| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Snezana Agatonovic-Kustrin, Ella Kustrin, David W Morto. Essential oils and functional herbs for healthy aging. Neural regeneration research. vol 14. issue 3. 2020-09-30. PMID:30539810. |
acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. |
2020-09-30 |
2023-08-13 |
Not clear |
| Donna L. Masterma. Role of Cholinesterase Inhibitors in Managing Behavioral Problems in Alzheimer's Disease. Primary care companion to the Journal of clinical psychiatry. vol 6. issue 3. 2020-09-29. PMID:15361927. |
the cholinergic system, which is the most consistently and dramatically affected neurotransmitter system in alzheimer's disease, has been strongly implicated in the emergence of neuropsychiatric symptoms. |
2020-09-29 |
2023-08-12 |
Not clear |
| Leah K Cuddy, Claudia Seah, Stephen H Pasternak, R Jane Rylet. Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:29163036. |
the deficits in cognition and attentional processing that are observed clinically in ad are linked to impaired function of cholinergic neurons that release the neurotransmitter acetylcholine (ach). |
2020-09-29 |
2023-08-13 |
Not clear |
| Toshihiro Kitamoto, Paul M Salvaterr. Developmental regulatory elements in the 5' flanking DNA of the Drosophila choline acetyltransferase gene. Roux's archives of developmental biology : the official organ of the EDBO. vol 202. issue 3. 2020-09-28. PMID:28305993. |
choline acetyltransferase (chat, ec 2.3.1.6) catalyzes the production of the neurotransmitter acetylcholine, and is an essential factor for neurons to be cholinergic. |
2020-09-28 |
2023-08-13 |
drosophila_melanogaster |
| Laia Guardia-Escote, Pia Basaure, Fiona Peris-Sampedro, Judit Biosca-Brull, Maria Cabré, Fernando Sánchez-Santed, José L Domingo, Maria Teresa Colomin. APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs. Behavioural brain research. vol 376. 2020-09-17. PMID:31473287. |
in order to study the contribution of cholinergic and gabaergic neurotransmitter systems to recognition memory, a pharmacological challenge was included. |
2020-09-17 |
2023-08-13 |
mouse |
| Laia Guardia-Escote, Pia Basaure, Fiona Peris-Sampedro, Judit Biosca-Brull, Maria Cabré, Fernando Sánchez-Santed, José L Domingo, Maria Teresa Colomin. APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs. Behavioural brain research. vol 376. 2020-09-17. PMID:31473287. |
overall, these results suggest complex interactions between sex, apoe genotype and postnatal cpf exposure and indicate a different functioning of both the cholinergic and gabaergic neurotransmitter system between groups. |
2020-09-17 |
2023-08-13 |
mouse |
| María Jesús Oset-Gasque, José Luis Marco-Contelle. Tacrine-Natural-Product Hybrids for Alzheimer's Disease Therapy. Current medicinal chemistry. vol 27. issue 26. 2020-09-16. PMID:29611473. |
alzheimer's disease (ad) is a complex, neurodegenerative pathology showing, among others, high cholinergic and neurotransmitter deficits, oxidative stress, inflammation, aβ-aggregation resulting in senile plaques formation, and hyperphosphorylation of tau-protein leading to neurofibrillary tangles. |
2020-09-16 |
2023-08-13 |
Not clear |
| Jesús M López, Ruth Morona, Agustín Gonzále. Pattern of nitrergic cells and fibers organization in the central nervous system of the Australian lungfish, Neoceratodus forsteri (Sarcopterygii: Dipnoi). The Journal of comparative neurology. vol 527. issue 11. 2020-09-14. PMID:30689201. |
combined immunohistochemistry was used for simultaneous detection of nos with catecholaminergic, cholinergic, and serotonergic structures, aiming to establish accurately the localization of the nitrergic elements and to assess possible interactions between these neurotransmitter systems. |
2020-09-14 |
2023-08-13 |
Not clear |
| Raffaele Nardone, Stefan Golaszewski, Kerstin Schwenker, Francesco Brigo, Miriam Maccarrone, Viviana Versace, Luca Sebastianelli, Leopold Saltuari, Yvonne Hölle. Cholinergic transmission is impaired in patients with idiopathic normal-pressure hydrocephalus: a TMS study. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 8. 2020-07-28. PMID:31227893. |
cholinergic and other neurotransmitter abnormalities have been reported in animal models of nph. |
2020-07-28 |
2023-08-13 |
human |
| Jennifer L Bruno, Sm Hadi Hosseini, Amy A Lightbody, Mai K Manchanda, Allan L Reis. Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome. Journal of psychopharmacology (Oxford, England). vol 33. issue 8. 2020-07-27. PMID:31264943. |
