| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W A Corrigall, K M Coe. Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938142. |
the nicotine cue was also tested for generalization to the dopamine reuptake blocker gbr 12909. |
1994-11-04 |
2023-08-12 |
rat |
| B A Horger, A Valadez, P J Wellman, S Schen. Augmentation of the neurochemical effects of cocaine in the ventral striatum and medial prefrontal cortex following preexposure to amphetamine, but not nicotine: an in vivo microdialysis study. Life sciences. vol 55. issue 15. 1994-10-25. PMID:7934622. |
this study assessed the ability of cocaine to increase synaptic levels of dopamine (da) in the ventral striatum (vs) and medial prefrontal cortex (mpfc) following repeated daily exposure to amphetamine or nicotine. |
1994-10-25 |
2023-08-12 |
human |
| E P Noble, S T St Jeor, T Ritchie, K Syndulko, S C St Jeor, R J Fitch, R L Brunner, R S Sparke. D2 dopamine receptor gene and cigarette smoking: a reward gene? Medical hypotheses. vol 42. issue 4. 1994-09-26. PMID:8072432. |
in as much as alcohol, cocaine, opiates, nicotine and food are known to increase brain dopamine levels and activate the mesocorticolimbic dopaminergic reward pathways of the brain, it is hypothesized that an inherited deficit of d2 dopamine receptor numbers in brain reward areas of a1 allelic subject predisposes them to substance abuse problems. |
1994-09-26 |
2023-08-12 |
human |
| K Fuxe, L Rosén, A Lippoldt, B Andbjer, U Hasselrot, U B Finnman, L F Agnat. Chronic continuous infusion of nicotine increases the disappearance of choline acetyltransferase immunoreactivity in the cholinergic cell bodies of the medial septal nucleus following a partial unilateral transection of the fimbria fornix. The Clinical investigator. vol 72. issue 4. 1994-09-01. PMID:8043972. |
previous studies have demonstrated that chronic continuous nicotine treatment via minipumps partially protects against mechanically induced degeneration of the nigrostriatal dopamine neurons in the male sprague-dawley rat. |
1994-09-01 |
2023-08-12 |
rat |
| M Shoaib, M E Benwell, M T Akbar, I P Stolerman, D J Balfou. Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists. British journal of pharmacology. vol 111. issue 4. 1994-08-17. PMID:8032593. |
pretreatment attenuated sensitization to the locomotor stimulant effect of nicotine (0.4 mg kg-1, s.c.) and prevented sensitization of nicotine-induced dopamine release in the nucleus accumbens. |
1994-08-17 |
2023-08-12 |
rat |
| P P Rowell, J A Hillebran. Characterization of nicotine-induced desensitization of evoked dopamine release from rat striatal synaptosomes. Journal of neurochemistry. vol 63. issue 2. 1994-08-12. PMID:8035180. |
in this study, the ability of nicotine pretreatment to produce functional desensitization was investigated in rat striatal synaptosomes in which the release of [3h]dopamine was measured with an in vitro superfusion system. |
1994-08-12 |
2023-08-12 |
rat |
| P P Rowell, J A Hillebran. Characterization of nicotine-induced desensitization of evoked dopamine release from rat striatal synaptosomes. Journal of neurochemistry. vol 63. issue 2. 1994-08-12. PMID:8035180. |
pretreatment of synaptosomes with low concentrations of l-nicotine resulted in a decrease in the ability of a subsequent nicotine challenge to evoke [3h]dopamine release. |
1994-08-12 |
2023-08-12 |
rat |
| H Kiba, A Jayarama. Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:7913201. |
nicotine induced c-fos expression in the striatum is mediated mostly by dopamine d1 receptor and is dependent on nmda stimulation. |
1994-08-08 |
2023-08-12 |
rat |
| H Kiba, A Jayarama. Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:7913201. |
to extend our understanding of nicotine and dopamine interactions, we mapped the pattern of c-fos expression in the striatum as an important marker of some of the earliest changes that occur at gene transcription level. |
1994-08-08 |
2023-08-12 |
rat |
| H Kiba, A Jayarama. Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:7913201. |
