| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alistair K Brown, Jonathan K Challis, Charles S Wong, Mark L Hanso. Selective serotonin reuptake inhibitors and β-blocker transformation products may not pose a significant risk of toxicity to aquatic organisms in wastewater effluent-dominated receiving waters. Integrated environmental assessment and management. vol 11. issue 4. 2016-02-12. PMID:25820351. |
a probabilistic ecological risk assessment was conducted for the transformation products (tps) of 3 β-blockers (atenolol, metoprolol, and propranolol) and 5 selective serotonin reuptake inhibitors (ssris; citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline) to assess potential threats to aquatic organisms in effluent-dominated surface waters. |
2016-02-12 |
2023-08-13 |
human |
| Hyang Mi Lee, Sang June Hahn, Bok Hee Cho. Blockade of Kv1.5 by paroxetine, an antidepressant drug. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 1. 2016-01-25. PMID:26807026. |
paroxetine, a selective serotonin reuptake inhibitor (ssri), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a ssri-independent manner. |
2016-01-25 |
2023-08-13 |
human |
| Joseph P Steiner, Muznabanu Bachani, Brett Wolfson-Stofko, Myoung-Hwa Lee, Tongguang Wang, Tonguang Wang, Guanhan Li, Wenxue Li, David Strayer, Norman J Haughey, Avindra Nat. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 1. 2016-01-19. PMID:25404050. |
interestingly, the inhibition of serotonin reuptake by paroxetine was not required for neuroprotection, since depletion of the serotonin transporter had no effect on its neuroprotective properties. |
2016-01-19 |
2023-08-13 |
Not clear |
| C Bétry, D Overstreet, N Haddjeri, A L Pehrson, C Bundgaard, C Sanchez, A Mør. A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant. Pharmacology, biochemistry, and behavior. vol 131. 2016-01-15. PMID:25697477. |
we studied if the selective 5-ht3 receptor antagonist ondansetron can potentiate the antidepressant potential of the selective serotonin (5-ht) reuptake inhibitor (ssri) paroxetine using behavioral, neurochemical and electrophysiological methods. |
2016-01-15 |
2023-08-13 |
rat |
| C Bétry, D Overstreet, N Haddjeri, A L Pehrson, C Bundgaard, C Sanchez, A Mør. A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant. Pharmacology, biochemistry, and behavior. vol 131. 2016-01-15. PMID:25697477. |
it partially prevented the suppressant effect of paroxetine on drn 5-ht neuronal firing and enhanced the paroxetine-induced increase of hippocampal extracellular 5-ht release. |
2016-01-15 |
2023-08-13 |
rat |
| Sarah M Schumacher, Erhe Gao, Weizhong Zhu, Xiongwen Chen, J Kurt Chuprun, Arthur M Feldman, John J G Tesmer, Walter J Koc. Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Science translational medicine. vol 7. issue 277. 2016-01-13. PMID:25739765. |
recently, we found that the selective serotonin reuptake inhibitor (ssri) paroxetine could inhibit grk2 with selectivity over other grks. |
2016-01-13 |
2023-08-13 |
mouse |
| Ishrat A Bhat, Kelly D Shannon, Anjum Ara, Ian Co. Ninety-six hours ordeal of priapism induced by paroxetine--A case report and literature review. International journal of psychiatry in medicine. vol 50. issue 3. 2016-01-07. PMID:26443710. |
the objective of this report is to highlight the importance of recognizing the possibility of priapism with selective serotonin reuptake inhibitors in general and paroxetine in particular since this condition is not commonly seen in clinical practice to be associated with selective serotonin reuptake inhibitors and may go unrecognized. |
2016-01-07 |
2023-08-13 |
Not clear |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) that is clinically used for the treatment of depression in human patients. |
2016-01-04 |
2023-08-13 |
mouse |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
because of recent reports on the role of serotonin in modulating inflammation and the link between inflammation and depression, we sought to test the effect of paroxetine directly on macrophage response to an inflammatory stimulus. |
2016-01-04 |
2023-08-13 |
mouse |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
to determine if the effects of paroxetine are mediated via modulation of the 5-ht system, we treated macrophages with 5-ht or 5-ht receptor antagonist (ly215840) in the presence of lps and/or paroxetine. |
2016-01-04 |
2023-08-13 |
mouse |
| Jihyeon Jeong, Minsun Park, Jeong Seon Yoon, Hyunjeong Kim, Su Kyoung Lee, Eun Lee, Kee Namkoong, Eosu Ki. Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine. Neuroreport. vol 26. issue 7. 2015-12-15. PMID:25839176. |
