| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Krzystanek, Ewa Krzystanek, Henryk I Trzeciak, Andrzej Małecki, Irena Krupka-Matuszczyk, Małgorzata Janas-Kozik, Janusz K Rybakowsk. Effects of olanzapine and paroxetine on phospholipase D activity in the rat brain. Pharmacological reports : PR. vol 65. issue 3. 2014-04-24. PMID:23950596. |
the aim of the study was to evaluate a possible effect of atypical antipsychotic drug, olanzapine (olz), and selective serotonin reuptake inhibitor (ssri) antidepressant, paroxetine (px), on oleate-activated pld activity in plasma membranes isolated from rat brain cortex. |
2014-04-24 |
2023-08-12 |
rat |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
serotonin toxicity via a low dose of paroxetine that is coadministered with perospirone, which acts agonistically on the 5-ht1a receptor and antagonistically on the 5-ht2a receptor, clearly indicated 5-ht1a receptor involvement in mild serotonin toxicity. |
2014-03-14 |
2023-08-12 |
Not clear |
| Kristoff T Homan, Emily Wu, Michael W Wilson, Puja Singh, Scott D Larsen, John J G Tesme. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Molecular pharmacology. vol 85. issue 2. 2014-02-18. PMID:24220010. |
recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of g protein-coupled receptor kinase 2 (grk2) that improves cardiac performance in live animals. |
2014-02-18 |
2023-08-12 |
Not clear |
| Jeanette Sigurdh, Per Allard, Olav Spigset, Bruno Hägglö. Platelet serotonin transporter and 5-HT2A receptor binding in adolescents with eating disorders. The International journal of neuroscience. vol 123. issue 5. 2014-01-21. PMID:23360120. |
[(3)h]paroxetine binding to the platelet serotonin transporter and [(3)h]lysergic acid diethylamide ([(3)h]lsd) binding to the 5-ht2a receptor was studied in 15 female adolescents with eating disorders (11 with anorexia nervosa and 4 with clearly anorectic eating behaviour not fulfilling the criteria for anorexia nervosa) and 32 controls. |
2014-01-21 |
2023-08-12 |
human |
| Jeanette Sigurdh, Per Allard, Olav Spigset, Bruno Hägglö. Platelet serotonin transporter and 5-HT2A receptor binding in adolescents with eating disorders. The International journal of neuroscience. vol 123. issue 5. 2014-01-21. PMID:23360120. |
the patients revealed a higher density of serotonin transporters and a lower density of 5-ht2a receptors compared with healthy controls of the same age (775 ± 165 vs. 614 ± 111 fmol/mg protein (p = 0.003) for [(3)h]paroxetine binding and 215 ± 59 vs. 314 ± 151 fmol/mg protein (p = 0.005) for [(3)h]lsd binding). |
2014-01-21 |
2023-08-12 |
human |
| Heiko Graf, Birgit Abler, Antonie Hartmann, Coraline D Metzger, Martin Walte. Modulation of attention network activation under antidepressant agents in healthy subjects. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23200084. |
in the context of erotic stimulation, a unidirectional modulation of attentional functioning despite opposite effects on sexual arousal has been suggested for the selective serotonin reuptake-inhibitor (ssri) paroxetine and the selective dopamine and noradrenaline reuptake-inhibitor (sdnri) bupropion. |
2014-01-15 |
2023-08-12 |
human |
| Hong-Mei Qiu, Jun-Xia Yang, Xiao-Hong Wu, Na Li, Dan Liu, Li-Jia Wang, Li-Juan Qin, Qi-Xin Zho. Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter. Neuroreport. vol 24. issue 10. 2014-01-10. PMID:23636256. |
antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter. |
2014-01-10 |
2023-08-12 |
rat |
| Hong-Mei Qiu, Jun-Xia Yang, Xiao-Hong Wu, Na Li, Dan Liu, Li-Jia Wang, Li-Juan Qin, Qi-Xin Zho. Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter. Neuroreport. vol 24. issue 10. 2014-01-10. PMID:23636256. |
paroxetine is a selective serotonin reuptake inhibitor used for the treatment of depression; this study investigated its other mechanisms by studying the expression and therefore involvement of norepinephrine transporter (net) and serotonin transporter (5-htt). |
2014-01-10 |
2023-08-12 |
rat |
| Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa, Ikumi Tama. Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. vol 41. issue 4. 2013-11-04. PMID:23303441. |
paroxetine, a selective serotonin reuptake inhibitor, is metabolized in the liver and excreted into bile and urine as metabolites, but species differences have been observed in hepatic disposition between rats and humans. |
2013-11-04 |
2023-08-12 |
human |
| Yuta Ohgi, Takashi Futamura, Tetsuro Kikuchi, Kenji Hashimot. Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration. Pharmacology, biochemistry, and behavior. vol 103. issue 4. 2013-10-24. PMID:23262300. |
pretreatment with ssris (fluoxetine and paroxetine), snris (venlafaxine and duloxetine), or 5-hydroxytryptophan (5-htp), a precursor of serotonin, attenuated lps-induced increases in tnfα, whereas it increased serum levels of il-10, in mice treated with lps. |
2013-10-24 |