fragile x syndrome, the most common inherited cause for intellectual disability, is associated with alterations in cholinergic among other neurotransmitter systems. |
2020-07-27 |
2023-08-13 |
Not clear |
| Theodosia Vallianatou, Mohammadreza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Patrik Källback, Nicoletta Schintu, Per Svenningsson, Per E André. Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 12. 2020-07-10. PMID:31009936. |
the neurotransmitter of the cholinergic system, acetylcholine plays a major role in the brain's cognitive function and is involved in neurodegenerative disorders. |
2020-07-10 |
2023-08-13 |
mouse |
| Maria Nicol Colombo, Maura Francolin. Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission. Cells. vol 8. issue 9. 2020-05-26. PMID:31466388. |
although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last. |
2020-05-26 |
2023-08-13 |
Not clear |
| E V Kur'yanova, V O Stupin, A V Tryasuchev, D L Teply. Effects of Blockage of Peripheral Choline, Serotonin, and Dopamine Receptors on Heart Rhythm Variability in Rats under Conditions of Stimulation of Neurotransmitter Systems. Bulletin of experimental biology and medicine. vol 168. issue 2. 2020-05-05. PMID:31776959. |
successive blockade of nicotinic (hexamethonium, 7 mg/kg) and muscarinic cholinergic receptors (atropine, 1 mg/kg) leads to a significant decrease in the variability of cardiointervals (almost to complete levelling) both under control conditions and after stimulation of the neurotransmitter systems. |
2020-05-05 |
2023-08-13 |
rat |
| Vida Alipour, Fahimeh Hoseinpour, Jafar Vatanparas. Persistent alterations in seizure susceptibility, drug responsiveness and comorbidities associated with chemical kindling after neonatal exposure to an organophosphate. Neurotoxicology. vol 73. 2020-04-27. PMID:30862509. |
developmental exposure to organophosphates (ops), at doses that do not cause cholinergic crisis, induces profound and lasting alterations in different neurotransmitter systems, which contribute to several behavioral outcomes. |
2020-04-27 |
2023-08-13 |
rat |
| b' Branka R Gavrilovi\\xc4\\x87, Marko D Proki\\xc4\\x87, Tamara G Petrovi\\xc4\\x87, Svetlana G Despotovi\\xc4\\x87, Tijana B Radovanovi\\xc4\\x87, Imre I Krizmani\\xc4\\x87, Milo\\xc5\\xa1 D \\xc4\\x86iri\\xc4\\x87, Jelena P Gavri\\xc4\\x8. Biochemical parameters in skin and muscle of Pelophylax kl. esculentus frogs: Influence of a cyanobacterial bloom in situ. Aquatic toxicology (Amsterdam, Netherlands). vol 220. 2020-04-23. PMID:31896464.' |
our results have also revealed that the cyanobacterial bloom conditions induced the cholinergic neurotransmitter system in both tissues. |
2020-04-23 |
2023-08-13 |
Not clear |
| Craig P Mantanona, Johan Alsiö, Joanna L Elson, Beth M Fisher, Jeffrey W Dalley, Timothy Bussey, Ilse S Pienaa. Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats. Brain structure & function. vol 224. issue 9. 2020-04-14. PMID:31506825. |
however, it was recently reported that transgenic mice overexpressing a bacterial artificial chromosome containing choline acetyltransferase (chat) gene, for synthesizing the neurotransmitter acetylcholine, present with multiple vesicular acetylcholine transporter (vacht) gene copies, resulting in altered cholinergic tone and accompanying behavioral abnormalities. |
2020-04-14 |
2023-08-13 |
mouse |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Feng Ma, Xiaohai Luo, Jingzu Ma, Ziyang Yang, Zhanchuan Yao, Xiaojun Lu. The effect of the α7nAChR agonist on Wnt/β-catenin signaling in osteoporosis. International journal of clinical and experimental pathology. vol 12. issue 8. 2020-03-25. PMID:31934123. |
the cholinergic pathway neurotransmitter acetylcholine (ach) regulates the inflammatory cascade through a specific α7 nicotinic acetylcholine receptor (α7nachr). |
2020-03-25 |
2023-08-13 |
mouse |
| Farah Deba, Steven Peterson, Ayman K Hamoud. An Animal Model to Test Reversal of Cognitive Decline Associated with Beta-Amyloid Pathologies. Methods in molecular biology (Clifton, N.J.). vol 2011. 2020-03-19. PMID:31273712. |
while ad is a multifactorial disease that includes other proteinopathies (e.g., hyperphosphorylated tau aggregates) and neurotransmitter disturbances (e.g., loss of cortical cholinergic innervation), aβ (soluble or in senile plaques) remains the major undisputed factor that contributes to the pathological and behavior presentation of ad. |
2020-03-19 |
2023-08-13 |
rat |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |