| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Sanz Muñoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Damian Hernández, Tracey Berg, Jennifer A Fifita, Natalie Grima, Shu Yang, Ian P Blair, Garth Nicholson, Anthony L Cook, Alex W Hewitt, Alice Pébay, Lezanne Oo. A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling. Cells. vol 9. issue 9. 2021-03-25. PMID:32887382. |
the cholinergic system, characterized by its use of the neurotransmitter acetylcholine, is one of the first to degenerate in alzheimer's disease and is also affected in frontotemporal dementia. |
2021-03-25 |
2023-08-13 |
Not clear |
| Adam Mergenthal, Jean-Marie C Bouteiller, Gene J Yu, Theodore W Berge. A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity. Frontiers in computational neuroscience. vol 14. 2021-03-24. PMID:33013341. |
the important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about the contribution of cholinergic modulation to healthy hippocampal function. |
2021-03-24 |
2023-08-13 |
Not clear |
| Mohammad Naderi, Pankaj Puar, Mahtab Zonouzi-Marand, Douglas P Chivers, Som Niyogi, Raymond W M Kwon. A comprehensive review on the neuropathophysiology of selenium. The Science of the total environment. vol 767. 2021-02-26. PMID:33445002. |
a wealth of evidence has shown that exposure to excess se may compromise the normal functioning of various key proteins, neurotransmitter systems (the glutamatergic, dopaminergic, serotonergic, and cholinergic systems), and signaling molecules involved in the control and regulation of cognitive, behavioral, and neuroendocrine functions. |
2021-02-26 |
2023-08-13 |
Not clear |
| Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinum. S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions. International immunopharmacology. vol 84. 2021-02-25. PMID:32325404. |
we have previously reported the development of a novel chemical compound, s-nitroso-n-pivaloyl-d-penicillamine (snpip), for the upregulation of the non-neuronal cardiac cholinergic system (nnccs), a cardiac acetylcholine (ach) synthesis system, which is different from the vagus nerve releasing of ach as a neurotransmitter. |
2021-02-25 |
2023-08-13 |
mouse |
| Kai K Kummer, Miodrag Mitrić, Theodora Kalpachidou, Michaela Kres. The Medial Prefrontal Cortex as a Central Hub for Mental Comorbidities Associated with Chronic Pain. International journal of molecular sciences. vol 21. issue 10. 2021-02-12. PMID:32414089. |
a multitude of neurotransmitter systems contributes to the fine-tuning of the local circuitry, of which cholinergic and gabaergic signaling are particularly emerging as relevant components of affective pain processing within the prefrontal cortex. |
2021-02-12 |
2023-08-13 |
Not clear |
| Zhe Ying Ha, Shintu Mathew, Keng Yoon Yeon. Butyrylcholinesterase: A Multifaceted Pharmacological Target and Tool. Current protein & peptide science. vol 21. issue 1. 2021-01-22. PMID:31702488. |
here, we review and summarize the biochemical properties of butyrylcholinesterase and its roles, as a cholinergic neurotransmitter, in various diseases, particularly neurodegenerative disorders. |
2021-01-22 |
2023-08-13 |
Not clear |
| Rekha C Balachandran, Katherine M Hatcher, Megan L Sieg, Emma K Sullivan, Leonardo M Molina, Megan M Mahoney, Paul A Eubi. Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats. Pharmacology, biochemistry, and behavior. vol 193. 2021-01-21. PMID:32224058. |
next, we performed drug challenges in a new rat cohort to examine the interaction between the cholinergic and dopaminergic neurotransmitter systems in regulating the behavioral changes caused by circadian disruption. |
2021-01-21 |
2023-08-13 |
rat |
| Xueying Du, Yu Tang, Yu Han, Sanghyok Ri, Tongchol Kim, Kwangjin Ju, Wei Shi, Shuge Sun, Weishang Zhou, Guangxu Li. Acetylcholine suppresses phagocytosis via binding to muscarinic- and nicotinic-acetylcholine receptors and subsequently interfering Ca Fish & shellfish immunology. vol 102. 2021-01-15. PMID:32320762. |
acetylcholine suppresses phagocytosis via binding to muscarinic- and nicotinic-acetylcholine receptors and subsequently interfering ca though immunomodulation via cholinergic neurotransmitter acetylcholine (ach), an important part of neuroendocrine-immune (nei) regulatory network, has been well established in vertebrate species, the mechanisms remain poorly understood in invertebrates. |
2021-01-15 |
2023-08-13 |
Not clear |
| Ai Hertati, Shusaku Hayashi, Hanako Ogata, Kana Miyata, Ryo Kato, Takeshi Yamamoto, Makoto Kadowak. Morphological elucidation of short-chain fatty acid receptor GPR41-positive enteric sensory neurons in the colon of mice with dextran sulfate sodium-induced colitis. Heliyon. vol 6. issue 12. 2020-12-16. PMID:33319102. |
in addition, gpr41-immunoreactive fibrous structures partly colocalized with calcitonin gene-related peptide (cgrp; a neurotransmitter of cholinergic enteric sensory neurons)-immunoreactive nerve fibers in the colonic lamina propria, indicating that gpr41 is expressed in cholinergic intrinsic sensory neurons. |
2020-12-16 |
