| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaki Kato, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Keiichiro Nishida, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshit. Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409234. |
this randomized control trial examined mirnas correlated with the early therapeutic effect of selective serotonin reuptake inhibitors (ssris; paroxetine or sertraline) and mirtazapine monotherapy. |
2022-04-12 |
2023-08-13 |
human |
| Miguel Ángel Bruni-Montero, José Manuel Caro-Teller, José Antonio Hernández-Ramos, Cristian Rosas-Espinoza, Dolores Canales-Siguero, José Miguel Ferrari-Piquer. Rivaroxaban and selective serotonin reuptake inhibitors: Bleeding risk resulting from their concomitant use. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. vol 46. issue 1. 2022-04-05. PMID:35379086. |
the combination of selective serotonin reuptake inhibitors with rivaroxaban may result in a dual interaction (pharmacokinetic and pharmacodynamic) depending on the type of selective serotonin reuptake inhibitor employed (cyp3a4-inhibiting vs. non-cyp3a4 inhibiting). the purpose of this study was to use real world data to determine if the type of selective serotonin reuptake inhibitor used plays a role in the risk and severity of bleeding in patients receiving rivaroxaban. method: this was a single-center retrospective longitudinal observational study carried out between january 2016 and february 2020 in patients aged 18 years or older treated concurrently with rivaroxaban (prescribed for treatments) and a selective serotonin reuptake nhibitor. patients were divided into two groups according to the selective serotonin reuptake inhibitor they received, i.e., a cyp3a4 inhibitor (group 1): sertraline, fluoxetine and paroxetine, or a non-cyp3a4 inhibitor (group 2): citalopram and escitalopram. |
2022-04-05 |
2023-08-13 |
Not clear |
| Cinthya Eloisa Chávez-Castillo, Julia Sagahón-Azúa, Karla Itzel Velasco-Gloria, Susanna Edith Medellín-Garibay, Rosa Del Carmen Milán-Segovia, Silvia Romano-Moren. Simultaneous determination of four serotonin selective reuptake inhibitors by an UPLC MS-MS method with clinical application in therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1193. 2022-02-22. PMID:35193100. |
an analytical method of ultra-high performance liquid chromatography coupled to tandem mass spectrometry detection was developed and validated for the simultaneous quantification in plasma of four selective serotonin reuptake inhibitor antidepressants: sertraline, escitalopram, paroxetine, fluoxetine, and its metabolite norfluoxetine. |
2022-02-22 |
2023-08-13 |
Not clear |
| Kuo-Hsuan Chang, Chiung-Mei Chen, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chan. Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants. Frontiers in aging neuroscience. vol 14. 2022-02-21. PMID:35185526. |
an increased risk of intracerebral hemorrhage (ich) was associated with the combinations of doacs with selective serotonin reuptake inhibitors (ssris, arr: 1.38, 95% ci: 1.08-1.76), particularly in paroxetine (arr: 2.11, 95% ci: 1.17-3.81), and tetracyclic antidepressants (tecas, arr: 1.34, 95% ci: 1.01-1.78). |
2022-02-21 |
2023-08-13 |
Not clear |
| Wisam Al Jumaili, Chintan Trivedi, Timothy Chao, Aaron Kubosumi, Shailesh Jai. The safety and efficacy of Ketamine NMDA receptor blocker as a therapeutic intervention for PTSD review of a randomized clinical trial. Behavioural brain research. 2022-02-19. PMID:35181391. |
the us food drug administration (fda) has approved only two serotonin selective reuptake inhibitors (ssri), sertraline, and paroxetine as pharmacological interventions for ptsd. |
2022-02-19 |
2023-08-13 |
Not clear |
| Peter Tyrer, Helen Tyrer, Min Yan. Relationships between treatments received in the Nottingham Study of Neurotic Disorder over 30 years and personality status. Personality and mental health. 2022-01-04. PMID:34981662. |
over 30 years, patients with dependent and anankastic personality disturbance and cothymia (the general neurotic syndrome) were 2.27 times more likely to receive selective serotonin reuptake inhibitors (ssris) and new antidepressants (95% confidence interval [ci]: 1.22-4.24), particularly paroxetine, and were 1.6 weeks (95% ci: 1.2-2.3) longer on the drug than those without the syndrome. |
2022-01-04 |
2023-08-13 |
Not clear |
| Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blie. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2021-12-27. PMID:34958348. |
differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. |
2021-12-27 |
2023-08-13 |
Not clear |
| Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blie. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2021-12-27. PMID:34958348. |
paroxetine is generally considered as a selective serotonin reuptake inhibitor but exhibits some affinity for net. |
2021-12-27 |
2023-08-13 |
Not clear |
