| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahdieh Kabiri, Anahid Hemmatpour, Fatemeh Zare, Hossein Hadinedoushan, Alireza Karimolla. Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32020710. |
nonetheless, jak2/stat3-modulated paroxetine effects were independent of serotonin, hence sufficiently applicable for inflammation repression. |
2021-01-07 |
2023-08-13 |
human |
| Timothy R Hudd, Christie S Blake, Yahiada Rimola-Dejesus, Thu-Trang Nguyen, Kathy Zaike. A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy. Journal of pharmacy practice. vol 33. issue 2. 2021-01-04. PMID:31030620. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) with several indications, one of which is for depression. |
2021-01-04 |
2023-08-13 |
Not clear |
| Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang, Jian-Hong Zh. Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes. Journal of neuroinflammation. vol 17. issue 1. 2020-11-23. PMID:32024542. |
we have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates lps-induced microglia activation. |
2020-11-23 |
2023-08-13 |
Not clear |
| Xiuqing Tian, Qing Wang, Rui Guo, Lingling Xu, Qin M Chen, Yinglong Ho. Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction. Neuropsychiatric disease and treatment. vol 12. 2020-10-01. PMID:27695334. |
paroxetine is a selective serotonin reuptake inhibitor utilized in the treatment of depression and anxiety disorders. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiuqing Tian, Qing Wang, Rui Guo, Lingling Xu, Qin M Chen, Yinglong Ho. Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction. Neuropsychiatric disease and treatment. vol 12. 2020-10-01. PMID:27695334. |
we determine the clinical importance of paroxetine on cardiac functions in patients having ami with depression (amid) in comparison with fluoxetine, an unrelated selective serotonin reuptake inhibitor that does not inhibit grk2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shelly L Gray, Joseph T Hanlo. Anticholinergic medication use and dementia: latest evidence and clinical implications. Therapeutic advances in drug safety. vol 7. issue 5. 2020-10-01. PMID:27695623. |
in contrast, a study conducted in nursing-home residents with depression did not find that paroxetine [a highly anticholinergic selective serotonin reuptake inhibitor antidepressant, (ssri)] increased risk for dementia compared with other ssris (without anticholinergic activity). |
2020-10-01 |
2023-08-13 |
Not clear |
| Ravi Doobay, Lili Sun, Amish Shah, Pardeep Masuta, Zachary Shepher. SSRI Facilitated Crack Dancing. Case reports in neurological medicine. vol 2017. 2020-10-01. PMID:28487792. |
we present a 32-year-old male who had been using cocaine for many years and was recently started on paroxetine, a selective serotonin reuptake inhibitor (ssri) for worsening depression four weeks before presentation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hyang Mi Lee, Ok Hee Chai, Sang June Hahn, Bok Hee Cho. Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 22. issue 1. 2020-10-01. PMID:29302214. |
to determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (ssri), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on kv3.1 potassium channels, which contribute to highfrequency firing of interneurons, using the whole-cell patch-clamp technique. |
2020-10-01 |
2023-08-13 |
rat |
| Shen He, Duan Zeng, Feikang Xu, Jianping Zhang, Nan Zhao, Qiang Wang, Jiali Shi, Zhiguang Lin, Wenjuan Yu, Huafang L. Baseline Serum Levels of Beclin-1, but Not Inflammatory Factors, May Predict Antidepressant Treatment Response in Chinese Han Patients With MDD: A Preliminary Study. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31244689. |
forty patients with mdd were treated with either a selective serotonin reuptake inhibitor (ssri) (paroxetine in 20 cases) or a serotonin-norepinephrine reuptake inhibitor (snri) (duloxetine in 13 cases and venlafaxine in 7 cases). |
2020-10-01 |
2023-08-13 |
Not clear |
| Maurizio Severino, Mithula Sivasaravanaparan, Louise Ø Olesen, Christian U von Linstow, Athanasios Metaxas, Elena V Bouzinova, Asif Manzoor Khan, Kate L Lambertsen, Alicia A Babcock, Jan Bert Gramsbergen, Ove Wiborg, Bente Finse. Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-09-29. PMID:29955664. |
established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine. |
2020-09-29 |
2023-08-13 |
Not clear |
| Frederik Dethloff, Fernando Vargas, Emmanuel Elijah, Robert Quinn, Dong Ik Park, David P Herzog, Marianne B Müller, Emily C Gentry, Rob Knight, Antonio Gonzalez, Pieter C Dorrestein, Christoph W Turc. Paroxetine Administration Affects Microbiota and Bile Acid Levels in Mice. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32581888. |
in the current study we chronically treated dba/2j mice for 2 weeks with paroxetine, a selective serotonin reuptake inhibitor, and collected fecal pellets as a proxy for the gut microbiota from the animals after 7 and 14 days. |
