| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madhu S Singh, Prudence A Francis, Michael Michae. Tamoxifen, cytochrome P450 genes and breast cancer clinical outcomes. Breast (Edinburgh, Scotland). vol 20. issue 2. 2011-07-11. PMID:21185724. |
selective serotonin reuptake inhibitor antidepressant drugs such as paroxetine and fluoxetine have also been used to manage tamoxifen induced hot flushes. |
2011-07-11 |
2023-08-12 |
human |
| Doreen Huppert, Michael Strupp, Harald Mückter, Thomas Brand. Which medication do I need to manage dizzy patients? Acta oto-laryngologica. vol 131. issue 3. 2011-06-02. PMID:21142898. |
examples of such causal therapy include aminopyridines for downbeat nystagmus and episodic ataxia type 2; carbamazepine for vestibular paroxysmia, paroxsymal dysarthria and ataxia in multiple sclerosis, and superior oblique myokymia; betahistine, dexamethasone, and gentamicin for menière's disease; gabapentin and memantine for different forms of acquired and congenital nystagmus; corticosteroids for acute vestibular neuritis and cogan's syndrome; metoprolol and topiramate for vestibular migraine; and selective serotonin reuptake inhibitors such as paroxetine for phobic postural vertigo. |
2011-06-02 |
2023-08-12 |
Not clear |
| Yuji Kitaichi, Takeshi Inoue, Shin Nakagawa, Shuken Boku, Aya Kakuta, Takeshi Izumi, Tsukasa Koyam. Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats. European journal of pharmacology. vol 647. issue 1-3. 2011-04-01. PMID:20816814. |
we examined effects of sertraline, fluvoxamine, and paroxetine on extracellular serotonin, dopamine, and noradrenaline levels in the medial prefrontal cortex, nucleus accumbens and striatum of rats using in vivo microdialysis. |
2011-04-01 |
2023-08-12 |
rat |
| Kristina Annerbrink, Marie Olsson, Jan Hedner, Elias Eriksso. Acute and chronic treatment with serotonin reuptake inhibitors exert opposite effects on respiration in rats: possible implications for panic disorder. Journal of psychopharmacology (Oxford, England). vol 24. issue 12. 2011-03-16. PMID:19825902. |
the effect on respiration after acute administration of compounds enhancing synaptic levels of serotonin, that is, the serotonin reuptake inhibitors paroxetine and fluoxetine, the serotonin-releasing agents m-chlorophenylpiperazine and d-fenfluramine, and the selective 5-ht1a antagonist way-100635, were investigated. |
2011-03-16 |
2023-08-12 |
rat |
| S C Stanford, B J Stanford, P K Gillma. Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: an update on a case report of post-operative delirium. Journal of psychopharmacology (Oxford, England). vol 24. issue 10. 2011-02-28. PMID:19423610. |
we noted that the delirium resembled serotonin toxicity and that the patient had been taking paroxetine until 2 days before surgery. |
2011-02-28 |
2023-08-12 |
Not clear |
| Takahashi Motonori, Kinoshita Hiroshi, Kuse Azumi, Morichika Mai, Nishiguchi Minori, Ouchi Harumi, Minami Takako, Matsui Kiyoshi, Yamamura Takehiko, Motomura Hiroyuki, Ohtsu Nao, Yoshida Shie, Adachi Nobuyuki, Ueno Yasuhiro, Hishida Shigeru, Nishio Hajim. An autopsy case of poisoning with selective serotonin reuptake inhibitor, paroxetine. Soudni lekarstvi. vol 55. issue 1. 2011-02-23. PMID:21275227. |
an autopsy case of poisoning with selective serotonin reuptake inhibitor, paroxetine. |
2011-02-23 |
2023-08-12 |
Not clear |
| Takahashi Motonori, Kinoshita Hiroshi, Kuse Azumi, Morichika Mai, Nishiguchi Minori, Ouchi Harumi, Minami Takako, Matsui Kiyoshi, Yamamura Takehiko, Motomura Hiroyuki, Ohtsu Nao, Yoshida Shie, Adachi Nobuyuki, Ueno Yasuhiro, Hishida Shigeru, Nishio Hajim. An autopsy case of poisoning with selective serotonin reuptake inhibitor, paroxetine. Soudni lekarstvi. vol 55. issue 1. 2011-02-23. PMID:21275227. |
taking into consideration postmortem diffusion of drugs, we evaluated postmortem data and concluded that the death was mainly due to toxicity of paroxetine with serotonin syndrome. |
2011-02-23 |
2023-08-12 |
Not clear |
| Siegfried Kasper, Markus Gastpar, Hans-Juergen Möller, Walter E Müller, Hans-Peter Volz, Angelika Dienel, Meinhard Kiese. Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. International clinical psychopharmacology. vol 25. issue 4. 2011-01-31. PMID:20568656. |
selective serotonin reuptake inhibitors (ssris) like paroxetine have replaced older antidepressants mainly because of a more favorable safety profile, but they are still associated with burdensome side effects. |
2011-01-31 |
2023-08-12 |
Not clear |
| Andrew J Muzyk, Rebekah J Jakel, Xavier Preud'homm. Serotonin syndrome after a massive overdose of controlled-release paroxetine. Psychosomatics. vol 51. issue 5. 2011-01-11. PMID:20833944. |
serotonin syndrome after a massive overdose of controlled-release paroxetine. |
2011-01-11 |
2023-08-12 |
Not clear |
