| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn Justesen, Darien Jourdain. Peripartum Depression: Detection and Treatment. American family physician. vol 108. issue 3. 2023-09-19. PMID:37725459. |
the benefits of selective serotonin reuptake inhibitors generally outweigh the risks; however, fluoxetine and paroxetine should be avoided during pregnancy because they can cause an increased risk of birth defects. |
2023-09-19 |
2023-10-07 |
Not clear |
| Flávia Luciana Beltrame, Thiago Henrique Pereira Moysés, Mônica Pereira Coelho, Maria Clara Rossetto Steinvascher, Salmo Azambuja de Oliveira, André Acácio Souza da Silva, Paulo Sérgio Cerri, Estela Sasso-Cerr. Role of serotonin, estrogen, and TNF-α in the paroxetine-impaired steroidogenesis and testicular macrophages polarization. Andrology. 2023-09-07. PMID:37675929. |
paroxetine, a selective serotonin reuptake inhibitor (ssri) antidepressant, has caused male sexual dysfunction; however, the paroxetine mechanisms of action in testes are still unclear. |
2023-09-07 |
2023-10-07 |
Not clear |
| Francesca R Brugnoli, Marion Holy, Marco Niello, Julian Maier, Marcus Hanreich, Mario Menzel, Matthias Haberler, Niklas Zulus, Thomas Pickl, Christa Ivanova, Lisa D Muiznieks, Benjamin Garlan, Harald H Sitt. Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro. Basic & clinical pharmacology & toxicology. 2023-09-02. PMID:37658634. |
d-amphetamine, gbr12909 (norepinephrine transporter) and p-chloroamphetamine, paroxetine (serotonin transporter) were used as control compounds to validate the system. |
2023-09-02 |
2023-09-07 |
Not clear |
| Khalid AlHezaimi, Ilan Rotstein, Joseph Katz, Marc Nevins, Myron Nevin. Effect of selective serotonin reuptake inhibitor (paroxetine) on newly formed bone volume: Real time in vivo micro computed tomographic analysis. Journal of endodontics. 2023-08-18. PMID:37595681. |
effect of selective serotonin reuptake inhibitor (paroxetine) on newly formed bone volume: real time in vivo micro computed tomographic analysis. |
2023-08-18 |
2023-10-07 |
Not clear |
| Harika Topal Önal, Derya Yetkin, Furkan Aya. Paroxetine's effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-17. PMID:37589738. |
paroxetine works by increasing serotonin levels in nerve cells in the brain. |
2023-08-17 |
2023-09-07 |
Not clear |
| G Tcherne. NITROSOGENESIS OF SKIN CANCER: THE NITROSAMINE CONTAMINATION IN THE CALCIUM CHANNEL BLOCKERS (AMLODIPINE), BETA BLOCKERS (BISOPROLOL), SARTANS (VALSARTAN/LOSARTAN), ACE INHIBITORS (PERINDOPRIL/ENALAPRIL), TRICYCLIC ANTIDEPRESSANTS (MELITRACEN), SSRIS (PAROXETINE), SNRIS (VENLAFAXINE) AND METFORMIN: THE MOST PROBABLE EXPLANATION FOR THE RISING SKIN CANCER INCIDENCE. Georgian medical news. issue 339. 2023-07-31. PMID:37522769. |
the possible contamination with nitrosamines of 1) other types of tricyclic antidepressant- melitracen; 2) antidepressant of the selective serotonin reuptake inhibitor (ssri) class: paroxetine; 3) antidepressant of the serotonin and noradrenaline reuptake inhibitor (snris) class: venlafaxine, as well as of the systemic anticoagulant: apixaban is highlighted for the first time in the world literature. |
2023-07-31 |
2023-08-14 |
human |
| Carla S S Ferreira, Cátia Venâncio, Peter Kille, Miguel Oliveir. Are early and young life stages of fish affected by paroxetine? A case study with Danio rerio. The Science of the total environment. 2023-07-27. PMID:37499832. |
paroxetine (par) is a selective serotonin reuptake inhibitor (ssri) antidepressant increasingly detected in surface waters worldwide. |
2023-07-27 |
2023-08-14 |
zebrafish |
| Yasemin Hoşgören Alıcı, Müge Kuzu Kumc. Potential Effect of Vortioxetine on Restless Leg Syndrome. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 21. issue 3. 2023-07-10. PMID:37424427. |
it has been reported that serotonin-noradrenaline reuptake inhibitors such as venlafaxine and selective serotonin reuptake inhibitors such as citalopram, fluoxetine, paroxetine, and sertraline can cause rls symptoms. |
2023-07-10 |
2023-08-14 |
Not clear |
| Tian-Shun Shi, Wei-Yu Li, Yan-Mei Chen, Jie Huang, Wei Guan, Da-Wei Xu, Bo Jian. The antidepressant-like effects of escitalopram in mice require salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus of the hypothalamus. Journal of affective disorders. 2023-05-31. PMID:37257779. |
like fluoxetine and paroxetine, escitalopram is also a well-known selective serotonin (5-ht) reuptake inhibitor (ssri). |
2023-05-31 |
2023-08-14 |
mouse |
| Jiawei Zhang, Xianzheng Zhang, Mingdian Lu, Yan Chang, Qingtong Wang, Jiajie Tu, Huaxun Wu, Chun Wang, Zhongyang Hong, Maoming Xiong, Lihua Song, Wei We. GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242446. |
paroxetine is acknowledged as one of the selective serotonin reuptake inhibitors (ssri), which is also considered as a potent grk2 inhibitor with a high selectivity for grk2. |
2023-05-27 |
2023-08-14 |
mouse |
