| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuan Gu, Xiaoying Wan. An overview of recent analysis and detection of acetylcholine. Analytical biochemistry. vol 632. 2021-12-01. PMID:34534543. |
acetylcholine (ach), the major neurotransmitter secreted by cholinergic neurons, is widely found in the peripheral and central nervous systems, and its main function is to complete the transmission of neural signals. |
2021-12-01 |
2023-08-13 |
Not clear |
| Ruiqing N. Positron Emission Tomography in Animal Models of Alzheimer's Disease Amyloidosis: Translational Implications. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832961. |
in this review, we focus on recent positron emission tomography studies of cerebral amyloid-beta accumulation, hypoglucose metabolism, synaptic and neurotransmitter receptor deficits (cholinergic and glutamatergic system), blood-brain barrier impairment, and neuroinflammation (microgliosis and astrocytosis) in animal models of alzheimer's disease amyloidosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Jiaqi Lv, Xiaoxiao Ji, Zhen Li, Huiqin Ha. The role of the cholinergic anti-inflammatory pathway in autoimmune rheumatic diseases. Scandinavian journal of immunology. vol 94. issue 4. 2021-11-25. PMID:34780075. |
the cholinergic anti-inflammatory pathway (cap) is a classic neuroimmune pathway, consisting of the vagus nerve, acetylcholine (ach)-the pivotal neurotransmitter of the vagus nerve-and its receptors. |
2021-11-25 |
2023-08-13 |
Not clear |
| Tun-Wei Hsu, Jong-Ling Fuh, Da-Wei Wang, Li-Fen Chen, Chia-Jung Chang, Wen-Sheng Huang, Hsiu-Mei Wu, Wan-Yuo Gu. Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686089. |
disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from dementia is related to the cellular accumulation of β-amyloid plaques, tau aggregates, or α-synuclein aggregates, or to neurotransmitter deficiencies in the dopaminergic and cholinergic pathways. |
2021-11-22 |
2023-08-13 |
human |
| Sina Marzoughi, Ankur Banerjee, Catherine R Jutzeler, Marco A M Prado, Jan Rosner, Jacquelyn J Cragg, Neil Cashma. Tardive neurotoxicity of anticholinergic drugs: A review. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33222198. |
the cholinergic system is a complex neurotransmitter system with functional involvement at multiple levels of the nervous system including the cerebral cortex, spinal cord, autonomic nervous system, and neuromuscular junction. |
2021-11-17 |
2023-08-13 |
human |
| Rosana Banzato, Nathalia M Pinheiro, Clarice R Olivo, Fernanda R Santana, Fernanda D T Q S Lopes, Luciana C Caperuto, Niels O Câmara, Milton A Martins, Iolanda F L C Tibério, Marco Antônio M Prado, Vânia F Prado, Carla M Prad. Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34354132. |
acetylcholine (ach), the neurotransmitter of the cholinergic system, regulates inflammation in several diseases including pulmonary diseases. |
2021-11-15 |
2023-08-13 |
mouse |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Cecilia Flores-Clemente, María Inés Nicolás-Vázquez, Elvia Mera Jiménez, Maricarmen Hernández-Rodrígue. Inhibition of Astrocytic Histamine Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680041. |
changes in neurotransmitter systems in patients with ad, including cholinergic, gabaergic, serotoninergic, noradrenergic, and histaminergic changes have been reported. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yoshihiko Kakinum. Significance of vagus nerve function in terms of pathogenesis of psychosocial disorders. Neurochemistry international. vol 143. 2021-11-04. PMID:33307153. |
the neurotransmitter acetylcholine, released from the cholinergic system including vn, has been known to play an anti-inflammatory role through the efferent pathways in regulating peripheral inflammatory responses profoundly involved in the pathogenesis of diseases. |
2021-11-04 |
2023-08-13 |
Not clear |
| Trevor Archer, Marlene Oscar-Berman, Kenneth Blum, Mark Gol. Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry. Journal of genetic syndromes & gene therapy. vol 3. issue 3. 2021-10-21. PMID:23264884. |
brain-derived neurotrophic factor (bdnf) affects the development and integrity of the noradrenergic, dopaminergic, serotonergic, glutamatergic, and cholinergic neurotransmitter systems, and plasma levels of the neurotrophin are associated with both cognitive and aggressive impulsiveness. |
