| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert M Cabrera, Ying Linda Lin, Elizabeth Law, Jimi Kim, Bogdan J Wlodarczy. The teratogenic effects of sertraline in mice. Birth defects research. vol 112. issue 13. 2021-08-18. PMID:32077266. |
selective serotonin reuptake inhibitors (ssris), which include paroxetine (paxil), sertraline (zoloft), fluoxetine (prozac), citalopram (celexa), and escitalopram (lexapro), are the most common antidepressants prescribed to pregnant women. |
2021-08-18 |
2023-08-13 |
mouse |
| Ayesha Afzal, Ammara Khan, Asma Khan, Rashida Farooqi, Bushra Tayyaba Khan, Iffat Ar. Effect of paroxetine on intestinal motility in the presence of ondansetron. Pakistan journal of pharmaceutical sciences. vol 33. issue 3. 2021-08-03. PMID:33191244. |
the effects of increasing concentrations of serotonin, ondansetron and paroxetine alone were observed. |
2021-08-03 |
2023-08-13 |
Not clear |
| Thaís Cristine Pereira, Raquel Teles de Menezes, Haroldo Cesar de Oliveira, Luciane Dias de Oliveira, Liliana Scorzon. In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans. Pathogens and disease. vol 79. issue 2. 2021-07-19. PMID:33417701. |
the present study aimed to validate the efficacy of selective serotonin reuptake inhibitors, fluoxetine hydrochloride (flh) and paroxetine hydrochloride (pah), alone and in combination with amphotericin b (amb) against c. neoformans. |
2021-07-19 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczy. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. vol 22. issue 12. 2021-07-14. PMID:34208199. |
due to the confirmed dependence of depression on serotonin, norepinephrine, dopamine and γ-aminobutyric acid levels, studies have been undertaken into paroxetine interactions with these primary neurotransmitters using in silico and in vitro methods. |
2021-07-14 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczy. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. vol 22. issue 12. 2021-07-14. PMID:34208199. |
however, studies of the potency inhibitors and binding affinity values indicate that the neurogenic mechanism of paroxetine's action may be determined mainly by its interactions with serotonin transporters. |
2021-07-14 |
2023-08-13 |
Not clear |
| Stacy A Henry, Selina Crivello, Tina M Nguyen, Magdalena Cybulska, Ngoc S Hoang, Mary Nguyen, Tajinder Badial, Nazgol Emami, Nasma Awada, Johnathen F Woodward, Christopher H S. G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. Cell stress & chaperones. vol 26. issue 1. 2021-07-06. PMID:33064264. |
treating c. elegans with a grk2 inhibitor, the selective serotonin reuptake inhibitor paroxetine, resulted in increased acute oxidative stress resistance compared with another selective serotonin reuptake inhibitor, fluoxetine. |
2021-07-06 |
2023-08-13 |
caenorhabditis_elegans |
| Paula L Jacobsen, George G Nomikos, Wei Zhong, Andrew J Cutler, John Affinito, Anita Clayto. Clinical implications of directly switching antidepressants in well-treated depressed patients with treatment-emergent sexual dysfunction: a comparison between vortioxetine and escitalopram. CNS spectrums. vol 25. issue 1. 2021-06-30. PMID:31010445. |
the objective of this work was to describe treatment-emergent sexual dysfunction (tesd) and tolerability following a switch from selective serotonin reuptake inhibitor (ssri: citalopram, paroxetine, or sertraline) monotherapy to vortioxetine or escitalopram monotherapy in adults with well-treated major depressive disorder (mdd) and ssri-induced sexual dysfunction. |
2021-06-30 |
2023-08-13 |
Not clear |
| Joana Santos, Maria Fernanda Proença, Ana Joao Rodrigues, Patricia Patrício, Helena Sofia Domingue. Recent Advances in the Synthesis of the Antidepressant Paroxetine. Current medicinal chemistry. vol 28. issue 15. 2021-06-14. PMID:33106133. |
paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. |
2021-06-14 |
2023-08-13 |
Not clear |
| Weiyan Zhou, Hongbo Yang, Haifeng Wan. Inverse in silico-in vitro fishing of unexpected paroxetine kinase targets from tumor druggable kinome. Journal of molecular modeling. vol 26. issue 8. 2021-05-27. PMID:32623519. |
the serotonin selective reuptake inhibitor paroxetine has been clinically observed to reposition a significant suppressing potency on human tumors by unexpectedly targeting diverse kinase pathways involved in tumorigenesis. |
2021-05-27 |
2023-08-13 |
human |
| Omar Al-Radideh, Kok Hoe Chan, Shawn Gupta, Jihad Slim, Sharath Bellar. Concurrent Serotonin Syndrome and Prolong QT Interval Induced by Paroxetine Overdose With Isotretinoin. Cureus. vol 13. issue 4. 2021-05-20. PMID:34007750. |