2020-09-28 |
2023-08-13 |
mouse |
| Shrutakirthi D Shenoi, Savitha Soman, Ravindra Munoli, Smitha Prabh. Update on Pharmacotherapy in Psychodermatological Disorders. Indian dermatology online journal. vol 11. issue 3. 2020-09-28. PMID:32695685. |
the commonly used antidepressants in dermatology include selective serotonin reuptake inhibitors (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), selective serotonin norepinephrine reuptake inhibitors (venlafaxine, desvenlefaxine, and duloxetine), norepinephrine dopamine reuptake inhibitors (bupropion), tricyclic antidepressants (doxepin, amitriptyline, imipramine, and clomipramine), and tetracyclic antidepressants (mirtazapine). |
2020-09-28 |
2023-08-13 |
Not clear |
| J V Pinkerton, R J Sante. Managing vasomotor symptoms in women after cancer. Climacteric : the journal of the International Menopause Society. vol 22. issue 6. 2020-09-16. PMID:31081391. |
randomized controlled trials have shown efficacy for vasomotor symptoms with selective serotonin reuptake inhibitors (paroxetine, citalopram, and escitalopram) and serotonin-norepinephrine reuptake inhibitors (venlafaxine and desvenlafaxine), as well as gabapentin, pregabalin, and clonidine. |
2020-09-16 |
2023-08-13 |
Not clear |
| Guangsen Li, Degui Chang, Di'ang Chen, Peihai Zhang, Yaodong You, Xiaopeng Huang, Jian Ca. Selective dorsal neurotomy in the treatment of premature ejaculation: A protocol for systematic review and meta-analysis. Medicine. vol 99. issue 34. 2020-09-08. PMID:32846840. |
at present, the major treatments include selective serotonin reuptake inhibitors antidepressants (dapoxetine, paroxetine), topical anesthetics, phosphodiesterase-5 inhibitor, circumcision, and selective dorsal neurotomy (sdn). |
2020-09-08 |
2023-08-13 |
Not clear |
| Rachel D Slack, Ara M Abramyan, Helen Tang, Sitaram Meena, Bruce A Davis, Alessandro Bonifazi, JoLynn B Giancola, Jeffrey R Deschamps, Sett Naing, Hideaki Yano, Satinder K Singh, Amy Hauck Newman, Lei Sh. A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter. ACS chemical neuroscience. vol 10. issue 9. 2020-08-31. PMID:31424193. |
a novel bromine-containing paroxetine analogue provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter. |
2020-08-31 |
2023-08-13 |
human |
| Hatylas Azevedo, Marcos Ferreira, Renata Watanabe Costa, Valter Russo, Elisa Russo, Alessandra Mascarello, Cristiano Ruch Werneck Guimarãe. Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31330215. |
the anxiolytic activity was comparable to that observed for serotonin reuptake inhibitors (paroxetine and fluoxetine) and benzodiazepines (alprazolam, diazepam and clobazam). |
2020-08-26 |
2023-08-13 |
Not clear |
| Toshiro Niwa, Shizuya Sugimot. Inhibitory and Stimulatory Effects of Selective Serotonin Reuptake Inhibitors on Cytochrome P450 2D6-mediated Dopamine Formation from p-Tyramine. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 22. issue 1. 2020-08-10. PMID:31804922. |
the effects of selective serotonin reuptake inhibitors (ssris) such as fluoxetine and paroxetine on dopamine formation from p-tyramine, mediated by cytochrome p450 (cyp) 2d6.2 (arg296cys, ser486thr) and cyp2d6.10 (pro34ser, ser486thr), were compared with their effects on cyp2d6.1 (wild type)-mediated dopamine formation, to investigate the influence of a cyp2d6 polymorphism on neuroactive amine metabolism in the brain. |
2020-08-10 |
2023-08-13 |
Not clear |
| Won-Jun Jang, Sung Keun Jung, Tam Thuy Lu Vo, Chul-Ho Jeon. Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-06-17. PMID:30421568. |
paroxetine, one of the selective serotonin reuptake inhibitors (ssris), has been widely prescribed for the treatment of depression and anxiety disorders. |
2020-06-17 |
2023-08-13 |
mouse |
| Keisuke Obara, Satoko Imanaka, Hiroka Fukuhara, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanak. Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles. Clinical and experimental pharmacology & physiology. vol 46. issue 5. 2020-06-10. PMID:30737814. |
paroxetine, a selective serotonin reuptake inhibitor (ssri), potentiated na-induced contraction at the distal urethra, while na-induced contraction was unaffected by fluvoxamine, sertraline, and escitalopram at the proximal and distal urethra. |
2020-06-10 |
2023-08-13 |
Not clear |
| Masayuki Uchida, Orie Kobayash. Novel effect of α-lactalbumin on the yohimbine-induced hot flush increase of the tail skin temperature in ovariectomized rats. Bioscience, biotechnology, and biochemistry. vol 82. issue 5. 2020-05-25. PMID:29504865. |
then, to clarify the relation between serotonergic and adrenergic nervous systems on the mechanism of hot flush, the effect of paroxetine, 5-ht reuptake inhibitor (ssri) was evaluated on the yohimbine-induced hot flush increase of tail skin temperature in ovariectomized female rats. |
2020-05-25 |
2023-08-13 |
rat |