| Chad A Bousman, James M Stevenson, Laura B Ramsey, Katrin Sangkuhl, J Kevin Hicks, Jeffrey R Strawn, Ajeet B Singh, Gualberto Ruaño, Daniel J Mueller, Evangelia Eirini Tsermpini, Jacob T Brown, Gillian C Bell, J Steven Leeder, Andrea Gaedigk, Stuart A Scott, Teri E Klein, Kelly E Caudle, Jeffrey R Bisho. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clinical pharmacology and therapeutics. 2023-04-09. PMID:37032427. |
serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (ssris; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (snris; i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with ssri-like properties (i.e., vilazodone and vortioxetine) are primary pharmacologic treatments for major depressive and anxiety disorders. |
2023-04-09 |
2023-08-14 |
Not clear |
| Kristine Hole, Tore Haslemo, Espen Molde. Impact of CYP2D6 Genotype on Paroxetine Serum Concentration. Therapeutic drug monitoring. 2023-04-04. PMID:37012633. |
paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome p450 (cyp)2d6. |
2023-04-04 |
2023-08-14 |
Not clear |
| Zachary Sartor, Lance Kelley, Ryan Laschobe. Posttraumatic Stress Disorder: Evaluation and Treatment. American family physician. vol 107. issue 3. 2023-03-15. PMID:36920821. |
selective serotonin reuptake inhibitors (i.e., fluoxetine, paroxetine, and sertraline) and the serotonin-norepinephrine reuptake inhibitor venlafaxine effectively treat primary ptsd symptoms. |
2023-03-15 |
2023-08-14 |
Not clear |
| Ananda Baskaran Venkatachalam, Bailey Levesque, John C Achenbach, Jane J Pappas, Lee D Elli. Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction. Toxics. vol 11. issue 2. 2023-02-28. PMID:36851026. |
long and short duration exposures to the selective serotonin reuptake inhibitors (ssris) fluoxetine, paroxetine and sertraline at environmentally relevant concentrations lead to adverse effects on zebrafish behaviour and reproduction. |
2023-02-28 |
2023-08-14 |
human |
| Luke R Cavanah, Jessica L Goldhirsh, Leighton Y Huey, Brian J Pipe. Specialty-type and state-level variation in paroxetine use among older adult patients. medRxiv : the preprint server for health sciences. 2023-02-24. PMID:36824839. |
paroxetine is an older "selective" serotonin reuptake inhibitor (ssri) that is notable for its lack of selectivity, resulting in a cholinergic adverse-effect profile, especially among older adults (65+). |
2023-02-24 |
2023-08-14 |
Not clear |
| Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J Hillard, Irit Akira. FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555739. |
we compared the effects of treatment with the fatty acid amide hydrolase (faah) inhibitor urb597, and the selective serotonin reuptake inhibitor paroxetine, on els-induced depressive-like behavior and the expression of micrornas (mirs) associated with depression in the medial prefrontal cortex (mpfc), hippocampal ca1 area, lateral habenula and dorsal raphe in rats. |
2022-12-23 |
2023-08-14 |
rat |
| Mark Abie Horowitz, Adele Framer, Michael P Hengartner, Anders Sørensen, David Taylo. Estimating Risk of Antidepressant Withdrawal from a Review of Published Data. CNS drugs. 2022-12-13. PMID:36513909. |
serotonin and noradrenaline reuptake inhibitors and paroxetine are associated with higher risks than other antidepressants, though data for some antidepressants are lacking. |
2022-12-13 |
2023-08-14 |
Not clear |
| Reyhane Aghajani, Marziyeh Tavalaee, Niloofar Sadeghi, Mazdak Razi, Parviz Gharagozloo, Maryam Arbabian, Joël R Drevet, Mohammad Hossein Nasr-Esfahan. Paroxetine treatment in an animal model of depression improves sperm quality. PloS one. vol 17. issue 12. 2022-12-08. PMID:36480503. |
we further show that administration of a conventional antidepressant of the serotonin reuptake inhibitor class (paroxetine) impairs male reproductive performance in terms of sperm production and quality when administered to healthy animals. |
2022-12-08 |
2023-08-14 |
mouse |
| Farzaneh Motafeghi, Romina Shahsavari, Parham Mortazavi, Mohammad Shokrzade. Anticancer effect of paroxetine and amitriptyline on HT29 and A549 cell lines. Toxicology in vitro : an international journal published in association with BIBRA. 2022-12-02. PMID:36460226. |
paroxetine is functionally classified as a selective serotonin reuptake inhibitor. |
2022-12-02 |
2023-08-14 |
Not clear |
| Faruk Ugu. The Relationship Between Maternal Antidepressants and Neonatal Hypoglycemia: A Systematic Review. Alpha psychiatry. vol 22. issue 5. 2022-11-30. PMID:36447450. |
the searched keywords were as follows: antidepressants, pregnancy, selective serotonin reuptake inhibitors (ssris), citalopram, fluoxetine, paroxetine, escitalopram, sertraline, fluvoxamine, selective serotonin-norepinephrine reuptake inhibitors (snris), venlafaxine, tricyclic antidepressants (tcas), neonatal outcomes, neonatal hypoglycemia, imipramine, clomipramine, amitriptyline, bupropion, trazodone, and mirtazapine. |
2022-11-30 |
2023-08-14 |
Not clear |