| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Foster, K L Go. Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder. CNS drugs. vol 8. issue 2. 2013-07-04. PMID:23338224. |
paroxetine is the first selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitor (ssri) to be approved for the treatment of patients with panic disorder with or without agoraphobia. |
2013-07-04 |
2023-08-12 |
Not clear |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
chronic treatment with ssris (fluoxetine and paroxetine) resulted in a dramatic further depletion of 5-ht tissue levels in r439h tph2 ki mice (down to 1-3% of wild type levels) while having little effects in wild-type controls. |
2013-07-02 |
2023-08-12 |
mouse |
| Jeffrey S Berger, Richard C Becker, Cynthia Kuhn, Michael J Helms, Thomas L Ortel, Redford William. Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. Thrombosis and haemostasis. vol 109. issue 1. 2013-06-24. PMID:23223800. |
transporter-dependent serotonin uptake rate was determined (vmax), as were serotonin transporter number (bmax) and binding affinity (kd) using 3h paroxetine binding in a homologous displacement assay, nonlinear regression and validated algorithms for kinetic modelling. |
2013-06-24 |
2023-08-12 |
human |
| Hee Jung Kim, Tae Hyeong Kim, Se Joon Choi, Yi Jae Hong, Ji Seon Yang, Ki-Wug Sung, Duck-Joo Rhie, Sang June Hahn, Shin Hee Yoo. Fluoxetine suppresses synaptically induced [Ca²⁺]i spikes and excitotoxicity in cultured rat hippocampal neurons. Brain research. vol 1490. 2013-05-29. PMID:23131584. |
however, other selective serotonin reuptake inhibitors, such as paroxetine and citalopram, did not significantly affect the spikes. |
2013-05-29 |
2023-08-12 |
rat |
| H Okayasu, Y Ozeki, K Fujii, Y Takano, Y Saeki, H Hori, M Horie, T Higuchi, H Kunugi, K Shimod. Pharmacotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder. Pharmacopsychiatry. vol 45. issue 7. 2013-04-26. PMID:22592502. |
the selective serotonin reuptake inhibitors investigated (fluvoxamine, paroxetine, sertraline) were not indicated as risk factors for qtc prolongation. |
2013-04-26 |
2023-08-12 |
Not clear |
| Lei Li, Sachio Morimoto, Sachiko Take, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshihiko Katafuchi, Toshiyuki Sasagur. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. Journal of molecular and cellular cardiology. vol 53. issue 6. 2013-04-19. PMID:22921782. |
since depression is common and associated with poor prognosis in hf patients, we examined therapeutic effects of anti-depression drug paroxetine and anti-anxiety drug buspirone that could improve the brain serotonin function in mice. |
2013-04-19 |
2023-08-12 |
mouse |
| David M Thal, Kristoff T Homan, Jun Chen, Emily K Wu, Patricia M Hinkle, Z Maggie Huang, J Kurt Chuprun, Jianliang Song, Erhe Gao, Joseph Y Cheung, Larry A Sklar, Walter J Koch, John J G Tesme. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS chemical biology. vol 7. issue 11. 2013-04-17. PMID:22882301. |
herein we identify the selective serotonin reuptake inhibitor (ssri) paroxetine as a selective inhibitor of grk2 activity both in vitro and in living cells. |
2013-04-17 |
2023-08-12 |
mouse |
| Domokos Gerö, Petra Szoleczky, Kunihiro Suzuki, Katalin Módis, Gabor Oláh, Ciro Coletta, Csaba Szab. Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction. Diabetes. vol 62. issue 3. 2013-04-17. PMID:23223176. |
the ability of paroxetine to improve hyperglycemic endothelial cell injury was unique among serotonin reuptake blockers and can be attributed to its antioxidant effect, which primarily resides within its sesamol moiety. |
2013-04-17 |
2023-08-12 |
rat |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
a novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. |
2013-04-05 |
2023-08-12 |
rat |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
unexpectedly, one of the tertiary amines under investigation, that is 3'-methoxy-8-methyl-spiro{8-azabicyclo[3.2.1]octane-3,5'(4'h)-isoxazole 7a, was able to enhance at a concentration of 10 μm both [(3)h]citalopram and [(3)h]paroxetine binding to sert in rat brain homogenate (up to 25%, due to an increase of b(max)) and [(3)h]serotonin uptake (up to 30%) in cortical synaptosomes. |
2013-04-05 |
2023-08-12 |
rat |
| Ester Sagristà, José Manuel Cortés, Estelle Larsson, Victòria Salvadó, Manuela Hidalgo, Jan Åke Jönsso. Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction. Journal of separation science. vol 35. issue 18. 2013-04-04. PMID:22753317. |
this paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (hf-lpme). |
2013-04-04 |
2023-08-12 |
Not clear |
| Ruchita Das, Y K Agrawa. Simultaneous monitoring of selective serotonin reuptake inhibitors in human urine, plasma and oral fluid by reverse-phase high performance liquid chromatography. Journal of chromatographic science. vol 51. issue 2. 2013-03-25. PMID:22914569. |
a simple and rapid reverse-phase high-performance liquid chromatography method is developed for the simultaneous determination of selective serotonin reuptake inhibitors (sertraline, citalopram, paroxetine and fluoxetine) in urine, plasma and oral fluid. |
2013-03-25 |
2023-08-12 |
human |
| Liang Peng, Jingyang Huan. Astrocytic 5-HT(2B) receptor as in vitro and in vivo target of SSRIs. Recent patents on CNS drug discovery. vol 7. issue 3. 2013-03-22. PMID:22963281. |
in cultured astrocytes acute treatment with any of the five ssris, fluoxetine, fluvoxamine, sertraline, paroxetine, and citalopram, stimulates equipotently and with sufficient affinity to be therapeutically relevant, the 5-ht(2b) receptor. |
2013-03-22 |
2023-08-12 |
mouse |
| Lior Brimberg, Itai Benhar, Adita Mascaro-Blanco, Kathy Alvarez, Dafna Lotan, Christine Winter, Julia Klein, Allon E Moses, Finn E Somnier, James F Leckman, Susan E Swedo, Madeleine W Cunningham, Daphna Joe. Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: a novel rat model of Sydenham chorea and related neuropsychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 9. 2013-03-17. PMID:22534626. |
these symptoms were alleviated by the d2 blocker haloperidol and the selective serotonin reuptake inhibitor paroxetine, respectively, drugs that are used to treat motor symptoms and compulsions in streptococcal-related neuropsychiatric disorders. |
2013-03-17 |
2023-08-12 |
human |
| Ayaka Tatara, Saki Shimizu, Noriyuki Shin, Maho Sato, Tomone Sugiuchi, Junta Imaki, Yukihiro Ohn. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22542492. |
the selective serotonin reuptake inhibitors (ssris), fluoxetine and paroxetine, and the tricyclic antidepressant (tca) clomipramine, which showed no eps by themselves, significantly potentiated hal-induced bradykinesia and catalepsy in a dose-dependent manner. |
2013-01-21 |
2023-08-12 |
mouse |
| Christopher Bishop, Jessica A George, William Buchta, Adam A Goldenberg, Mohamed Mohamed, Sando O Dickinson, Satie Eissa, Karen L Eskow Jaunaraj. Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22762478. |
rats in experiment 1 were administered the selective serotonin reuptake inhibitors paroxetine, citalopram or fluoxetine, followed by l-dopa. |
2013-01-09 |
2023-08-12 |
rat |
| Sahar M Kama. Combination of valproate and paroxetine in mice exposed to picrotoxin. International journal of nanomedicine. vol 7. 2012-12-10. PMID:22679369. |
the present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhibitor) administered alone or in combination with the antiepileptic drug sodium valproate on chemoconvulsions induced by picrotoxin (ptx). |
2012-12-10 |
2023-08-12 |
mouse |
| Nagahisa Okamoto, Kota Sakamoto, Maki Yamad. Transient serotonin syndrome by concurrent use of electroconvulsive therapy and selective serotonin reuptake inhibitor: a case report and review of the literature. Case reports in psychiatry. vol 2012. 2012-12-06. PMID:23213590. |
we present the case of a female patient with major depressive disorder (mdd) who developed transient serotonin syndrome soon after the first session of ect in combination with paroxetine. |
2012-12-06 |
2023-08-12 |
Not clear |
| Ismene L Petrakis, Elizabeth Ralevski, Nitigna Desai, Louis Trevisan, Ralitza Gueorguieva, Bruce Rounsaville, John H Krysta. Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 4. 2012-11-19. PMID:22089316. |
the current study compared the serotonin uptake inhibitor, paroxetine, to the norepinephrine uptake inhibitor, desipramine. |
2012-11-19 |
2023-08-12 |
Not clear |
| Michal Dubovický, Eszter Császárová, Zuzana Brnoliaková, Eduard Ujházy, Jana Navarová, Mojmír Mac. Effect of prenatal administration of venlafaxine on postnatal development of rat offspring. Interdisciplinary toxicology. vol 5. issue 2. 2012-11-05. PMID:23118594. |
most prescribed antidepressants in pregnancy are selective serotonin re-uptake inhibitors and/or serotonin and noradrenaline re-uptake inhibitors, such as fluoxetine, paroxetine, sertraline, citalopram and venlafaxine (venf). |
2012-11-05 |
2023-08-12 |
rat |