| Ian D Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G Bellocchio, Travis Josephs, Sandra J Rosentha. A Novel Biotinylated Homotryptamine Derivative for Quantum Dot Imaging of Serotonin Transporter in Live Cells. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867196. |
we demonstrated that idt785 enabled quantum dot (qd) labeling of membrane sert in transfected hek-293 cultures that could be blocked using the high affinity serotonin reuptake inhibitor paroxetine. |
2021-12-07 |
2023-08-13 |
Not clear |
| Selin Acar, Hilal Erol, Elif Keskin Arslan, Nusret Uysal, Barış Karadaş, Tijen Kaya Temiz, Yusuf Cem Kapla. Paroxetine overdose during pregnancy. Forensic sciences research. vol 6. issue 3. 2021-12-07. PMID:34868717. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) used in the treatment of depression and anxiety disorders. |
2021-12-07 |
2023-08-13 |
Not clear |
| Tyler Thomas Henderson, Jacob R Thorstensen, Steven Morrison, Murray G Tucker, Justin J Kavanag. Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue. Journal of neurophysiology. 2021-12-01. PMID:34851768. |
the selective serotonin reuptake inhibitor, paroxetine, suppressed physiological tremor and increased force steadiness when performing the isometric contractions. |
2021-12-01 |
2023-08-13 |
Not clear |
| Ahmed Hassen Elshafeey, Rania Moataz El-Dahm. Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers. Pharmaceutics. vol 13. issue 11. 2021-11-29. PMID:34834284. |
paroxetine (px) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. |
2021-11-29 |
2023-08-13 |
human |
| B Raccah-Tebeka, G Boutet, G Plu-Burea. [Non-hormonal alternatives for the management of menopausal hot flushes. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines]. Gynecologie, obstetrique, fertilite & senologie. vol 49. issue 5. 2021-11-24. PMID:33757925. |
hence, some selective serotonin reuptake inhibitors (paroxetine, citalopram and escitalopram), serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine) gabapentin, pregabalin and clonidine have a statistically effect as compared with placebo in reducing, the frequency and/or severity of hf. |
2021-11-24 |
2023-08-13 |
Not clear |
| Soobeen Hwang, Jong-Hui Kim, Su-Hyun J. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. European journal of pharmacology. vol 912. 2021-11-22. PMID:34662565. |
inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human kv1.3 channels. |
2021-11-22 |
2023-08-13 |
human |
| Soobeen Hwang, Jong-Hui Kim, Su-Hyun J. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. European journal of pharmacology. vol 912. 2021-11-22. PMID:34662565. |
paroxetine is one of the most effective selective serotonin reuptake inhibitors used to treat depressive and panic disorders that reduce the viability of human t lymphocytes, in which kv1.3 channels are highly expressed. |
2021-11-22 |
2023-08-13 |
human |
| Gohei Yamada, Takanari Toyoda, Eiichi Katada, Noriyuki Matsukaw. Index finger pointing posture in a patient with drug-induced foot tremor. Clinical parkinsonism & related disorders. vol 5. 2021-10-26. PMID:34693272. |
co-administration of paroxetine and tramadol increases the risk of serotonin toxicity. |
2021-10-26 |
2023-08-13 |
Not clear |
| Yogesh S Singh, Lauren E Sawarynski, Heather M Michael, Robert E Ferrell, Michael A Murphey-Corb, Greg M Swain, Bhavik A Patel, Anne M Andrew. Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short Allele of the 5-HTTLPR. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352073. |
serotonin clearance by lymphocytes is na(+)-dependent and inhibited by the serotonin-selective reuptake inhibitor paroxetine (paxil®), indicative of active uptake by serotonin transporters. |
2021-10-20 |
2023-08-12 |
monkey |
| Hiltrud Brauch, Werner Schroth, Michel Eichelbaum, Matthias Schwab, Nadia Harbec. Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer. Breast care (Basel, Switzerland). vol 3. issue 1. 2021-10-20. PMID:20824020. |
moreover, strong cyp2d6 inhibitors such as the selective serotonin reuptake inhibitor paroxetine should be avoided as co-medication. |
2021-10-20 |
2023-08-12 |
Not clear |
| Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Ca. Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension. Journal of the American Heart Association. vol 10. issue 1. 2021-10-18. PMID:33372534. |
meanwhile, we discovered a selective serotonin reuptake inhibitor paroxetine specifically blockades grk2 and adrb1 interaction. |
2021-10-18 |
2023-08-13 |
rat |
| Li Chen, Jincheng Wang, Tyllis Xu, Xinrui Feng, Chuixiu Huang, Xiantao She. Recent sample pretreatment methods for determination of selective serotonin reuptake inhibitors (SSRIs) in biological samples. Journal of pharmaceutical and biomedical analysis. vol 206. 2021-10-13. PMID:34543943. |
selective serotonin reuptake inhibitors (ssris) such as fluoxetine (flu), sertraline (ser), paroxetine (par), fluvoxamine (flv) and citalopram (cit) have been the first treatment drugs for pregnant and breastfeeding women. |
2021-10-13 |
2023-08-13 |
Not clear |