| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Rowell, S Wonnacot. Evidence for functional activity of up-regulated nicotine binding sites in rat striatal synaptosomes. Journal of neurochemistry. vol 55. issue 6. 1990-12-20. PMID:2230812. |
a strong positive correlation (r = 0.64) was found between the density of [3h]nicotine binding sites and the nicotine-induced stimulation of [3h]dopamine release in individual animals. |
1990-12-20 |
2023-08-11 |
rat |
| P P Rowell, S Wonnacot. Evidence for functional activity of up-regulated nicotine binding sites in rat striatal synaptosomes. Journal of neurochemistry. vol 55. issue 6. 1990-12-20. PMID:2230812. |
these results indicate that (+)-anatoxin-a, like nicotine, produces an up-regulation of nicotine binding sites following chronic administration, and that these additional sites are functional receptors capable of mediating the release of dopamine from striatal synaptosomes. |
1990-12-20 |
2023-08-11 |
rat |
| K Fuxe, L F Agnati, A Jansson, G von Euler, S Tanganelli, K Andersson, P Enerot. Regulation of endocrine function by the nicotinic cholinergic receptor. Ciba Foundation symposium. vol 152. 1990-10-29. PMID:2209250. |
in view of the hypothesis that the mesolimbic dopamine pathways mediate the euphoric effects of nicotine, the secretion of corticosterone induced by nicotine in the smoking male may substantially influence the mood elevating activity of nicotine. |
1990-10-29 |
2023-08-11 |
rat |
| P B Clark. Mesolimbic dopamine activation--the key to nicotine reinforcement? Ciba Foundation symposium. vol 152. 1990-10-29. PMID:2209252. |
mesolimbic dopamine activation--the key to nicotine reinforcement? |
1990-10-29 |
2023-08-11 |
rat |
| P B Clark. Mesolimbic dopamine activation--the key to nicotine reinforcement? Ciba Foundation symposium. vol 152. 1990-10-29. PMID:2209252. |
functional studies are consistent with this proposal: nicotine can increase the firing rate of these neurons, and nicotine-induced dopamine release has been demonstrated in vitro and in vivo. |
1990-10-29 |
2023-08-11 |
rat |
| T H Svensson, J Grenhoff, G Engber. Effect of nicotine on dynamic function of brain catecholamine neurons. Ciba Foundation symposium. vol 152. 1990-10-29. PMID:2209253. |
burst firing in the mesolimbocortical dopamine (da) neurons, originating in the ventral tegmental area (vta), is facilitated by systemic administration of nicotine. |
1990-10-29 |
2023-08-11 |
Not clear |
| K Fuxe, A M Janson, A Jansson, K Andersson, P Eneroth, L F Agnat. Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:2342600. |
chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. |
1990-06-27 |
2023-08-11 |
rat |
| K Fuxe, A M Janson, A Jansson, K Andersson, P Eneroth, L F Agnat. Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:2342600. |
in order to further study the previously demonstrated protective action of chronic nicotine treatment on lesioned meso-striatal dopamine (da) pathways, the following study was carried out on da utilization in these lesioned neurons. |
1990-06-27 |
2023-08-11 |
rat |
| C S Tung, J Grenhoff, T H Svensso. Nicotine counteracts midbrain dopamine cell dysfunction induced by prefrontal cortex inactivation. Acta physiologica Scandinavica. vol 138. issue 3. 1990-05-24. PMID:2327269. |
nicotine counteracts midbrain dopamine cell dysfunction induced by prefrontal cortex inactivation. |
1990-05-24 |
2023-08-11 |
Not clear |
| P Boksa, M Quik, J B Mitchell, B Collier, W O'Neil, R Quirio. Pharmacological activity of N-methyl-carbamylcholine, a novel acetylcholine receptor agonist with selectivity for nicotinic receptors. European journal of pharmacology. vol 173. issue 1. 1990-02-22. PMID:2606158. |
n-methyl-carbachol, like nicotine, stimulated the release of [3h]dopamine from rat striatal synaptosomes, pre-loaded with [3h]dopamine; release induced by either n-methyl-carbachol or nicotine was inhibited by mecamylamine but not by atropine. |
1990-02-22 |
2023-08-11 |
rat |
| H K Kramer, H Sershen, A Lajtha, M E Reit. The effect of nicotine on catecholaminergic storage vesicles. Brain research. vol 503. issue 2. 1990-02-12. PMID:2605521. |