2023-08-12 |
mouse |
| David Germann, George Ma, Feixue Han, Anna Tikhomirov. Paroxetine hydrochloride. Profiles of drug substances, excipients, and related methodology. vol 38. 2013-08-27. PMID:23668408. |
paroxetine hydrochloride (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3s,4r)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. |
2013-08-27 |
2023-08-12 |
Not clear |
| Clare M Mathes, Jillian R Gregson, Alan C Specto. The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions. Chemical senses. vol 38. issue 3. 2013-08-16. PMID:23254343. |
the selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions. |
2013-08-16 |
2023-08-12 |
rat |
| Clare M Mathes, Jillian R Gregson, Alan C Specto. The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions. Chemical senses. vol 38. issue 3. 2013-08-16. PMID:23254343. |
here, we examined the effect of paroxetine, a selective serotonin reuptake inhibitor, on appetitive responding for a preferred and an avoided taste solution using a progressive ratio (pr) task in which licking was employed as the operant. |
2013-08-16 |
2023-08-12 |
rat |
| Mohamed A El-Nabarawi, Ehab R Bendas, Randa Tag A El Rehem, Mohammed Y S Abar. Transdermal drug delivery of paroxetine through lipid-vesicular formulation to augment its bioavailability. International journal of pharmaceutics. vol 443. issue 1-2. 2013-08-15. PMID:23337629. |
paroxetine (pax) is the most potent serotonin reuptake blocker antidepressant clinically available. |
2013-08-15 |
2023-08-12 |
Not clear |
| Madhusudan Grover, Michael Camiller. Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases. Journal of gastroenterology. vol 48. issue 2. 2013-08-05. PMID:23254779. |
paroxetine, a selective serotonin reuptake inhibitor, accelerates small bowel but not colonic transit, and this property may not be relevant to improve gut function in functional gastrointestinal disorders. |
2013-08-05 |
2023-08-12 |
Not clear |
| Tanel Visnapuu, Sirli Raud, Maarja Loomets, Riin Reimets, Silva Sütt, Hendrik Luuk, Mario Plaas, Sulev Kõks, Vallo Volke, Aet Alttoa, Jaanus Harro, Eero Vasa. Wfs1-deficient mice display altered function of serotonergic system and increased behavioral response to antidepressants. Frontiers in neuroscience. vol 7. 2013-08-05. PMID:23914152. |
therefore, in this study, the effects of imipramine, an inhibitor of serotonin (5-ht) and noradrenaline (na) reuptake, and paroxetine, a selective inhibitor of 5-ht reuptake, were studied in tests of behavioral despair. |
2013-08-05 |
2023-08-12 |
mouse |
| Tanel Visnapuu, Sirli Raud, Maarja Loomets, Riin Reimets, Silva Sütt, Hendrik Luuk, Mario Plaas, Sulev Kõks, Vallo Volke, Aet Alttoa, Jaanus Harro, Eero Vasa. Wfs1-deficient mice display altered function of serotonergic system and increased behavioral response to antidepressants. Frontiers in neuroscience. vol 7. 2013-08-05. PMID:23914152. |
taken together, the blunted 5-ht metabolism and reduced levels of sert are a likely reason for the elevated sensitivity of these mice to the action of imipramine and paroxetine. |
2013-08-05 |
2023-08-12 |
mouse |
| Zhiyuan Ma, Mary Rudacille, Howard M Prentice, Rui Ta. Characterization of electroencephalographic and biochemical responses at 5-HT promoting drug-induced onset of serotonin syndrome in rats. Journal of neurochemistry. vol 125. issue 5. 2013-07-19. PMID:23286698. |
experiments were carried out in rats with the syndrome being elicited by three groups of 5ht-promoting drugs: (i) (±)-3,4-methylenedioxymethamphetamine (mdma); (ii) a combination of the monoamine oxidase inhibitor clorgyline with the 5ht precursor 5-hydroxytryptophan; (iii) clorgyline combined with the serotonin-selective reuptake inhibitor paroxetine. |
2013-07-19 |
2023-08-12 |
rat |
| Y R A van Zeeland, N J Schoemaker, A Haritova, J W Smit, E M van Maarseveen, J T Lumeij, J Fink-Gremmel. Pharmacokinetics of paroxetine, a selective serotonin reuptake inhibitor, in Grey parrots (Psittacus erithacus erithacus): influence of pharmaceutical formulation and length of dosing. Journal of veterinary pharmacology and therapeutics. vol 36. issue 1. 2013-07-12. PMID:22435778. |
pharmacokinetics of paroxetine, a selective serotonin reuptake inhibitor, in grey parrots (psittacus erithacus erithacus): influence of pharmaceutical formulation and length of dosing. |
2013-07-12 |
2023-08-12 |
Not clear |
| Y R A van Zeeland, N J Schoemaker, A Haritova, J W Smit, E M van Maarseveen, J T Lumeij, J Fink-Gremmel. Pharmacokinetics of paroxetine, a selective serotonin reuptake inhibitor, in Grey parrots (Psittacus erithacus erithacus): influence of pharmaceutical formulation and length of dosing. Journal of veterinary pharmacology and therapeutics. vol 36. issue 1. 2013-07-12. PMID:22435778. |
paroxetine, a selective serotonin reuptake inhibitor, may be beneficial in the treatment of behavioural disorders in pet birds. |
2013-07-12 |
2023-08-12 |
Not clear |