| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Endrit Ziu, Charles P Mercado, Yicong Li, Preeti Singh, Billow A Ahmed, Samuel Freyaldenhoven, Shelly Lensing, Jerry Ware, Fusun Kili. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. Journal of molecular and cellular cardiology. vol 52. issue 5. 2012-08-07. PMID:22366712. |
5-ht-infused mice were treated with paroxetine (prx) to block 5-ht uptake via the serotonin transporter (sert). |
2012-08-07 |
2023-08-12 |
mouse |
| Byung-Sang Lee, In-Gu Jun, Sung-Hoon Kim, Jong Yeon Par. Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain. Journal of Korean medical science. vol 27. issue 4. 2012-07-18. PMID:22468108. |
citalopram and paroxetine are selective serotonin reuptake inhibitors and also have antinociceptive effects. |
2012-07-18 |
2023-08-12 |
rat |
| Byung-Sang Lee, In-Gu Jun, Sung-Hoon Kim, Jong Yeon Par. Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain. Journal of Korean medical science. vol 27. issue 4. 2012-07-18. PMID:22468108. |
we suggest that the mu opioid receptor and serotonin receptors play major roles in production of the antiallodynic and antihyperalgesic effects of morphine, citalopram, paroxetine, and combinations thereof, in animals experiencing inflammatory pain. |
2012-07-18 |
2023-08-12 |
rat |
| Molly L Rovin, Katherine A Boss-Williams, Reid S Alisch, James C Ritchie, David Weinshenker, Charles H K West, Jay M Weis. Influence of chronic administration of antidepressant drugs on mRNA for galanin, galanin receptors, and tyrosine hydroxylase in catecholaminergic and serotonergic cell-body regions in rat brain. Neuropeptides. vol 46. issue 2. 2012-07-17. PMID:22317959. |
the present study examined the influence of chronic administration (for 14days, via subcutaneously-implanted minipump) of antidepressant (ad) drugs representing three different classes (tricyclic [desipramine], selective serotonin reuptake inhibitor [ssri] [paroxetine], and monoamine oxidase inhibitor [maoi] [phenelzine]) on mrna for gal, gal receptors (galr1, galr2, and galr3), and tyrosine hydroxylase (th), the rate-limiting enzyme for ne synthesis, in four brain regions--lc, a1/c1, dorsal raphe (drn), and ventral tegmentum (vta) of rats. |
2012-07-17 |
2023-08-12 |
rat |
| Junji Saruwatari, Norio Yasui-Furukori, Takenori Niioka, Yumiko Akamine, Ayaka Takashima, Sunao Kaneko, Tsukasa Un. Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers. Journal of clinical psychopharmacology. vol 32. issue 2. 2012-06-18. PMID:22367658. |
different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers. |
2012-06-18 |
2023-08-12 |
human |
| M Franklin, I Bermudez, H Murck, N Singewald, S Gaburr. Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. Journal of psychiatric research. vol 46. issue 2. 2012-05-25. PMID:22074993. |
5-ht(2) receptor binding bmax was enhanced but was reversed by paroxetine. |
2012-05-25 |
2023-08-12 |
rat |
| Birgit Abler, Angela Seeringer, Antonie Hartmann, Georg Grön, Coraline Metzger, Martin Walter, Julia Sting. Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled fMRI study on healthy males under subchronic paroxetine and bupropion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 9. 2012-05-08. PMID:21544071. |
sexual dysfunction is a common side effect of selective serotonin reuptake inhibitors (ssris) like paroxetine in the treatment of depression, imposing a considerable risk on medication adherence and hence therapeutic success. |
2012-05-08 |
2023-08-12 |
Not clear |
| Nicolas Ansermot, Marlyse Brawand-Amey, Chin B Ea. Simultaneous quantification of selective serotonin reuptake inhibitors and metabolites in human plasma by liquid chromatography-electrospray mass spectrometry for therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 885-886. 2012-05-04. PMID:22285965. |
a simple and sensitive liquid chromatography-electrospray ionization mass spectrometry method was developed for the simultaneous quantification in human plasma of all selective serotonin reuptake inhibitors (citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) and their main active metabolites (desmethyl-citalopram and norfluoxetine). |
2012-05-04 |
2023-08-12 |
human |
| Carla S Lima, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21871486. |
we evaluated three serotonergic biomarkers during (pn89) and after (pn100) the exposure period: 5ht(1a) receptor binding with [(3)h]oh-dpat, 5ht(2) receptor binding with [(3)h]ketanserin and 5ht transporter binding with [(3)h]paroxetine. |
2012-05-02 |
2023-08-12 |
mouse |
| Pinky Dharmshaktu, Vandana Tayal, Bhupinder Singh Kalr. Efficacy of antidepressants as analgesics: a review. Journal of clinical pharmacology. vol 52. issue 1. 2012-04-26. PMID:21415285. |
evidence suggests that although the analgesic effects of selective serotonin reuptake inhibitors (fluoxetine, paroxetine, citalopram) are limited and inconsistent, yet they have a superior tolerability profile compared with tricyclic antidepressants. |
2012-04-26 |
2023-08-12 |
Not clear |
| Yumi Sugimoto, Masami Yamamoto, Noriko Tagawa, Yoshiharu Kobayashi, Kumiko Mitsui-Saitoh, Yoshihiro Hotta, Jun Yamad. Differences between mice strains in response to paroxetine in the forced swimming test: involvement of serotonergic or noradrenergic systems. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:22004611. |
we studied the effect of the selective serotonin reuptake inhibitor (ssri) paroxetine on the immobility time in the forced swimming test using different strains of mice (icr, ddy, c57bl/6, balb/c and dba/2). |