injections of the selective dopamine d1 antagonist sch 23390, but not d2 antagonist ym 09151-2 or clozapine, a drug with high affinity to d4 receptors, before nicotine injections, completely blocked fos expression in the striatum. |
1994-08-08 |
2023-08-12 |
rat |
| P Vezina, D Hervé, J Glowinski, J P Tassi. Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. Neuroscience letters. vol 168. issue 1-2. 1994-08-08. PMID:8028761. |
injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. |
1994-08-08 |
2023-08-12 |
rat |
| P Vezina, D Hervé, J Glowinski, J P Tassi. Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. Neuroscience letters. vol 168. issue 1-2. 1994-08-08. PMID:8028761. |
the locomotor response to nicotine was assessed four weeks following destruction of mesolimbic dopamine (da) neurons in rats by infusion of 6-hydroxydopamine into the ventral tegmental area. |
1994-08-08 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, L F Khadr. Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. The Clinical investigator. vol 72. issue 3. 1994-07-25. PMID:8012168. |
studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. |
1994-07-25 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, L F Khadr. Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. The Clinical investigator. vol 72. issue 3. 1994-07-25. PMID:8012168. |
the present study examined the effects of constant nicotine infusions on dopamine overflow in the nucleus accumbens and on locomotor activity and compared them with the changes evoked by repeated daily injections (one injection per day for 5 days) of the drug. |
1994-07-25 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, L F Khadr. Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. The Clinical investigator. vol 72. issue 3. 1994-07-25. PMID:8012168. |
repetitive daily subcutaneous injections of nicotine (0.4 mg/kg) enhanced (p < 0.01) the overflow of dopamine evoked by a challenge dose of the drug (0.4 mg/kg) and increased (p < 0.01) its stimulatory effects on locomotor activity. |
1994-07-25 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, L F Khadr. Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. The Clinical investigator. vol 72. issue 3. 1994-07-25. PMID:8012168. |
the constant infusion of nicotine, at doses of 1 and 4 mg/kg per day, abolished (p < 0.05) the effects of a bolus injection of nicotine on extracellular dopamine and attenuated (p < 0.01) the enhanced locomotor response evoked by daily pretreatment with nicotine boli. |
1994-07-25 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, L F Khadr. Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine. The Clinical investigator. vol 72. issue 3. 1994-07-25. PMID:8012168. |
the mesolimbic dopamine response to a bolus injection of nicotine was not significantly attenuated by nicotine infusions when the dose was reduced to 0.25 mg/kg per day. |
1994-07-25 |
2023-08-12 |
rat |
| M Nisell, G G Nomikos, T H Svensso. Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse (New York, N.Y.). vol 16. issue 1. 1994-04-19. PMID:8134899. |
stimulation of the mesolimbic dopamine (da) system is considered of major importance for the rewarding and dependence producing properties of nicotine (nic). |
1994-04-19 |
2023-08-12 |
rat |
| A M Janson, A Mølle. Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: an analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat. Neuroscience. vol 57. issue 4. 1994-03-17. PMID:8309553. |
these findings suggest that continuous nicotine infusion exerts protective effects on lesioned nigroneostriatal dopamine systems and that these protective effects are selective for the nigral dopamine neurons not affecting other populations of neurons or non-neuronal cells. |
1994-03-17 |
2023-08-12 |
rat |
| S N Mitchel. Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine. Neuropharmacology. vol 32. issue 10. 1994-02-25. PMID:8295716. |
in both anaesthetised and freely moving animals nicotine increased extracellular levels of dihydroxyphenylacetic acid and homovanillic acid in the hippocampus, but failed to alter levels of dopamine or 5-hydroxyindoleacetic acid. |
1994-02-25 |
2023-08-12 |
Not clear |