| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
the effects of constant nicotine infusions (0.25, 1.0 and 4.0 mg kg-1 day-1) on extracellular dopamine levels in the nucleus accumbens (nac) and on locomotor activity have been compared with the changes evoked by repeated daily injections (0.4 mg kg-1 day-1 for 5 days) of the drug. |
1995-04-10 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
the extracellular dopamine concentration in the nac was significantly increased (p < 0.05) following a challenge dose of nicotine (0.4 mg kg-1, s.c.) in animals which had been pretreated with daily injections of the drug. |
1995-04-10 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
the stimulant effects of nicotine on mesolimbic dopamine secretion and on locomotor activity were significantly inhibited (p < 0.01) by the prior administration of mecamylamine (2.0 mg kg-1, s.c.) but not by hexamethonium (2.0 mg kg-1, s.c.). |
1995-04-10 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
the constant infusion of nicotine at a rate of 1 and 4 but not 0.25 mg kg-1 day-1 abolished the sensitized dopamine response in the nac to an injection of nicotine in animals pretreated with the drug. |
1995-04-10 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
significantly (p<0.01) enhanced mesolimbic dopamine responses, to a challenge injection of nicotine(0.4 mg kg-1, s.c.), were observed 2 and 7 days after termination of the infusion of nicotine (4 mg kg-1 day-1 for 14 days); locomotor responses were enhanced (p<0.01) 1, 2 and 7 days after termination of the infusion.6. |
1995-04-10 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, C E Birrel. Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. British journal of pharmacology. vol 114. issue 2. 1995-04-10. PMID:7881744. |
the results suggest that sensitized mesolimbic dopamine responses to nicotine occur as a result of stimulation of centrally located nicotinic receptors but that these receptors may be desensitized during periods of chronic exposure to nicotine at doses which may be relevant to smoking. |
1995-04-10 |
2023-08-12 |
rat |
| J L Evenden, M Turpin, L Oliver, C Jenning. Caffeine and nicotine improve visual tracking by rats: a comparison with amphetamine, cocaine and apomorphine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870879. |
the present study was undertaken to determine whether these performance enhancing effects of amphetamine could also be obtained with cocaine and apomorphine, which both have psychomotor stimulant effects through their actions as, respectively, indirect and direct dopamine agonists, and by caffeine and nicotine, which do not have a direct dopaminergic mechanism of action. |
1995-03-29 |
2023-08-12 |
rat |
| M H Joseph, S L Peters, J A Gra. Nicotine blocks latent inhibition in rats: evidence for a critical role of increased functional activity of dopamine in the mesolimbic system at conditioning rather than pre-exposure. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870882. |
nicotine blocks latent inhibition in rats: evidence for a critical role of increased functional activity of dopamine in the mesolimbic system at conditioning rather than pre-exposure. |
1995-03-29 |
2023-08-12 |
human |
| M I Damaj, B R Marti. Is the dopaminergic system involved in the central effects of nicotine in mice? Psychopharmacology. vol 111. issue 1. 1995-03-29. PMID:7870924. |
our data indicate that the dopamine receptors d1 and d2 are not involved in all the central effects of nicotine in mice, but seems to be a substrate for locomotor activation induced by nicotine under specific experimental conditions. |
1995-03-29 |
2023-08-12 |
mouse |
| M E Benwell, D J Balfour, H M Lucch. Influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine. Psychopharmacology. vol 112. issue 4. 1995-03-29. PMID:7871059. |
influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine. |
1995-03-29 |
2023-08-12 |
rat |
| M E Benwell, D J Balfour, H M Lucch. Influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine. Psychopharmacology. vol 112. issue 4. 1995-03-29. PMID:7871059. |
the influence of tetrodotoxin (ttx) and calcium on the increase of extracellular dopamine (da) levels in the nucleus accumbens (nacc), evoked by the systemic administration of nicotine, cocaine and d-amphetamine, have been studied in conscious, freely moving rats using in vivo microdialysis. |
1995-03-29 |
2023-08-12 |
rat |
| D J Balfou. Neural mechanisms underlying nicotine dependence. Addiction (Abingdon, England). vol 89. issue 11. 1995-03-08. PMID:7841851. |
the critique focuses specifically on the evidence that many central nicotinic receptors, including those which mediate the effects of the drug on dopamine secretion, are readily desensitized by chronic exposure to agonist and that hypotheses which assume that nicotine inhaled from tobacco smoke invariably results in stimulation of the receptors must be treated with caution. |
1995-03-08 |
2023-08-12 |
Not clear |
| B Ferger, K Kuschinsk. Activation of dopamine D1 receptors or alpha 1 adrenoceptors is not involved in the EEG effect of nicotine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7845471. |
activation of dopamine d1 receptors or alpha 1 adrenoceptors is not involved in the eeg effect of nicotine in rats. |
1995-03-07 |
2023-08-12 |
rat |
| B Ferger, K Kuschinsk. Activation of dopamine D1 receptors or alpha 1 adrenoceptors is not involved in the EEG effect of nicotine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7845471. |
the effect of nicotine (0.2 mg/kg) was not antagonized by blockade of dopamine d1 receptors by sch 23390 (0.1 mg/kg s.c., 30 min before nicotine), although this drug by itself increased the power in most of the frequency bands. |
1995-03-07 |
2023-08-12 |
rat |
| N Lerner-Marmarosh, F I Carroll, L G Aboo. Antagonism of nicotine's action by cocaine analogs. Life sciences. vol 56. issue 3. 1995-02-16. PMID:7823767. |
there appeared to be a relationship between the potency of the analogs in inhibiting the dopamine transporter and nicotine antagonism. |
1995-02-16 |
2023-08-12 |
mouse |
| A M Janson, P B Hedlund, K Fuxe, G von Eule. Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812781. |
chronic nicotine treatment counteracts dopamine d2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat. |
1995-02-06 |
2023-08-12 |
rat |
| A M Janson, P B Hedlund, K Fuxe, G von Eule. Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812781. |
to further elucidate the previously demonstrated protective actions of nicotine on lesioned nigrostriatal dopamine (da) systems (janson and møller, neuroscience, 57 (1993) 931-941), the present receptor binding experiments were carried out. |
1995-02-06 |
2023-08-12 |
rat |
| M Okamoto, T Kita, H Okuda, T Tanaka, T Nakashim. Effects of aging on acute toxicity of nicotine in rats. Pharmacology & toxicology. vol 75. issue 1. 1994-11-28. PMID:7971729. |
nicotine significantly increased dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in striatum and hippocampus in young rats, but not those in old rats. |
1994-11-28 |
2023-08-12 |
rat |
| W A Corrigall, K M Coe. Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938142. |
dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. |
1994-11-04 |
2023-08-12 |
rat |
| W A Corrigall, K M Coe. Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938142. |
the ability of d1 and d2 dopamine antagonists to reduce the subjective effects of nicotine was examined in rats trained to discriminate nicotine (0.3 mg/kg, base) from saline. |
1994-11-04 |
2023-08-12 |
rat |