the present study examined the action of nicotine on the accumulation of [3h]dopamine into synaptic vesicles prepared from mouse cerebral cortex or bovine striatum. |
1990-02-12 |
2023-08-11 |
mouse |
| H K Kramer, H Sershen, A Lajtha, M E Reit. The effect of nicotine on catecholaminergic storage vesicles. Brain research. vol 503. issue 2. 1990-02-12. PMID:2605521. |
nicotine was shown to be a weak inhibitor of [3h]dopamine accumulation, with an ic50 of approximately 0.2-0.4 mm. |
1990-02-12 |
2023-08-11 |
mouse |
| H K Kramer, H Sershen, A Lajtha, M E Reit. The effect of nicotine on catecholaminergic storage vesicles. Brain research. vol 503. issue 2. 1990-02-12. PMID:2605521. |
in addition, repeated nicotine administration (1.2 mg (-)-nicotine di-(+)tartrate/kg s.c., twice daily for 10 days) in vivo in balb/cby male mice did not alter the potency of reserpine in inhibiting [3h]dopamine accumulation into synaptic vesicles, nor did it change the slight shift induced by nicotine in the potency of reserpine in inhibiting [3h]dopamine accumulation. |
1990-02-12 |
2023-08-11 |
mouse |
| H K Kramer, H Sershen, A Lajtha, M E Reit. The effect of nicotine on catecholaminergic storage vesicles. Brain research. vol 503. issue 2. 1990-02-12. PMID:2605521. |
the present results show that nicotine is an inhibitor of vesicular dopamine accumulation at high concentrations. |
1990-02-12 |
2023-08-11 |
mouse |
| C Owman, K Fuxe, A M Janson, J Kåhrströ. Studies of protective actions of nicotine on neuronal and vascular functions in the brain of rats: comparison between sympathetic noradrenergic and mesostriatal dopaminergic fiber systems, and the effect of a dopamine agonist. Progress in brain research. vol 79. 1990-01-10. PMID:2573912. |
studies of protective actions of nicotine on neuronal and vascular functions in the brain of rats: comparison between sympathetic noradrenergic and mesostriatal dopaminergic fiber systems, and the effect of a dopamine agonist. |
1990-01-10 |
2023-08-11 |
rat |
| C Owman, K Fuxe, A M Janson, J Kåhrströ. Studies of protective actions of nicotine on neuronal and vascular functions in the brain of rats: comparison between sympathetic noradrenergic and mesostriatal dopaminergic fiber systems, and the effect of a dopamine agonist. Progress in brain research. vol 79. 1990-01-10. PMID:2573912. |
it is concluded that nicotine, mainly through its protective action on the meso-striatal dopaminergic system, is able to improve striatal glucose utilization and associated blood flow, probably reflecting a tendency to amelioration of neurotransmission function of surviving terminals belonging to the nigro-striatal dopamine neurons. |
1990-01-10 |
2023-08-11 |
rat |
| T C Westfall, G Mereu, L Vickery, H Perry, L Naes, K W Yoo. Regulation by nicotine of midbrain dopamine neurons. Progress in brain research. vol 79. 1990-01-10. PMID:2587742. |
regulation by nicotine of midbrain dopamine neurons. |
1990-01-10 |
2023-08-11 |
Not clear |
| A M Janson, K Fuxe, L F Agnati, A Jansson, B Bjelke, E Sundström, K Andersson, A Härfstrand, M Goldstein, C Owma. Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat. Progress in brain research. vol 79. 1990-01-10. PMID:2587746. |
protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat. |
1990-01-10 |
2023-08-11 |
rat |
| G Damsma, J Day, H C Fibige. Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens. European journal of pharmacology. vol 168. issue 3. 1990-01-03. PMID:2479574. |
in vivo microdialysis was used to sample extracellular dopamine and metabolites after a nicotine challenge (0.35 mg/kg) in (1) naive rats, (2) acutely pretreated rats (1 prior nicotine injection), and (3) chronically pretreated rats (12-15 prior daily nicotine injections, 0.35 mg/kg per injection). |
1990-01-03 |
2023-08-11 |
rat |
| C Owman, K Fuxe, A M Janson, J Kåhrströ. Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats. Neuroscience letters. vol 102. issue 2-3. 1989-11-27. PMID:2812507. |
the eliminated asymmetry probably reflects an increased survival of the dopamine neurons and/or of striatal nerve cells on the lesioned side due to protective effects of nicotine resulting from desensitization of nicotinic-type cholinergic receptors following continuous administration of the drug. |
1989-11-27 |
2023-08-11 |
rat |