| Hideki Horikawa, Takahiro A Kato, Yoshito Mizoguchi, Akira Monji, Yoshihiro Seki, Takatoshi Ohkuri, Leo Gotoh, Megumi Yonaha, Tadashi Ueda, Sadayuki Hashioka, Shigenobu Kanb. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20654672. |
our results showed that the selective serotonin reuptake inhibitors (ssris) paroxetine and sertraline significantly inhibited the generation of no and tumor necrosis factor (tnf)-α from interferon (ifn)-γ-activated 6-3 microglia. |
2010-12-29 |
2023-08-12 |
Not clear |
| H Dalton King, Zhaoxing Meng, Jeffrey A Deskus, Charles P Sloan, Qi Gao, Brett R Beno, Edward S Kozlowski, Melissa A Lapaglia, Gail K Mattson, Thaddeus F Molski, Matthew T Taber, Nicholas J Lodge, Ronald J Mattson, John E Maco. Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. Journal of medicinal chemistry. vol 53. issue 21. 2010-12-28. PMID:20949929. |
8a, dosed at 1 and 3 mg/kg po, produced a robust, dose-dependent increase in extracellular serotonin in the frontal cortex of rats, similar to that induced by paroxetine at 5 mg/kg, po. |
2010-12-28 |
2023-08-12 |
rat |
| Jane E Sarginson, Laura C Lazzeroni, Heather S Ryan, Alan F Schatzberg, Greer M Murph. FKBP5 polymorphisms and antidepressant response in geriatric depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19676097. |
these two polymorphisms had previously been reported to predict efficacy in depressed patients treated with selective serotonin reuptake inhibitors such as paroxetine, and those treated with mirtazapine, an agent with both serotonergic and noradrenergic actions. |
2010-12-20 |
2023-08-12 |
Not clear |
| Subhodeep Sarker, René Weissensteiner, Ilka Steiner, Harald H Sitte, Gerhard F Ecker, Michael Freissmuth, Sonja Suci. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular pharmacology. vol 78. issue 6. 2010-12-17. PMID:20829432. |
binding of releasers (para-chloroamphetamine, methylene-dioxy-methamphetamine/ecstasy) and of carbamazepine were mutually exclusive, but dixon plots generated in the presence of carbamazepine yielded intersecting lines for serotonin, mpp(+), paroxetine, and ibogaine. |
2010-12-17 |
2023-08-12 |
Not clear |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
s41744, a dual neurokinin (nk)1 receptor antagonist and serotonin (5-ht) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (mk869) and paroxetine. |
2010-12-08 |
2023-08-12 |
mouse |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
like paroxetine, s41744 recognised h5-ht transporters, reduced synaptosomal uptake of 5-ht (pk(b), 7.9), and dose-dependently (0.63-10.0 mg/kg) elevated dialysis levels of 5-ht in the hippocampus and frontal cortex of freely-moving guinea pigs. |
2010-12-08 |
2023-08-12 |
mouse |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
further, s41744 increased extracellular levels of 5-ht in frontal cortex and hippocampus of rats to a greater extent than paroxetine, and its inhibitory influence upon serotonergic perikarya was blunted relative to its affinity for 5-ht transporters. |
2010-12-08 |
2023-08-12 |
mouse |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
while aprepitant displayed anxiolytic actions in stress-induced foot-tapping and social interaction tests in gerbils, paroxetine was anxiogenic and s41744 "neutral", reflecting balanced nk(1) antagonism and suppression of 5-ht reuptake. |
2010-12-08 |
2023-08-12 |
mouse |
| S J Mathew, R B Price, D C Shungu, X Mao, E L P Smith, J M Amiel, J D Copla. A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 24. issue 8. 2010-12-02. PMID:19204062. |
the effect of chronic administration (12 weeks) of paroxetine, a selective serotonin reuptake inhibitor, on n-acetylaspartate (naa), a marker of neuronal viability, was evaluated in adults with gad using proton magnetic resonance spectroscopic imaging ((1)h mrsi) at 1.5 t. we hypothesized that, pretreatment abnormalities in hippocampal naa/creatine (naa/cr) would normalize with symptomatic improvement. |
2010-12-02 |
2023-08-12 |
human |
| Brian Leonard, David Taylo. Escitalopram--translating molecular properties into clinical benefit: reviewing the evidence in major depression. Journal of psychopharmacology (Oxford, England). vol 24. issue 8. 2010-12-02. PMID:20147575. |
these studies reveal that escitalopram has some efficacy advantage over citalopram and paroxetine, but no consistent advantage over other selective serotonin reuptake inhibitors. |
2010-12-02 |
2023-08-12 |
Not clear |
| Raymond Mongeau, Cédric B P Martin, Caroline Chevarin, Rafael Maldonado, Michel Hamon, Patricia Robledo, Laurence Lanfume. 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. Journal of neurochemistry. vol 115. issue 2. 2010-11-22. PMID:20796171. |
5-ht2c receptor activation prevents stress-induced enhancement of brain 5-ht turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. |
2010-11-22 |
2023-08-12 |
mouse |