given that amp-activated protein kinase (ampk) is a master switch for energy homeostasis, we aimed to determine whether selective serotonin reuptake inhibitor paroxetine enhances energy metabolism by activating ampk in neuroblastoma cells. |
2015-12-15 |
2023-08-13 |
Not clear |
| Mostafa El Mansari, Stella Manta, Chris Oosterhof, Kareem S El Iskandrani, Franck Chenu, Stacey Shim, Pierre Blie. Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. The international journal of neuropsychopharmacology. vol 18. issue 4. 2015-11-20. PMID:25522394. |
restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. |
2015-11-20 |
2023-08-13 |
rat |
| Mostafa El Mansari, Stella Manta, Chris Oosterhof, Kareem S El Iskandrani, Franck Chenu, Stacey Shim, Pierre Blie. Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. The international journal of neuropsychopharmacology. vol 18. issue 4. 2015-11-20. PMID:25522394. |
the purpose of the present study was first to characterize the firing activity of dorsal raphe serotonin neurons in olfactory bulbectomized rats and then examine the effects of 2 antidepressants, bupropion and paroxetine. |
2015-11-20 |
2023-08-13 |
rat |
| Levent Ozcan, Emre Can Polat, Alper Otunctemur, Emin Ozbe. Duloxetine, dual serotonin and norepinephrine reuptake inhibitor, versus paroxetine, selective serotonin reuptake inhibitor, in the treatment for premature ejaculation. International urology and nephrology. vol 47. issue 2. 2015-11-03. PMID:25557853. |
duloxetine, dual serotonin and norepinephrine reuptake inhibitor, versus paroxetine, selective serotonin reuptake inhibitor, in the treatment for premature ejaculation. |
2015-11-03 |
2023-08-13 |
Not clear |
| Marianna Purgato, Davide Papola, Chiara Gastaldon, Carlotta Trespidi, Laura R Magni, Carla Rizzo, Toshi A Furukawa, Norio Watanabe, Andrea Cipriani, Corrado Barbu. Paroxetine versus other anti-depressive agents for depression. The Cochrane database of systematic reviews. issue 4. 2015-10-01. PMID:24696195. |
paroxetine is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors (ssris) and has been studied in many randomised controlled trials (rcts). |
2015-10-01 |
2023-08-13 |
Not clear |
| Shannon M Gaukler, James S Ruff, Tessa Galland, Kirstie A Kandaris, Tristan K Underwood, Nicole M Liu, Elizabeth L Young, Linda C Morrison, Garold S Yost, Wayne K Pott. Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay. Neurotoxicology and teratology. vol 47. 2015-09-10. PMID:25446017. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) that is currently available on the market and is suspected of causing congenital malformations in babies born to mothers who take the drug during the first trimester of pregnancy. |
2015-09-10 |
2023-08-13 |
mouse |
| Molly R Belkin, Thomas L Schwart. Alpha-2 receptor agonists for the treatment of posttraumatic stress disorder. Drugs in context. vol 4. 2015-08-31. PMID:26322115. |
currently, the only us food and drug administration (fda)-approved medications for ptsd are the selective serotonin reuptake inhibitors (ssris) sertraline and paroxetine. |
2015-08-31 |
2023-08-13 |
Not clear |
| Suat Bilici, Ozgur Yigit, Umit Taskin, Ayse Pelin Gor, Enver Demirel Yilma. Medium-term results of combined treatment with transcranial magnetic stimulation and antidepressant drug for chronic tinnitus. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 272. issue 2. 2015-08-26. PMID:24337899. |
we compared the effects of repetitive transcranial magnetic stimulation (rtms) and paroxetine [a selective serotonin reuptake inhibitor (ssri)] on tinnitus in terms of effectiveness and medium-term results. |
2015-08-26 |
2023-08-12 |
human |
| Julie Philbert, Sandra Beeské, Catherine Belzung, Guy Griebe. The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine. Behavioural brain research. vol 279. 2015-08-20. PMID:25446760. |
effects of ssr125543 were compared to those of the 5-ht reuptake inhibitor, paroxetine (10 mg/kg/day/i.p. |
2015-08-20 |
2023-08-13 |
mouse |
| Nitasha Agrawal, Sergio Marco-Peiró, Josep Esteve-Romero, Abhilasha Durgbanshi, Devasish Bose, Juan Peris-Vicente, Samuel Carda-Broc. Determination of paroxetine in blood and urine using micellar liquid chromatography with electrochemical detection. Journal of chromatographic science. vol 52. issue 10. 2015-07-02. PMID:24448669. |
paroxetine is a potent selective serotonin reuptake inhibitor used for the treatment of depression and related mood disorders. |
2015-07-02 |
2023-08-12 |
human |