2012-03-07 |
2023-08-12 |
mouse |
| Yumi Sugimoto, Masami Yamamoto, Noriko Tagawa, Yoshiharu Kobayashi, Kumiko Mitsui-Saitoh, Yoshihiro Hotta, Jun Yamad. Differences between mice strains in response to paroxetine in the forced swimming test: involvement of serotonergic or noradrenergic systems. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:22004611. |
in dba/2 and icr mice, the anti-immobility effects of paroxetine were significantly antagonized by the selective 5-ht(1a) receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohexanecarboxamide (way 100635). |
2012-03-07 |
2023-08-12 |
mouse |
| Kelan L H Thomas, Vicki L Ellingrod, Jeffrey R Bishop, Michael J Keise. A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patients: a novel pharmacogenetic approach. Psychopharmacology bulletin. vol 43. issue 1. 2012-03-02. PMID:20581797. |
binding site prediction results for fluoxetine and paroxetine in a bioinformatics model estimated that each of these particular selective serotonin reuptake inhibitors (ssris) have high receptor affinity as an "adrenergic (beta) blocker," which was confirmed in vitro. |
2012-03-02 |
2023-08-12 |
human |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
the inhibitory action by the selective serotonin re-uptake inhibitor (ssri) paroxetine on hippocampal bdnf mrna was also attenuated by cgp 46381. |
2012-03-01 |
2023-08-12 |
rat |
| Klaus Seppi, Daniel Weintraub, Miguel Coelho, Santiago Perez-Lloret, Susan H Fox, Regina Katzenschlager, Eva-Maria Hametner, Werner Poewe, Olivier Rascol, Christopher G Goetz, Cristina Sampai. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 26 Suppl 3. 2012-02-27. PMID:22021174. |
this includes the tricyclic antidepressant amitriptyline, all selective serotonin reuptake inhibitors (ssris) reviewed (paroxetine, citalopram, sertraline, and fluoxetine), the newer antidepressants atomoxetine and nefazodone, pergolide, Ω-3 fatty acids as well as repetitive transcranial magnetic stimulation (rtms) for the treatment of depression or depressive symptoms; methylphenidate and modafinil for the treatment of fatigue; amantadine for the treatment of pathological gambling; donepezil, galantamine, and memantine for the treatment of dementia; quetiapine for the treatment of psychosis; fludrocortisone and domperidone for the treatment of orthostatic hypotension; sildenafil for the treatment of erectile dysfunction, ipratropium bromide spray for the treatment of sialorrhea; levodopa/carbidopa controlled release (cr), pergolide, eszopiclone, melatonin 3 to 5 mg and melatonin 50 mg for the treatment of insomnia and modafinil for the treatment of excessive daytime sleepiness. |
2012-02-27 |
2023-08-12 |
Not clear |
| Alan G Mallinger, Ellen Frank, Michael E Thase, Michelle M Barwell, Nancy Diazgranados, David A Luckenbaugh, David J Kupfe. Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior? Psychopharmacology bulletin. vol 42. issue 2. 2012-02-23. PMID:19629023. |
the role of antidepressants in treating bipolar disorder is controversial, and the comparative effectiveness of specific drugs is insufficiently studied.we report here a comparison of monoamine oxidase inhibitors (maois) with the serotonin reuptake inhibitor paroxetine (parox). |
2012-02-23 |
2023-08-12 |
Not clear |
| Jennifer L Pilgrim, Dimitri Gerostamoulos, Olaf H Drumme. Deaths involving contraindicated and inappropriate combinations of serotonergic drugs. International journal of legal medicine. vol 125. issue 6. 2012-02-09. PMID:21120513. |
in the australian state of victoria, all fatalities that were recorded from 2002 through to 2008 involving the use of certain serotonin active drugs (tramadol, venlafaxine, fluoxetine, sertraline, citalopram and paroxetine), were reviewed to assess the incidence of contraindicated or ill advised drug combinations. |
2012-02-09 |
2023-08-12 |
Not clear |
| Claire Roberts, Amir Inamdar, Annelize Koch, Pauline Kitchiner, Odile Dewit, Emilio Merlo-Pich, Paolo Fina, Don J McFerran, David M Bagule. A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. vol 32. issue 5. 2011-12-15. PMID:21646935. |
vestipitant was investigated for potential effect against chronic tinnitus as a stand-alone treatment and in conjunction with a selective serotonin reuptake inhibitor, paroxetine. |
2011-12-15 |
2023-08-12 |
human |
| Alexander V Kulikov, Maria A Tikhonova, Daria V Osipova, Victor A Kulikov, Nina K Popov. Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21726574. |
here, the influence of the 1473g allele on the antidepressant effect of selective serotonin reuptake inhibitors (ssris), citalopram (2.5 or 5.0mg/kg) and paroxetine (5.0 or 10.0mg/kg), in the forced swim test was studied using b6-1473g and b6-1473c congenic mouse lines with the 1473g (decreased tph2 activity) or 1473c (normal tph2 activity) alleles, respectively, transferred to the genome of c57bl/6 mouse strain. |
2011-12-09 |
2023-08-12 |
mouse |
| Prakash S Masand, Meera Narasimhan, Ashwin A Patka. Paroxetine for somatic pain associated with physical illness: a review. Primary care companion to the Journal of clinical psychiatry. vol 8. issue 3. 2011-11-10. PMID:16912814. |
the purpose of this article is to review the prevalence of somatic pain with and without depression or anxiety and the pharmacologic effects of the selective serotonin reuptake inhibitor paroxetine on pain in physical conditions with and without comorbid depression or anxiety. |
2011-11-10 |
2023-08-12 |
Not clear |