cholinergic cells of all nuclei of the basal ganglia, and in neurons of layers ii/iii and v of the cerebral cortex. |
2008-12-22 |
2023-08-12 |
mouse |