| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Costall, R J Naylo. Serotonin and psychiatric disorders. A key to new therapeutic approaches. Arzneimittel-Forschung. vol 42. issue 2A. 1992-06-16. PMID:1586395. |
the 5-ht3 receptor antagonists exert a breadth of action over a wide dose range in rodent and primate models to inhibit aversive behaviour in animal models of anxiety and certain symptoms of withdrawal from drugs of abuse, alcohol, nicotine, diazepam and cocaine, to antagonise increased locomotor activity caused by mesolimbic dopamine excess, and facilitate performance in cognitive tests. |
1992-06-16 |
2023-08-11 |
Not clear |
| H Miyata, K Ando, T Yanagit. [Studies on the involvement of the nucleus accumbens in the discriminative effects of nicotine in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 98. issue 5. 1992-06-16. PMID:1813370. |
2) among the drugs, acetylcholine at 0.5-10 micrograms administered into the lateral ventricle and methamphetamine at 5-40 micrograms and dopamine at 1-10 micrograms administered into the nucleus accumbens, none substituted for subcutaneously administered nicotine. |
1992-06-16 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain research. vol 573. issue 1. 1992-06-08. PMID:1576529. |
inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. |
1992-06-08 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain research. vol 573. issue 1. 1992-06-08. PMID:1576529. |
chronic administration of cocaine (50 mg/kg/day for 7 days, s.c. via an osmotic minipump) produced tolerance to inhibition of [3h]dopamine uptake by cocaine in rat striatum but did not produce cross-tolerance to inhibition of [3h]dopamine uptake by nicotine. |
1992-06-08 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain research. vol 573. issue 1. 1992-06-08. PMID:1576529. |
chronic nicotinic treatment (6 mg/kg/day for 7 days, s.c. via an osmotic minipump), however, produced tolerance to the inhibition of [3h]dopamine uptake by nicotine and cross-tolerance to inhibition of uptake by cocaine in rat striatum. |
1992-06-08 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain research. vol 573. issue 1. 1992-06-08. PMID:1576529. |
nicotine did not inhibit uptake of [3h]dopamine in the nucleus accumbens of saline-treated animals. |
1992-06-08 |
2023-08-11 |
rat |
| P Vezina, G Blanc, J Glowinski, J P Tassi. Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1578364. |
nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. |
1992-06-05 |
2023-08-11 |
Not clear |
| Y K Fung, Y S La. Chronic effects of nicotine on mesolimbic dopaminergic system in rats. Pharmacology, biochemistry, and behavior. vol 41. issue 1. 1992-04-02. PMID:1347177. |
chronic nicotine treatment did not alter the characteristics of [3h]spiperone binding site, the rate of dopamine turnover and the concentrations of gamma-aminobutyric acid in the nucleus accumbens. |
1992-04-02 |
2023-08-11 |
rat |
| J M Paris, K A Cunningha. Serotonin 5-HT3 antagonists do not alter the discriminative stimulus properties of cocaine. Psychopharmacology. vol 104. issue 4. 1992-03-09. PMID:1780417. |
behavioral evidence suggests that 5-ht3 receptors interact with mesolimbic dopamine (da) systems and that 5-ht3 antagonists can interfere with the hyperlocomotive effects of amphetamine and cocaine and the rewarding and stimulus effects of morphine, nicotine and ethanol. |
1992-03-09 |
2023-08-11 |
rat |
| J Grenhoff, A M Janson, T H Svensson, K Fux. Chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction. Brain research. vol 562. issue 2. 1992-03-03. PMID:1773346. |
chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction. |
1992-03-03 |
2023-08-11 |
rat |
| J Grenhoff, A M Janson, T H Svensson, K Fux. Chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction. Brain research. vol 562. issue 2. 1992-03-03. PMID:1773346. |
chronic continuous administration of nicotine (0.125 mg/kg/h, 14 days) to male sprague-dawley rats with a partial hemitransection at the meso-diencephalic junction caused a significant reduction in burst firing of remaining dopamine (da) neurons in the zona compacta, substantia nigra, whereas neither the firing rate nor the number of spontaneously active da cells per track were altered in comparison with saline-treated, hemitransected controls. |
1992-03-03 |
2023-08-11 |
rat |
| M Shirahata, R S Fitzgerald, S Lahir. Sympathetic influence on carotid chemoreceptor response to substance P in the cat. Journal of the autonomic nervous system. vol 35. issue 2. 1991-12-06. PMID:1719058. |
the effects of the commonly used pharmacological agents (nicotine, cyanide, dopamine) on carotid chemoreceptor activity were not affected by the transection of the cvsn, ggn activity was also increased by exogenous sp. |
1991-12-06 |
2023-08-11 |
cat |
| Y K Fung, L A Fiske, Y S La. Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice. General pharmacology. vol 22. issue 4. 1991-12-06. PMID:1936899. |
nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by mptp. |
1991-12-06 |
2023-08-11 |
mouse |
| H Sershen, A Hashim, L Harsing, A Lajth. Chronic nicotine-induced changes in dopaminergic system: effect on behavioral response to dopamine agonist. Pharmacology, biochemistry, and behavior. vol 39. issue 2. 1991-11-26. PMID:1682953. |
the results suggest that chronic nicotine may induce changes in the dopaminergic system, which is reflected in altered behavioral response to a dopamine agonist. |
1991-11-26 |
2023-08-11 |
mouse |
| M F O'Neill, C T Dourish, S D Iverse. Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats. Psychopharmacology. vol 104. issue 3. 1991-11-18. PMID:1833784. |
in addition, the role of dopamine receptors in mediating nicotine-induced locomotor stimulation was investigated by examining the effects of selective d1 and d2 dopamine receptor antagonists on activity induced by nicotine. |
1991-11-18 |
2023-08-11 |
rat |
| M F O'Neill, C T Dourish, S D Iverse. Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats. Psychopharmacology. vol 104. issue 3. 1991-11-18. PMID:1833784. |
the effect appears to be mediated by central nicotine receptors, possibly located on dopaminergic neurons, and also requires the activation of both d1 and d2 dopamine receptors. |
1991-11-18 |
2023-08-11 |
rat |
| W A Corrigall, K M Coe. Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1876661. |
selective dopamine antagonists reduce nicotine self-administration. |
1991-09-26 |
2023-08-11 |
rat |
| W A Corrigall, K M Coe. Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1876661. |
the effects of selective d1 (sch23390) and d2 (spiperone) dopamine antagonists, as well as of haloperidol, were examined on nicotine self-administration, food-maintained responding, and locomotor activity in rats. |
1991-09-26 |
2023-08-11 |
rat |
| W A Corrigall, K M Coe. Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1876661. |
the effects of dopamine antagonists on nicotine self-administration are different from the effects of these antagonists on cocaine self-administration. |
1991-09-26 |
2023-08-11 |
rat |
| D J Balfou. The influence of stress on psychopharmacological responses to nicotine. British journal of addiction. vol 86. issue 5. 1991-09-05. PMID:1859910. |
circumstantial evidence which suggests that the increase in mesolimbic dopamine secretion evoked by nicotine may not only be rewarding per se but may also contribute to the ability of the drug to alleviate the effects of stress is presented. |
1991-09-05 |
2023-08-11 |
Not clear |