concurrent serotonin syndrome and prolong qt interval induced by paroxetine overdose with isotretinoin. |
2021-05-20 |
2023-08-13 |
Not clear |
| Yu Miyahara, Hideki Funahashi, Rumi Naono-Nakayama, Ayaka Haruta-Tsukamoto, Chiyo Muroi, Yoichiro Kogoh, Toshikazu Nishimori, Yasushi Ishid. Serotonin and noradrenaline modulate chronic itch processing in mice. European journal of pharmacology. vol 883. 2021-05-18. PMID:32619678. |
the administration of a serotonin reuptake inhibitor, such as fluvoxamine and paroxetine, but not escitalopram, or a noradrenaline reuptake inhibitor, such as atomoxetine and nisoxetine, ameliorated the induction of spontaneous scratching behavior in mice with chronic itch. |
2021-05-18 |
2023-08-13 |
mouse |
| Caitrin Crudden, Takashi Shibano, Dawei Song, Mihnea P Dragomir, Sonia Cismas, Julianna Serly, Daniela Nedelcu, Enrique Fuentes-Mattei, Andrei Tica, George A Calin, Ada Girnita, Leonard Girnit. Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. Cancer research. vol 81. issue 2. 2021-05-03. PMID:33158816. |
pharmacologic inhibition of grk2 by the clinically approved antidepressant, serotonin reuptake inhibitor paroxetine (px), recapitulated the effects of grk2 silencing with dose- and time-dependent igf1r downregulation without associated β-arr-bs. |
2021-05-03 |
2023-08-13 |
Not clear |
| Mark W Mille. Leveraging genetics to enhance the efficacy of PTSD pharmacotherapies. Neuroscience letters. vol 726. 2021-04-19. PMID:29689343. |
this paper provides a review of the pharmacogenetics of the four serotonin reuptake inhibitors (sris) that are currently endorsed for the treatment of ptsd (paroxetine, sertraline, fluoxetine and venlafaxine). |
2021-04-19 |
2023-08-13 |
Not clear |
| Karl T Re. Men's Health: Male Sexual Dysfunction. FP essentials. vol 503. 2021-04-19. PMID:33856181. |
first-line treatment options include daily selective serotonin reuptake inhibitors (eg, paroxetine), on-demand clomipramine, and topical penile anesthetics. |
2021-04-19 |
2023-08-13 |
human |
| Jonathan A Coleman, Vikas Navratna, Daniele Antermite, Dongxue Yang, James A Bull, Eric Gouau. Chemical and structural investigation of the paroxetine-human serotonin transporter complex. eLife. vol 9. 2021-04-16. PMID:32618269. |
these studies provide mutually consistent insights into how paroxetine and its analogues bind to the central substrate-binding site of sert, stabilize the outward-open conformation, and inhibit serotonin transport. |
2021-04-16 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Jacek Nowaczyk, Łukasz Fijałkowski, Alicja Nowaczy. Paroxetine-Overview of the Molecular Mechanisms of Action. International journal of molecular sciences. vol 22. issue 4. 2021-04-12. PMID:33562229. |
recent studies indicate that paroxetine (atc code: n06ab), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. |
2021-04-12 |
2023-08-13 |
Not clear |
| Ya Bin Wei, Michael McCarthy, Hongyan Ren, Tania Carrillo-Roa, Tatyana Shekhtman, Anna DeModena, Jia Jia Liu, Susan G Leckband, Ole Mors, Marcella Rietschel, Neven Henigsberg, Annamaria Cattaneo, Elisabeth B Binder, Katherine J Aitchison, John R Kelso. A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30874608. |
in this report, in the first stage, we used a cost-effective pooled-sequencing strategy to sequence the entire htr7 gene and its regulatory regions to investigate the association of common variants in htr7 and clinical response to four selective serotonin reuptake inhibitors (ssris: citalopram, paroxetine, fluoxetine and sertraline) in a retrospective cohort mainly consisting of subjects with bipolar disorder (n = 359). |
2021-03-09 |
2023-08-13 |
human |
| Mahdieh Kabiri, Anahid Hemmatpour, Fatemeh Zare, Hossein Hadinedoushan, Alireza Karimolla. Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32020710. |
paroxetine, a representative of serotonin reuptake inhibitors, has recently gained attention due to its anti-inflammatory properties. |
2021-01-07 |
2023-08-13 |
human |
| Mahdieh Kabiri, Anahid Hemmatpour, Fatemeh Zare, Hossein Hadinedoushan, Alireza Karimolla. Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32020710. |
in conclusion, paroxetine can exert its anti-inflammatory effects via both the 5-ht systems present in immune cells and the jak2-stat3 pathway. |
2021-01-07 |
2023-08-13 |
human |
| Mahdieh Kabiri, Anahid Hemmatpour, Fatemeh Zare, Hossein Hadinedoushan, Alireza Karimolla. Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32020710. |
our results also suggest that paroxetine exerted its immunosuppressive effects partially via serotonin. |
2021-01-07 |
2023-08-13 |
human |