2023-08-13 |
mouse |
| Yasha Sheynin, Pedro Rosa-Neto, Robert F Hess, Elvire Vauche. Cholinergic Modulation of Binocular Vision. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 27. 2020-11-23. PMID:32457075. |
considering recent evidence that perceptual suppression during binocular rivalry is causally modulated by the inhibitory neurotransmitter gaba, our results suggest that cholinergic activity counteracts the effect of gaba with regards to interocular dynamics and may modulate the inhibitory drive within the visual cortex. |
2020-11-23 |
2023-08-13 |
human |
| Vinay Parikh, Debra A Bangasse. Cholinergic Signaling Dynamics and Cognitive Control of Attention. Current topics in behavioral neurosciences. vol 45. 2020-11-09. PMID:32447715. |
the central cholinergic system is one of the most important modulator neurotransmitter system implicated in diverse behavioral processes. |
2020-11-09 |
2023-08-13 |
Not clear |
| Chiara Celotto, Carlos Sanchez, Konstantinos A Mountris, Pablo Laguna, Esther Puey. SK Channel Block and Adrenergic Stimulation Counteract Acetylcholine-Induced Arrhythmogenic Effects in Human Atria. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2020. 2020-10-23. PMID:33018468. |
additionally, recent investigations have proved that pharmacological therapies inhibiting small-conductance calcium-activated potassium (sk) channels are able to lessen cholinergic effects in the atria.in this study we use computational modeling and simulation to test individual and combined effects of sk channel block and adrenergic stimulation in counteracting detrimental effects induced by the parasympathetic neurotransmitter acetylcholine (ach) on human atrial electrophysiology. |
2020-10-23 |
2023-08-13 |
human |
| Gilneia da Rosa, Davi F Alba, Anielen D Silva, Vanessa V Miron, Vera Maria Morsch, Marcel M Boiago, Lenita M Stefani, Matheus M Baldissera, Marcos T Lopes, Ricardo E Mendes, Aleksandro S da Silv. Impacts of Escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function. Microbial pathogenesis. vol 138. 2020-10-15. PMID:31604153. |
impacts of escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function. |
2020-10-15 |
2023-08-13 |
Not clear |
| Pichet Termsarasab, Thananan Thammongkolchai, Steven J Fruch. Medical treatment of dystonia. Journal of clinical movement disorders. vol 3. 2020-10-01. PMID:28031858. |
we review the medical treatment of dystonia, focusing on three major neurotransmitter systems: cholinergic, gabaergic and dopaminergic. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ahmed Al-Qassabi, Seyed-Mohammad Fereshtehnejad, Ronald B Postum. Sleep Disturbances in the Prodromal Stage of Parkinson Disease. Current treatment options in neurology. vol 19. issue 6. 2020-10-01. PMID:28466429. |
disturbances in serotonergic, cholinergic, dopaminergic, and glutamatergic neurotransmitter systems have made sleep disorders potential candidates for prodromal pd. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yu-Min Xu, Xin-Chen Wang, Ting-Ting Xu, Hong-Ying Li, Shang-Yan Hei, Na-Chuan Luo, Hong Wang, Wei Zhao, Shu-Huan Fang, Yun-Bo Chen, Li Guan, Yong-Qi Fang, Shi-Jie Zhang, Qi Wang, Wei-Xiong Lian. Neural regeneration research. vol 14. issue 5. 2020-10-01. PMID:30688265. |
the effects of kxs on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. |
2020-10-01 |
2023-08-13 |
mouse |
| Julie M Miwa, Kristin R Anderson, Katie M Hoffma. Lynx Prototoxins: Roles of Endogenous Mammalian Neurotoxin-Like Proteins in Modulating Nicotinic Acetylcholine Receptor Function to Influence Complex Biological Processes. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31114495. |
the cholinergic system modulates many biological functions, due to the widespread distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter, acetylcholine. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kazushige Mizoguchi, Yasushi Ikarash. Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28979206. |
regarding the pharmacological mechanisms underlying its efficacy, we recently reviewed the multiple effects of yks on the neurotransmitter systems (e.g., glutamatergic, serotonergic, dopaminergic, cholinergic, gabaergic, and adrenergic neurotransmission) in various brain regions that are related to the psychological, emotional, cognitive, or memory functions. |
2020-09-30 |
2023-08-13 |
Not clear |
| Trevor M Morey, Warren Winick-Ng, Claudia Seah, R Jane Rylet. Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29311808. |
choline acetyltransferase (chat) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (cms). |
2020-09-30 |
2023-08-13 |
Not clear |
| Lim Ya Chee, Alaistair Cummin. Polymorphisms in the Cholinergic Receptors Muscarinic Avicenna journal of medical biotechnology. vol 10. issue 3. 2020-09-30. PMID:30090216. |
polymorphisms in the cholinergic receptors muscarinic disruption of the cholinergic neurotransmitter pathway which is important for cognition, memory and learning abilities has been reported in alzheimer's disease (ad) patients. |
2020-09-30 |
2023-08-13 |
Not clear |