| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
using the in vivo microdialysis method, we investigated the effects of systemic injections of varenicline on the extracellular accumbal dopamine levels in response to a systemic challenge of ethanol, nicotine, or the combination of nicotine and ethanol in the experimental rat. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
furthermore, after varenicline pretreatment an acute injection of varenicline antagonized the dopamine stimulatory effect of acute nicotine as well as that of systemic coadministration of ethanol and nicotine. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
in contrast, a pronounced additive dopamine increase was observed when nicotine and ethanol were coadministered in vehicle-pretreated rats. |
2009-04-28 |
2023-08-12 |
rat |
| Neal L Benowit. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual review of pharmacology and toxicology. vol 49. 2009-04-27. PMID:18834313. |
dopamine, glutamate, and gamma aminobutyric acid release are particularly important in the development of nicotine dependence, and corticotropin-releasing factor appears to contribute to nicotine withdrawal. |
2009-04-27 |
2023-08-12 |
Not clear |
| Xiomara A Perez, Kathryn T O'Leary, Neeraja Parameswaran, J Michael McIntosh, Maryka Qui. Prominent role of alpha3/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment. Molecular pharmacology. vol 75. issue 4. 2009-04-23. PMID:19144785. |
prominent role of alpha3/alpha6beta2* nachrs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment. |
2009-04-23 |
2023-08-12 |
monkey |
| Xiomara A Perez, Kathryn T O'Leary, Neeraja Parameswaran, J Michael McIntosh, Maryka Qui. Prominent role of alpha3/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment. Molecular pharmacology. vol 75. issue 4. 2009-04-23. PMID:19144785. |
rodent studies show that short-term nicotine exposure influences stimulated striatal dopamine release with responsiveness dependent on neuronal activity. |
2009-04-23 |
2023-08-12 |
monkey |
| Xiomara A Perez, Kathryn T O'Leary, Neeraja Parameswaran, J Michael McIntosh, Maryka Qui. Prominent role of alpha3/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment. Molecular pharmacology. vol 75. issue 4. 2009-04-23. PMID:19144785. |
nicotine treatment altered both non-burst- and burst-stimulated dopamine release in ventral but not dorsal putamen. |
2009-04-23 |
2023-08-12 |
monkey |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. |
2009-04-23 |
2023-08-12 |
rat |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
despite similarities that extend throughout the striatum, only the nac shell has a conspicuous increase in basal dopamine upon the initial administration of psychostimulant drugs such as nicotine. |
2009-04-23 |
2023-08-12 |
rat |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
to examine this general functional difference between nicotine's action on the dorsolateral striatum and nac shell, we directly monitored dopamine release in rat striatal slices using fast-scan cyclic voltammetry. |
2009-04-23 |
2023-08-12 |
rat |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
nicotine administration increased the firing frequency of dopamine neurons and specifically increased the number and the length of phasic burst firing. |
2009-04-23 |
2023-08-12 |
rat |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
although nicotine decreased low-frequency (tonic) dopamine release in both areas, the increased ratio of phasic bursts relative to tonic firing caused by nicotine boosted the basal dopamine concentration predominantly in the nac shell. |
2009-04-23 |
2023-08-12 |
rat |
| Tianxiang Zhang, Lifen Zhang, Yong Liang, Athanassios G Siapas, Fu-Ming Zhou, John A Dan. Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339599. |
by favoring release from bursts while depressing release from tonic signals, nicotine spreads the range of dopamine signaling and effectively increases the signal-to-noise relationship along dopamine afferents. |
2009-04-23 |
2023-08-12 |
rat |
| Laura E O'Del. A psychobiological framework of the substrates that mediate nicotine use during adolescence. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18723034. |
this pathway originates in the ventral tegmental area (vta) and terminates in the nucleus accumbens (nacc) where dopamine is increased by nicotine but decreased during withdrawal. |
2009-04-15 |
2023-08-12 |
Not clear |
| Laura E O'Del. A psychobiological framework of the substrates that mediate nicotine use during adolescence. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18723034. |
thus, it is hypothesized that adolescents display enhanced nicotine reward and reduced withdrawal via enhanced excitation and reduced inhibition of vta cell bodies that release dopamine in the nacc. |
2009-04-15 |
2023-08-12 |
Not clear |
| Massimo Grilli, Anna Pittaluga, Emilio Merlo-Pich, Mario March. NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. Journal of neurochemistry. vol 108. issue 2. 2009-04-08. PMID:19046354. |
nmda-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. |
2009-04-08 |
2023-08-12 |
rat |
| Massimo Grilli, Anna Pittaluga, Emilio Merlo-Pich, Mario March. NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. Journal of neurochemistry. vol 108. issue 2. 2009-04-08. PMID:19046354. |
in this study, we investigate the effects of chronic administration of (-)nicotine on the function of the nmda-mediated modulation of [(3)h]dopamine (da) release in rat prefrontal cortex (pfc) and nucleus accumbens (nac). |
2009-04-08 |
2023-08-12 |
rat |
| Jacques Barik, Susan Wonnacot. Molecular and cellular mechanisms of action of nicotine in the CNS. Handbook of experimental pharmacology. issue 192. 2009-04-07. PMID:19184650. |
in this chapter, we briefly overview the fundamental characteristics of nachrs that are germane to nicotine's effects and then consider the cellular responses to acute and chronic nicotine, with particular emphasis on dopamine systems because they have been the most widely studied in the context of nicotine dependence. |
2009-04-07 |
2023-08-12 |
Not clear |
| David J K Balfou. The neuronal pathways mediating the behavioral and addictive properties of nicotine. Handbook of experimental pharmacology. issue 192. 2009-04-07. PMID:19184651. |
it focuses on the data (derived principally from studies with experimental animals) showing that nicotine, like other drugs of dependence, stimulates the mesolimbic dopamine (da) neurones that project to the nucleus accumbens and that these effects play a pivotal role in the biology underlying nicotine dependence. |
2009-04-07 |
2023-08-12 |
Not clear |
| Janice W Smith, Ian P Stolerma. Recognising nicotine: the neurobiological basis of nicotine discrimination. Handbook of experimental pharmacology. issue 192. 2009-04-07. PMID:19184654. |
additionally, it appears that interactions of nicotine with the dopamine, serotonin, cannabinoid and probably glutamate systems all contribute to the final perceived stimulus. |
2009-04-07 |
2023-08-12 |
human |