2021-10-21 |
2023-08-12 |
Not clear |
| Uğur Güller, Pınar Güller, Mehmet Çiftc. Radical Scavenging and Antiacetylcholinesterase Activities of Ethanolic Extracts of Carob, Clove, and Linden. Alternative therapies in health and medicine. vol 27. issue 5. 2021-10-12. PMID:32619207. |
it's a neurotransmitter involved in cholinergic transmission in the brain. |
2021-10-12 |
2023-08-13 |
Not clear |
| Kelly Smart, Mika Naganawa, Stephen R Baldassarri, Nabeel Nabulsi, Jim Ropchan, Soheila Najafzadeh, Hong Gao, Antonio Navarro, Vanessa Barth, Irina Esterlis, Kelly P Cosgrove, Yiyun Huang, Richard E Carson, Ansel T Hillme. PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33442731. |
the goal of this work was to leverage positron emission tomography (pet) imaging estimates of drug occupancy at cholinergic receptors to explore ach variation across the human brain, because these measures can be influenced by competition with endogenous neurotransmitter. |
2021-10-11 |
2023-08-13 |
human |
| Aijaz Ahmad Malik, Suvash Chandra Ojha, Nalini Schaduangrat, Chanin Nantasenama. ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors. Molecular diversity. 2021-10-05. PMID:34609711. |
the deficiency of the cholinergic neurotransmitter known as acetylcholine (ach) is associated with ad. |
2021-10-05 |
2023-08-13 |
Not clear |
| Miranda L Fisher, James R Pauly, Brett Froeliger, Jill R Turne. Translational Research in Nicotine Addiction. Cold Spring Harbor perspectives in medicine. vol 11. issue 6. 2021-09-29. PMID:32513669. |
likewise, translational studies investigating single-nucleotide polymorphisms (snps) within the cholinergic, dopaminergic, and opioid systems have found high levels of involvement of these neurotransmitter systems in regulating the reinforcing aspects of nicotine in both humans and mouse models. |
2021-09-29 |
2023-08-13 |
mouse |
| Laura DeCristofano, Steven Decker, Marvin K Schulte, Asha Suryanarayana. Desformylflustrabromine (dFBr), a positive allosteric modulator of the α Alcohol (Fayetteville, N.Y.). vol 93. 2021-09-23. PMID:33652092. |
ethanol targets multiple neurotransmitter systems; however, not much is known about its effects on the cholinergic system. |
2021-09-23 |
2023-08-13 |
Not clear |
| Masayuki Yamaga, Toshihiro Imada, Hiroko Tani, Shigeru Nakamura, Ayanori Yamaki, Kazuo Tsubot. Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice. Nutrients. vol 13. issue 8. 2021-09-15. PMID:34444696. |
rj contains acetylcholine, which is a major cholinergic neurotransmitter, and a unique set of fatty acids with c 8 to 12 chains, which are expected to be associated with health benefits. |
2021-09-15 |
2023-08-13 |
mouse |
| Rosana Reyes-Pinto, José L Ferrán, Tomas Vega-Zuniga, Cristian González-Cabrera, Harald Luksch, Jorge Mpodozis, Luis Puelles, Gonzalo J Marí. Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. The Journal of comparative neurology. 2021-09-11. PMID:34363623. |
to explore how the ipc neurotransmitter identity is established during ontogeny, we analyzed the expression of mrnas coding for cholinergic (chat, vacht, and cht) and glutamatergic (vglut2 and vglut3) markers in chick embryos at different developmental stages. |
2021-09-11 |
2023-08-13 |
chicken |
| Christian Humpe. NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimer's Disease? Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453299. |
acetylcholine is the most important neurotransmitter for memory, and cholinergic neurons selectively degenerate in ad, and a loss of acetylcholine directly correlates with cognitive decline. |
2021-08-31 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| María-Ángeles Cortés-Gómez, Esther Llorens-Álvarez, Jordi Alom, Teodoro Del Ser, Jesús Avila, Javier Sáez-Valero, María-Salud García-Aylló. Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:32955735. |
moreover, in sh-sy5y cells differentiated into neurons by exposure to retinoic acid (10 µm), over-expression of gsk3β and tau provokes an imbalance in cholinergic activity with a decrease in the neurotransmitter acetylcholine in the cell (45 ± 10%). |
2021-08-24 |
2023-08-13 |
mouse |